product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
caspase-4 (4B9) Antibody
catalog :
sc-56056
quantity :
100 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4B9
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 12
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig s4b
  • western blot; human; loading ...; fig 1g
Fernández Duran I, Quintanilla A, Tarrats N, Birch J, Hari P, Millar F, et al. Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence. Cell Death Differ. 2022;29:1267-1282 pubmed publisher
  • western blot; human; loading ...; fig 7a
Choi Y, Kim S, Choi Y, Nielsen T, Yan J, Lu A, et al. SERPINB1-mediated checkpoint of inflammatory caspase activation. Nat Immunol. 2019;20:276-287 pubmed publisher
  • western blot; human; loading ...; fig 5m
Chu L, Indramohan M, Ratsimandresy R, Gangopadhyay A, Morris E, Monack D, et al. The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages. Nat Commun. 2018;9:996 pubmed publisher
  • western blot; human; fig 2b
Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed publisher
  • western blot; human; fig 3a
Okondo M, Johnson D, Sridharan R, Go E, Chui A, Wang M, et al. DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis. Nat Chem Biol. 2017;13:46-53 pubmed publisher
  • western blot; human; loading ...; fig 3b
Pallett M, Crepin V, Serafini N, Habibzay M, Kotik O, Sanchez Garrido J, et al. Bacterial virulence factor inhibits caspase-4/11 activation in intestinal epithelial cells. Mucosal Immunol. 2017;10:602-612 pubmed publisher
  • western blot; human; 1:500; fig 2
Zheng X, Xu J, Chen X, Li W, Wang T. Attenuation of oxygen fluctuation-induced endoplasmic reticulum stress in human lens epithelial cells. Exp Ther Med. 2015;10:1883-1887 pubmed
Rojas López M, Gil Marqu xe9 s M, Kharbanda V, Zajac A, Miller K, Wood T, et al. NLRP11 is a pattern recognition receptor for bacterial lipopolysaccharide in the cytosol of human macrophages. Sci Immunol. 2023;8:eabo4767 pubmed publisher
Kroken A, Klein K, Mitchell P, Nieto V, Jedel E, Evans D, et al. Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome. bioRxiv. 2023;: pubmed publisher
Xiong S, Zhang L, Richner J, Class J, Rehman J, Malik A. Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice. Arterioscler Thromb Vasc Biol. 2021;41:2773-2785 pubmed publisher
Goddard P, Sanchez Garrido J, Slater S, Kalyan M, Ruano Gallego D, Marches O, et al. Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages. Cell Rep. 2019;27:1008-1017.e6 pubmed publisher
Wang X, Cui X, Zhu C, Li M, Zhao J, Shen Z, et al. FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease. Mol Med Rep. 2018;18:4428-4438 pubmed publisher
product information
Catalog Number :
sc-56056
Product Name :
caspase-4 (4B9) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
4B9
Isotype :
IgG1
Size :
100 µg/ml
List Price :
316 USD
Immunogen :
caspase-4
Specificity :
human
Uses :
WB, IP
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA