Bustos V, Pulina M, Kelahmetoglu Y, Sinha S, Gorelick F, Flajolet M, et al. Bidirectional regulation of A? levels by Presenilin 1. Proc Natl Acad Sci U S A. 2017;114:7142-7147 pubmed publisher

Bustos V, Pulina M, Bispo A, Lam A, Flajolet M, Gorelick F, et al. Phosphorylated Presenilin 1 decreases ?-amyloid by facilitating autophagosome-lysosome fusion. Proc Natl Acad Sci U S A. 2017;114:7148-7153 pubmed publisher

Tao C, Hsu W, Ma Y, Cheng S, Lee E. Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease. Cell Death Differ. 2017;24:597-614 pubmed publisher

Lu Y, Wan J, Yang Z, Lei X, Niu Q, Jiang L, et al. Regulated intramembrane proteolysis of the AXL receptor kinase generates an intracellular domain that localizes in the nucleus of cancer cells. FASEB J. 2017;31:1382-1397 pubmed publisher

Kim H, Lee K, Kim A, Choi M, Choi K, Kang M, et al. A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition. Dis Model Mech. 2016;9:839-48 pubmed publisher

Kuzuya A, Zoltowska K, Post K, Arimon M, Li X, Svirsky S, et al. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016;14:25 pubmed publisher

Wang J, Lu R, Yang J, Li H, He Z, Jing N, et al. TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun. 2015;6:8876 pubmed publisher

Alam M, Gaida M, Bergmann F, Lasitschka F, Giese T, Giese N, et al. Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med. 2015;21:1337-43 pubmed publisher

Liu J, Liu S, Matsumoto Y, Murakami S, Sugakawa Y, Kami A, et al. Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology. Sci Rep. 2015;5:12059 pubmed publisher

Steuble M, Diep T, Sch tzle P, Ludwig A, Tagaya M, Kunz B, et al. Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport. Biol Open. 2012;1:761-74 pubmed publisher

Sutinen E, Pirttila T, Anderson G, Salminen A, Ojala J. Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-? production in human neuron-like cells. J Neuroinflammation. 2012;9:199 pubmed

Devi L, Alldred M, Ginsberg S, Ohno M. Mechanisms underlying insulin deficiency-induced acceleration of ?-amyloidosis in a mouse model of Alzheimer's disease. PLoS ONE. 2012;7:e32792 pubmed publisher

Massone S, Vassallo I, Castelnuovo M, Fiorino G, Gatta E, Robello M, et al. RNA polymerase III drives alternative splicing of the potassium channel-interacting protein contributing to brain complexity and neurodegeneration. J Cell Biol. 2011;193:851-66 pubmed publisher

Laky K, Fowlkes B. Presenilins regulate alphabeta T cell development by modulating TCR signaling. J Exp Med. 2007;204:2115-29 pubmed

Chen Q, Kimura H, Schubert D. A novel mechanism for the regulation of amyloid precursor protein metabolism. J Cell Biol. 2002;158:79-89 pubmed

Mah A, Perry G, Smith M, Monteiro M. Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation. J Cell Biol. 2000;151:847-62 pubmed