product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Fatty Acid Synthase (A-5) Antibody
catalog :
sc-55580
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A-5
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 3b
Viscarra J, Wang Y, Nguyen H, Choi Y, Sul H. Histone demethylase JMJD1C is phosphorylated by mTOR to activate de novo lipogenesis. Nat Commun. 2020;11:796 pubmed publisher
  • western blot; mouse; loading ...; fig s9a
  • western blot; human; loading ...; fig s7
Viscarra J, Wang Y, Hong I, Sul H. Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2. Sci Signal. 2017;10: pubmed publisher
  • western blot; mouse; loading ...; fig 5A
Kim I, Nam T. Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBP? in 3T3-L1 adipocytes. Int J Mol Med. 2017;39:636-644 pubmed publisher
  • western blot; rat; loading ...; fig 9a
Serviddio G, Bellanti F, Villani R, Tamborra R, Zerbinati C, Blonda M, et al. Effects of dietary fatty acids and cholesterol excess on liver injury: A lipidomic approach. Redox Biol. 2016;9:296-305 pubmed publisher
  • western blot; human; fig 5
Jeong H, Cho Y, Kim K, Kim Y, Kim K, Na Y, et al. Anti-lipoapoptotic effects of Alisma orientalis extract on non-esterified fatty acid-induced HepG2 cells. BMC Complement Altern Med. 2016;16:239 pubmed publisher
  • western blot; human; fig 2
Bollu L, Katreddy R, Blessing A, Pham N, Zheng B, Wu X, et al. Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation. Oncotarget. 2015;6:34992-5003 pubmed publisher
  • western blot; rat
Dettlaff Pokora A, Sledzinski T, Swierczynski J. Up-Regulation Mttp and Apob Gene Expression in Rat Liver is Related to Post-Lipectomy Hypertriglyceridemia. Cell Physiol Biochem. 2015;36:1767-77 pubmed
  • western blot; human; fig 7
  • western blot; mouse; fig 7
Li S, Oh Y, Yue P, Khuri F, Sun S. Inhibition of mTOR complex 2 induces GSK3/FBXW7-dependent degradation of sterol regulatory element-binding protein 1 (SREBP1) and suppresses lipogenesis in cancer cells. Oncogene. 2016;35:642-50 pubmed publisher
  • western blot; human; 0.3 ug/ml; fig s6c
Koizume S, Ito S, Nakamura Y, Yoshihara M, Furuya M, Yamada R, et al. Lipid starvation and hypoxia synergistically activate ICAM1 and multiple genes in an Sp1-dependent manner to promote the growth of ovarian cancer. Mol Cancer. 2015;14:77 pubmed publisher
  • western blot; human; fig 5b
Kang O, Kim S, Mun S, Seo Y, Hwang H, Lee Y, et al. Puerarin ameliorates hepatic steatosis by activating the PPARα and AMPK signaling pathways in hepatocytes. Int J Mol Med. 2015;35:803-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 4
  • immunoprecipitation; human; fig 5
  • immunocytochemistry; human; fig 4
  • western blot; human; fig 4
Bollu L, Ren J, Blessing A, Katreddy R, Gao G, Xu L, et al. Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells. Cell Cycle. 2014;13:2415-30 pubmed publisher
  • western blot; mouse
Patterson V, Damrau C, Paudyal A, Reeve B, Grimes D, Stewart M, et al. Mouse hitchhiker mutants have spina bifida, dorso-ventral patterning defects and polydactyly: identification of Tulp3 as a novel negative regulator of the Sonic hedgehog pathway. Hum Mol Genet. 2009;18:1719-39 pubmed publisher
Boese A, Kang J, Hwang J, Kim J, Eun K, Malin C, et al. Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis. Proc Natl Acad Sci U S A. 2023;120:e2217332120 pubmed publisher
Bartolacci C, Andreani C, Vale G, Berto S, Melegari M, Crouch A, et al. Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer. Nat Commun. 2022;13:4327 pubmed publisher
Täuber S, Sieckmann M, Erler K, Stahl W, Klotz L, Steinbrenner H. Activation of Nrf2 by Electrophiles Is Largely Independent of the Selenium Status of HepG2 Cells. Antioxidants (Basel). 2021;10: pubmed publisher
Wei Q, Zhou B, Yang G, Hu W, Zhang L, Liu R, et al. JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism. Cell Death Dis. 2018;9:859 pubmed publisher
Fan Q, Nørgaard R, Bindesbøll C, Lucas C, Dalen K, Babaie E, et al. LXRα Regulates Hepatic ChREBPα Activity and Lipogenesis upon Glucose, but Not Fructose Feeding in Mice. Nutrients. 2017;9: pubmed publisher
Tongluan N, Ramphan S, Wintachai P, Jaresitthikunchai J, Khongwichit S, Wikan N, et al. Involvement of fatty acid synthase in dengue virus infection. Virol J. 2017;14:28 pubmed publisher
Guo J, Kong L, Peng A, Long X, Zhou Y, Shu Y. Transcription factor NF?YA promotes a malignant phenotype by upregulating fatty acid synthase expression. Mol Med Rep. 2016;14:5007-5014 pubmed publisher
Murdoch J, Damrau C, Paudyal A, Bogani D, Wells S, Greene N, et al. Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice. Dis Model Mech. 2014;7:1153-63 pubmed publisher
Yang Y, Lane A, Ricketts C, Sourbier C, Wei M, Shuch B, et al. Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma. PLoS ONE. 2013;8:e72179 pubmed publisher
Boden G, Salehi S, Cheung P, Homko C, Song W, Loveland Jones C, et al. Comparison of in vivo effects of insulin on SREBP-1c activation and INSIG-1/2 in rat liver and human and rat adipose tissue. Obesity (Silver Spring). 2013;21:1208-14 pubmed publisher
Xu L, Kim J, Bai Q, Zhang X, Kakiyama G, Min H, et al. 5-cholesten-3?,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic fatty liver disease mouse model. Mol Pharmacol. 2013;83:648-58 pubmed publisher
Zeng T, Zhang C, Song F, Zhao X, Xie K. Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-?, and CYP2E1. Food Chem Toxicol. 2012;50:485-91 pubmed publisher
Paudyal A, Damrau C, Patterson V, Ermakov A, Formstone C, Lalanne Z, et al. The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol. 2010;10:87 pubmed publisher
Xu L, Bai Q, Rodriguez Agudo D, Hylemon P, Heuman D, Pandak W, et al. Regulation of hepatocyte lipid metabolism and inflammatory response by 25-hydroxycholesterol and 25-hydroxycholesterol-3-sulfate. Lipids. 2010;45:821-32 pubmed publisher
Wang Y, Jacome Sosa M, Ruth M, Goruk S, Reaney M, Glimm D, et al. Trans-11 vaccenic acid reduces hepatic lipogenesis and chylomicron secretion in JCR:LA-cp rats. J Nutr. 2009;139:2049-54 pubmed publisher
product information
Catalog Number :
sc-55580
Product Name :
Fatty Acid Synthase (A-5) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
A-5
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Fatty Acid Synthase
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA