product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
NFATc2 (4G6-G5) Antibody
catalog :
sc-7296
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4G6-G5
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:500; loading ...; fig 4c
Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, et al. Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk. Sci Rep. 2017;7:46064 pubmed publisher
  • western blot; human; loading ...; fig 3a
Bao M, Wang Y, Liu Y, Shi P, Lu H, Sha W, et al. NFATC3 promotes IRF7 transcriptional activity in plasmacy--toid dendritic cells. J Exp Med. 2016;213:2383-2398 pubmed
  • western blot; human; fig 2
Eriksson J, Le Joncour V, Nummela P, Jahkola T, Virolainen S, Laakkonen P, et al. Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression. Oncotarget. 2016;7:15065-92 pubmed publisher
  • western blot; mouse; fig 6c
Zou Q, Jin J, Xiao Y, Hu H, Zhou X, Jie Z, et al. T cell development involves TRAF3IP3-mediated ERK signaling in the Golgi. J Exp Med. 2015;212:1323-36 pubmed publisher
  • chromatin immunoprecipitation; human; fig 5h
SCANLON C, Banerjee R, Inglehart R, Liu M, Russo N, Hariharan A, et al. Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Nat Commun. 2015;6:6885 pubmed publisher
  • western blot; mouse
Heo D, Lim H, Nam J, Lee M, Kim J. Regulation of phagocytosis and cytokine secretion by store-operated calcium entry in primary isolated murine microglia. Cell Signal. 2015;27:177-86 pubmed publisher
  • western blot; human; loading ...; fig 4e
Geismann C, Grohmann F, Sebens S, Wirths G, Dreher A, Häsler R, et al. c-Rel is a critical mediator of NF-κB-dependent TRAIL resistance of pancreatic cancer cells. Cell Death Dis. 2014;5:e1455 pubmed publisher
Lee S, Kieu C, Martin C, Han J, Chen W, Kim J, et al. NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4. Oncotarget. 2019;10:2306-2319 pubmed publisher
Kycia I, Wolford B, Huyghe J, Fuchsberger C, Vadlamudi S, Kursawe R, et al. A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression. Am J Hum Genet. 2018;102:620-635 pubmed publisher
Chan J, Bhattacharyya D, Lassen K, Ruelas D, Greene W. Calcium/calcineurin synergizes with prostratin to promote NF-?B dependent activation of latent HIV. PLoS ONE. 2013;8:e77749 pubmed publisher
Xing L, Salas M, Zhang H, Gittler J, Ludwig T, Lin C, et al. Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Mamm Genome. 2013;24:30-43 pubmed publisher
Ren Y, Chaerkady R, Hu S, Wan J, Qian J, Zhu H, et al. Unbiased discovery of interactions at a control locus driving expression of the cancer-specific therapeutic and diagnostic target, mesothelin. J Proteome Res. 2012;11:5301-10 pubmed publisher
Braeuer R, Zigler M, Kamiya T, Dobroff A, Huang L, Choi W, et al. Galectin-3 contributes to melanoma growth and metastasis via regulation of NFAT1 and autotaxin. Cancer Res. 2012;72:5757-66 pubmed publisher
Gibson H, Mishra A, Chan D, Hake T, Porcu P, Wong H. Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for Sézary syndrome. J Invest Dermatol. 2013;133:249-57 pubmed publisher
Wake M, Hamada Y, Kumagai K, Tanaka N, Ikeda Y, Nakatani Y, et al. Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibular joints affected by synovial chondromatosis. Br J Oral Maxillofac Surg. 2013;51:164-9 pubmed publisher
Ueberham U, Hilbrich I, Ueberham E, Rohn S, Glöckner P, Dietrich K, et al. Transcriptional control of cell cycle-dependent kinase 4 by Smad proteins--implications for Alzheimer's disease. Neurobiol Aging. 2012;33:2827-40 pubmed publisher
Lunde I, Kvaløy H, Austbø B, Christensen G, Carlson C. Angiotensin II and norepinephrine activate specific calcineurin-dependent NFAT transcription factor isoforms in cardiomyocytes. J Appl Physiol (1985). 2011;111:1278-89 pubmed publisher
Liu J, Yoshida Y, Kunugita N, Noguchi J, Sugiura T, Ding N, et al. Thymocytes are activated by toluene inhalation through the transcription factors NF-?B, STAT5 and NF-AT. J Appl Toxicol. 2010;30:656-60 pubmed publisher
Letelier C, Sanchez M, Garcia Fernandez R, Sanchez B, Garcia Palencia P, Gonzalez Bulnes A, et al. Deleterious effects of progestagen treatment in VEGF expression in corpora lutea of pregnant ewes. Reprod Domest Anim. 2011;46:481-8 pubmed publisher
Murakami S, Fujino H, Takeda I, Momota R, Kumagishi K, Ohtsuka A. Comparison of capillary architecture between slow and fast muscles in rats using a confocal laser scanning microscope. Acta Med Okayama. 2010;64:11-8 pubmed
Ku W, Chiu S, Chen Y, Huang H, Wu W, Chen Y. Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2. Mol Cell Proteomics. 2009;8:2034-50 pubmed publisher
Chen M, Sinha M, Luxon B, Bresnick A, O Connor K. Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. J Biol Chem. 2009;284:1484-94 pubmed publisher
Granja A, Perkins N, Revilla Y. A238L inhibits NF-ATc2, NF-kappa B, and c-Jun activation through a novel mechanism involving protein kinase C-theta-mediated up-regulation of the amino-terminal transactivation domain of p300. J Immunol. 2008;180:2429-42 pubmed
Chandrasekar B, Patel D, Mummidi S, Kim J, Clark R, Valente A. Interleukin-18 suppresses adiponectin expression in 3T3-L1 adipocytes via a novel signal transduction pathway involving ERK1/2-dependent NFATc4 phosphorylation. J Biol Chem. 2008;283:4200-9 pubmed
Medyouf H, Alcalde H, Berthier C, Guillemin M, dos Santos N, Janin A, et al. Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. Nat Med. 2007;13:736-41 pubmed
Chattree V, Khanna N, Rao D. Alterations in T cell signal transduction by M. leprae antigens is associated with downregulation of second messengers PKC, calcium, calcineurin, MAPK and various transcription factors in leprosy patients. Mol Immunol. 2007;44:2066-77 pubmed
Yaghi A, Sims S. Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005;289:L1061-74 pubmed
product information
Product Name :
NFATc2 (4G6-G5) Antibody
Gene Name :
NFATC2
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7296
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
NFATc2
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
433-567 (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA