product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
NFATc1 (7A6) Antibody
catalog :
sc-7294
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7A6
reactivity :
Salmonella enterica, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
citations: 107
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; fig 2
  • immunocytochemistry; mouse; fig 1
Pachulec E, Neitzke Montinelli V, Viola J. NFAT2 Regulates Generation of Innate-Like CD8+ T Lymphocytes and CD8+ T Lymphocytes Responses. Front Immunol. 2016;7:411 pubmed
  • immunohistochemistry - paraffin section; human; loading ...; fig 1c
  • western blot; human; loading ...; fig 1c
Li W, Yu X, Zhu C, Wang Z, Zhao Z, Li Y, et al. Notum attenuates HBV-related liver fibrosis through inhibiting Wnt 5a mediated non-canonical pathways. Biol Res. 2019;52:10 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 4c
Tiedemann K, Sadvakassova G, Mikolajewicz N, Juhas M, Sabirova Z, Tabariès S, et al. Exosomal Release of L-Plastin by Breast Cancer Cells Facilitates Metastatic Bone Osteolysis. Transl Oncol. 2019;12:462-474 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Fujita S, Mukai T, Mito T, Kodama S, Nagasu A, Kittaka M, et al. Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis. Bone. 2018;106:156-166 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 4c
Honjoh C, Chihara K, Yoshiki H, Yamauchi S, Takeuchi K, Kato Y, et al. Association of C-Type Lectin Mincle with FcεRIβγ Subunits Leads to Functional Activation of RBL-2H3 Cells through Syk. Sci Rep. 2017;7:46064 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4p
Wu M, Chen W, Lu Y, Zhu G, Hao L, Li Y. Gα13 negatively controls osteoclastogenesis through inhibition of the Akt-GSK3β-NFATc1 signalling pathway. Nat Commun. 2017;8:13700 pubmed publisher
  • western blot; mouse; 1:600; fig 4a
Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, et al. Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis. Biochim Biophys Acta Mol Basis Dis. 2017;1863:560-568 pubmed publisher
  • western blot; mouse; loading ...; fig 4b
Li S, Yang B, Teguh D, Zhou L, Xu J, Rong L. Amyloid ? Peptide Enhances RANKL-Induced Osteoclast Activation through NF-?B, ERK, and Calcium Oscillation Signaling. Int J Mol Sci. 2016;17: pubmed
  • western blot; human; 1:200; fig 2
Amara S, Alotaibi D, Tiriveedhi V. NFAT5/STAT3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells. Oncol Lett. 2016;12:933-943 pubmed
  • western blot; mouse; loading ...; fig 1f
Fujiwara T, Zhou J, Ye S, Zhao H. RNA-binding protein Musashi2 induced by RANKL is critical for osteoclast survival. Cell Death Dis. 2016;7:e2300 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 7d
Klein Hessling S, Rudolf R, Muhammad K, Knobeloch K, Maqbool M, Cauchy P, et al. A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development. Nat Commun. 2016;7:11841 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 4
Chen C, Lee C, Liu F, Chen T, Ahmed Ali A, Chang D, et al. Design, synthesis and SARs of novel salicylanilides as potent inhibitors of RANKL-induced osteoclastogenesis and bone resorption. Eur J Med Chem. 2016;117:70-84 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 3a
  • western blot; human; 1:200; loading ...; fig 3b
Huang Y, Chen S, Liu R, Chen Y, Lin C, Huang C, et al. CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis. J Mol Med (Berl). 2016;94:1025-37 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 2
  • western blot; mouse; 1:1000; fig s4
Park S, Yun Y, Lim J, Kim M, Kim S, Kim J, et al. Stabilin-2 modulates the efficiency of myoblast fusion during myogenic differentiation and muscle regeneration. Nat Commun. 2016;7:10871 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 5
Munger S, Geng X, Srinivasan R, Witte M, Paul D, Simon A. Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and Connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 2016;412:173-90 pubmed publisher
  • western blot; mouse; fig 7
Shin J, Nunomiya A, Kitajima Y, Dan T, Miyata T, Nagatomi R. Prolyl hydroxylase domain 2 deficiency promotes skeletal muscle fiber-type transition via a calcineurin/NFATc1-dependent pathway. Skelet Muscle. 2016;6:5 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; fig 2
Monaghan M, Linneweh M, Liebscher S, Van Handel B, Layland S, Schenke Layland K. Endocardial-to-mesenchymal transformation and mesenchymal cell colonization at the onset of human cardiac valve development. Development. 2016;143:473-82 pubmed publisher
  • immunocytochemistry; rat; 1:200; fig 6
  • immunocytochemistry; human; 1:200; fig s9
Shen W, Taylor B, Jin Q, Nguyen Tran V, Meeusen S, Zhang Y, et al. Inhibition of DYRK1A and GSK3B induces human β-cell proliferation. Nat Commun. 2015;6:8372 pubmed publisher
  • western blot; mouse; loading ...; fig 7c
Lucena P, Faget D, Pachulec E, Robaina M, Klumb C, Robbs B, et al. NFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains. Mol Cell Biol. 2016;36:119-31 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 3c
Lisak D, Schacht T, Gawlitza A, Albrecht P, Aktas O, Koop B, et al. BAX inhibitor-1 is a Ca(2+) channel critically important for immune cell function and survival. Cell Death Differ. 2016;23:358-68 pubmed publisher
  • western blot; mouse; fig 2
Gurt I, Artsi H, Cohen Kfir E, Hamdani G, Ben Shalom G, Feinstein B, et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS ONE. 2015;10:e0134391 pubmed publisher
  • immunocytochemistry; mouse; fig 3
  • western blot; mouse; fig 3
Li C, Li W, Xiao J, Jiao S, Teng F, Xue S, et al. ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy. EMBO Mol Med. 2015;7:754-69 pubmed publisher
  • immunocytochemistry; human; 1:100
Rafiei S, Tiedemann K, Tabariès S, Siegel P, Komarova S. Peroxiredoxin 4: a novel secreted mediator of cancer induced osteoclastogenesis. Cancer Lett. 2015;361:262-70 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
  • western blot; Salmonella enterica
  • western blot; mouse; loading ...; fig 2a
Quang C, Leboucher S, Passaro D, Fuhrmann L, Nourieh M, Vincent Salomon A, et al. The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells. Cell Death Dis. 2015;6:e1658 pubmed publisher
  • western blot; mouse
Zhao X, Zhu L, Chang Q, Jiang C, You Y, Luo T, et al. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation. J Biol Chem. 2014;289:30052-62 pubmed publisher
  • western blot; mouse
Lu S, Li M, Lin Y. Mitf regulates osteoclastogenesis by modulating NFATc1 activity. Exp Cell Res. 2014;328:32-43 pubmed publisher
  • chromatin immunoprecipitation; mouse
  • western blot; mouse; 1:1000
Yu B, Chang J, Liu Y, Li J, Kevork K, Al Hezaimi K, et al. Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-?B. Nat Med. 2014;20:1009-17 pubmed publisher
  • western blot; mouse
Baek J, Kim J, Cheon Y, Park S, Ahn S, Yoon K, et al. Aconitum pseudo-laeve var. erectum inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis via the c-Fos/nuclear factor of activated T-cells, cytoplasmic 1 signaling pathway and prevents lipopolysaccharide-induced bone. Molecules. 2014;19:11628-44 pubmed publisher
  • western blot; human; fig 7f
Tam A, Wadsworth S, Dorscheid D, Man S, Sin D. Estradiol increases mucus synthesis in bronchial epithelial cells. PLoS ONE. 2014;9:e100633 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Yucel G, Altindag B, Gomez Ospina N, Rana A, Panagiotakos G, Lara M, et al. State-dependent signaling by Cav1.2 regulates hair follicle stem cell function. Genes Dev. 2013;27:1217-22 pubmed publisher
  • immunohistochemistry - paraffin section; human; 4 ug/mL
Crotti T, Dharmapatni A, Alias E, Zannettino A, Smith M, Haynes D. The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints. Arthritis Res Ther. 2012;14:R245 pubmed publisher
Atsuta Y, Tomizawa R, Levin M, Tabin C. L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019;116:21592-21601 pubmed publisher
Costa R, Peruzzo R, Bachmann M, Montà G, Vicario M, Santinon G, et al. Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Cell Rep. 2019;28:1949-1960.e6 pubmed publisher
Pujol J, Heikkila E, Savoia C, Hajibeigi A, De Marchi U, Battiprolu P, et al. Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function. Int J Mol Sci. 2018;19: pubmed publisher
Baek J, Cheon Y, Kwak S, Jun H, Yoon K, Lee M, et al. Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling. Exp Mol Med. 2018;50:50 pubmed publisher
Schubert F, Rapp J, Brauns Schubert P, Schlicher L, Stock K, Wissler M, et al. Requirement of GSK-3 for PUMA induction upon loss of pro-survival PI3K signaling. Cell Death Dis. 2018;9:470 pubmed publisher
Gao Y, Ge W. The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis. Cell Death Dis. 2018;9:33 pubmed publisher
Gabriel C, Gross F, Karl M, Stephanowitz H, Hennig A, Weber M, et al. Identification of Novel Nuclear Factor of Activated T Cell (NFAT)-associated Proteins in T Cells. J Biol Chem. 2016;291:24172-24187 pubmed
Teramachi J, Silbermann R, Yang P, Zhao W, Mohammad K, Guo J, et al. Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo. Leukemia. 2016;30:390-8 pubmed publisher
Hajibeigi A, Dioum E, Guo J, Öz O. Identification of novel regulatory NFAT and TFII-I binding elements in the calbindin-D28k promoter in response to serum deprivation. Biochem Biophys Res Commun. 2015;465:414-420 pubmed publisher
Krzeszinski J, Wei W, Huynh H, Jin Z, Wang X, Chang T, et al. miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2. Nature. 2014;512:431-5 pubmed publisher
Zhao D, Shi Z, Warriner A, Qiao P, Hong H, Wang Y, et al. Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis. PLoS ONE. 2014;9:e102706 pubmed publisher
Chan J, Bhattacharyya D, Lassen K, Ruelas D, Greene W. Calcium/calcineurin synergizes with prostratin to promote NF-?B dependent activation of latent HIV. PLoS ONE. 2013;8:e77749 pubmed publisher
Zhou J, Ye S, Fujiwara T, Manolagas S, Zhao H. Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. J Biol Chem. 2013;288:30064-74 pubmed publisher
Yamaguchi T, Omori M, Tanaka N, Fukui N. Distinct and additive effects of sodium bicarbonate and continuous mild heat stress on fiber type shift via calcineurin/NFAT pathway in human skeletal myoblasts. Am J Physiol Cell Physiol. 2013;305:C323-33 pubmed publisher
Sakai E, Shimada Sugawara M, Yamaguchi Y, Sakamoto H, Fumimoto R, Fukuma Y, et al. Fisetin inhibits osteoclastogenesis through prevention of RANKL-induced ROS production by Nrf2-mediated up-regulation of phase II antioxidant enzymes. J Pharmacol Sci. 2013;121:288-98 pubmed
van der Kraan A, Chai R, Singh P, Lang B, Xu J, Gillespie M, et al. HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors. Biochem J. 2013;451:235-44 pubmed publisher
Mueller K, Quandt J, Marienfeld R, Weihrich P, Fiedler K, Claussnitzer M, et al. Octamer-dependent transcription in T cells is mediated by NFAT and NF-?B. Nucleic Acids Res. 2013;41:2138-54 pubmed publisher
Braun T, Lepper J, Ruiz Heiland G, Hofstetter W, Siegrist M, Lezuo P, et al. Mitogen-activated protein kinase 2 regulates physiological and pathological bone turnover. J Bone Miner Res. 2013;28:936-47 pubmed publisher
Xing L, Salas M, Zhang H, Gittler J, Ludwig T, Lin C, et al. Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Mamm Genome. 2013;24:30-43 pubmed publisher
Gannon S, Cantley M, Haynes D, Hirsch R, Bartold P. Azithromycin suppresses human osteoclast formation and activity in vitro. J Cell Physiol. 2013;228:1098-107 pubmed publisher
Ren Y, Chaerkady R, Hu S, Wan J, Qian J, Zhu H, et al. Unbiased discovery of interactions at a control locus driving expression of the cancer-specific therapeutic and diagnostic target, mesothelin. J Proteome Res. 2012;11:5301-10 pubmed publisher
Hermann Kleiter N, Meisel M, Fresser F, Thuille N, Muller M, Roth L, et al. Nuclear orphan receptor NR2F6 directly antagonizes NFAT and ROR?t binding to the Il17a promoter. J Autoimmun. 2012;39:428-40 pubmed publisher
Pont J, McArdle C, Lopez Bernal A. Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol Endocrinol. 2012;26:1743-56 pubmed
Katika M, Hendriksen P, Shao J, Van Loveren H, Peijnenburg A. Transcriptome analysis of the human T lymphocyte cell line Jurkat and human peripheral blood mononuclear cells exposed to deoxynivalenol (DON): New mechanistic insights. Toxicol Appl Pharmacol. 2012;264:51-64 pubmed publisher
Sakamoto H, Sakai E, Fumimoto R, Yamaguchi Y, Fukuma Y, Nishishita K, et al. Deltamethrin inhibits osteoclast differentiation via regulation of heme oxygenase-1 and NFATc1. Toxicol In Vitro. 2012;26:817-22 pubmed publisher
Pei L, Choi J, Liu J, Lee E, McCarthy B, Wilson J, et al. Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia. Epigenetics. 2012;7:567-78 pubmed publisher
Ishida Kitagawa N, Tanaka K, Bao X, Kimura T, Miura T, Kitaoka Y, et al. Siglec-15 protein regulates formation of functional osteoclasts in concert with DNAX-activating protein of 12 kDa (DAP12). J Biol Chem. 2012;287:17493-502 pubmed publisher
van Kol S, Hendriksen P, Van Loveren H, Peijnenburg A. Transcriptomics analysis of primary mouse thymocytes exposed to bis(tri-n-butyltin)dioxide (TBTO). Toxicology. 2012;296:37-47 pubmed publisher
Jules J, Zhang P, Ashley J, Wei S, Shi Z, Liu J, et al. Molecular basis of requirement of receptor activator of nuclear factor ?B signaling for interleukin 1-mediated osteoclastogenesis. J Biol Chem. 2012;287:15728-38 pubmed publisher
Youn M, Yokoyama A, Fujiyama Nakamura S, Ohtake F, Minehata K, Yasuda H, et al. JMJD5, a Jumonji C (JmjC) domain-containing protein, negatively regulates osteoclastogenesis by facilitating NFATc1 protein degradation. J Biol Chem. 2012;287:12994-3004 pubmed publisher
Verron E, Loubat A, Carle G, Vignes Colombeix C, Strazic I, Guicheux J, et al. Molecular effects of gallium on osteoclastic differentiation of mouse and human monocytes. Biochem Pharmacol. 2012;83:671-9 pubmed publisher
Cheng J, Liu J, Shi Z, Jules J, Xu D, Luo S, et al. Molecular mechanisms of the biphasic effects of interferon-? on osteoclastogenesis. J Interferon Cytokine Res. 2012;32:34-45 pubmed publisher
Vollmers A, Wallace L, Fullard N, Höher T, Alexander M, Reichelt J. Two- and three-dimensional culture of keratinocyte stem and precursor cells derived from primary murine epidermal cultures. Stem Cell Rev. 2012;8:402-13 pubmed publisher
Höher T, Wallace L, Khan K, Cathomen T, Reichelt J. Highly efficient zinc-finger nuclease-mediated disruption of an eGFP transgene in keratinocyte stem cells without impairment of stem cell properties. Stem Cell Rev. 2012;8:426-34 pubmed publisher
Kukita A, Kukita T, Nagata K, Teramachi J, Li Y, Yoshida H, et al. The transcription factor FBI-1/OCZF/LRF is expressed in osteoclasts and regulates RANKL-induced osteoclast formation in vitro and in vivo. Arthritis Rheum. 2011;63:2744-54 pubmed publisher
Morita Y, Ono A, Serizawa A, Yogo K, Ishida Kitagawa N, Takeya T, et al. Purification and identification of lactoperoxidase in milk basic proteins as an inhibitor of osteoclastogenesis. J Dairy Sci. 2011;94:2270-9 pubmed publisher
Bishop K, Coy H, Nerenz R, Meyer M, Pike J. Mouse Rankl expression is regulated in T cells by c-Fos through a cluster of distal regulatory enhancers designated the T cell control region. J Biol Chem. 2011;286:20880-91 pubmed publisher
Guo X, Zhou C, Sun N. The neuropeptide catestatin promotes vascular smooth muscle cell proliferation through the Ca2+-calcineurin-NFAT signaling pathway. Biochem Biophys Res Commun. 2011;407:807-12 pubmed publisher
Cantley M, Fairlie D, Bartold P, Rainsford K, Le G, Lucke A, et al. Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro. J Cell Physiol. 2011;226:3233-41 pubmed publisher
Motegi H, Shimo Y, Akiyama T, Inoue J. TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling. Genes Cells. 2011;16:179-89 pubmed publisher
Uchida K, Aramaki M, Nakazawa M, Yamagishi C, Makino S, Fukuda K, et al. Gene knock-outs of inositol 1,4,5-trisphosphate receptors types 1 and 2 result in perturbation of cardiogenesis. PLoS ONE. 2010;5: pubmed publisher
Lapierre D, Tanabe N, Pereverzev A, Spencer M, Shugg R, Dixon S, et al. Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival. J Biol Chem. 2010;285:25792-801 pubmed publisher
Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, et al. The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med. 2010;207:751-62 pubmed publisher
Maruyama T, Fukushima H, Nakao K, Shin M, Yasuda H, Weih F, et al. Processing of the NF-kappa B2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation. J Bone Miner Res. 2010;25:1058-67 pubmed publisher
Bahtiar A, Matsumoto T, Nakamura T, Akiyama M, Yogo K, Ishida Kitagawa N, et al. Identification of a novel L-serine analog that suppresses osteoclastogenesis in vitro and bone turnover in vivo. J Biol Chem. 2009;284:34157-66 pubmed publisher
Kotake S, Nanke Y, Kawamoto M, Yago T, Udagawa N, Ichikawa N, et al. T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis. Bone. 2009;45:627-39 pubmed publisher
Rinne A, Banach K, Blatter L. Regulation of nuclear factor of activated T cells (NFAT) in vascular endothelial cells. J Mol Cell Cardiol. 2009;47:400-10 pubmed publisher
Tsuji M, Yamamoto H, Sato T, Mizuha Y, Kawai Y, Taketani Y, et al. Dietary quercetin inhibits bone loss without effect on the uterus in ovariectomized mice. J Bone Miner Metab. 2009;27:673-81 pubmed publisher
Rosenkranz A, Rauch B, Freidel K, Schror K. Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT. Cardiovasc Res. 2009;83:778-84 pubmed publisher
Courtwright A, Siamakpour Reihani S, Arbiser J, Banet N, Hilliard E, Fried L, et al. Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. Cancer Res. 2009;69:4621-8 pubmed publisher
Giordano C, Rousseau A, Wagner N, Gaudel C, Murdaca J, Jehl Pietri C, et al. Peroxisome proliferator-activated receptor beta activation promotes myonuclear accretion in skeletal muscle of adult and aged mice. Pflugers Arch. 2009;458:901-13 pubmed publisher
Xue J, Thippegowda P, Hu G, Bachmaier K, Christman J, Malik A, et al. NF-kappaB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappaB site in the ICAM-1 gene. Physiol Genomics. 2009;38:42-53 pubmed publisher
Pang X, Sun N. Calcineurin-NFAT signaling is involved in phenylephrine-induced vascular smooth muscle cell proliferation. Acta Pharmacol Sin. 2009;30:537-44 pubmed publisher
Liu J, Wang S, Zhang P, Said Al Naief N, Michalek S, Feng X. Molecular mechanism of the bifunctional role of lipopolysaccharide in osteoclastogenesis. J Biol Chem. 2009;284:12512-23 pubmed publisher
Friedman M, Oyserman S, Hankenson K. Wnt11 promotes osteoblast maturation and mineralization through R-spondin 2. J Biol Chem. 2009;284:14117-25 pubmed publisher
Li G, Zhang X, Li R, Wang Y, Wang Y, Han K, et al. CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. J Biol Chem. 2008;283:32660-8 pubmed publisher
Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, et al. Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis. J Biol Chem. 2008;283:29593-601 pubmed publisher
Guo Y, Tiedemann K, Khalil J, Russo C, Siegel P, Komarova S. Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation. Bone. 2008;43:386-93 pubmed publisher
Park C, Lee Y, Chang E, Lee M, Yoon J, Ryu J, et al. Bavachalcone inhibits osteoclast differentiation through suppression of NFATc1 induction by RANKL. Biochem Pharmacol. 2008;75:2175-82 pubmed publisher
Fretz J, Shevde N, Singh S, Darnay B, Pike J. Receptor activator of nuclear factor-kappaB ligand-induced nuclear factor of activated T cells (C1) autoregulates its own expression in osteoclasts and mediates the up-regulation of tartrate-resistant acid phosphatase. Mol Endocrinol. 2008;22:737-50 pubmed
Pereverzev A, Komarova S, Korcok J, Armstrong S, Tremblay G, Dixon S, et al. Extracellular acidification enhances osteoclast survival through an NFAT-independent, protein kinase C-dependent pathway. Bone. 2008;42:150-61 pubmed
Park C, Kim H, Kwak H, Lee T, Bang M, Kim C, et al. Inhibitory effects of Stewartia koreana on osteoclast differentiation and bone resorption. Int Immunopharmacol. 2007;7:1507-16 pubmed
Yeo H, Beck L, Thompson S, Farach Carson M, McDonald J, Clemens T, et al. Conditional disruption of calcineurin B1 in osteoblasts increases bone formation and reduces bone resorption. J Biol Chem. 2007;282:35318-27 pubmed
Lehtonen A, Ahlfors H, Veckman V, Miettinen M, Lahesmaa R, Julkunen I. Gene expression profiling during differentiation of human monocytes to macrophages or dendritic cells. J Leukoc Biol. 2007;82:710-20 pubmed
Medyouf H, Alcalde H, Berthier C, Guillemin M, dos Santos N, Janin A, et al. Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. Nat Med. 2007;13:736-41 pubmed
Lejard V, Brideau G, Blais F, Salingcarnboriboon R, Wagner G, Roehrl M, et al. Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts. J Biol Chem. 2007;282:17665-75 pubmed
Shi L, Qiu D, Zhao G, Corthesy B, Lees Miller S, Reeves W, et al. Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells. Nucleic Acids Res. 2007;35:2302-10 pubmed
Alfieri C, Evans Anderson H, Yutzey K. Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscle. Am J Physiol Cell Physiol. 2007;292:C1887-94 pubmed
Nilsson L, Sun Z, Nilsson J, Nordström I, Chen Y, Molkentin J, et al. Novel blocker of NFAT activation inhibits IL-6 production in human myometrial arteries and reduces vascular smooth muscle cell proliferation. Am J Physiol Cell Physiol. 2007;292:C1167-78 pubmed
Yaghi A, Sims S. Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2005;289:L1061-74 pubmed
Angus L, Chakkalakal J, Mejat A, Eibl J, Belanger G, Megeney L, et al. Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. Am J Physiol Cell Physiol. 2005;289:C908-17 pubmed
Komarova S, Pereverzev A, Shum J, Sims S, Dixon S. Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc Natl Acad Sci U S A. 2005;102:2643-8 pubmed
Marafioti T, Marafiot T, Pozzobon M, Hansmann M, Ventura R, Pileri S, et al. The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomas. Br J Haematol. 2005;128:333-42 pubmed
Widlund H, Horstmann M, Price E, Cui J, Lessnick S, Wu M, et al. Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 2002;158:1079-87 pubmed
Wada H, Hasegawa K, Morimoto T, Kakita T, Yanazume T, Abe M, et al. Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription. J Cell Biol. 2002;156:983-91 pubmed
product information
Product Name :
NFATc1 (7A6) Antibody
Gene Name :
NFATC1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7294
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
NFATc1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
197-304 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA