product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
MDR1 (D-11) Antibody
catalog :
sc-55510
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-11
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 36
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; loading ...; fig s1a
Chung J, Chan M, Tang P, Chan A, Chung J, Meng X, et al. AANG: A natural compound formula for overcoming multidrug resistance via synergistic rebalancing the TGF-β/Smad signalling in hepatocellular carcinoma. J Cell Mol Med. 2021;25:9805-9813 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 7i
Loureiro J, Raimundo L, Calheiros J, Carvalho C, Barcherini V, Lima N, et al. Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance. Cancers (Basel). 2021;13: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2
Liu C, He S, Zhang J, Li S, Chen J, Han C. Silencing TCF4 Sensitizes Melanoma Cells to Vemurafenib Through Inhibiting GLUT3-Mediated Glycolysis. Onco Targets Ther. 2020;13:4905-4915 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 6a
Mrowczynski O, Madhankumar A, Slagle Webb B, Lee S, Zacharia B, Connor J. HFE genotype affects exosome phenotype in cancer. Biochim Biophys Acta Gen Subj. 2017;1861:1921-1928 pubmed publisher
  • western blot; human; fig 4
Jiang P, Wang P, Sun X, Yuan Z, Zhan R, Ma X, et al. Knockdown of long noncoding RNA H19 sensitizes human glioma cells to temozolomide therapy. Onco Targets Ther. 2016;9:3501-9 pubmed publisher
  • western blot; human; 1:500; fig 4
Han L, Guo X, Bian H, Yang L, Chen Z, Zang W, et al. Guizhi Fuling Wan, a Traditional Chinese Herbal Formula, Sensitizes Cisplatin-Resistant Human Ovarian Cancer Cells through Inactivation of the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2016;2016:4651949 pubmed publisher
  • western blot; human; fig 4A
Liu L, Zhang J, Yang X, Fang C, Xu H, Xi X. SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer. PLoS ONE. 2015;10:e0138515 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5aa
Wang Y, Wu K, Yang Z, Zhao Q, Fan D, Xu P, et al. Multidrug-Resistance Related Long Non-Coding RNA Expression Profile Analysis of Gastric Cancer. PLoS ONE. 2015;10:e0135461 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 1
  • western blot; human; 1:200; fig 5
Zhao W, Chen R, Zhao M, Li L, Fan L, Che X. High glucose promotes gastric cancer chemoresistance in vivo and in vitro. Mol Med Rep. 2015;12:843-50 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 1
  • western blot; human; loading ...; fig 2B
Ma H, Yue X, Gao L, Liang X, Yan W, Zhang Z, et al. ZHX2 enhances the cytotoxicity of chemotherapeutic drugs in liver tumor cells by repressing MDR1 via interfering with NF-YA. Oncotarget. 2015;6:1049-63 pubmed
  • western blot; human; fig 4
Wang C, Zhang W, Fu M, Yang A, Huang H, Xie J. Establishment of human pancreatic cancer gemcitabine‑resistant cell line with ribonucleotide reductase overexpression. Oncol Rep. 2015;33:383-90 pubmed publisher
  • western blot; human; fig 4c
Yang Y, Zhou W, Xia J, Gu Z, Wendlandt E, Zhan X, et al. NEK2 mediates ALDH1A1-dependent drug resistance in multiple myeloma. Oncotarget. 2014;5:11986-97 pubmed
  • immunocytochemistry; human; 1:500
  • western blot; human; 1:100
Salomon J, Muchitsch V, Gausterer J, Schwagerus E, Huwer H, Daum N, et al. The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier. Mol Pharm. 2014;11:995-1006 pubmed publisher
Zhao Y, Zeng C, Li X, Yang T, Kuang X, Du J. Klotho overexpression improves amyloid-β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease. Aging Cell. 2020;:e13239 pubmed publisher
Huang Y, Lin C, Tsai H, Fong Y, Han C, Huang Y, et al. Amphiregulin promotes cisplatin chemoresistance by upregulating ABCB1 expression in human chondrosarcoma. Aging (Albany NY). 2020;12:9475-9488 pubmed publisher
Yang H, Shen J, Wang Y, Liu Y, Shen D, Quan S. Tankyrase Promotes Aerobic Glycolysis and Proliferation of Ovarian Cancer through Activation of Wnt/β-Catenin Signaling. Biomed Res Int. 2019;2019:2686340 pubmed publisher
Liu H, Liao Y, Tang M, Wu T, Tan D, Zhang S, et al. Trps1 is associated with the multidrug resistance of lung cancer cell by regulating MGMT gene expression. Cancer Med. 2018;7:1921-1932 pubmed publisher
Vaidyanathan A, Sawers L, Gannon A, Chakravarty P, Scott A, Bray S, et al. ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells. Br J Cancer. 2016;115:431-41 pubmed publisher
Tang B, Hu Z, Li Y, Yuan S, Wang Z, Yu S, et al. Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug‑resistant human hepatocellular carcinoma cells to 5‑FU. Mol Med Rep. 2016;13:59-66 pubmed publisher
Tang J, Fu Q, Wang Y, Racette K, Wang D, Liu F. Vitamin E reverses multidrug resistance in vitro and in vivo. Cancer Lett. 2013;336:149-57 pubmed publisher
Han H, Bourboulia D, Jensen Taubman S, Isaac B, Wei B, Stetler Stevenson W. An endogenous inhibitor of angiogenesis inversely correlates with side population phenotype and function in human lung cancer cells. Oncogene. 2014;33:1198-206 pubmed publisher
Tang J, Wang Y, Wang D, Wang Y, Xu Z, Racette K, et al. Key structure of brij for overcoming multidrug resistance in cancer. Biomacromolecules. 2013;14:424-30 pubmed publisher
Harati R, Villegier A, Banks W, Mabondzo A. Susceptibility of juvenile and adult blood-brain barrier to endothelin-1: regulation of P-glycoprotein and breast cancer resistance protein expression and transport activity. J Neuroinflammation. 2012;9:273 pubmed publisher
Su L, Mruk D, Cheng C. Regulation of drug transporters in the testis by environmental toxicant cadmium, steroids and cytokines. Spermatogenesis. 2012;2:285-293 pubmed
Dulin J, Moore M, Grill R. The dual cyclooxygenase/5-lipoxygenase inhibitor licofelone attenuates p-glycoprotein-mediated drug resistance in the injured spinal cord. J Neurotrauma. 2013;30:211-26 pubmed publisher
Shi Z, Yang W, Chen L, Yang D, Zhou Q, Zhu J, et al. Enhanced chemosensitization in multidrug-resistant human breast cancer cells by inhibition of IL-6 and IL-8 production. Breast Cancer Res Treat. 2012;135:737-47 pubmed publisher
Kong Y, Bai P, Sun H, Nan K, Chen N, Qi X. The deoxycholic acid targets miRNA-dependent CAC1 gene expression in multidrug resistance of human colorectal cancer. Int J Biochem Cell Biol. 2012;44:2321-32 pubmed publisher
Cheng C, Liu Z, Zhang H, Xie J, Chen X, Zhao X, et al. Enhancing chemosensitivity in ABCB1- and ABCG2-overexpressing cells and cancer stem-like cells by an Aurora kinase inhibitor CCT129202. Mol Pharm. 2012;9:1971-82 pubmed publisher
Lee J, Jiffar T, Kupferman M. A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma. PLoS ONE. 2012;7:e30246 pubmed publisher
Shi R, Li W, Zhang X, Zhang Y, Peng H, Xie Y, et al. A novel indirubin derivative PHII-7 potentiates adriamycin cytotoxicity via inhibiting P-glycoprotein expression in human breast cancer MCF-7/ADR cells. Eur J Pharmacol. 2011;669:38-44 pubmed publisher
Garrido W, Munoz M, San Martin R, Quezada C. FK506 confers chemosensitivity to anticancer drugs in glioblastoma multiforme cells by decreasing the expression of the multiple resistance-associated protein-1. Biochem Biophys Res Commun. 2011;411:62-8 pubmed publisher
Boyerinas B, Park S, Murmann A, Gwin K, Montag A, Zillhardt M, et al. Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1. Int J Cancer. 2012;130:1787-97 pubmed publisher
Peigñan L, Garrido W, Segura R, Melo R, Rojas D, Cárcamo J, et al. Combined use of anticancer drugs and an inhibitor of multiple drug resistance-associated protein-1 increases sensitivity and decreases survival of glioblastoma multiforme cells in vitro. Neurochem Res. 2011;36:1397-406 pubmed publisher
Mi Y, Liang Y, Huang H, Zhao H, Wu C, Wang F, et al. Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res. 2010;70:7981-91 pubmed publisher
Su L, Cheng C, Mruk D. Drug transporter, P-glycoprotein (MDR1), is an integrated component of the mammalian blood-testis barrier. Int J Biochem Cell Biol. 2009;41:2578-87 pubmed publisher
Zhao L, Li S, Ge J, Sun A, Zou Y, Zhang S. Temporal changes in stem cells in the circulation and myocardium of mice with Coxsackie virus B3-induced myocarditis. Microvasc Res. 2008;75:358-66 pubmed publisher
product information
Catalog Number :
sc-55510
Product Name :
MDR1 (D-11) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
D-11
Isotype :
IgG2b
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
MDR1
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA