product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
α-synuclein (LB 509) Antibody
catalog :
sc-58480
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
LB 509
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - free floating section
citations: 12
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; human; 1:500; loading ...; fig 3b
  • western blot; human; 1:1000; fig 5d
Stein C, McLendon J, Witmer N, Boudreau R. Modulation of miR-181 influences dopaminergic neuronal degeneration in a mouse model of Parkinson's disease. Mol Ther Nucleic Acids. 2022;28:1-15 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 2a
Suzuki G, Imura S, Hosokawa M, Katsumata R, Nonaka T, Hisanaga S, et al. α-synuclein strains that cause distinct pathologies differentially inhibit proteasome. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:10,000
Kett L, Stiller B, Bernath M, Tasset I, Blesa J, Jackson Lewis V, et al. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. J Neurosci. 2015;35:5724-42 pubmed publisher
  • western blot; human; fig 6
Dettmer U, Newman A, Luth E, Bartels T, Selkoe D. In vivo cross-linking reveals principally oligomeric forms of ?-synuclein and ?-synuclein in neurons and non-neural cells. J Biol Chem. 2013;288:6371-85 pubmed publisher
Inoue S, Nishimura K, Gima S, Nakano M, Takata K. CRISPR-Cas9-Edited SNCA Knockout Human Induced Pluripotent Stem Cell-Derived Dopaminergic Neurons and Their Vulnerability to Neurotoxicity. Biol Pharm Bull. 2023;46:517-522 pubmed publisher
Siracusa R, Scuto M, Fusco R, Trovato A, Ontario M, Crea R, et al. Anti-inflammatory and Anti-oxidant Activity of Hidrox® in Rotenone-Induced Parkinson's Disease in Mice. Antioxidants (Basel). 2020;9: pubmed publisher
Vasquez V, Mitra J, Perry G, Rao K, Hegde M. An Inducible Alpha-Synuclein Expressing Neuronal Cell Line Model for Parkinson's Disease1. J Alzheimers Dis. 2018;66:453-460 pubmed publisher
Mackenzie I, Nicholson A, Sarkar M, Messing J, Purice M, Pottier C, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 2017;95:808-816.e9 pubmed publisher
Brahmachari S, Ge P, Lee S, Kim D, Karuppagounder S, Kumar M, et al. Activation of tyrosine kinase c-Abl contributes to ?-synuclein-induced neurodegeneration. J Clin Invest. 2016;126:2970-88 pubmed publisher
Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, et al. The role of NUB1 in α-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016;470:635-642 pubmed publisher
Dansithong W, Paul S, Scoles D, Pulst S, Huynh D. Generation of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug Screening. PLoS ONE. 2015;10:e0136930 pubmed publisher
Arawaka S, Fukushima S, Sato H, Sasaki A, Koga K, Koyama S, et al. Zonisamide attenuates ?-synuclein neurotoxicity by an aggregation-independent mechanism in a rat model of familial Parkinson's disease. PLoS ONE. 2014;9:e89076 pubmed publisher
product information
Catalog Number :
sc-58480
Product Name :
α-synuclein (LB 509) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
LB 509
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
α-synuclein
Specificity :
human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA