This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Lamin B (M-20)
catalog :
sc-6217
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section
citations: 52
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:200; loading ...; fig 2b
Saito T, Kuma A, Sugiura Y, Ichimura Y, Obata M, Kitamura H, et al. Autophagy regulates lipid metabolism through selective turnover of NCoR1. Nat Commun. 2019;10:1567 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Ko Y, Chan Y, Liu C, Liang J, Chuang T, Hsueh Y, et al. Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M. Front Immunol. 2018;9:1828 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Yeh Y, Gunasekharan V, Manuelidis L. A prokaryotic viral sequence is expressed and conserved in mammalian brain. Proc Natl Acad Sci U S A. 2017;114:7118-7123 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Shin C, Ito Y, Ichikawa S, Tokunaga M, Sakata Sogawa K, Tanaka T. MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses. Sci Rep. 2017;7:46097 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Ku C, Sekiguchi J, Panwar B, Guan Y, Takahashi S, Yoh K, et al. GATA3 Abundance Is a Critical Determinant of T Cell Receptor ? Allelic Exclusion. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; mouse; loading ...; fig 6e
Ganesan R, Hos N, Gutierrez S, Fischer J, Stepek J, Daglidu E, et al. Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy. PLoS Pathog. 2017;13:e1006227 pubmed publisher
  • western blot; human; loading ...; fig 4b
Sánchez Morgan N, Kirsch K, Trackman P, Sonenshein G. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. J Cell Biochem. 2017;118:2347-2356 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 1i
Griffiths K, Ahmed M, Das S, Gopal R, Horne W, Connell T, et al. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun. 2016;7:13894 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 3b
Kubben N, Brimacombe K, Donegan M, Li Z, Misteli T. A high-content imaging-based screening pipeline for the systematic identification of anti-progeroid compounds. Methods. 2016;96:46-58 pubmed publisher
  • immunocytochemistry; human; 1:100; fig s4
Jovičić A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada S, et al. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nat Neurosci. 2015;18:1226-9 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 1a
  • western blot; mouse; 1:1000; loading ...; fig 1c
Furusawa T, Rochman M, Taher L, Dimitriadis E, Nagashima K, Anderson S, et al. Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun. 2015;6:6138 pubmed publisher
Ruan X, Hu K, Zhang X. PIE-seq: identifying RNA-binding protein targets by dual RNA-deaminase editing and sequencing. Nat Commun. 2023;14:3275 pubmed publisher
Mac Kain A, Maarifi G, Aicher S, Arhel N, Baidaliuk A, Munier S, et al. Identification of DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen. Nat Commun. 2022;13:2442 pubmed publisher
Dupont L, Bloor S, Williamson J, Cuesta S, Shah R, Teixeira Silva A, et al. The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr. Cell Host Microbe. 2021;29:792-805.e6 pubmed publisher
Brea R, Valdecantos P, Rada P, Alen R, García Monzón C, Bosca L, et al. Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. Aging (Albany NY). 2021;13:7800-7827 pubmed publisher
Stengel K, Ellis J, Spielman C, Bomber M, Hiebert S. Definition of a small core transcriptional circuit regulated by AML1-ETO. Mol Cell. 2021;81:530-545.e5 pubmed publisher
Talwar D, Messens J, Dick T. A role for annexin A2 in scaffolding the peroxiredoxin 2-STAT3 redox relay complex. Nat Commun. 2020;11:4512 pubmed publisher
Escoll M, Lastra D, Robledinos Antón N, Wandosell F, Anton I, Cuadrado A. WIP Modulates Oxidative Stress through NRF2/KEAP1 in Glioblastoma Cells. Antioxidants (Basel). 2020;9: pubmed publisher
Lee D, Yun S, Song M, Jung K, Kim E. Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells. Antioxidants (Basel). 2020;9: pubmed publisher
Escoll M, Lastra D, Pajares M, Robledinos Antón N, Rojo A, Fernández Ginés R, et al. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. Redox Biol. 2020;30:101425 pubmed publisher
Wang W, Wang J, Lin W, Kao C, Hung M, Teng Y, et al. Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis. Aging Cell. 2020;19:e13090 pubmed publisher
Kim D, Dollé M, Vermeij W, Gyenis A, Vogel K, Hoeijmakers J, et al. Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin. Aging Cell. 2020;19:e13072 pubmed publisher
Loo T, Ye X, Chai R, Ito M, Bonne G, Ferguson Smith A, et al. The mammalian LINC complex component SUN1 regulates muscle regeneration by modulating drosha activity. elife. 2019;8: pubmed publisher
Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, et al. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nat Commun. 2019;10:3329 pubmed publisher
Xia Y, Pfeifer C, Zhu K, Irianto J, Liu D, Pannell K, et al. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. J Cell Biol. 2019;: pubmed publisher
Smith L, Irianto J, Xia Y, Pfeifer C, Discher D. Constricted migration modulates stem cell differentiation. Mol Biol Cell. 2019;:mbcE19020090 pubmed publisher
Jevtic P, Schibler A, Wesley C, Pegoraro G, Misteli T, Levy D. The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity. EMBO Rep. 2019;20: pubmed publisher
Meyer K, Feldman H, Lu T, Drake D, Lim E, Ling K, et al. REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease. Cell Rep. 2019;26:1112-1127.e9 pubmed publisher
Grigoryan A, Guidi N, Senger K, Liehr T, Soller K, Marka G, et al. LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells. Genome Biol. 2018;19:189 pubmed publisher
Xia Y, Ivanovska I, Zhu K, Smith L, Irianto J, Pfeifer C, et al. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. J Cell Biol. 2018;217:3796-3808 pubmed publisher
Travers J, Rochman M, Miracle C, Habel J, Brusilovsky M, Caldwell J, et al. Chromatin regulates IL-33 release and extracellular cytokine activity. Nat Commun. 2018;9:3244 pubmed publisher
Ferrandino F, Bernardini G, Tsaouli G, Grazioli P, Campese A, Noce C, et al. Intrathymic Notch3 and CXCR4 combinatorial interplay facilitates T-cell leukemia propagation. Oncogene. 2018;37:6285-6298 pubmed publisher
Djekidel M, Inoue A, Matoba S, Suzuki T, Zhang C, Lu F, et al. Reprogramming of Chromatin Accessibility in Somatic Cell Nuclear Transfer Is DNA Replication Independent. Cell Rep. 2018;23:1939-1947 pubmed publisher
Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, et al. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018;37:4385-4397 pubmed publisher
El Kasmi K, Vue P, Anderson A, Devereaux M, Ghosh S, Balasubramaniyan N, et al. Macrophage-derived IL-1β/NF-κB signaling mediates parenteral nutrition-associated cholestasis. Nat Commun. 2018;9:1393 pubmed publisher
Cho S, Abbas A, Irianto J, Ivanovska I, Xia Y, Tewari M, et al. Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells. Nucleus. 2018;9:230-245 pubmed publisher
Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, et al. Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome. Protein Cell. 2018;9:333-350 pubmed publisher
Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, et al. ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells. Cell Discov. 2018;4:2 pubmed publisher
Poleshko A, Shah P, Gupta M, Babu A, Morley M, Manderfield L, et al. Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction. Cell. 2017;171:573-587.e14 pubmed publisher
Tamahara T, Ochiai K, Muto A, Kato Y, Sax N, Matsumoto M, et al. The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation. Mol Cell Biol. 2017;37: pubmed publisher
Knittle A, Helkkula M, Johnson M, Sundvall M, Elenius K. SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase. J Biol Chem. 2017;292:19890-19904 pubmed publisher
Isoda T, Moore A, He Z, Chandra V, Aida M, Denholtz M, et al. Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell. 2017;171:103-119.e18 pubmed publisher
Yu L, Moriguchi T, Kaneko H, Hayashi M, Hasegawa A, Nezu M, et al. Reducing Inflammatory Cytokine Production from Renal Collecting Duct Cells by Inhibiting GATA2 Ameliorates Acute Kidney Injury. Mol Cell Biol. 2017;37: pubmed publisher
Ohm A, Tan A, Heasley L, Reyland M. Co-dependency of PKC? and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer. Oncogene. 2017;36:4370-4378 pubmed publisher
Jin W, Kim B, Kim D, Park Choo H, Kim H, Ha H, et al. NF-κB signaling regulates cell-autonomous regulation of CXCL10 in breast cancer 4T1 cells. Exp Mol Med. 2017;49:e295 pubmed publisher
Falik Zaccai T, Barsheshet Y, Mandel H, Segev M, Lorber A, Gelberg S, et al. Sequence variation in PPP1R13L results in a novel form of cardio-cutaneous syndrome. EMBO Mol Med. 2017;9:319-336 pubmed publisher
van den Berg D, Azzarelli R, Oishi K, Martynoga B, Urbán N, Dekkers D, et al. Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. Neuron. 2017;93:348-361 pubmed publisher
Wu D, Yates P, Zhang H, Cao K. Comparing lamin proteins post-translational relative stability using a 2A peptide-based system reveals elevated resistance of progerin to cellular degradation. Nucleus. 2016;7:585-596 pubmed publisher
Puglisi R, Maccari I, Pipolo S, Mangia F, Boitani C. The nuclear form of glutathione peroxidase 4 colocalizes and directly interacts with protamines in the nuclear matrix during mouse sperm chromatin assembly. Spermatogenesis. 2014;4:e28460 pubmed
Pajaniradje S, Mohankumar K, Pamidimukkala R, Subramanian S, Rajagopalan R. Antiproliferative and apoptotic effects of Sesbania grandiflora leaves in human cancer cells. Biomed Res Int. 2014;2014:474953 pubmed publisher
Chan E, Teng G, Corbett E, Choudhury K, Bassing C, Schatz D, et al. Peripheral subnuclear positioning suppresses Tcrb recombination and segregates Tcrb alleles from RAG2. Proc Natl Acad Sci U S A. 2013;110:E4628-37 pubmed publisher
Chao H, Lai Y, Lu Y, Lin C, Mai W, Huang Y. NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3. Nucleic Acids Res. 2012;40:8484-98 pubmed
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA