Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; mouse; loading ...; fig 3c
- western blot; human; loading ...; fig 5b
| Choiniere J, Wu J, Wang L. Pyruvate Dehydrogenase Kinase 4 Deficiency Results in Expedited Cellular Proliferation through E2F1-Mediated Increase of Cyclins. Mol Pharmacol. 2017;91:189-196 pubmed publisher
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- immunocytochemistry; rat; 1:200; fig 7g
| Mihola O, Landa V, Pratto F, Brick K, Kobets T, Kusari F, et al. Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility. BMC Biol. 2021;19:86 pubmed publisher
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- western blot; mouse; 1:200; loading ...; fig 7a
| Dewhurst M, Ow J, Zafer G, Van Hul N, Wollmann H, Bisteau X, et al. Loss of hepatocyte cell division leads to liver inflammation and fibrosis. PLoS Genet. 2020;16:e1009084 pubmed publisher
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- immunohistochemistry; mouse; 1:20; loading ...; fig 6c
| Felipe Medina N, Caburet S, Sánchez Sáez F, Condezo Y, de Rooij D, Gómez H L, et al. A missense in HSF2BP causing primary ovarian insufficiency affects meiotic recombination by its novel interactor C19ORF57/BRME1. elife. 2020;9: pubmed publisher
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- western blot; rat; 1:200; loading ...; fig 5b
| Lin Y, Huang X, Chang K, Liao K, Tsai N. Encapsulated n-Butylidenephthalide Efficiently Crosses the Blood-Brain Barrier and Suppresses Growth of Glioblastoma. Int J Nanomedicine. 2020;15:749-760 pubmed publisher
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- western blot; mouse; 1:1000; fig 3l
| Giera S, Luo R, Ying Y, Ackerman S, Jeong S, Stoveken H, et al. Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. elife. 2018;7: pubmed publisher
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- western blot; human; 1:200; loading ...; fig 2
| Ren A, Fu G, Qiu Y, Cui H. Leflunomide inhibits proliferation and tumorigenesis of oral squamous cell carcinoma. Mol Med Rep. 2017;16:9125-9130 pubmed publisher
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- western blot; human; 1:300; loading ...; fig 1b
| Shu S, Xu Y, Xie L, Ouyang Y. The role of C/EBP? phosphorylation in modulating membrane phospholipids repairing in LPS-induced human lung/bronchial epithelial cells. Gene. 2017;629:76-85 pubmed publisher
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- immunocytochemistry; human; 1:200; loading ...; fig s6e
- western blot; human; 1:500; loading ...; fig s6g
| Li X, Song N, Liu L, Liu X, Ding X, Song X, et al. USP9X regulates centrosome duplication and promotes breast carcinogenesis. Nat Commun. 2017;8:14866 pubmed publisher
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- immunocytochemistry; mouse; 1:50; loading ...; fig s5d
| Tu Z, Bayazit M, Liu H, Zhang J, Busayavalasa K, Risal S, et al. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. Proc Natl Acad Sci U S A. 2017;114:592-597 pubmed publisher
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- immunohistochemistry; human; loading ...; fig s12
- western blot; human; loading ...; fig 3d
- immunocytochemistry; rat; loading ...; fig s7
- immunoprecipitation; mouse; loading ...; fig s13d
- immunocytochemistry; mouse; loading ...; fig s7
- immunohistochemistry; mouse; loading ...; fig 3f
- western blot; mouse; loading ...; fig s13e
| Polanco M, Parodi S, Piol D, Stack C, Chivet M, Contestabile A, et al. Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy. Sci Transl Med. 2016;8:370ra181 pubmed publisher
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- western blot; mouse; loading ...; fig 6c
| Jablonska B, Gierdalski M, Chew L, Hawley T, Catron M, Lichauco A, et al. Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury. Nat Commun. 2016;7:13866 pubmed publisher
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- immunoprecipitation; mouse; 1:1000; loading ...; fig s3c
- western blot; mouse; 1:1000; loading ...; fig s3c
| Kanakkanthara A, Jeganathan K, Limzerwala J, Baker D, Hamada M, Nam H, et al. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science. 2016;353:1549-1552 pubmed
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- western blot; mouse; fig s3
| Diril M, Bisteau X, Kitagawa M, Caldez M, Wee S, Gunaratne J, et al. Loss of the Greatwall Kinase Weakens the Spindle Assembly Checkpoint. PLoS Genet. 2016;12:e1006310 pubmed publisher
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- western blot; human; 1:500; fig 1
| Bao H, Liu P, Jiang K, Zhang X, Xie L, Wang Z, et al. Huaier polysaccharide induces apoptosis in hepatocellular carcinoma cells through p38 MAPK. Oncol Lett. 2016;12:1058-1066 pubmed
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- immunoprecipitation; human; fig 4
| Toledo C, Ding Y, Hoellerbauer P, Davis R, Basom R, Girard E, et al. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells. Cell Rep. 2015;13:2425-2439 pubmed publisher
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- western blot; human; fig 3
| Lohberger B, Leithner A, Stuendl N, Kaltenegger H, Kullich W, Steinecker Frohnwieser B. Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation. BMC Cancer. 2015;15:891 pubmed publisher
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- western blot; human; fig 6
| Tang J, Chen Y, Cui R, Li D, Xiao L, Lin P, et al. Upregulation of fractalkine contributes to the proliferative response of prostate cancer cells to hypoxia via promoting the G1/S phase transition. Mol Med Rep. 2015;12:7907-14 pubmed publisher
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- chromatin immunoprecipitation; mouse; fig 6
| Orlando S, Gallastegui E, Besson A, Abril G, Aligué R, Pujol M, et al. p27Kip1 and p21Cip1 collaborate in the regulation of transcription by recruiting cyclin-Cdk complexes on the promoters of target genes. Nucleic Acids Res. 2015;43:6860-73 pubmed publisher
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- western blot; human; fig 7
| Guha G, Lu W, Li S, Liang X, Kulesz Martin M, Mahmud T, et al. Novel Pactamycin Analogs Induce p53 Dependent Cell-Cycle Arrest at S-Phase in Human Head and Neck Squamous Cell Carcinoma (HNSCC) Cells. PLoS ONE. 2015;10:e0125322 pubmed publisher
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- western blot; human; 1:200; fig 3b
| Chung Y, Kim H, Park S, Yoon J, Kim M, Nam S, et al. Transcriptome analysis reveals that Müllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis. Int J Oncol. 2015;46:2039-46 pubmed publisher
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- western blot; human; fig 3
| Bele A, Mirza S, Zhang Y, Ahmad Mir R, Lin S, Kim J, et al. The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells. Cell Cycle. 2015;14:990-1000 pubmed publisher
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- western blot; mouse; 1:1000; fig 5
| Giera S, Deng Y, Luo R, Ackerman S, Mogha A, Monk K, et al. The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development. Nat Commun. 2015;6:6121 pubmed publisher
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- western blot; mouse; 1:400
| Brun C, Périé L, Baraige F, Vernus B, Bonnieu A, Blanquet V. Absence of hyperplasia in Gasp-1 overexpressing mice is dependent on myostatin up-regulation. Cell Physiol Biochem. 2014;34:1241-59 pubmed publisher
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- western blot; human; 1:500-1:1000
| Lupino E, Ramondetti C, Buccinnà B, Piccinini M. Exposure of neuroblastoma cell lines to imatinib results in the upregulation of the CDK inhibitor p27(KIP1) as a consequence of c-Abl inhibition. Biochem Pharmacol. 2014;92:235-50 pubmed publisher
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- western blot; human; loading ...; fig 5a
| Chen K, Yang T, Wu C, Cheng C, Hsu S, Hung H, et al. Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway. PLoS ONE. 2014;9:e97888 pubmed publisher
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| Machado Neto J, Lazarini M, Favaro P, Franchi G, Nowill A, Saad S, et al. ANKHD1, a novel component of the Hippo signaling pathway, promotes YAP1 activation and cell cycle progression in prostate cancer cells. Exp Cell Res. 2014;324:137-45 pubmed publisher
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- western blot; human; 1:200
| Qi L, Zhang Y. Truncation of inhibitor of growth family protein 5 effectively induces senescence, but not apoptosis in human tongue squamous cell carcinoma cell line. Tumour Biol. 2014;35:3139-44 pubmed publisher
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| Ledoux A, Sellier H, Gillies K, Iannetti A, James J, Perkins N. NF?B regulates expression of Polo-like kinase 4. Cell Cycle. 2013;12:3052-62 pubmed publisher
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- western blot; mouse; fig 4
| Diril M, Ratnacaram C, Padmakumar V, Du T, Wasser M, Coppola V, et al. Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc Natl Acad Sci U S A. 2012;109:3826-31 pubmed publisher
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| Marsaud V, Tchakarska G, Andrieux G, Liu J, Dembele D, Jost B, et al. Cyclin K and cyclin D1b are oncogenic in myeloma cells. Mol Cancer. 2010;9:103 pubmed publisher
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- western blot; human; fig 3
| Yang G, Chang B, Yang F, Guo X, Cai K, Xiao X, et al. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010;16:3171-81 pubmed publisher
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| Bondarieva A, Raveendran K, Telychko V, Rao H, Ravindranathan R, Zorzompokou C, et al. Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse. Nat Commun. 2020;11:3101 pubmed publisher
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| Pereira E, Burns J, Lee C, Marohl T, Calderon D, Wang L, et al. Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies. Sci Signal. 2020;13: pubmed publisher
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| Xia P, Chen J, Liu Y, Fletcher M, Jensen B, Cheng Z. Doxorubicin induces cardiomyocyte apoptosis and atrophy through cyclin-dependent kinase 2-mediated activation of forkhead box O1. J Biol Chem. 2020;295:4265-4276 pubmed publisher
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| Cho H, Min H, Won Y, Ahn H, Cho Y, Seo K. Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells. BMC Complement Altern Med. 2019;19:241 pubmed publisher
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| Dutta P, Islam S, Choppara S, Sengupta P, Kumar A, Kumar A, et al. The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels. J Biol Chem. 2019;294:14879-14895 pubmed publisher
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| Ivanov A, Lin X, Ammosova T, Ilatovskiy A, Kumari N, Lassiter H, et al. HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription. Retrovirology. 2018;15:39 pubmed publisher
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| Qiao L, Zheng J, Tian Y, Zhang Q, Wang X, Chen J, et al. Regulator of chromatin condensation 1 abrogates the G1 cell cycle checkpoint via Cdk1 in human papillomavirus E7-expressing epithelium and cervical cancer cells. Cell Death Dis. 2018;9:583 pubmed publisher
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| Ehedego H, Mohs A, Jansen B, Hiththetiya K, Sicinski P, Liedtke C, et al. Loss of Cyclin E1 attenuates hepatitis and hepatocarcinogenesis in a mouse model of chronic liver injury. Oncogene. 2018;37:3329-3339 pubmed publisher
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| Yang J, Liu Y, Wang B, Lan H, Liu Y, Chen F, et al. Sumoylation in p27kip1 via RanBP2 promotes cancer cell growth in cholangiocarcinoma cell line QBC939. BMC Mol Biol. 2017;18:23 pubmed publisher
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| Singh A, Sun Y, Li L, Zhang W, Wu T, Zhao S, et al. Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports. 2015;5:323-36 pubmed publisher
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| Brookes S, Gagrica S, Sanij E, Rowe J, Gregory F, Hara E, et al. Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. Cell Cycle. 2015;14:1164-73 pubmed publisher
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| Leem Y, Ha H, Bae J, Baek K, Kang J. CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and tumorigenicity through Hedgehog signaling. PLoS ONE. 2014;9:e111701 pubmed publisher
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| Shi H, Fu C, Wang W, Li Y, Du S, Cao R, et al. The FGF-1-specific single-chain antibody scFv1C9 effectively inhibits breast cancer tumour growth and metastasis. J Cell Mol Med. 2014;18:2061-70 pubmed publisher
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| Martinerie L, Manterola M, Chung S, Panigrahi S, Weisbach M, Vasileva A, et al. Mammalian E-type cyclins control chromosome pairing, telomere stability and CDK2 localization in male meiosis. PLoS Genet. 2014;10:e1004165 pubmed publisher
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| Qiao H, Prasada Rao H, Yang Y, Fong J, Cloutier J, Deacon D, et al. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet. 2014;46:194-9 pubmed publisher
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| Zhang X, Hagen J, Muniz V, Smith T, Coombs G, Eischen C, et al. RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. PLoS ONE. 2013;8:e80228 pubmed publisher
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| Sidler C, Woycicki R, Ilnytskyy Y, METZ G, Kovalchuk I, Kovalchuk O. Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs. Front Genet. 2013;4:211 pubmed publisher
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| Falkenberg N, Anastasov N, Rappl K, Braselmann H, Auer G, Walch A, et al. MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion. Br J Cancer. 2013;109:2714-23 pubmed publisher
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| Moritani M, Ishimi Y. Inhibition of DNA binding of MCM2-7 complex by phosphorylation with cyclin-dependent kinases. J Biochem. 2013;154:363-72 pubmed publisher
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| Ludyga N, Englert S, Pflieger K, Rauser S, Braselmann H, Walch A, et al. The impact of cysteine-rich intestinal protein 1 (CRIP1) in human breast cancer. Mol Cancer. 2013;12:28 pubmed publisher
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| Ling H, Peng L, Seto E, Fukasawa K. Suppression of centrosome duplication and amplification by deacetylases. Cell Cycle. 2012;11:3779-91 pubmed publisher
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| Mohibi S, Gurumurthy C, Nag A, Wang J, Mirza S, Mian Y, et al. Mammalian alteration/deficiency in activation 3 (Ada3) is essential for embryonic development and cell cycle progression. J Biol Chem. 2012;287:29442-56 pubmed publisher
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| Oh H, Lee H, Park S, Cho Y, Bae H, Cho M, et al. Zinc balance is critical for NFI-C mediated regulation of odontoblast differentiation. J Cell Biochem. 2012;113:877-87 pubmed publisher
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| Bechard M, Trost R, Singh A, Dalton S. Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3? subcellular localization in pluripotent cells. Mol Cell Biol. 2012;32:288-96 pubmed publisher
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| Lin Y, Chiang B. 4-acetylantroquinonol B isolated from Antrodia cinnamomea arrests proliferation of human hepatocellular carcinoma HepG2 cell by affecting p53, p21 and p27 levels. J Agric Food Chem. 2011;59:8625-31 pubmed publisher
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| Bandiera S, Rüberg S, Girard M, Cagnard N, Hanein S, Chretien D, et al. Nuclear outsourcing of RNA interference components to human mitochondria. PLoS ONE. 2011;6:e20746 pubmed publisher
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| Fang Y, Zhou X, Lin M, Jing H, Zhong L, Ying M, et al. The ubiquitin-proteasome pathway plays essential roles in ATRA-induced leukemia cells G0/G1 phase arrest and transition into granulocytic differentiation. Cancer Biol Ther. 2010;10:1157-67 pubmed
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| Lupino E, Buccinnà B, Ramondetti C, Lomartire A, De Marco G, Ricotti E, et al. In CD28-costimulated human naïve CD4+ T cells, I-?B kinase controls the expression of cell cycle regulatory proteins via interleukin-2-independent mechanisms. Immunology. 2010;131:231-41 pubmed publisher
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| Peck B, Chen C, Ho K, Di Fruscia P, Myatt S, Coombes R, et al. SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2. Mol Cancer Ther. 2010;9:844-55 pubmed publisher
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| Bento C, Andersson M, Aman P. DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2. BMC Cell Biol. 2009;10:89 pubmed publisher
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| Zhang W, Li J, Kanginakudru S, Zhao W, Yu X, Chen J. The human papillomavirus type 58 E7 oncoprotein modulates cell cycle regulatory proteins and abrogates cell cycle checkpoints. Virology. 2010;397:139-44 pubmed publisher
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| Levin V, Panchabhai S, Shen L, Kornblau S, Qiu Y, Baggerly K. Different changes in protein and phosphoprotein levels result from serum starvation of high-grade glioma and adenocarcinoma cell lines. J Proteome Res. 2010;9:179-91 pubmed publisher
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| Stolfi C, Sarra M, Caruso R, Fantini M, Fina D, Pellegrini R, et al. Inhibition of colon carcinogenesis by 2-methoxy-5-amino-N-hydroxybenzamide, a novel derivative of mesalamine. Gastroenterology. 2010;138:221-30 pubmed publisher
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| Bechard M, Dalton S. Subcellular localization of glycogen synthase kinase 3beta controls embryonic stem cell self-renewal. Mol Cell Biol. 2009;29:2092-104 pubmed publisher
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| Bertz J, Zang C, Liu H, Wächter M, Possinger K, Koeffler H, et al. Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib. Leuk Res. 2009;33:686-92 pubmed publisher
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| Chen H, Wang L, D Mello S. A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. Eur J Neurosci. 2008;28:2003-16 pubmed publisher
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| Hu H, Zielinska Kwiatkowska A, Munro K, Wilcox J, Wu D, Yang L, et al. EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells. J Orthop Res. 2008;26:886-93 pubmed publisher
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| James M, Ray A, Leznova D, Blain S. Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity. Mol Cell Biol. 2008;28:498-510 pubmed
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| De Castro Arce J, Göckel Krzikalla E, Rösl F. Retinoic acid receptor beta silences human papillomavirus-18 oncogene expression by induction of de novo methylation and heterochromatinization of the viral control region. J Biol Chem. 2007;282:28520-9 pubmed
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| Chang Y, Liao C, Hsieh P, Liou M, Liu Y. Expression of tumor suppressor p53 facilitates DNA repair but not UV-induced G2/M arrest or apoptosis in Chinese hamster ovary CHO-K1 cells. J Cell Biochem. 2008;103:528-37 pubmed
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| Lévêque C, Marsaud V, Renoir J, Sola B. Alternative cyclin D1 forms a and b have different biological functions in the cell cycle of B lymphocytes. Exp Cell Res. 2007;313:2719-29 pubmed
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| Johnson W, Li C, Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics. 2007;8:118-27 pubmed
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