| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; loading ...; fig 2b
| Lu Y, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, et al. MARK2 phosphorylates eIF2α in response to proteotoxic stress. PLoS Biol. 2021;19:e3001096 pubmed publisher |
- western blot knockout validation; mouse; fig 5c
| Liu X, Bennett R, Cheng X, Byrne M, Reinhard M, May W. PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells. Blood. 2013;121:3364-74 pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Farabaugh K, Krokowski D, Guan B, Gao Z, Gao X, Wu J, et al. PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation. elife. 2020;9: pubmed publisher |
- western blot; mouse; loading ...; fig 5h
| Theivanthiran B, Evans K, Devito N, Plebanek M, Sturdivant M, Wachsmuth L, et al. A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. J Clin Invest. 2020;130:2570-2586 pubmed publisher |
- western blot; rat; loading ...; fig 7a
| Qin W, Wu X, Jia Y, Tong X, Guo C, Chen D, et al. Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma. Biomed Pharmacother. 2019;118:109188 pubmed publisher |
- western blot; mouse; 1:200; loading ...; fig 2a
| Goodman D, Pretto C, Krepostman T, Carnahan K, Spindler K. Enhanced Replication of Mouse Adenovirus Type 1 following Virus-Induced Degradation of Protein Kinase R (PKR). MBio. 2019;10: pubmed publisher |
- western blot; mouse; loading ...; fig 6d, s13c
| Hato T, Maier B, Syed F, Myslinski J, Zollman A, Plotkin Z, et al. Bacterial sepsis triggers an antiviral response that causes translation shutdown. J Clin Invest. 2019;129:296-309 pubmed publisher |
- western blot; human; fig 5
| Ren S, Wang J, Chen T, Li H, Wan Y, Peng N, et al. Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms. PLoS ONE. 2016;11:e0152721 pubmed publisher |
- western blot; human; fig 4
| Oh S, Onomoto K, Wakimoto M, Onoguchi K, Ishidate F, Fujiwara T, et al. Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules. PLoS Pathog. 2016;12:e1005444 pubmed publisher |
- western blot; mouse; 1:1000; fig 5
| Lancaster G, Kammoun H, Kraakman M, Kowalski G, Bruce C, Febbraio M. PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications. Nat Commun. 2016;7:10626 pubmed publisher |
- western blot; human; fig 4
- western blot; mouse; fig 4
| So J, Cho S, Min S, Kimball S, Lee A. IRE1α-Dependent Decay of CReP/Ppp1r15b mRNA Increases Eukaryotic Initiation Factor 2α Phosphorylation and Suppresses Protein Synthesis. Mol Cell Biol. 2015;35:2761-70 pubmed publisher |
| Humeau J, Leduc M, Cerrato G, Loos F, Kepp O, Kroemer G. Phosphorylation of eukaryotic initiation factor-2α (eIF2α) in autophagy. Cell Death Dis. 2020;11:433 pubmed publisher |
| Cubas Gaona L, Diaz Beneitez E, Ciscar M, Rodriguez J, Rodriguez D. Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha. J Virol. 2018;92: pubmed publisher |
| Wang D, de Weerd N, Willard B, Polekhina G, Williams B, Sadler A. Auto-phosphorylation Represses Protein Kinase R Activity. Sci Rep. 2017;7:44340 pubmed publisher |
| Zhang M, Qi Y, Li H, Cui J, Dai L, Frank J, et al. AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 ? and IL-18. Oncoimmunology. 2016;5:e1160182 pubmed publisher |
| Li H, Chen J, Qi Y, Dai L, Zhang M, Frank J, et al. Deficient PKR in RAX/PKR Association Ameliorates Ethanol-Induced Neurotoxicity in the Developing Cerebellum. Cerebellum. 2015;14:386-97 pubmed publisher |
| Brennan G, Kitzman J, Rothenburg S, Shendure J, Geballe A. Adaptive gene amplification as an intermediate step in the expansion of virus host range. PLoS Pathog. 2014;10:e1004002 pubmed publisher |
| Li W, Li J, Sama A, Wang H. Carbenoxolone blocks endotoxin-induced protein kinase R (PKR) activation and high mobility group box 1 (HMGB1) release. Mol Med. 2013;19:203-11 pubmed publisher |
| He Y, Franchi L, Nunez G. The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages. Eur J Immunol. 2013;43:1147-52 pubmed publisher |
| Onomoto K, Jogi M, Yoo J, Narita R, Morimoto S, Takemura A, et al. Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity. PLoS ONE. 2012;7:e43031 pubmed publisher |
| Clavarino G, Cláudio N, Couderc T, Dalet A, Judith D, Camosseto V, et al. Induction of GADD34 is necessary for dsRNA-dependent interferon-? production and participates in the control of Chikungunya virus infection. PLoS Pathog. 2012;8:e1002708 pubmed publisher |
| Child S, Brennan G, Braggin J, Geballe A. Species specificity of protein kinase r antagonism by cytomegalovirus TRS1 genes. J Virol. 2012;86:3880-9 pubmed publisher |
| Maestre A, Garzón A, Rodriguez D. Equine torovirus (BEV) induces caspase-mediated apoptosis in infected cells. PLoS ONE. 2011;6:e20972 pubmed publisher |
| Guan Z, Liu D, Mi S, Zhang J, Ye Q, Wang M, et al. Interaction of Hsp40 with influenza virus M2 protein: implications for PKR signaling pathway. Protein Cell. 2010;1:944-55 pubmed publisher |
| Groskreutz D, Babor E, Monick M, Varga S, Hunninghake G. Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication. J Biol Chem. 2010;285:24023-31 pubmed publisher |
| Child S, Geballe A. Binding and relocalization of protein kinase R by murine cytomegalovirus. J Virol. 2009;83:1790-9 pubmed publisher |
| Chen H, Wang L, D Mello S. A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. Eur J Neurosci. 2008;28:2003-16 pubmed publisher |
| Tamassia N, Le Moigne V, Rossato M, Donini M, McCartney S, Calzetti F, et al. Activation of an immunoregulatory and antiviral gene expression program in poly(I:C)-transfected human neutrophils. J Immunol. 2008;181:6563-73 pubmed |
| Baltzis D, Pluquet O, Papadakis A, Kazemi S, Qu L, Koromilas A. The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53. J Biol Chem. 2007;282:31675-87 pubmed |
| Fleming J, Shen G, Holloway S, Davis M, Brekken R. Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy. Mol Cancer Res. 2005;3:413-23 pubmed |
