product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
β-Actin (AC-15)
catalog :
sc-69879
quantity :
100 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
AC-15
reactivity :
human, mouse, rat, pigs
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 197
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 1h
Huang F, Sun J, Chen W, He X, Zhu Y, Dong H, et al. HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML. Aging (Albany NY). 2020;12:16759-16774 pubmed publisher
  • western blot; rat; 1:1000; loading ...; fig 6g, 6i
Kim O, Booth C, Choi H, Lee J, Kang J, Hur J, et al. High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss. elife. 2020;9: pubmed publisher
  • western blot; human; fig 5
Jung J, Ravi S, Lee D, McFadden K, Kamradt M, Toussaint L, et al. NIK/MAP3K14 Regulates Mitochondrial Dynamics and Trafficking to Promote Cell Invasion. Curr Biol. 2016;26:3288-3302 pubmed publisher
  • western blot; human; 1:2000; fig 2
Sousa A, Rei M, Freitas R, Ricardo S, Caffrey T, David L, et al. Effect of MUC1/?-catenin interaction on the tumorigenic capacity of pancreatic CD133+ cells. Oncol Lett. 2016;12:1811-1817 pubmed
  • western blot; human; fig 3
Nassour H, Wang Z, Saad A, Papaluca A, Brosseau N, Affar E, et al. Peroxiredoxin 1 interacts with and blocks the redox factor APE1 from activating interleukin-8 expression. Sci Rep. 2016;6:29389 pubmed publisher
  • western blot; human; 1:4000; fig 6
Nicolas E, Parisot P, Pinto Monteiro C, de Walque R, De Vleeschouwer C, Lafontaine D. Involvement of human ribosomal proteins in nucleolar structure and p53-dependent nucleolar stress. Nat Commun. 2016;7:11390 pubmed publisher
  • western blot; human; fig 2
Jung J, Kang K, Kim J, Hong S, Park Y, Kim B. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, ?-Catenin, and hTERT Activities. Stem Cells Dev. 2016;25:1006-19 pubmed publisher
  • western blot; human; 1:1000; fig 1
Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger M, Heldin C, et al. Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation. J Biol Chem. 2016;291:12706-23 pubmed publisher
  • western blot; mouse; 1:10,000; fig 5
Chen W, Cao Z, Sugaya S, Lopez M, Sendra V, Laver N, et al. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun. 2016;7:11302 pubmed publisher
  • western blot; human; 1:1000; fig 5
Parameswaran R, Ramakrishnan P, Moreton S, Xia Z, Hou Y, Lee D, et al. Repression of GSK3 restores NK cell cytotoxicity in AML patients. Nat Commun. 2016;7:11154 pubmed publisher
  • western blot; human; fig S7
Almqvist H, Axelsson H, Jafari R, Dan C, Mateus A, Haraldsson M, et al. CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil. Nat Commun. 2016;7:11040 pubmed publisher
  • western blot; mouse; fig s7
Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, et al. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016;64:425-38 pubmed publisher
  • western blot; pigs ; fig 3
Zhao X, Song X, Bai X, Fei N, Huang Y, Zhao Z, et al. miR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1). Peerj. 2016;4:e1635 pubmed publisher
  • western blot; human; fig 5
  • western blot; mouse; fig 7
Ajiro M, Jia R, Yang Y, Zhu J, Zheng Z. A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells. Nucleic Acids Res. 2016;44:1854-70 pubmed publisher
  • western blot; human; fig 4
Ochiai K, Morimatsu M, Kato Y, Ishiguro Oonuma T, Udagawa C, Rungsuriyawiboon O, et al. Tumor suppressor REIC/DKK-3 and co-chaperone SGTA: Their interaction and roles in the androgen sensitivity. Oncotarget. 2016;7:3283-96 pubmed publisher
  • western blot; mouse
Yuniati L, van der Meer L, Tijchon E, van Ingen Schenau D, van Emst L, Levers M, et al. Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress. Oncotarget. 2016;7:3128-43 pubmed publisher
  • western blot; human; fig 1
Yamagishi M, Katano H, Hishima T, Shimoyama T, Ota Y, Nakano K, et al. Coordinated loss of microRNA group causes defenseless signaling in malignant lymphoma. Sci Rep. 2015;5:17868 pubmed publisher
  • western blot; human; 1:2000; fig 7
Yang M, Lin X, Rowe A, Rognes T, Eide L, Bjørås M. Transcriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway. Sci Rep. 2015;5:17409 pubmed publisher
  • western blot; mouse; fig 3
da Rocha A, Pereira B, Pauli J, Cintra D, De Souza C, Ropelle E, et al. Downhill Running-Based Overtraining Protocol Improves Hepatic Insulin Signaling Pathway without Concomitant Decrease of Inflammatory Proteins. PLoS ONE. 2015;10:e0140020 pubmed publisher
  • western blot; human; fig 2
Zhang X, Wang X, Wu T, Li B, Liu T, Wang R, et al. Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. Sci Rep. 2015;5:12579 pubmed publisher
  • western blot; human; fig s1
  • western blot; mouse; fig 1
Chen I, Hsu P, Hsu W, Chen N, Tseng P. Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation. Sci Rep. 2015;5:12300 pubmed publisher
  • western blot; mouse
Homma T, Okano S, Lee J, Ito J, Otsuki N, Kurahashi T, et al. SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse. Biochem Biophys Res Commun. 2015;463:1040-6 pubmed publisher
  • western blot; mouse; fig 4
Chimura T, Launey T, Yoshida N. Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo. PLoS ONE. 2015;10:e0125119 pubmed publisher
  • western blot; human; 1:2000
Masuda K, Chiyoda T, Sugiyama N, Segura Cabrera A, Kabe Y, Ueki A, et al. LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C. PLoS ONE. 2015;10:e0118662 pubmed publisher
  • western blot; human; fig 1
Su C, Zhang C, Tecle A, Fu X, He J, Song J, et al. Tudor staphylococcal nuclease (Tudor-SN), a novel regulator facilitating G1/S phase transition, acting as a co-activator of E2F-1 in cell cycle regulation. J Biol Chem. 2015;290:7208-20 pubmed publisher
  • western blot; human; fig 2
Tang C, Pan Y, Luo H, Xiong W, Zhu H, Ruan H, et al. Hedgehog signaling stimulates the conversion of cholesterol to steroids. Cell Signal. 2015;27:487-97 pubmed publisher
  • western blot; mouse; 1:10,000; fig 6
Chen W, Cao Z, Truong L, Sugaya S, Panjwani N. Fingerprinting of galectins in normal, P. aeruginosa-infected, and chemically burned mouse corneas. Invest Ophthalmol Vis Sci. 2015;56:515-25 pubmed publisher
  • western blot; human; 1:2000
Porter K, Hirt J, Stamer W, Liton P. Autophagic dysregulation in glaucomatous trabecular meshwork cells. Biochim Biophys Acta. 2015;1852:379-85 pubmed publisher
  • western blot; mouse; fig 1
Hatano R, Akiyama K, Tamura A, Hosogi S, Marunaka Y, Caplan M, et al. Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice. Hepatology. 2015;61:1660-71 pubmed publisher
  • western blot; mouse
Yuan Y, Zhai R, Liu X, Khan H, Zhen Y, Huo L. SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation. Mol Reprod Dev. 2014;81:712-24 pubmed publisher
  • western blot; mouse; 1:1000
Stilling R, Rönicke R, Benito E, Urbanke H, Capece V, Burkhardt S, et al. K-Lysine acetyltransferase 2a regulates a hippocampal gene expression network linked to memory formation. EMBO J. 2014;33:1912-27 pubmed publisher
  • western blot; human
Kerdivel G, Boudot A, Habauzit D, Percevault F, Demay F, Pakdel F, et al. Activation of the MKL1/actin signaling pathway induces hormonal escape in estrogen-responsive breast cancer cell lines. Mol Cell Endocrinol. 2014;390:34-44 pubmed publisher
  • western blot; mouse; 1:1000
Koch S, Scifo E, Rokka A, Trippner P, Lindfors M, Korhonen R, et al. Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain. Neurobiol Dis. 2013;50:107-19 pubmed publisher
Cui Y, Wang L, Ding Q, Shin J, Cassel J, Liu Q, et al. Elevated pre-mRNA 3' end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation. Nat Commun. 2023;14:4480 pubmed publisher
Roy M, Surudoi M, Kropp A, Hou J, Dai W, Hardy J, et al. Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling. Nat Commun. 2023;14:3542 pubmed publisher
Sutandy F, G xf6 xdf ner I, Tascher G, M xfc nch C. A cytosolic surveillance mechanism activates the mitochondrial UPR. Nature. 2023;618:849-854 pubmed publisher
Osterburg C, Ferniani M, Antonini D, Frombach A, D Auria L, Osterburg S, et al. Disease-related p63 DBD mutations impair DNA binding by distinct mechanisms and varying degree. Cell Death Dis. 2023;14:274 pubmed publisher
Abuhamad A, Mohamad Zamberi N, Vanharanta S, Mohd Yusuf S, Mohtar M, Syafruddin S. Cancer Cell-Derived PDGFB Stimulates mTORC1 Activation in Renal Carcinoma. Int J Mol Sci. 2023;24: pubmed publisher
Pflug K, Lee D, McFadden K, Herrera L, Sitcheran R. Transcriptional Induction of NF-kB-Inducing Kinase by E2F4/5 Facilitates Collective Invasion of Glioma Cells. Res Sq. 2023;: pubmed publisher
Semesta K, Garces A, Tsvetanova N. The psychosis risk factor RBM12 encodes a novel repressor of GPCR/cAMP signal transduction. bioRxiv. 2023;: pubmed publisher
Yang X, Cruz M, Nguyen E, Huang C, Schittenhelm R, Luu J, et al. The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer. Oncogene. 2023;42:833-847 pubmed publisher
Giordano F, Montalto F, Panno M, Ando S, De Amicis F. A Notch inhibitor plus Resveratrol induced blockade of autophagy drives glioblastoma cell death by promoting a switch to apoptosis. Am J Cancer Res. 2021;11:5933-5950 pubmed
Molagoda I, Kavinda M, Choi Y, Lee H, Kang C, Lee M, et al. Fisetin Protects HaCaT Human Keratinocytes from Fine Particulate Matter (PM2.5)-Induced Oxidative Stress and Apoptosis by Inhibiting the Endoplasmic Reticulum Stress Response. Antioxidants (Basel). 2021;10: pubmed publisher
Molagoda I, Athapaththu A, Choi Y, Park C, Jin C, Kang C, et al. Fisetin Inhibits NLRP3 Inflammasome by Suppressing TLR4/MD2-Mediated Mitochondrial ROS Production. Antioxidants (Basel). 2021;10: pubmed publisher
Yamagishi M, Kubokawa M, Kuze Y, Suzuki A, Yokomizo A, Kobayashi S, et al. Chronological genome and single-cell transcriptome integration characterizes the evolutionary process of adult T cell leukemia-lymphoma. Nat Commun. 2021;12:4821 pubmed publisher
Karunarathne W, Molagoda I, Lee K, Choi Y, Yu S, Kang C, et al. Protective Effect of Anthocyanin-Enriched Polyphenols from Hibiscus syriacus L. (Malvaceae) against Ultraviolet B-Induced Damage. Antioxidants (Basel). 2021;10: pubmed publisher
Itoh R, Hatano N, Murakami M, Mitsumori K, Kawasaki S, Wakagi T, et al. Both IRBIT and long-IRBIT bind to and coordinately regulate Cl-/HCO3- exchanger AE2 activity through modulating the lysosomal degradation of AE2. Sci Rep. 2021;11:5990 pubmed publisher
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Molagoda I, Lee K, Choi Y, Kim G. Anthocyanins from Hibiscus syriacus L. Inhibit Oxidative Stress-Mediated Apoptosis by Activating the Nrf2/HO-1 Signaling Pathway. Antioxidants (Basel). 2020;9: pubmed publisher
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Yoo S, Lee C, An H, Lee J, Lee H, Kang H, et al. RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity. Int J Mol Sci. 2019;20: pubmed publisher
Lee R, Zhang L, Berger A, Lawrence M, Song J, Niranjan B, et al. Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target. Neoplasia. 2019;21:389-400 pubmed publisher
Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, et al. Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis. Protein Cell. 2019;: pubmed publisher
Saini H, Hakeem I, Mukherjee S, Chowdhury S, Chowdhury R. Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells. J Oncol. 2019;2019:6164807 pubmed publisher
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Pan H, Guan D, Liu X, Li J, Wang L, Wu J, et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016;26:190-205 pubmed publisher
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product information
Catalog Number :
sc-69879
Product Name :
β-Actin (AC-15)
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
AC-15
Isotype :
IgG1
Size :
100 µg/ml
List Price :
316 USD
Immunogen :
cytoplasmic beta-Actin
Specificity :
broad species
Uses :
WB, IP, IF
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA