product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
BRCA1 (D-9) Antibody
catalog :
sc-6954
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-9
reactivity :
human, mouse, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 112
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; fig 5c
  • western blot; human; loading ...; fig 6f
Liu F, Han Q, Zhang T, Chang F, Deng J, Huang X, et al. CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability. Int J Biol Sci. 2022;18:1434-1450 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2d
  • western blot; human; loading ...; fig 4c
Li W, Gu X, Liu C, Shi Y, Wang P, Zhang N, et al. A synergetic effect of BARD1 mutations on tumorigenesis. Nat Commun. 2021;12:1243 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 5j
Nouws J, Wan F, Finnemore E, Roque W, Kim S, Bazan I, et al. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. JCI Insight. 2021;6: pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 7f
Mita P, Sun X, Fenyo D, Kahler D, Li D, Agmon N, et al. BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Nat Struct Mol Biol. 2020;27:179-191 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2b
  • western blot; human; loading ...; fig 2f
Huo D, Chen H, Cheng Y, Song X, Zhang K, Li M, et al. JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity. Cell Death Differ. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 1h
Wang H, Xiang D, Liu B, He A, Randle H, Zhang K, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178:135-151.e19 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 5i
Xie Y, Fan H, Lu W, Yang Q, Nurkesh A, Yeleussizov T, et al. Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer. Oncogene. 2019;38:2967-2983 pubmed publisher
  • immunocytochemistry; human; 1:250; loading ...; fig s3b
Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, et al. ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage. Nat Commun. 2018;9:2736 pubmed publisher
  • western blot; human; 1:200; fig 4d
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018;19:37 pubmed publisher
  • western blot; human; fig 3a
Kim J, Sturgill D, Sebastian R, Khurana S, Tran A, Edwards G, et al. Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions. Mol Cell. 2018;69:36-47.e7 pubmed publisher
  • western blot; human; loading ...; fig 2a
Paculova H, Kramara J, Simečková S, Fedr R, Soucek K, Hylse O, et al. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Tumour Biol. 2017;39:1010428317727479 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4c
Paul A, Wang B. RNF8- and Ube2S-Dependent Ubiquitin Lysine 11-Linkage Modification in Response to DNA Damage. Mol Cell. 2017;66:458-472.e5 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4a
Smith E, Gole B, Willis N, Soria R, Starnes L, Krumpelbeck E, et al. DEK is required for homologous recombination repair of DNA breaks. Sci Rep. 2017;7:44662 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 6d
  • western blot; human; loading ...; fig 7e
Leung J, Makharashvili N, Agarwal P, Chiu L, Pourpre R, Cammarata M, et al. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes Dev. 2017;31:260-274 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5a
Urban V, Dobrovolna J, Huhn D, Fryzelkova J, Bartek J, Janscak P. RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells. J Cell Biol. 2016;214:401-15 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 3a
  • western blot; human; loading ...; fig s1
Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, et al. Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Oncotarget. 2016;7:57679-57693 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 5
Jullien D, Vignard J, Fedor Y, Bery N, Olichon A, Crozatier M, et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J Cell Sci. 2016;129:2673-83 pubmed publisher
  • western blot; human; fig 2
Yalon M, Tuval Kochen L, Castel D, Moshe I, Mazal I, Cohen O, et al. Overcoming Resistance of Cancer Cells to PARP-1 Inhibitors with Three Different Drug Combinations. PLoS ONE. 2016;11:e0155711 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 2e
Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed publisher
  • immunocytochemistry; human; fig s2
Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed publisher
  • immunocytochemistry; human; fig 3
Moudry P, Watanabe K, Wolanin K, Bartkova J, Wassing I, Watanabe S, et al. TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity. J Cell Biol. 2016;212:281-8 pubmed publisher
  • immunocytochemistry; human; 1:400; fig 4
Soo Lee N, Jin Chung H, Kim H, Yun Lee S, Ji J, Seo Y, et al. TRAIP/RNF206 is required for recruitment of RAP80 to sites of DNA damage. Nat Commun. 2016;7:10463 pubmed publisher
  • immunocytochemistry; human; fig 4
Kuo C, Li X, Stark J, Shih H, Ann D. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle. 2016;15:787-98 pubmed publisher
  • western blot; human
Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, et al. Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature. 2015;527:389-93 pubmed publisher
  • immunocytochemistry; human; fig 3
  • western blot; human; fig s10
Castella M, Jacquemont C, Thompson E, Yeo J, Cheung R, Huang J, et al. FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2. PLoS Genet. 2015;11:e1005563 pubmed publisher
  • immunocytochemistry; human; fig 4
Hedstrom E, Pederiva C, Farnebo J, Nodin B, Jirstrom K, Brennan D, et al. Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome. Cell Death Dis. 2015;6:e1892 pubmed publisher
  • immunoprecipitation; human; fig 1b
Lüddecke S, Ertych N, Stenzinger A, Weichert W, Beissbarth T, Dyczkowski J, et al. The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. Oncogene. 2016;35:2398-406 pubmed publisher
  • western blot; mouse; fig 3b
Lin H, Ha K, Lu G, Fang X, Cheng R, Zuo Q, et al. Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break Repair. Mol Cell Biol. 2015;35:3657-68 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 2a
Wang Y, Deng O, Feng Z, Du Z, Xiong X, Lai J, et al. RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. Oncogene. 2016;35:1363-72 pubmed publisher
  • immunocytochemistry; human; fig 4
Lin Y, Yuan J, Pei H, Liu T, Ann D, Lou Z. KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair. PLoS ONE. 2015;10:e0123935 pubmed publisher
  • western blot; human; 1:50; fig 2
Raymond A, Benhamouche S, Neaud V, Di Martino J, Javary J, Rosenbaum J. Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma. PLoS ONE. 2015;10:e0123333 pubmed publisher
  • immunocytochemistry; human; fig 2a
Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, et al. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev. 2014;28:2726-38 pubmed publisher
  • western blot; human; 1:500; fig 5
Bursomanno S, Beli P, Khan A, Minocherhomji S, Wagner S, Bekker Jensen S, et al. Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. DNA Repair (Amst). 2015;25:84-96 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunoprecipitation; human
  • western blot; human
Peng Y, Dai H, Wang E, Lin C, Mo W, Peng G, et al. TUSC4 functions as a tumor suppressor by regulating BRCA1 stability. Cancer Res. 2015;75:378-86 pubmed publisher
  • chromatin immunoprecipitation; human; fig 7
  • western blot; human; fig 1
Pickholtz I, Saadyan S, Keshet G, Wang V, Cohen R, Bouwman P, et al. Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells. Oncotarget. 2014;5:11827-46 pubmed
  • immunocytochemistry; human
Carvalho S, Vítor A, Sridhara S, Martins F, Raposo A, Desterro J, et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. elife. 2014;3:e02482 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Wang Y, Wang Z, Qi Z, Yin S, Zhang N, Liu Y, et al. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Mol Cancer. 2014;13:94 pubmed publisher
  • western blot; human
Savage K, Gorski J, Barros E, Irwin G, Manti L, Powell A, et al. Identification of a BRCA1-mRNA splicing complex required for efficient DNA repair and maintenance of genomic stability. Mol Cell. 2014;54:445-59 pubmed publisher
  • western blot; human
Zhou Y, Caron P, Legube G, Paull T. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res. 2014;42:e19 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Ogiwara H, Kohno T. CBP and p300 histone acetyltransferases contribute to homologous recombination by transcriptionally activating the BRCA1 and RAD51 genes. PLoS ONE. 2012;7:e52810 pubmed publisher
  • immunocytochemistry; human
Culver Cochran A, Chadwick B. The WSTF-ISWI chromatin remodeling complex transiently associates with the human inactive X chromosome during late S-phase prior to BRCA1 and γ-H2AX. PLoS ONE. 2012;7:e50023 pubmed publisher
  • western blot; human
Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, et al. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells. 2012;17:962-70 pubmed publisher
  • western blot; rhesus macaque; fig 3
Boichuk S, Hu L, Hein J, Gjoerup O. Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen. J Virol. 2010;84:8007-20 pubmed publisher
  • immunocytochemistry; human
Shao G, Patterson Fortin J, Messick T, Feng D, Shanbhag N, Wang Y, et al. MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks. Genes Dev. 2009;23:740-54 pubmed publisher
Pinto L, Pailas A, Bondarchenko M, Sharma A, Neumann K, Rizzo A, et al. DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks. Nucleic Acids Res. 2023;: pubmed publisher
Maurer A, Benyamini B, Fan V, Whitney O, Dailey G, Darzacq X, et al. Double-Strand Break Repair Pathways Differentially Affect Processing and Transduction by Dual AAV Vectors. bioRxiv. 2023;: pubmed publisher
Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, et al. Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells. Nat Commun. 2023;14:5607 pubmed publisher
Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, et al. DePARylation is critical for S phase progression and cell survival. bioRxiv. 2023;: pubmed publisher
Bu C, Zhao L, Wang L, Yu Z, Zhou J. mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance. Oncol Res. 2023;31:495-503 pubmed publisher
Hovland H, Mchaina E, H xf8 berg Vetti H, Ariansen S, Sjursen W, Van Ghelue M, et al. Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions. Genes (Basel). 2023;14: pubmed publisher
Sigismondo G, Arseni L, Palacio Escat N, Hofmann T, Seiffert M, Krijgsveld J. Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair. Nucleic Acids Res. 2023;51:687-711 pubmed publisher
Berthault N, Bergam P, Pereira F, Girard P, Dutreix M. Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA. Cells. 2022;11: pubmed publisher
Bunch H, Jeong J, Kang K, Jo D, Cong A, Kim D, et al. BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ. Open Biol. 2021;11:210221 pubmed publisher
Xu S, Wu X, Wang P, Cao S, Peng B, Xu X. ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. iScience. 2021;24:102534 pubmed publisher
Xu X, Ni K, He Y, Ren J, Sun C, Liu Y, et al. The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation. Nat Commun. 2021;12:3520 pubmed publisher
Miyauchi T, Suzuki S, Takeda M, Peh J, Aiba M, Natsuga K, et al. Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism. Am J Hum Genet. 2021;108:1026-1039 pubmed publisher
Minten E, Kapoor Vazirani P, Li C, Zhang H, Balakrishnan K, Yu D. SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation. Cell Rep. 2021;34:108921 pubmed publisher
Kaur A, Lim J, Sepramaniam S, Patnaik S, Harmston N, Lee M, et al. WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. EMBO Mol Med. 2021;13:e13349 pubmed publisher
Cuella Martin R, Hayward S, Fan X, Chen X, Huang J, Taglialatela A, et al. Functional interrogation of DNA damage response variants with base editing screens. Cell. 2021;184:1081-1097.e19 pubmed publisher
McKinzey D, Gomathinayagam S, Griffin W, Klinzing K, Jeffries E, Rajkovic A, et al. Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment. J Biol Chem. 2021;296:100355 pubmed publisher
Dong C, An L, Yu C, Huen M. A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Res. 2021;: pubmed publisher
Eckelmann B, Bacolla A, Wang H, Ye Z, Guerrero E, Jiang W, et al. XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. NAR Cancer. 2020;2:zcaa013 pubmed publisher
Zhu C, Rogers A, Asleh K, Won J, Gao D, Leung S, et al. Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer. Cell Rep. 2020;31:107745 pubmed publisher
Fan L, Xu S, Zhang F, Cui X, Fazli L, Gleave M, et al. Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells. Cell Death Dis. 2020;11:214 pubmed publisher
Chen H, Shan J, Liu J, Feng Y, Ke Y, Qi W, et al. RNF8 promotes efficient DSB repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60. Cell Prolif. 2020;53:e12780 pubmed publisher
Cárdenas H, Jiang G, Thomes Pepin J, Parker J, Condello S, Nephew K, et al. Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer. NPJ Precis Oncol. 2019;3:32 pubmed publisher
Kanakkanthara A, Huntoon C, Hou X, Zhang M, Heinzen E, O Brien D, et al. ZC3H18 specifically binds and activates the BRCA1 promoter to facilitate homologous recombination in ovarian cancer. Nat Commun. 2019;10:4632 pubmed publisher
Parvin S, Ramírez Labrada A, Aumann S, Lu X, Weich N, Santiago G, et al. LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. Cancer Cell. 2019;36:237-249.e6 pubmed publisher
Kim H, Lin Q, Yun Z. BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors. Sci Rep. 2019;9:9702 pubmed publisher
Jayavaradhan R, Pillis D, Goodman M, Zhang F, Zhang Y, Andreassen P, et al. CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites. Nat Commun. 2019;10:2866 pubmed publisher
Xia Y, Pfeifer C, Zhu K, Irianto J, Liu D, Pannell K, et al. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019;: pubmed publisher
Zhang J, Lee Y, Dang F, Gan W, Menon A, Katon J, et al. PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage. Cancer Discov. 2019;: pubmed publisher
West K, Kelliher J, Xu Z, An L, Reed M, Eoff R, et al. LC8/DYNLL1 is a 53BP1 effector and regulates checkpoint activation. Nucleic Acids Res. 2019;: pubmed publisher
Nakamura K, Saredi G, Becker J, Foster B, Nguyen N, Beyer T, et al. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nat Cell Biol. 2019;21:311-318 pubmed publisher
Chen H, Shan J, Chen D, Wang R, Qi W, Wang H, et al. CtIP promotes G2/M arrest in etoposide-treated HCT116 cells in a p53-independent manner. J Cell Physiol. 2018;: pubmed publisher
Baek H, Kim S, Choi E, Kim J, Shin D, Park E, et al. Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation. Int J Biol Sci. 2018;14:1755-1768 pubmed publisher
Simhadri S, Vincelli G, Huo Y, Misenko S, Foo T, Ahlskog J, et al. PALB2 connects BRCA1 and BRCA2 in the G2/M checkpoint response. Oncogene. 2019;38:1585-1596 pubmed publisher
Milevskiy M, Sandhu G, Wronski A, Korbie D, Brewster B, Shewan A, et al. MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer. Oncotarget. 2018;9:33577-33588 pubmed publisher
Teng Y, Yadav T, Duan M, Tan J, Xiang Y, Gao B, et al. ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB. Nat Commun. 2018;9:4115 pubmed publisher
Xia Y, Ivanovska I, Zhu K, Smith L, Irianto J, Pfeifer C, et al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018;217:3796-3808 pubmed publisher
Hollingsworth J, Lau A, Tone A, Kollara A, Allen L, Colgan T, et al. BRCA1 Mutation Status and Follicular Fluid Exposure Alters NFκB Signaling and ISGylation in Human Fallopian Tube Epithelial Cells. Neoplasia. 2018;20:697-709 pubmed publisher
Lesport E, Ferster A, Biver A, Roch B, Vasquez N, Jabado N, et al. Reduced recruitment of 53BP1 during interstrand crosslink repair is associated with genetically inherited attenuation of mitomycin C sensitivity in a family with Fanconi anemia. Oncotarget. 2018;9:3779-3793 pubmed publisher
Onyango D, Lee G, Stark J. PRPF8 is important for BRCA1-mediated homologous recombination. Oncotarget. 2017;8:93319-93337 pubmed publisher
Hromas R, Kim H, Sidhu G, Williamson E, Jaiswal A, Totterdale T, et al. The endonuclease EEPD1 mediates synthetic lethality in RAD52-depleted BRCA1 mutant breast cancer cells. Breast Cancer Res. 2017;19:122 pubmed publisher
Nath S, Somyajit K, Mishra A, Scully R, Nagaraju G. FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids. Nucleic Acids Res. 2017;45:8886-8900 pubmed publisher
Hollingworth R, Horniblow R, Forrest C, Stewart G, Grand R. Localization of Double-Strand Break Repair Proteins to Viral Replication Compartments following Lytic Reactivation of Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2017;91: pubmed publisher
Clarke T, Sanchez Bailon M, Chiang K, Reynolds J, Herrero Ruiz J, Bandeiras T, et al. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017;65:900-916.e7 pubmed publisher
Biehs R, Steinlage M, Barton O, Juhasz S, Künzel J, Spies J, et al. DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination. Mol Cell. 2017;65:671-684.e5 pubmed publisher
Moureau S, Luessing J, Harte E, Voisin M, Lowndes N. A role for the p53 tumour suppressor in regulating the balance between homologous recombination and non-homologous end joining. Open Biol. 2016;6: pubmed
Wang Y, Krais J, Bernhardy A, Nicolas E, Cai K, Harrell M, et al. RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. J Clin Invest. 2016;126:3145-57 pubmed publisher
Xu Y, Wu X, Her C. hMSH5 Facilitates the Repair of Camptothecin-induced Double-strand Breaks through an Interaction with FANCJ. J Biol Chem. 2015;290:18545-58 pubmed publisher
Li D, Dong Q, Tao Q, Gu J, Cui Y, Jiang X, et al. c-Abl regulates proteasome abundance by controlling the ubiquitin-proteasomal degradation of PSMA7 subunit. Cell Rep. 2015;10:484-96 pubmed publisher
Benada J, Burdová K, Lidak T, von Morgen P, Macurek L. Polo-like kinase 1 inhibits DNA damage response during mitosis. Cell Cycle. 2015;14:219-31 pubmed publisher
Leung J, Agarwal P, Canny M, Gong F, Robison A, Finkelstein I, et al. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. PLoS Genet. 2014;10:e1004178 pubmed publisher
Peng G, Chun Jen Lin C, Mo W, Dai H, Park Y, Kim S, et al. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun. 2014;5:3361 pubmed publisher
Culver Cochran A, Chadwick B. Loss of WSTF results in spontaneous fluctuations of heterochromatin formation and resolution, combined with substantial changes to gene expression. BMC Genomics. 2013;14:740 pubmed publisher
Cron K, Zhu K, Kushwaha D, Hsieh G, Merzon D, Rameseder J, et al. Proteasome inhibitors block DNA repair and radiosensitize non-small cell lung cancer. PLoS ONE. 2013;8:e73710 pubmed publisher
Yüce O, West S. Senataxin, defective in the neurodegenerative disorder ataxia with oculomotor apraxia 2, lies at the interface of transcription and the DNA damage response. Mol Cell Biol. 2013;33:406-17 pubmed publisher
Chun J, Buechelmaier E, Powell S. Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway. Mol Cell Biol. 2013;33:387-95 pubmed publisher
Choi J, Park M, Lee J. Suppression and recovery of BRCA1-mediated transcription by HP1? via modulation of promoter occupancy. Nucleic Acids Res. 2012;40:11321-38 pubmed publisher
Lok B, Carley A, Tchang B, Powell S. RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination. Oncogene. 2013;32:3552-8 pubmed publisher
Tkocz D, Crawford N, Buckley N, Berry F, Kennedy R, Gorski J, et al. BRCA1 and GATA3 corepress FOXC1 to inhibit the pathogenesis of basal-like breast cancers. Oncogene. 2012;31:3667-78 pubmed publisher
Bott M, Brevet M, Taylor B, Shimizu S, Ito T, Wang L, et al. The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat Genet. 2011;43:668-72 pubmed publisher
Devgan S, Sanal O, Doil C, Nakamura K, Nahas S, Pettijohn K, et al. Homozygous deficiency of ubiquitin-ligase ring-finger protein RNF168 mimics the radiosensitivity syndrome of ataxia-telangiectasia. Cell Death Differ. 2011;18:1500-6 pubmed publisher
Larsen D, Poinsignon C, Gudjonsson T, Dinant C, Payne M, Hari F, et al. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol. 2010;190:731-40 pubmed publisher
Patterson Fortin J, Shao G, Bretscher H, Messick T, Greenberg R. Differential regulation of JAMM domain deubiquitinating enzyme activity within the RAP80 complex. J Biol Chem. 2010;285:30971-81 pubmed publisher
Pani E, Stojic L, El Shemerly M, Jiricny J, Ferrari S. Mismatch repair status and the response of human cells to cisplatin. Cell Cycle. 2007;6:1796-802 pubmed
Scardocci A, Guidi F, D Alo F, Gumiero D, Fabiani E, Diruscio A, et al. Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia. Br J Cancer. 2006;95:1108-13 pubmed
Barcaroli D, Dinsdale D, Neale M, Bongiorno Borbone L, Ranalli M, Munarriz E, et al. FLASH is an essential component of Cajal bodies. Proc Natl Acad Sci U S A. 2006;103:14802-7 pubmed
Barcaroli D, Bongiorno Borbone L, Terrinoni A, Hofmann T, Rossi M, Knight R, et al. FLASH is required for histone transcription and S-phase progression. Proc Natl Acad Sci U S A. 2006;103:14808-12 pubmed
Chadwick B, Lane T. BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation. Chromosoma. 2005;114:432-9 pubmed
Jurvansuu J, Raj K, Stasiak A, Beard P. Viral transport of DNA damage that mimics a stalled replication fork. J Virol. 2005;79:569-80 pubmed
product information
Product Name :
BRCA1 (D-9) Antibody
Gene Name :
BRCA1
Size :
200 µg/ml
Catalog Number :
sc-6954
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
BRCA1
reactive species  :
human
Application :
WB, IP, IF, ELISA
Epitope :
C-terminal (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA