product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Lamin A/C (346) Antibody
catalog :
sc-7293
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
346
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, western blot knockout validation
citations: 43
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; fig 1
González J, Navarro Puche A, Casar B, Crespo P, Andres V. Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope. J Cell Biol. 2008;183:653-66 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Kim M, Morales L, Baek M, Slaga T, DiGiovanni J, Kim D. UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3? axis inhibits keratinocyte survival and proliferation. Oncotarget. 2017;8:90674-90692 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Higuchi Y, Nguyen C, Yasuda S, McMillan M, Hasegawa K, Kahn M. Specific Direct Small Molecule p300/?-Catenin Antagonists Maintain Stem Cell Potency. Curr Mol Pharmacol. 2016;9:272-279 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 2a
Feng X, Krogh K, Wu C, Lin Y, Tsai H, Thayer S, et al. Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death. Nat Commun. 2014;5:4487 pubmed publisher
  • immunocytochemistry; mouse
Legartova S, Stixova L, Laur O, Kozubek S, Sehnalová P, Bartova E. Nuclear structures surrounding internal lamin invaginations. J Cell Biochem. 2014;115:476-87 pubmed publisher
Wang Z, Dong Y, Yang J, He Y, Lin X, Wu F, et al. A new laminopathy caused by an Arg133/Leu mutation in lamin A/C and the effects thereof on adipocyte differentiation and the transcriptome. Adipocyte. 2019;8:280-291 pubmed publisher
Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher
Li J, Aponte Paris S, Thakur H, Kapiloff M, Dodge Kafka K. Muscle A-kinase-anchoring protein-β-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D. J Biol Chem. 2019;294:2543-2554 pubmed publisher
Chi B, O Connell J, Iocolano A, Coady J, Yu Y, Gangopadhyay J, et al. The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex. Nucleic Acids Res. 2018;46:11939-11951 pubmed publisher
Gu W, Mochizuki K, Otsuka K, Hamada R, Takehara A, Matsui Y. Dnd1-mediated epigenetic control of teratoma formation in mouse. Biol Open. 2018;7: pubmed publisher
Yang Z, Maciejowski J, de Lange T. Nuclear Envelope Rupture Is Enhanced by Loss of p53 or Rb. Mol Cancer Res. 2017;15:1579-1586 pubmed publisher
Xu Y, Luo Q, Lin T, Zeng Z, Wang G, Zeng D, et al. U12, a UDCA derivative, acts as an anti-hepatoma drug lead and inhibits the mTOR/S6K1 and cyclin/CDK complex pathways. PLoS ONE. 2014;9:e113479 pubmed publisher
Tin A, Park A, Sundar S, Firestone G. Essential role of the cancer stem/progenitor cell marker nucleostemin for indole-3-carbinol anti-proliferative responsiveness in human breast cancer cells. BMC Biol. 2014;12:72 pubmed publisher
Booth Gauthier E, Du V, Ghibaudo M, Rape A, Dahl K, Ladoux B. Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates. Integr Biol (Camb). 2013;5:569-77 pubmed publisher
Legartova S, Jugova A, Stixova L, Kozubek S, Fojtova M, Zdrahal Z, et al. Epigenetic aspects of HP1 exchange kinetics in apoptotic chromatin. Biochimie. 2013;95:167-79 pubmed publisher
Persaud S, Lin Y, Wu C, Kagechika H, Wei L. Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid. Cell Signal. 2013;25:19-25 pubmed publisher
Ward T, Iorns E, Liu X, Hoe N, Kim P, Singh S, et al. Truncated p110 ERBB2 induces mammary epithelial cell migration, invasion and orthotopic xenograft formation, and is associated with loss of phosphorylated STAT5. Oncogene. 2013;32:2463-74 pubmed publisher
Ho J, Metcalf J, Yan M, Turgeon P, Wang J, Chalsev M, et al. Functional importance of Dicer protein in the adaptive cellular response to hypoxia. J Biol Chem. 2012;287:29003-20 pubmed publisher
Stixova L, Matula P, Kozubek S, Gombitová A, Cmarko D, Raska I, et al. Trajectories and nuclear arrangement of PML bodies are influenced by A-type lamin deficiency. Biol Cell. 2012;104:418-32 pubmed publisher
Gómez Díaz B, Rosas Vargas H, Roque Ramírez B, Meza Espinoza P, Ruano Calderón L, Fernández Valverde F, et al. Immunodetection analysis of muscular dystrophies in Mexico. Muscle Nerve. 2012;45:338-45 pubmed publisher
Kedar P, Stefanick D, Horton J, Wilson S. Increased PARP-1 association with DNA in alkylation damaged, PARP-inhibited mouse fibroblasts. Mol Cancer Res. 2012;10:360-8 pubmed publisher
Butin Israeli V, Ben nun Shaul O, Kopatz I, Adam S, Shimi T, Goldman R, et al. Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry. Nucleus. 2011;2:320-30 pubmed publisher
Arduini A, Serviddio G, Escobar J, Tormos A, Bellanti F, Vina J, et al. Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. Am J Physiol Gastrointest Liver Physiol. 2011;301:G119-27 pubmed publisher
Liu G, Barkho B, Ruiz S, Diep D, Qu J, Yang S, et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature. 2011;472:221-5 pubmed publisher
Frohnert C, Schweizer S, Hoyer Fender S. SPAG4L/SPAG4L-2 are testis-specific SUN domain proteins restricted to the apical nuclear envelope of round spermatids facing the acrosome. Mol Hum Reprod. 2011;17:207-18 pubmed publisher
Tan Y, Chen Y, Yu L, Zhu H, Meng X, Huang X, et al. Two-fold elevation of expression of FoxM1 transcription factor in mouse embryonic fibroblasts enhances cell cycle checkpoint activity by stimulating p21 and Chk1 transcription. Cell Prolif. 2010;43:494-504 pubmed publisher
Zhu F, Dollé M, Berton T, Kuiper R, Capps C, Espejo A, et al. Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res. 2010;70:5851-9 pubmed publisher
Guillaumond F, Grechez Cassiau A, Subramaniam M, Brangolo S, Peteri Brünback B, Staels B, et al. Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver. Mol Cell Biol. 2010;30:3059-70 pubmed publisher
Warters R, Cassidy P, Sunseri J, Parsawar K, Zhuplatov S, Kramer G, et al. The nuclear matrix shell proteome of human epidermis. J Dermatol Sci. 2010;58:113-22 pubmed publisher
Flanagan L, Whyte L, Chatterjee N, Tenniswood M. Effects of clusterin over-expression on metastatic progression and therapy in breast cancer. BMC Cancer. 2010;10:107 pubmed publisher
Fuster J, Gonzalez J, Edo M, Viana R, Boya P, Cervera J, et al. Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6. FASEB J. 2010;24:2998-3009 pubmed publisher
Larsson E, Fredlund Fuchs P, Heldin J, Barkefors I, Bondjers C, Genove G, et al. Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1. Genome Med. 2009;1:108 pubmed publisher
Fish J, Yan M, Matouk C, St Bernard R, Ho J, Gavryushova A, et al. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem. 2010;285:810-26 pubmed publisher
Evdokimova V, Tognon C, Ng T, Sorensen P. Reduced proliferation and enhanced migration: two sides of the same coin? Molecular mechanisms of metastatic progression by YB-1. Cell Cycle. 2009;8:2901-6 pubmed
Schilling S, Hjelmeland A, Radiloff D, Liu I, Wakeman T, Fielhauer J, et al. NDRG4 is required for cell cycle progression and survival in glioblastoma cells. J Biol Chem. 2009;284:25160-9 pubmed publisher
Biddick R, Law G, Chin K, Young E. The transcriptional coactivators SAGA, SWI/SNF, and mediator make distinct contributions to activation of glucose-repressed genes. J Biol Chem. 2008;283:33101-9 pubmed publisher
Biddick R, Law G, Young E. Adr1 and Cat8 mediate coactivator recruitment and chromatin remodeling at glucose-regulated genes. PLoS ONE. 2008;3:e1436 pubmed publisher
Warters R, Williams D, Zhuplatov S, Pond C, Leachman S. Protein phosphorylation in irradiated human melanoma cells. Radiat Res. 2007;168:535-44 pubmed
Gehrig K, Cornell R, Ridgway N. Expansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha. Mol Biol Cell. 2008;19:237-47 pubmed
Aranha M, Borralho P, Ravasco P, Moreira da Silva I, Correia L, Fernandes A, et al. NF-kappaB and apoptosis in colorectal tumourigenesis. Eur J Clin Invest. 2007;37:416-24 pubmed
Hunt M, Brown D. Role of sialidase in Mycoplasma alligatoris-induced pulmonary fibroblast apoptosis. Vet Microbiol. 2007;121:73-82 pubmed
Hunt M, Brown D. Mycoplasma alligatoris infection promotes CD95 (FasR) expression and apoptosis of primary cardiac fibroblasts. Clin Diagn Lab Immunol. 2005;12:1370-7 pubmed
Toth J, Yang S, Qiao X, Beigneux A, Gelb M, Moulson C, et al. Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc Natl Acad Sci U S A. 2005;102:12873-8 pubmed
product information
Product Name :
Lamin A/C (346) Antibody
Gene Name :
LMNA
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7293
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Lamin A/C
reactive species  :
m, r, h
Application :
WB, IP, IF
Epitope :
mouse
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA