product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Lamin A/C (636) Antibody
catalog :
sc-7292
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
636
reactivity :
human, mouse, swine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 143
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1b
Jeppesen D, Fenix A, Franklin J, Higginbotham J, Zhang Q, Zimmerman L, et al. Reassessment of Exosome Composition. Cell. 2019;177:428-445.e18 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 1b
Bejarano D, Peng K, Laketa V, Börner K, Jost K, Lucic B, et al. HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex. elife. 2019;8: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:400; loading ...; fig s1c
Full F, van Gent M, Sparrer K, Chiang C, Zurenski M, Scherer M, et al. Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity. Nat Microbiol. 2019;4:164-176 pubmed publisher
  • immunocytochemistry; human; 1:2000; loading ...; fig 1c
Arii J, Watanabe M, Maeda F, Tokai Nishizumi N, Chihara T, Miura M, et al. ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity. Nat Commun. 2018;9:3379 pubmed publisher
  • western blot; human; loading ...; fig s5b
Melchionna R, Iapicca P, Di Modugno F, Trono P, Sperduti I, Fassan M, et al. The pattern of hMENA isoforms is regulated by TGF-?1 in pancreatic cancer and may predict patient outcome. Oncoimmunology. 2016;5:e1221556 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 3a
  • western blot; human; loading ...; fig 3b
Wu S, Pan S, Zhang L, Baines J, Roller R, Ames J, et al. Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the γ134.5 Protein That Facilitates Nuclear Egress. J Virol. 2016;90:10414-10422 pubmed publisher
  • western blot; human; loading ...; fig 3c
Jinesh G, Molina J, Huang L, Laing N, Mills G, Bar Eli M, et al. Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis. Cell Death Discov. 2016;2:16003 pubmed publisher
  • western blot; human; 1:1000; fig 5g
Kaukonen R, Mai A, Georgiadou M, Saari M, De Franceschi N, Betz T, et al. Normal stroma suppresses cancer cell proliferation via mechanosensitive regulation of JMJD1a-mediated transcription. Nat Commun. 2016;7:12237 pubmed publisher
  • immunocytochemistry; human; fig 1C
Jagadish N, Parashar D, Gupta N, Agarwal S, Suri V, Kumar R, et al. Heat shock protein 70-2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth. BMC Cancer. 2016;16:561 pubmed publisher
  • western blot; human; 1:100; loading ...; fig s4
Calise S, Purich D, Nguyen T, Saleem D, Krueger C, Yin J, et al. 'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway. J Cell Sci. 2016;129:3042-52 pubmed publisher
  • immunocytochemistry; human; fig 3
  • western blot; human; 1:1000; fig 1
Tatsuno T, Nakamura Y, Ma S, Tomosugi N, Ishigaki Y. Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm. Mol Med Rep. 2016;14:655-60 pubmed publisher
  • western blot; human; fig 4
Lee J, Kuo C, Tsai S, Cheng S, Chen S, Chan H, et al. Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells. Front Pharmacol. 2016;7:81 pubmed publisher
  • western blot; human; fig 7
Hall A, Lu W, Godfrey J, Antonov A, Paicu C, Moxon S, et al. The cytoskeleton adaptor protein ankyrin-1 is upregulated by p53 following DNA damage and alters cell migration. Cell Death Dis. 2016;7:e2184 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Huang Y, Peng W, Furuuchi N, DuHadaway J, Jimbo M, Pirritano A, et al. Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy. Oncotarget. 2016;7:21812-24 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 1
Moiseeva O, Lopes Paciencia S, Huot G, Lessard F, Ferbeyre G. Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase. Aging (Albany NY). 2016;8:366-81 pubmed
  • immunocytochemistry; human; 1:500; loading ...; fig 2c
  • western blot; human; 1:2000; loading ...; fig 4c
Moriuchi T, Kuroda M, Kusumoto F, Osumi T, Hirose F. Lamin A reassembly at the end of mitosis is regulated by its SUMO-interacting motif. Exp Cell Res. 2016;342:83-94 pubmed publisher
  • western blot; human; fig 1
Liu L, Liu X, Ren X, Tian Y, Chen Z, Xu X, et al. Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification. Sci Rep. 2016;6:21602 pubmed publisher
  • western blot; human; fig 2
Moudry P, Watanabe K, Wolanin K, Bartkova J, Wassing I, Watanabe S, et al. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J Cell Biol. 2016;212:281-8 pubmed publisher
  • western blot; human; 1:1000; fig 1H
Konzack A, Jakupovic M, Kubaichuk K, Görlach A, Dombrowski F, Miinalainen I, et al. Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. Antioxid Redox Signal. 2015;23:1059-75 pubmed publisher
  • western blot; mouse; 1:1000; fig s1
Marchi S, Corricelli M, Trapani E, Bravi L, Pittaro A, Delle Monache S, et al. Defective autophagy is a key feature of cerebral cavernous malformations. EMBO Mol Med. 2015;7:1403-17 pubmed publisher
  • western blot; human; fig 6
Kim J, Sato M, Choi J, Kim H, Yeh B, Larsen J, et al. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS ONE. 2015;10:e0134842 pubmed publisher
  • immunocytochemistry; human; 1:400; fig s4c
Xu Y, Zhang H, Nguyen V, Angelopoulos N, Nunes J, Reid A, et al. LMTK3 Represses Tumor Suppressor-like Genes through Chromatin Remodeling in Breast Cancer. Cell Rep. 2015;12:837-49 pubmed publisher
  • immunocytochemistry; human; fig s3
  • western blot; human; fig s3
Sadaie M, Dillon C, Narita M, Young A, Cairney C, Godwin L, et al. Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell. 2015;26:2971-85 pubmed publisher
  • western blot; human; 1:1000; fig 1
Moiseeva O, Lessard F, Acevedo Aquino M, Vernier M, Tsantrizos Y, Ferbeyre G. Mutant lamin A links prophase to a p53 independent senescence program. Cell Cycle. 2015;14:2408-21 pubmed publisher
  • western blot; human; fig 2
Sahu G, Farley K, El Hage N, Aiamkitsumrit B, Fassnacht R, Kashanchi F, et al. Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR. Virology. 2015;483:185-202 pubmed publisher
  • western blot; human; 1:1000; fig 1c
Janes K. An analysis of critical factors for quantitative immunoblotting. Sci Signal. 2015;8:rs2 pubmed publisher
  • western blot; human; 1:500; fig s7
Lelek M, Casartelli N, Pellin D, Rizzi E, Souque P, Severgnini M, et al. Chromatin organization at the nuclear pore favours HIV replication. Nat Commun. 2015;6:6483 pubmed publisher
  • immunohistochemistry; human; fig 1
Gibbs Seymour I, Markiewicz E, Bekker Jensen S, Mailand N, Hutchison C. Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage. Aging Cell. 2015;14:162-9 pubmed publisher
  • western blot; human; fig 2
Banach Orlowska M, Szymańska E, Miaczynska M. APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription. FEBS Lett. 2015;589:532-9 pubmed publisher
  • western blot; human; 1:1000
Duque S, Arnold W, Odermatt P, Li X, Porensky P, Schmelzer L, et al. A large animal model of spinal muscular atrophy and correction of phenotype. Ann Neurol. 2015;77:399-414 pubmed publisher
  • immunocytochemistry; human
Eifler M, Uecker R, Weisbach H, Bogdanow B, Richter E, König L, et al. PUL21a-Cyclin A2 interaction is required to protect human cytomegalovirus-infected cells from the deleterious consequences of mitotic entry. PLoS Pathog. 2014;10:e1004514 pubmed publisher
  • immunocytochemistry; human
  • western blot; human; fig 4
Wang Y, Yang Y, Wu S, Pan S, Zhou C, Ma Y, et al. p32 is a novel target for viral protein ICP34.5 of herpes simplex virus type 1 and facilitates viral nuclear egress. J Biol Chem. 2014;289:35795-805 pubmed publisher
  • western blot; human
Kuga T, Nie H, Kazami T, Satoh M, Matsushita K, Nomura F, et al. Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation. Oncogenesis. 2014;3:e94 pubmed publisher
  • western blot; human
Fleischmann K, Pagel P, Schmid I, Roscher A. RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes. Mol Cancer. 2014;13:27 pubmed publisher
  • western blot; human
Zhao X, Nogawa A, Matsunaga T, Takegami T, Nakagawa H, Ishigaki Y. Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells. Int J Oncol. 2014;44:222-8 pubmed publisher
  • western blot; human
Bahammam M, Black S, Sume S, Assaggaf M, Faibish M, Trackman P. Requirement for active glycogen synthase kinase-3? in TGF-?1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts. Am J Physiol Cell Physiol. 2013;305:C581-90 pubmed publisher
  • western blot; swine; 1:40,000
Bosse K, Hans C, Zhao N, Koenig S, Huang N, Guggilam A, et al. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. J Mol Cell Cardiol. 2013;60:27-35 pubmed publisher
  • western blot; human; 1:1000
Chatain N, Ziegler P, Fahrenkamp D, Jost E, Moriggl R, Schmitz Van de Leur H, et al. Src family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene. 2013;32:3587-97 pubmed publisher
  • immunocytochemistry; human
Clever M, Funakoshi T, Mimura Y, Takagi M, Imamoto N. The nucleoporin ELYS/Mel28 regulates nuclear envelope subdomain formation in HeLa cells. Nucleus. 2012;3:187-99 pubmed publisher
  • western blot; human
Ghosh S, Choudary A, Ghosh S, Musi N, Hu Y, Li R. IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells. Mol Endocrinol. 2009;23:662-70 pubmed publisher
Yokoi A, Villar Prados A, Oliphint P, Zhang J, Song X, De Hoff P, et al. Mechanisms of nuclear content loading to exosomes. Sci Adv. 2019;5:eaax8849 pubmed publisher
Xia Y, Pfeifer C, Zhu K, Irianto J, Liu D, Pannell K, et al. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019;: pubmed publisher
Smith L, Irianto J, Xia Y, Pfeifer C, Discher D. Constricted migration modulates stem cell differentiation. Mol Biol Cell. 2019;:mbcE19020090 pubmed publisher
Yang S, Zhang X, Qu H, Qu B, Yin X, Zhao H. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway. Cancer Gene Ther. 2019;: pubmed publisher
Ahn J, Cho M, Sohn S, Lee J. Inhibition of PP2A activity by H2O2 during mitosis disrupts nuclear envelope reassembly and alters nuclear shape. Exp Mol Med. 2019;51:64 pubmed publisher
Zhang L, Yang Z, Huang W, Wu J. H19 potentiates let-7 family expression through reducing PTBP1 binding to their precursors in cholestasis. Cell Death Dis. 2019;10:168 pubmed publisher
Borrenberghs D, Zurnic I, De Wit F, Acke A, Dirix L, Cereseto A, et al. Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration. Nucleic Acids Res. 2019;47:1195-1210 pubmed publisher
Bejarano D, Puertas M, Börner K, Martinez Picado J, Muller B, Kräusslich H. Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages. Viruses. 2018;10: pubmed publisher
Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018;19:189 pubmed publisher
Xia Y, Ivanovska I, Zhu K, Smith L, Irianto J, Pfeifer C, et al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018;217:3796-3808 pubmed publisher
Chow H, Dong B, Valencia C, Zeng C, Koch J, Prudnikova T, et al. Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer. Nat Commun. 2018;9:3473 pubmed publisher
Horiuchi M, Kuga T, Saito Y, Nagano M, Adachi J, Tomonaga T, et al. The tyrosine kinase v-Src causes mitotic slippage by phosphorylating an inhibitory tyrosine residue of Cdk1. J Biol Chem. 2018;293:15524-15537 pubmed publisher
Weydert C, van Heertum B, Dirix L, De Houwer S, De Wit F, Mast J, et al. Y-box-binding protein 1 supports the early and late steps of HIV replication. PLoS ONE. 2018;13:e0200080 pubmed publisher
Galarza Torre A, Shaw J, Wood A, Gilbert H, Dobre O, Genever P, et al. An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness. Sci Rep. 2018;8:8981 pubmed publisher
Zhang Y, Paikari A, Sumazin P, Ginter Summarell C, Crosby J, Boerwinkle E, et al. Metformin induces FOXO3-dependent fetal hemoglobin production in human primary erythroid cells. Blood. 2018;132:321-333 pubmed publisher
Miyai T, Takano J, Endo T, Kawakami E, Agata Y, Motomura Y, et al. Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells. Genes Dev. 2018;32:112-126 pubmed publisher
Browne J, Leir S, Eggener S, Harris A. Region-specific innate antiviral responses of the human epididymis. Mol Cell Endocrinol. 2018;473:72-78 pubmed publisher
Yang Y, Lei T, Du S, Tong R, Wang H, Yang J, et al. Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma. Int J Oncol. 2018;52:709-720 pubmed publisher
Lu Y, Zhao X, Liu Q, Li C, Graves Deal R, Cao Z, et al. lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling. Nat Med. 2017;23:1331-1341 pubmed publisher
Oldenburg A, Briand N, Sørensen A, Cahyani I, Shah A, Moskaug J, et al. A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus. J Cell Biol. 2017;216:2731-2743 pubmed publisher
Petrini S, Borghi R, D Oria V, Restaldi F, Moreno S, Novelli A, et al. Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging. Aging (Albany NY). 2017;9:1453-1469 pubmed publisher
Mayca Pozo F, Tang J, Bonk K, Keri R, Yao X, Zhang Y. Regulatory cross-talk determines the cellular levels of 53BP1 protein, a critical factor in DNA repair. J Biol Chem. 2017;292:5992-6003 pubmed publisher
Wiggan O, Schroder B, Krapf D, Bamburg J, DeLuca J. Cofilin Regulates Nuclear Architecture through a Myosin-II Dependent Mechanotransduction Module. Sci Rep. 2017;7:40953 pubmed publisher
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Yadav S, Magre I, Singh A, Khuperkar D, Joseph J. Regulation of aPKC activity by Nup358 dependent SUMO modification. Sci Rep. 2016;6:34100 pubmed publisher
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Harada T, Swift J, Irianto J, Shin J, Spinler K, Athirasala A, et al. Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. J Cell Biol. 2014;204:669-82 pubmed publisher
Kanojia D, Garg M, Saini S, Agarwal S, Parashar D, Jagadish N, et al. Sperm associated antigen 9 plays an important role in bladder transitional cell carcinoma. PLoS ONE. 2013;8:e81348 pubmed publisher
Stieber D, Golebiewska A, Evers L, Lenkiewicz E, Brons N, Nicot N, et al. Glioblastomas are composed of genetically divergent clones with distinct tumourigenic potential and variable stem cell-associated phenotypes. Acta Neuropathol. 2014;127:203-19 pubmed publisher
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Lund E, Oldenburg A, Delbarre E, Freberg C, Duband Goulet I, Eskeland R, et al. Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes. Genome Res. 2013;23:1580-9 pubmed publisher
Nobata T, Kyougoku H, Miyano T. Hematoxylin staining reveals a decrease in nucleolar diameter of pig oocytes before germinal vesicle breakdown. J Reprod Dev. 2013;59:500-5 pubmed
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Liu L, Zhou Z, Huang S, Guo Y, Fan Y, Zhang J, et al. Zc3h12c inhibits vascular inflammation by repressing NF-?B activation and pro-inflammatory gene expression in endothelial cells. Biochem J. 2013;451:55-60 pubmed publisher
Kyogoku H, Ogushi S, Miyano T. Nucleoli from two-cell embryos support the development of enucleolated germinal vesicle oocytes in the pig. Biol Reprod. 2012;87:113 pubmed publisher
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Hupalowska A, Pyrzynska B, Miaczynska M. APPL1 regulates basal NF-?B activity by stabilizing NIK. J Cell Sci. 2012;125:4090-102 pubmed publisher
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Box A, Kim S, Demetrick D. AKT loss in human epithelial cells treated with severe hypoxia. Biochim Biophys Acta. 2010;1803:951-9 pubmed publisher
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Kyogoku H, Ogushi S, Miyano T. Nucleoli from growing oocytes support the development of enucleolated full-grown oocytes in the pig. Mol Reprod Dev. 2010;77:167-73 pubmed publisher
Ciro M, Prosperini E, Quarto M, Grazini U, Walfridsson J, McBlane F, et al. ATAD2 is a novel cofactor for MYC, overexpressed and amplified in aggressive tumors. Cancer Res. 2009;69:8491-8 pubmed publisher
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Osoata G, Yamamura S, Ito M, Vuppusetty C, Adcock I, Barnes P, et al. Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun. 2009;384:366-71 pubmed publisher
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Dominici S, Fiori V, Magnani M, Schena E, Capanni C, Camozzi D, et al. Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria. Eur J Histochem. 2009;53:43-52 pubmed
Trougakos I, Lourda M, Antonelou M, Kletsas D, Gorgoulis V, Papassideri I, et al. Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. Clin Cancer Res. 2009;15:48-59 pubmed publisher
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Akter R, Rivas D, Geneau G, Drissi H, Duque G. Effect of lamin A/C knockdown on osteoblast differentiation and function. J Bone Miner Res. 2009;24:283-93 pubmed publisher
Kudlow B, Stanfel M, Burtner C, Johnston E, Kennedy B. Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Mol Biol Cell. 2008;19:5238-48 pubmed publisher
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product information
Product Name :
Lamin A/C (636) Antibody
Gene Name :
LMNA
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7292
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Lamin A/C
reactive species  :
human, porcine
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
FL (porcine)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA