product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
ADAR1 (15.8.6) Antibody
catalog :
sc-73408
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
15.8.6
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; fig s3
Anantharaman A, Jadaliha M, Tripathi V, Nakagawa S, Hirose T, Jantsch M, et al. Paraspeckles modulate the intranuclear distribution of paraspeckle-associated Ctn RNA. Sci Rep. 2016;6:34043 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s7a, s7b
Zhang Q, Xiu B, Zhang L, Chen M, Chi W, Li L, et al. Immunosuppressive lncRNA LINC00624 promotes tumor progression and therapy resistance through ADAR1 stabilization. J Immunother Cancer. 2022;10: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
Guo X, Wiley C, Steinman R, Sheng Y, Ji B, Wang J, et al. Aicardi-Goutières syndrome-associated mutation at ADAR1 gene locus activates innate immune response in mouse brain. J Neuroinflammation. 2021;18:169 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c
Ilik I, Malszycki M, Lübke A, Schade C, Meierhofer D, Aktas T. SON and SRRM2 are essential for nuclear speckle formation. elife. 2020;9: pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Ishizuka J, Manguso R, Cheruiyot C, Bi K, Panda A, Iracheta Vellve A, et al. Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade. Nature. 2019;565:43-48 pubmed publisher
  • western blot; human; fig s7b
Ahmad S, Mu X, Yang F, Greenwald E, Park J, Jacob E, et al. Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation. Cell. 2018;172:797-810.e13 pubmed publisher
  • western blot; human; loading ...; fig s5a
Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Aktas T, Avşar Ilık İ, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G, et al. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. 2017;544:115-119 pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig s2
Behm M, Wahlstedt H, Widmark A, Eriksson M, Ohman M. Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development. J Cell Sci. 2017;130:745-753 pubmed publisher
  • immunocytochemistry; human; fig 8a
Nawaz M, Vik E, Berges N, Fladeby C, Bjørås M, Dalhus B, et al. Regulation of Human Endonuclease V Activity and Relocalization to Cytoplasmic Stress Granules. J Biol Chem. 2016;291:21786-21801 pubmed
  • western blot; mouse; fig 2
Wang H, Wang G, Zhang L, Zhang J, Zhang J, Wang Q, et al. ADAR1 Suppresses the Activation of Cytosolic RNA-Sensing Signaling Pathways to Protect the Liver from Ischemia/Reperfusion Injury. Sci Rep. 2016;6:20248 pubmed publisher
  • immunoprecipitation; human; fig s1
  • western blot; human; 1:1000; fig s11
Bahn J, Ahn J, Lin X, Zhang Q, Lee J, Civelek M, et al. Genomic analysis of ADAR1 binding and its involvement in multiple RNA processing pathways. Nat Commun. 2015;6:6355 pubmed publisher
  • western blot; mouse
Yang S, Deng P, Zhu Z, Zhu J, Wang G, Zhang L, et al. Adenosine deaminase acting on RNA 1 limits RIG-I RNA detection and suppresses IFN production responding to viral and endogenous RNAs. J Immunol. 2014;193:3436-45 pubmed publisher
Cottrell K, Ryu S, Torres L, Schab A, Weber J. Induction of viral mimicry upon loss of DHX9 and ADAR1 in breast cancer cells. bioRxiv. 2023;: pubmed publisher
Voss G, Edsjö A, Bjartell A, Ceder Y. Quantification of microRNA editing using two-tailed RT-qPCR for improved biomarker discovery. RNA. 2021;27:1412-1424 pubmed publisher
Liao G, Tseng Y, Tseng C, Lin F, Yamada Y, Liu H, et al. Adenosine Deaminase Acting on RNA 1 Associates with Orf Virus OV20.0 and Enhances Viral Replication. J Virol. 2019;93: pubmed publisher
Fritzell K, Xu L, Otrocka M, Andréasson C, Ohman M. Sensitive ADAR editing reporter in cancer cells enables high-throughput screening of small molecule libraries. Nucleic Acids Res. 2019;47:e22 pubmed publisher
Giacopuzzi E, Gennarelli M, Sacco C, Filippini A, Mingardi J, Magri C, et al. Genome-wide analysis of consistently RNA edited sites in human blood reveals interactions with mRNA processing genes and suggests correlations with cell types and biological variables. BMC Genomics. 2018;19:963 pubmed publisher
Chen Y, Chang I, Liu H, Ma C, Kuo Y, Shih C, et al. Tumor-associated intronic editing of HNRPLL generates a novel splicing variant linked to cell proliferation. J Biol Chem. 2018;293:10158-10171 pubmed publisher
Nakano M, Fukami T, Gotoh S, Nakajima M. A-to-I RNA Editing Up-regulates Human Dihydrofolate Reductase in Breast Cancer. J Biol Chem. 2017;292:4873-4884 pubmed publisher
Ben Zvi M, Amariglio N, Paret G, Nevo Caspi Y. F11R expression upon hypoxia is regulated by RNA editing. PLoS ONE. 2013;8:e77702 pubmed publisher
Weissbach R, Scadden A. Tudor-SN and ADAR1 are components of cytoplasmic stress granules. RNA. 2012;18:462-71 pubmed publisher
product information
Catalog Number :
sc-73408
Product Name :
ADAR1 (15.8.6) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
15.8.6
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
ADAR1
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA