| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:1000; loading ...; fig ev2
| Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. EMBO Mol Med. 2016;8:1005-18 pubmed publisher |
- western blot; human; fig 4
| Kurbatskaya K, Phillips E, Croft C, Dentoni G, Hughes M, Wade M, et al. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun. 2016;4:34 pubmed publisher |
- immunoprecipitation; rat
- western blot; rat
| Kim B, Serebreni L, Fallica J, Hamdan O, Wang L, Johnston L, et al. Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia. PLoS ONE. 2015;10:e0124189 pubmed publisher |
- western blot; human; fig 7
| Xie Q, Wu Q, Horbinski C, Flavahan W, Yang K, Zhou W, et al. Mitochondrial control by DRP1 in brain tumor initiating cells. Nat Neurosci. 2015;18:501-10 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:200
- immunoprecipitation; human
- western blot; human
| Tripathi B, Qian X, Mertins P, Wang D, Papageorge A, Carr S, et al. CDK5 is a major regulator of the tumor suppressor DLC1. J Cell Biol. 2014;207:627-42 pubmed publisher |
- immunocytochemistry; mouse; 1:100; fig 4
| Nishimura Y, Shikanai M, Hoshino M, Ohshima T, Nabeshima Y, Mizutani K, et al. Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons. Development. 2014;141:3540-50 pubmed publisher |
- immunoprecipitation; human; fig 1
- western blot; human; fig 1
| Tripathi B, Lowy D, Zelenka P. The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. Exp Cell Res. 2015;330:186-98 pubmed publisher |
- western blot; rat
- immunocytochemistry; human
- western blot; human
| Absalon S, Kochanek D, Raghavan V, Krichevsky A. MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neurons. J Neurosci. 2013;33:14645-59 pubmed publisher |
| Ko Y, Kim C, Lee J, Kim D, Kim Y, Yun N, et al. Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity. Cell Death Dis. 2019;10:579 pubmed publisher |
| Salissou M, Mahaman Y, Zhu F, Huang F, Wang Y, Xu Z, et al. Methanolic extract of Tamarix Gallica attenuates hyperhomocysteinemia induced AD-like pathology and cognitive impairments in rats. Aging (Albany NY). 2018;10:3229-3248 pubmed publisher |
| Lee J, Ko Y, Chung Y, Yun N, Kim M, Kim K, et al. The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons. Sci Rep. 2018;8:13676 pubmed publisher |
| Cho B, Cho H, Kim H, Jeong J, Park S, Hwang E, et al. CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation. Exp Mol Med. 2014;46:e105 pubmed publisher |
| Zhong B, Wang T, Lun X, Zhang J, Zheng S, Yang W, et al. Contribution of nestin positive esophageal squamous cancer cells on malignant proliferation, apoptosis, and poor prognosis. Cancer Cell Int. 2014;14:57 pubmed publisher |
| Oaks A, Frankfurt M, Finkelstein D, Sidhu A. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS ONE. 2013;8:e60378 pubmed publisher |
| Cantrup R, Sathanantham K, Rushlow W, Rajakumar N. Chronic hyperdopaminergic activity of schizophrenia is associated with increased ?FosB levels and cdk-5 signaling in the nucleus accumbens. Neuroscience. 2012;222:124-35 pubmed publisher |
| Busso C, Wedgeworth C, Izumi T. Ubiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5. Nucleic Acids Res. 2011;39:8017-28 pubmed publisher |
| Corbel C, Wang Q, Bousserouel H, Hamdi A, Zhang B, Lozach O, et al. First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors. Biotechnol J. 2011;6:860-70 pubmed publisher |
| Poore C, Sundaram J, Pareek T, Fu A, Amin N, Mohamed N, et al. Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity. J Neurosci. 2010;30:8457-67 pubmed publisher |
| Tripathi B, Zelenka P. Cdk5-dependent regulation of Rho activity, cytoskeletal contraction, and epithelial cell migration via suppression of Src and p190RhoGAP. Mol Cell Biol. 2009;29:6488-99 pubmed publisher |
| Chen H, Wang L, D Mello S. A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. Eur J Neurosci. 2008;28:2003-16 pubmed publisher |
| Alvira D, Tajes M, Verdaguer E, Acuna Castroviejo D, Folch J, Camins A, et al. Inhibition of the cdk5/p25 fragment formation may explain the antiapoptotic effects of melatonin in an experimental model of Parkinson's disease. J Pineal Res. 2006;40:251-8 pubmed |
| Verdaguer E, Jorda E, Alvira D, Jiménez A, Canudas A, Folch J, et al. Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons. J Mol Neurosci. 2005;26:71-84 pubmed |
| Johnson K, Liu L, Majdzadeh N, Chavez C, Chin P, Morrison B, et al. Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs. J Neurochem. 2005;93:538-48 pubmed |
| Lu G, Seta K, Millhorn D. Novel role for cyclin-dependent kinase 2 in neuregulin-induced acetylcholine receptor epsilon subunit expression in differentiated myotubes. J Biol Chem. 2005;280:21731-8 pubmed |
