product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Lyn (H-6) Antibody
catalog :
sc-7274
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H-6
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 23
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 3e
  • western blot; human; loading ...; fig 2e
Xiong X, Lee C, Li W, Yu J, Zhu L, Kim Y, et al. Acid Sphingomyelinase regulates the localization and trafficking of palmitoylated proteins. Biol Open. 2019;: pubmed publisher
  • western blot; mouse; fig s8a
  • western blot; human; loading ...; fig s8a
Reckel S, Hamelin R, Georgeon S, Armand F, Jolliet Q, Chiappe D, et al. Differential signaling networks of Bcr-Abl p210 and p190 kinases in leukemia cells defined by functional proteomics. Leukemia. 2017;31:1502-1512 pubmed publisher
  • western blot; human; fig 3
Amigo Jiménez I, Bailón E, Aguilera Montilla N, Terol M, García Marco J, García Pardo A. Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathways. Oncotarget. 2015;6:44832-48 pubmed publisher
  • western blot; human; fig 1g
Fukumoto Y, Morii M, Miura T, Kubota S, Ishibashi K, Honda T, et al. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. J Biol Chem. 2014;289:12313-29 pubmed publisher
  • western blot; human
Liu L, Wen Q, Gong R, Gilles L, Stankiewicz M, Guo M, et al. PSTPIP2 dysregulation contributes to aberrant terminal differentiation in GATA-1-deficient megakaryocytes by activating LYN. Cell Death Dis. 2014;5:e988 pubmed publisher
Morii M, Kubota S, Honda T, Yuki R, Morinaga T, Kuga T, et al. Src Acts as an Effector for Ku70-dependent Suppression of Apoptosis through Phosphorylation of Ku70 at Tyr-530. J Biol Chem. 2017;292:1648-1665 pubmed publisher
Hoshina S, Sekizuka T, Kataoka M, Hasegawa H, Hamada H, Kuroda M, et al. Profile of Exosomal and Intracellular microRNA in Gamma-Herpesvirus-Infected Lymphoma Cell Lines. PLoS ONE. 2016;11:e0162574 pubmed publisher
Ho N, Gendron R, Grozinger K, Whelan M, Hicks E, Tennakoon B, et al. Tubedown regulation of retinal endothelial permeability signaling pathways. Biol Open. 2015;4:970-9 pubmed publisher
Watzlawik J, Warrington A, Rodriguez M. PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation. PLoS ONE. 2013;8:e55149 pubmed publisher
Xu W, Allbritton N, Lawrence D. SRC kinase regulation in progressively invasive cancer. PLoS ONE. 2012;7:e48867 pubmed publisher
Delaney M, Liu J, Zheng Y, Berndt M, Du X. The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation. Arterioscler Thromb Vasc Biol. 2012;32:2761-8 pubmed publisher
Yue H, Tanaka K, Furukawa T, Karnik S, Li W. Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3. Biochim Biophys Acta. 2012;1823:1316-23 pubmed publisher
Shuh M, Morse B, Heidecker G, Derse D. Association of SRC-related kinase Lyn with the interleukin-2 receptor and its role in maintaining constitutive phosphorylation of JAK/STAT in human T-cell leukemia virus type 1-transformed T cells. J Virol. 2011;85:4623-7 pubmed publisher
Watzlawik J, Holicky E, Edberg D, Marks D, Warrington A, Wright B, et al. Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes. Glia. 2010;58:1782-93 pubmed publisher
Zumaquero E, Munoz P, Cobo M, Lucena G, Pavón E, Martin A, et al. Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn. Exp Cell Res. 2010;316:2692-706 pubmed publisher
Bilodeau N, Fiset A, Boulanger M, Bhardwaj S, Winstall E, Lavoie J, et al. Proteomic analysis of Src family kinases signaling complexes in Golgi/endosomal fractions using a site-selective anti-phosphotyrosine antibody: identification of LRP1-insulin receptor complexes. J Proteome Res. 2010;9:708-17 pubmed publisher
Chakravarti A, Raquil M, Tessier P, Poubelle P. Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption. Blood. 2009;114:1633-44 pubmed publisher
Zhang Q, Han D, Hu S, Li C, Yu C, Wang R, et al. Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn-ERK1/2-CREB signaling in rat brain ischemia. Hippocampus. 2010;20:65-77 pubmed publisher
Chudakova D, Zeidan Y, Wheeler B, Yu J, Novgorodov S, Kindy M, et al. Integrin-associated Lyn kinase promotes cell survival by suppressing acid sphingomyelinase activity. J Biol Chem. 2008;283:28806-16 pubmed publisher
Popa Nita O, Marois L, Pare G, Naccache P. Crystal-induced neutrophil activation: X. Proinflammatory role of the tyrosine kinase Tec. Arthritis Rheum. 2008;58:1866-76 pubmed publisher
Alessandri Haber N, Dina O, Joseph E, Reichling D, Levine J. Interaction of transient receptor potential vanilloid 4, integrin, and SRC tyrosine kinase in mechanical hyperalgesia. J Neurosci. 2008;28:1046-57 pubmed publisher
Caparros E, Munoz P, Sierra Filardi E, Serrano Gomez D, Puig Kröger A, Rodríguez Fernández J, et al. DC-SIGN ligation on dendritic cells results in ERK and PI3K activation and modulates cytokine production. Blood. 2006;107:3950-8 pubmed
Mock J, Vakevainen M, Deng K, Latimer J, Young J, van Oers N, et al. Haemophilus ducreyi targets Src family protein tyrosine kinases to inhibit phagocytic signaling. Infect Immun. 2005;73:7808-16 pubmed
product information
Product Name :
Lyn (H-6) Antibody
Gene Name :
LYN
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-7274
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Lyn
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
N-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA