product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PCNA (PC10) AC
catalog :
sc-56 AC
quantity :
500 µg/ml, 25% ag
price :
416 USD
clonality :
monoclonal
host :
mouse
conjugate :
agarose
clone name :
PC10
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay
citations: 40
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 8
Centrone M, Gena P, Ranieri M, Di Mise A, D Agostino M, Mastrodonato M, et al. In Vitro and In Vivo Nutraceutical Characterization of Two Chickpea Accessions: Differential Effects on Hepatic Lipid Over-Accumulation. Antioxidants (Basel). 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 1s1a
Wutz G, Ladurner R, St Hilaire B, Stocsits R, Nagasaka K, Pignard B, et al. ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL. elife. 2020;9: pubmed publisher
  • western blot; human; fig s3a
Ong D, Hu B, Ho Y, Sauvé C, Bristow C, Wang Q, et al. PAF promotes stemness and radioresistance of glioma stem cells. Proc Natl Acad Sci U S A. 2017;114:E9086-E9095 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Martín Ibáñez R, Pardo M, Giralt A, Miguez A, Guardia I, Marion Poll L, et al. Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons. Development. 2017;144:1566-1577 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 6F
Tu Y, Liu H, Zhu X, Shen H, Ma X, Wang F, et al. Ataxin-3 promotes genome integrity by stabilizing Chk1. Nucleic Acids Res. 2017;45:4532-4549 pubmed publisher
  • western blot; human; loading ...; fig 3a
Jo U, Cai W, Wang J, Kwon Y, D Andrea A, Kim H. PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. PLoS Genet. 2016;12:e1006465 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1d
Kais Z, Rondinelli B, Holmes A, O Leary C, Kozono D, D Andrea A, et al. FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair. Cell Rep. 2016;15:2488-99 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
Hasegawa K, Yasuda T, Shiraishi C, Fujiwara K, Przedborski S, Mochizuki H, et al. Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults. Nat Commun. 2016;7:10943 pubmed publisher
  • immunohistochemistry; mouse; fig 5
Egan C, Sodhi C, Good M, Lin J, Jia H, Yamaguchi Y, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126:495-508 pubmed
  • proximity ligation assay; human; 1:500; fig 3
  • immunocytochemistry; human; 1:400; fig 3
Harley M, Murina O, Leitch A, Higgs M, Bicknell L, Yigit G, et al. TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism. Nat Genet. 2016;48:36-43 pubmed publisher
  • western blot; human; fig 7
Graindorge D, Martineau S, Machon C, Arnoux P, Guitton J, Francesconi S, et al. Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication. PLoS ONE. 2015;10:e0140645 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 6
  • western blot; mouse; fig 6
Lee S, Kim J, Hong S, Lee A, Park E, Seo H, et al. High Inorganic Phosphate Intake Promotes Tumorigenesis at Early Stages in a Mouse Model of Lung Cancer. PLoS ONE. 2015;10:e0135582 pubmed publisher
  • western blot; mouse
Yan H, Solozobova V, Zhang P, Armant O, Kuehl B, Brenner Weiss G, et al. p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53. Cell Death Dis. 2015;6:e1662 pubmed publisher
  • western blot; human; fig 1
Ceccaldi R, Liu J, Amunugama R, Hajdu I, Primack B, Petalcorin M, et al. Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair. Nature. 2015;518:258-62 pubmed publisher
  • western blot; human; fig 3
Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed publisher
  • western blot; human; 1:1000; fig 4
Bürgler S, Gimeno A, Parente Ribes A, Wang D, Os A, Devereux S, et al. Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-γ by a T-bet-dependent mechanism. J Immunol. 2015;194:827-35 pubmed publisher
  • western blot; human; fig 1
Hayashi A, Suenaga N, Shiomi Y, Nishitani H. PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells. Methods Mol Biol. 2014;1170:367-82 pubmed publisher
  • immunohistochemistry; human; 1:40
Hassan H, Varney M, Jain S, Weisenburger D, Singh R, Dave B. Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma. Leuk Lymphoma. 2014;55:2924-31 pubmed publisher
  • western blot; human
Lee M, Wang L, Chang Z. The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stress. Nucleic Acids Res. 2014;42:4972-84 pubmed publisher
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
Chen M, Zhang Y, Yu V, Chong Y, Yoshioka T, Ge R. Isthmin targets cell-surface GRP78 and triggers apoptosis via induction of mitochondrial dysfunction. Cell Death Differ. 2014;21:797-810 pubmed publisher
  • western blot; human
Wei Q, Li J, Liu T, Tong X, Ye X. Phosphorylation of minichromosome maintenance protein 7 (MCM7) by cyclin/cyclin-dependent kinase affects its function in cell cycle regulation. J Biol Chem. 2013;288:19715-25 pubmed publisher
  • western blot; human
Jin L, Craven R. The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor. Oncogene. 2014;33:326-35 pubmed publisher
Prakash A, Moharana K, Wallace S, DOUBLIE S. Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase. Nucleic Acids Res. 2017;45:2897-2909 pubmed publisher
Moura D, Fernández I, Marín Royo G, López Sánchez I, Martín Doncel E, Vega F, et al. Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Sci Rep. 2016;6:28532 pubmed publisher
Hoffmann S, Smedegaard S, Nakamura K, Mortuza G, Räschle M, Ibañez de Opakua A, et al. TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J Cell Biol. 2016;212:63-75 pubmed publisher
Kanu N, Zhang T, Burrell R, Chakraborty A, Cronshaw J, DaCosta C, et al. RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene. 2016;35:4009-19 pubmed publisher
Rocha Caldas G, Oliveira A, Araújo A, Lafayette S, Albuquerque G, Silva Neto J, et al. Gastroprotective Mechanisms of the Monoterpene 1,8-Cineole (Eucalyptol). PLoS ONE. 2015;10:e0134558 pubmed publisher
Porazinski S, Wang H, Asaoka Y, Behrndt M, Miyamoto T, Morita H, et al. YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature. 2015;521:217-221 pubmed publisher
Kanao R, Masuda Y, Deguchi S, Yumoto Sugimoto M, Hanaoka F, Masutani C. Relevance of simultaneous mono-ubiquitinations of multiple units of PCNA homo-trimers in DNA damage tolerance. PLoS ONE. 2015;10:e0118775 pubmed publisher
Baldeck N, Janel Bintz R, Wagner J, Tissier A, Fuchs R, Burkovics P, et al. FF483-484 motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance. Nucleic Acids Res. 2015;43:2116-25 pubmed publisher
Chen R, Zhao Y, Huang Y, Yang Q, Zeng X, Jiang W, et al. Nanomicellar TGX221 blocks xenograft tumor growth of prostate cancer in nude mice. Prostate. 2015;75:593-602 pubmed publisher
Gao X, Dan S, Xie Y, Qin H, Tang D, Liu X, et al. 14-3-3ζ reduces DNA damage by interacting with and stabilizing proliferating cell nuclear antigen. J Cell Biochem. 2015;116:158-69 pubmed publisher
Cazzalini O, Sommatis S, Tillhon M, Dutto I, Bachi A, Rapp A, et al. CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 2014;42:8433-48 pubmed publisher
Fattah F, Hara K, Fattah K, Yang C, Wu N, Warrington R, et al. The transcription factor TFII-I promotes DNA translesion synthesis and genomic stability. PLoS Genet. 2014;10:e1004419 pubmed publisher
Katyal S, Lee Y, Nitiss K, Downing S, Li Y, Shimada M, et al. Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes. Nat Neurosci. 2014;17:813-21 pubmed publisher
Gilljam K, Müller R, Liabakk N, Otterlei M. Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA. PLoS ONE. 2012;7:e49199 pubmed publisher
Gali H, Juhasz S, Mórocz M, Hajdu I, Fatyol K, Szukacsov V, et al. Role of SUMO modification of human PCNA at stalled replication fork. Nucleic Acids Res. 2012;40:6049-59 pubmed publisher
Shumaker D, Solimando L, Sengupta K, Shimi T, Adam S, Grunwald A, et al. The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication. J Cell Biol. 2008;181:269-80 pubmed publisher
Rimoldi G, Christoffel J, Seidlova Wuttke D, Jarry H, Wuttke W. Effects of chronic genistein treatment in mammary gland, uterus, and vagina. Environ Health Perspect. 2007;115 Suppl 1:62-8 pubmed publisher
Frouin I, Toueille M, Ferrari E, Shevelev I, Hubscher U. Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen. Nucleic Acids Res. 2005;33:5354-61 pubmed
product information
Catalog Number :
sc-56 AC
Product Name :
PCNA (PC10) AC
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Conjugation :
agarose
Clone Name :
PC10
Isotype :
IgG2a
Size :
500 µg/ml, 25% ag
List Price :
416 USD
Immunogen :
PCNA
Specificity :
mouse, rat, human, insect, S. pombe
Uses :
IP
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA