Published Application/Species/Sample/Dilution | Reference |
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- immunocytochemistry; human; fig 5c
- western blot; human; loading ...; fig 6f
| Liu F, Han Q, Zhang T, Chang F, Deng J, Huang X, et al. CRL4-DCAF8L1 Regulates BRCA1 and BARD1 Protein Stability. Int J Biol Sci. 2022;18:1434-1450 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 2d
- western blot; human; loading ...; fig 4c
| Li W, Gu X, Liu C, Shi Y, Wang P, Zhang N, et al. A synergetic effect of BARD1 mutations on tumorigenesis. Nat Commun. 2021;12:1243 pubmed publisher
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- western blot; human; 1:100; loading ...; fig 5j
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- immunocytochemistry; human; 1:100; loading ...; fig 7f
| Mita P, Sun X, Fenyo D, Kahler D, Li D, Agmon N, et al. BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells. Nat Struct Mol Biol. 2020;27:179-191 pubmed publisher
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- immunohistochemistry; human; loading ...; fig 2b
- western blot; human; loading ...; fig 2f
| Huo D, Chen H, Cheng Y, Song X, Zhang K, Li M, et al. JMJD6 modulates DNA damage response through downregulating H4K16ac independently of its enzymatic activity. Cell Death Differ. 2019;: pubmed publisher
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- western blot; human; loading ...; fig 1h
| Wang H, Xiang D, Liu B, He A, Randle H, Zhang K, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178:135-151.e19 pubmed publisher
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- immunocytochemistry; human; 1:100; loading ...; fig 5i
| Xie Y, Fan H, Lu W, Yang Q, Nurkesh A, Yeleussizov T, et al. Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer. Oncogene. 2019;38:2967-2983 pubmed publisher
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- immunocytochemistry; human; 1:250; loading ...; fig s3b
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- western blot; human; 1:200; fig 4d
| Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018;19:37 pubmed publisher
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- western blot; human; fig 3a
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- western blot; human; loading ...; fig 2a
| Paculova H, Kramara J, Simečková S, Fedr R, Soucek K, Hylse O, et al. BRCA1 or CDK12 loss sensitizes cells to CHK1 inhibitors. Tumour Biol. 2017;39:1010428317727479 pubmed publisher
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- immunocytochemistry; human; loading ...; fig 4c
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- immunocytochemistry; human; loading ...; fig 4a
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- immunocytochemistry; human; loading ...; fig 6d
- western blot; human; loading ...; fig 7e
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- immunocytochemistry; human; loading ...; fig 5a
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- immunocytochemistry; human; loading ...; fig 3a
- western blot; human; loading ...; fig s1
| Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, et al. Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Oncotarget. 2016;7:57679-57693 pubmed publisher
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- immunocytochemistry; human; 1:1000; fig 5
| Jullien D, Vignard J, Fedor Y, Bery N, Olichon A, Crozatier M, et al. Chromatibody, a novel non-invasive molecular tool to explore and manipulate chromatin in living cells. J Cell Sci. 2016;129:2673-83 pubmed publisher
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- western blot; human; fig 2
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- western blot; human; 1:200; loading ...; fig 2e
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- immunocytochemistry; human; fig s2
| Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed publisher
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- immunocytochemistry; human; fig 3
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- immunocytochemistry; human; 1:400; fig 4
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- immunocytochemistry; human; fig 4
| Kuo C, Li X, Stark J, Shih H, Ann D. RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner. Cell Cycle. 2016;15:787-98 pubmed publisher
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| Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, et al. Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature. 2015;527:389-93 pubmed publisher
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- immunocytochemistry; human; fig 3
- western blot; human; fig s10
| Castella M, Jacquemont C, Thompson E, Yeo J, Cheung R, Huang J, et al. FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2. PLoS Genet. 2015;11:e1005563 pubmed publisher
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- immunocytochemistry; human; fig 4
| Hedstrom E, Pederiva C, Farnebo J, Nodin B, Jirstrom K, Brennan D, et al. Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome. Cell Death Dis. 2015;6:e1892 pubmed publisher
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- immunoprecipitation; human; fig 1b
| Lüddecke S, Ertych N, Stenzinger A, Weichert W, Beissbarth T, Dyczkowski J, et al. The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability. Oncogene. 2016;35:2398-406 pubmed publisher
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- western blot; mouse; fig 3b
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- western blot; human; 1:200; loading ...; fig 2a
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- immunocytochemistry; human; fig 4
| Lin Y, Yuan J, Pei H, Liu T, Ann D, Lou Z. KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair. PLoS ONE. 2015;10:e0123935 pubmed publisher
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- western blot; human; 1:50; fig 2
| Raymond A, Benhamouche S, Neaud V, Di Martino J, Javary J, Rosenbaum J. Reptin regulates DNA double strand breaks repair in human hepatocellular carcinoma. PLoS ONE. 2015;10:e0123333 pubmed publisher
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- immunocytochemistry; human; fig 2a
| Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, et al. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev. 2014;28:2726-38 pubmed publisher
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- western blot; human; 1:500; fig 5
| Bursomanno S, Beli P, Khan A, Minocherhomji S, Wagner S, Bekker Jensen S, et al. Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells. DNA Repair (Amst). 2015;25:84-96 pubmed publisher
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- immunohistochemistry - paraffin section; human
- immunoprecipitation; human
- western blot; human
| Peng Y, Dai H, Wang E, Lin C, Mo W, Peng G, et al. TUSC4 functions as a tumor suppressor by regulating BRCA1 stability. Cancer Res. 2015;75:378-86 pubmed publisher
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- chromatin immunoprecipitation; human; fig 7
- western blot; human; fig 1
| Pickholtz I, Saadyan S, Keshet G, Wang V, Cohen R, Bouwman P, et al. Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells. Oncotarget. 2014;5:11827-46 pubmed
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- immunocytochemistry; human
| Carvalho S, Vítor A, Sridhara S, Martins F, Raposo A, Desterro J, et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. elife. 2014;3:e02482 pubmed publisher
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- immunocytochemistry; human
- western blot; human
| Wang Y, Wang Z, Qi Z, Yin S, Zhang N, Liu Y, et al. The negative interplay between Aurora A/B and BRCA1/2 controls cancer cell growth and tumorigenesis via distinct regulation of cell cycle progression, cytokinesis, and tetraploidy. Mol Cancer. 2014;13:94 pubmed publisher
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| Zhou Y, Caron P, Legube G, Paull T. Quantitation of DNA double-strand break resection intermediates in human cells. Nucleic Acids Res. 2014;42:e19 pubmed publisher
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- immunocytochemistry; human
- western blot; human
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- immunocytochemistry; human
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| Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, et al. CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication. Genes Cells. 2012;17:962-70 pubmed publisher
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- western blot; rhesus macaque; fig 3
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- immunocytochemistry; human
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| Pinto L, Pailas A, Bondarchenko M, Sharma A, Neumann K, Rizzo A, et al. DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks. Nucleic Acids Res. 2023;: pubmed publisher
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| Maurer A, Benyamini B, Fan V, Whitney O, Dailey G, Darzacq X, et al. Double-Strand Break Repair Pathways Differentially Affect Processing and Transduction by Dual AAV Vectors. bioRxiv. 2023;: pubmed publisher
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| Tomita A, Sasanuma H, Owa T, Nakazawa Y, Shimada M, Fukuoka T, et al. Inducing multiple nicks promotes interhomolog homologous recombination to correct heterozygous mutations in somatic cells. Nat Commun. 2023;14:5607 pubmed publisher
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| Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, et al. DePARylation is critical for S phase progression and cell survival. bioRxiv. 2023;: pubmed publisher
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| Bu C, Zhao L, Wang L, Yu Z, Zhou J. mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance. Oncol Res. 2023;31:495-503 pubmed publisher
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| Sigismondo G, Arseni L, Palacio Escat N, Hofmann T, Seiffert M, Krijgsveld J. Multi-layered chromatin proteomics identifies cell vulnerabilities in DNA repair. Nucleic Acids Res. 2023;51:687-711 pubmed publisher
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| Berthault N, Bergam P, Pereira F, Girard P, Dutreix M. Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA. Cells. 2022;11: pubmed publisher
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| Bunch H, Jeong J, Kang K, Jo D, Cong A, Kim D, et al. BRCA1-BARD1 regulates transcription through modulating topoisomerase IIβ. Open Biol. 2021;11:210221 pubmed publisher
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| Xu S, Wu X, Wang P, Cao S, Peng B, Xu X. ASPM promotes homologous recombination-mediated DNA repair by safeguarding BRCA1 stability. iScience. 2021;24:102534 pubmed publisher
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| Xu X, Ni K, He Y, Ren J, Sun C, Liu Y, et al. The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation. Nat Commun. 2021;12:3520 pubmed publisher
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| Miyauchi T, Suzuki S, Takeda M, Peh J, Aiba M, Natsuga K, et al. Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism. Am J Hum Genet. 2021;108:1026-1039 pubmed publisher
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| Minten E, Kapoor Vazirani P, Li C, Zhang H, Balakrishnan K, Yu D. SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation. Cell Rep. 2021;34:108921 pubmed publisher
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| Kaur A, Lim J, Sepramaniam S, Patnaik S, Harmston N, Lee M, et al. WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. EMBO Mol Med. 2021;13:e13349 pubmed publisher
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| McKinzey D, Gomathinayagam S, Griffin W, Klinzing K, Jeffries E, Rajkovic A, et al. Motifs of the C-terminal domain of MCM9 direct localization to sites of mitomycin-C damage for RAD51 recruitment. J Biol Chem. 2021;296:100355 pubmed publisher
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| Dong C, An L, Yu C, Huen M. A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Res. 2021;: pubmed publisher
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| Zhu C, Rogers A, Asleh K, Won J, Gao D, Leung S, et al. Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer. Cell Rep. 2020;31:107745 pubmed publisher
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| Fan L, Xu S, Zhang F, Cui X, Fazli L, Gleave M, et al. Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells. Cell Death Dis. 2020;11:214 pubmed publisher
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| Chen H, Shan J, Liu J, Feng Y, Ke Y, Qi W, et al. RNF8 promotes efficient DSB repair by inhibiting the pro-apoptotic activity of p53 through regulating the function of Tip60. Cell Prolif. 2020;53:e12780 pubmed publisher
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| Parvin S, Ramírez Labrada A, Aumann S, Lu X, Weich N, Santiago G, et al. LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. Cancer Cell. 2019;36:237-249.e6 pubmed publisher
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| Kim H, Lin Q, Yun Z. BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors. Sci Rep. 2019;9:9702 pubmed publisher
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| Jayavaradhan R, Pillis D, Goodman M, Zhang F, Zhang Y, Andreassen P, et al. CRISPR-Cas9 fusion to dominant-negative 53BP1 enhances HDR and inhibits NHEJ specifically at Cas9 target sites. Nat Commun. 2019;10:2866 pubmed publisher
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