product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
HPV16 E7 (ED17) Antibody
catalog :
sc-6981
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
ED17
reactivity :
Human papillomavirus, human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot; Human papillomavirus; loading ...; fig 6c
Periyasamy M, Singh A, Gemma C, Kranjec C, Farzan R, Leach D, et al. p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells. Nucleic Acids Res. 2017;45:11056-11069 pubmed publisher
  • immunocytochemistry; Human papillomavirus; loading ...; fig 7d
  • western blot; Human papillomavirus; 1:500; loading ...; fig 5a
Zhang X, Hou W, Epperly M, Rigatti L, Wang H, Franicola D, et al. Evolution of malignant plasmacytoma cell lines from K14E7 Fancd2-/- mouse long-term bone marrow cultures. Oncotarget. 2016;7:68449-68472 pubmed publisher
  • western blot; Human papillomavirus; fig 6
Zhou N, Yuan S, Wang R, Zhang W, Chen J. Role of dual specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1B) in S-phase entry of HPV E7 expressing cells from quiescence. Oncotarget. 2015;6:30745-61 pubmed publisher
  • chromatin immunoprecipitation; human; fig 7
Chalertpet K, Pakdeechaidan W, Patel V, Mutirangura A, Yanatatsaneejit P. Human papillomavirus type 16 E7 oncoprotein mediates CCNA1 promoter methylation. Cancer Sci. 2015;106:1333-40 pubmed publisher
  • western blot; human; fig 2c
Li Y, Ma Z, Zhao Y, Zhang J. Immunization with mutant HPV16 E7 protein inhibits the growth of TC-1 cells in tumor-bearing mice. Oncol Lett. 2015;9:1851-1856 pubmed
  • immunocytochemistry; human; loading ...; fig 4
  • western blot; human; 1:1000; loading ...; fig 3
Wu J, Chen K, Gao M, Chen G, Jin S, Zhuang F, et al. Genetic stability of a recombinant adenovirus vaccine vector seed library expressing human papillomavirus type 16 E6 and E7 proteins. Exp Ther Med. 2015;9:1161-1165 pubmed
  • western blot; human
Ding W, Hu Z, Zhu D, Jiang X, Yu L, Wang X, et al. Zinc finger nucleases targeting the human papillomavirus E7 oncogene induce E7 disruption and a transformed phenotype in HPV16/18-positive cervical cancer cells. Clin Cancer Res. 2014;20:6495-503 pubmed publisher
  • immunohistochemistry; human; 1:80-1:100
Chakraborty C, Dutta S, Mukherjee N, Samadder S, Roychowdhury A, Roy A, et al. Inactivation of PTCH1 is associated with the development of cervical carcinoma: clinical and prognostic implication. Tumour Biol. 2015;36:1143-54 pubmed publisher
  • western blot; human
Pang C, Toh S, He P, Teissier S, Ben Khalifa Y, Xue Y, et al. A functional interaction of E7 with B-Myb-MuvB complex promotes acute cooperative transcriptional activation of both S- and M-phase genes. (129 c). Oncogene. 2014;33:4039-49 pubmed publisher
Shankar S, Sreekumar A, Prasad D, Das A, Pillai M. Genome editing of oncogenes with ZFNs and TALENs: caveats in nuclease design. Cancer Cell Int. 2018;18:169 pubmed publisher
Qiao L, Zheng J, Tian Y, Zhang Q, Wang X, Chen J, et al. Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells. Cell Death Dis. 2018;9:583 pubmed publisher
Bienkowska Haba M, Luszczek W, Myers J, Keiffer T, DiGiuseppe S, Polk P, et al. A new cell culture model to genetically dissect the complete human papillomavirus life cycle. PLoS Pathog. 2018;14:e1006846 pubmed publisher
Westrich J, Warren C, Klausner M, Guo K, Liu C, Santiago M, et al. Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation. J Virol. 2018;92: pubmed publisher
Kim K, Godarova A, Seedle K, Kim M, Ince T, Wells S, et al. Rb suppresses collective invasion, circulation and metastasis of breast cancer cells in CD44-dependent manner. PLoS ONE. 2013;8:e80590 pubmed publisher
Benson E, Mungamuri S, Attie O, Kracikova M, Sachidanandam R, Manfredi J, et al. p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes. Oncogene. 2014;33:3959-69 pubmed publisher
Debata P, Castellanos M, Fata J, Baggett S, Rajupet S, Szerszen A, et al. A novel curcumin-based vaginal cream Vacurin selectively eliminates apposed human cervical cancer cells. Gynecol Oncol. 2013;129:145-53 pubmed publisher
Ribelles P, Benbouziane B, Langella P, Suárez J, Bermúdez Humarán L. Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface. Appl Microbiol Biotechnol. 2013;97:1231-9 pubmed publisher
Fan X, Liu Y, Heilman S, Chen J. Human papillomavirus E7 induces rereplication in response to DNA damage. J Virol. 2013;87:1200-10 pubmed publisher
Milrot E, Jackman A, Kniazhanski T, Gonen P, Flescher E, Sherman L. Methyl jasmonate reduces the survival of cervical cancer cells and downregulates HPV E6 and E7, and survivin. Cancer Lett. 2012;319:31-8 pubmed publisher
van der Watt P, Ngarande E, Leaner V. Overexpression of Kpn?1 and Kpn?2 importin proteins in cancer derives from deregulated E2F activity. PLoS ONE. 2011;6:e27723 pubmed publisher
WARD M, van der Watt P, Tzoneva G, Leaner V. Deregulated LAP2? expression in cervical cancer associates with aberrant E2F and p53 activities. IUBMB Life. 2011;63:1018-26 pubmed publisher
Deng X, Li W, Zhang X, Wang C, Dong Z, Zhang X, et al. RNA interference of human papillomavirus type 16 E7 increases HLA class I antigen expression in HaCaT-E7 cells. Int J Gynecol Cancer. 2011;21:28-34 pubmed publisher
Luevano M, Bernard H, Barrera Saldaña H, Trevino V, Garcia Carranca A, Villa L, et al. High-throughput profiling of the humoral immune responses against thirteen human papillomavirus types by proteome microarrays. Virology. 2010;405:31-40 pubmed publisher
Sulg M, Kirjavainen A, Pajusola K, Bueler H, Ylikoski J, Laiho M, et al. Differential sensitivity of the inner ear sensory cell populations to forced cell cycle re-entry and p53 induction. J Neurochem. 2010;112:1513-26 pubmed publisher
Dutta T, Burgess M, McMillan N, Parekh H. Dendrosome-based delivery of siRNA against E6 and E7 oncogenes in cervical cancer. Nanomedicine. 2010;6:463-70 pubmed publisher
Bellone S, El Sahwi K, Cocco E, Casagrande F, Cargnelutti M, Palmieri M, et al. Human papillomavirus type 16 (HPV-16) virus-like particle L1-specific CD8+ cytotoxic T lymphocytes (CTLs) are equally effective as E7-specific CD8+ CTLs in killing autologous HPV-16-positive tumor cells in cervical cancer patients: implications for L. J Virol. 2009;83:6779-89 pubmed publisher
Li W, Kotoshiba S, Berthet C, Hilton M, Kaldis P. Rb/Cdk2/Cdk4 triple mutant mice elicit an alternative mechanism for regulation of the G1/S transition. Proc Natl Acad Sci U S A. 2009;106:486-91 pubmed publisher
Li H, Ou X, Xiong J, Wang T. HPV16E7 mediates HADC chromatin repression and downregulation of MHC class I genes in HPV16 tumorigenic cells through interaction with an MHC class I promoter. Biochem Biophys Res Commun. 2006;349:1315-21 pubmed
Fikaris A, Lewis A, Abulaiti A, Tsygankova O, Meinkoth J. Ras triggers ataxia-telangiectasia-mutated and Rad-3-related activation and apoptosis through sustained mitogenic signaling. J Biol Chem. 2006;281:34759-67 pubmed
Tang S, Tao M, McCoy J, Zheng Z. The E7 oncoprotein is translated from spliced E6*I transcripts in high-risk human papillomavirus type 16- or type 18-positive cervical cancer cell lines via translation reinitiation. J Virol. 2006;80:4249-63 pubmed
Tang S, Tao M, McCoy J, Zheng Z. Short-term induction and long-term suppression of HPV16 oncogene silencing by RNA interference in cervical cancer cells. Oncogene. 2006;25:2094-104 pubmed
Lentini L, Iovino F, Amato A, Di Leonardo A. Centrosome amplification induced by hydroxyurea leads to aneuploidy in pRB deficient human and mouse fibroblasts. Cancer Lett. 2006;238:153-60 pubmed
Valdespino V, Gorodezky C, Ortiz V, Kaufmann A, Román Basaure E, Vazquez A, et al. HPV16-specific cytotoxic T lymphocyte responses are detected in all HPV16-positive cervical cancer patients. Gynecol Oncol. 2005;96:92-102 pubmed
product information
Product Name :
HPV16 E7 (ED17) Antibody
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-6981
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
HPV16 E7
reactive species  :
HPV-16
Application :
WB, IP, IF, ELISA
Epitope :
1-98
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA