Due S, Watson D, Bastian I, Eichelmann A, Hussey D. Oestrogen Receptor Isoforms May Represent a Therapeutic Target in Oesophageal Adenocarcinoma. Cancers (Basel). 2022;14: pubmed publisher

Lee Y, Ho S, Graves J, Xiao Y, Huang S, Lin W. CGRRF1, a growth suppressor, regulates EGFR ubiquitination in breast cancer. Breast Cancer Res. 2019;21:134 pubmed publisher

Browne A, Charmsaz S, Varešlija D, Fagan A, Cosgrove N, Cocchiglia S, et al. Network analysis of SRC-1 reveals a novel transcription factor hub which regulates endocrine resistant breast cancer. Oncogene. 2018;37:2008-2021 pubmed publisher

Khanal T, Choi K, Leung Y, Wang J, Kim D, Janakiram V, et al. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 2017;7:10662 pubmed publisher

Toska E, Osmanbeyoglu H, Castel P, Chan C, Hendrickson R, Elkabets M, et al. PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D. Science. 2017;355:1324-1330 pubmed publisher

Teveroni E, Pellegrino M, Sacconi S, Calandra P, Cascino I, Farioli Vecchioli S, et al. Estrogens enhance myoblast differentiation in facioscapulohumeral muscular dystrophy by antagonizing DUX4 activity. J Clin Invest. 2017;127:1531-1545 pubmed publisher

Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher

McDermott M, Chumanevich A, Lim C, Liang J, Chen M, Altilia S, et al. Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer. Oncotarget. 2017;8:12558-12575 pubmed publisher

Konings G, Reynaert N, Delvoux B, Verhamme F, Bracke K, Brusselle G, et al. Increased levels of enzymes involved in local estradiol synthesis in chronic obstructive pulmonary disease. Mol Cell Endocrinol. 2017;443:23-31 pubmed publisher

Rahman S, Zorca C, Traboulsi T, Noutahi E, Krause M, Mader S, et al. Single-cell profiling reveals that eRNA accumulation at enhancer-promoter loops is not required to sustain transcription. Nucleic Acids Res. 2017;45:3017-3030 pubmed publisher

Liao X, Li J, Dong X, Wang X, Xiang Y, Li H, et al. ER? inhibited myocardin-induced differentiation in uterine fibroids. Exp Cell Res. 2017;350:73-82 pubmed publisher

Tu S, Lin Y, Huang C, Yang P, Chang H, Chang C, et al. Protein phosphatase Mg2+/Mn2+ dependent 1F promotes smoking-induced breast cancer by inactivating phosphorylated-p53-induced signals. Oncotarget. 2016;7:77516-77531 pubmed publisher

Grindstad T, Skjefstad K, Andersen S, Ness N, Nordby Y, Al Saad S, et al. Estrogen receptors ? and ? and aromatase as independent predictors for prostate cancer outcome. Sci Rep. 2016;6:33114 pubmed publisher

Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, Yamaji R. pVHL-mediated degradation of HIF-2? regulates estrogen receptor ? expression in normoxic breast cancer cells. FEBS Lett. 2016;590:2690-9 pubmed publisher

Wang W, Kantorovich S, Babayan A, Hou B, Gall C, Lynch G. Estrogen's Effects on Excitatory Synaptic Transmission Entail Integrin and TrkB Transactivation and Depend Upon ?1-integrin function. Neuropsychopharmacology. 2016;41:2723-32 pubmed publisher

Varešlija D, McBryan J, Fagan A, Redmond A, Hao Y, Sims A, et al. Adaptation to AI Therapy in Breast Cancer Can Induce Dynamic Alterations in ER Activity Resulting in Estrogen-Independent Metastatic Tumors. Clin Cancer Res. 2016;22:2765-77 pubmed publisher

Zhuang T, Zhu J, Li Z, Lorent J, Zhao C, Dahlman Wright K, et al. p21-activated kinase group II small compound inhibitor GNE-2861 perturbs estrogen receptor alpha signaling and restores tamoxifen-sensitivity in breast cancer cells. Oncotarget. 2015;6:43853-68 pubmed publisher

Bentin Toaldo C, Alexi X, Beelen K, Kok M, Hauptmann M, Jansen M, et al. Protein Kinase A-induced tamoxifen resistance is mediated by anchoring protein AKAP13. BMC Cancer. 2015;15:588 pubmed publisher

Wang Y, Zhou D, Chen S. SGK3 is an androgen-inducible kinase promoting prostate cancer cell proliferation through activation of p70 S6 kinase and up-regulation of cyclin D1. Mol Endocrinol. 2014;28:935-48 pubmed publisher

Wang Y, Xu W, Zhou D, Neckers L, Chen S. Coordinated regulation of serum- and glucocorticoid-inducible kinase 3 by a C-terminal hydrophobic motif and Hsp90-Cdc37 chaperone complex. J Biol Chem. 2014;289:4815-26 pubmed publisher

Antal C, Oh T, Aigner S, Luo E, Yee B, Campos T, et al. A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer. Nat Commun. 2023;14:5195 pubmed publisher

Yu L, Xu L, Chu H, Peng J, Sacharidou A, Hsieh H, et al. Macrophage-to-endothelial cell crosstalk by the cholesterol metabolite 27HC promotes atherosclerosis in male mice. Nat Commun. 2023;14:4101 pubmed publisher

Jehanno C, Le Page Y, Flouriot G, Le Goff P, Michel D. Synergistic activation of genes promoting invasiveness by dual deprivation in oxygen and nutrients. Int J Exp Pathol. 2023;104:64-75 pubmed publisher

Li Z, McGinn O, Wu Y, Bahreini A, Priedigkeit N, Ding K, et al. ESR1 mutant breast cancers show elevated basal cytokeratins and immune activation. Nat Commun. 2022;13:2011 pubmed publisher

Sharma V, Joshi J, Yeh I, Doughman Y, Blankenberg D, Wald D, et al. Re-Expression of ERα and AR in Receptor Negative Endocrine Cancers via GSK3 Inhibition. Front Oncol. 2022;12:824594 pubmed publisher

Silveira M, Tav C, Bérubé Simard F, Cuppens T, Leclercq M, Fournier E, et al. Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response. Life Sci Alliance. 2021;4: pubmed publisher

Abdalla M, Yamamoto T, Maehara K, Nogami J, Ohkawa Y, Miura H, et al. The Eleanor ncRNAs activate the topological domain of the ESR1 locus to balance against apoptosis. Nat Commun. 2019;10:3778 pubmed publisher

Zhu C, Li L, Zhang Z, Bi M, Wang H, Su W, et al. A Non-canonical Role of YAP/TEAD Is Required for Activation of Estrogen-Regulated Enhancers in Breast Cancer. Mol Cell. 2019;75:791-806.e8 pubmed publisher

Rutkovsky A, Yeh E, Guest S, Findlay V, Muise Helmericks R, Armeson K, et al. Eukaryotic initiation factor 4E-binding protein as an oncogene in breast cancer. BMC Cancer. 2019;19:491 pubmed publisher

Toska E, Castel P, Chhangawala S, Arruabarrena Aristorena A, Chan C, Hristidis V, et al. PI3K Inhibition Activates SGK1 via a Feedback Loop to Promote Chromatin-Based Regulation of ER-Dependent Gene Expression. Cell Rep. 2019;27:294-306.e5 pubmed publisher

Bossart E, Tasdemir N, Sikora M, Bahreini A, Levine K, Chen J, et al. SNAIL is induced by tamoxifen and leads to growth inhibition in invasive lobular breast carcinoma. Breast Cancer Res Treat. 2019;175:327-337 pubmed publisher

Nassa G, Salvati A, Tarallo R, Gigantino V, Alexandrova E, Memoli D, et al. Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells. Sci Adv. 2019;5:eaav5590 pubmed publisher

Hey F, Andreadi C, Noble C, Patel B, Jin H, Kamata T, et al. Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK. Heliyon. 2018;4:e01065 pubmed publisher

Xu B, Li Q, Chen N, Zhu C, Meng Q, Ayyanathan K, et al. The LIM protein Ajuba recruits DBC1 and CBP/p300 to acetylate ERα and enhances ERα target gene expression in breast cancer cells. Nucleic Acids Res. 2019;47:2322-2335 pubmed publisher

Helzer K, Szatkowski Ozers M, Meyer M, Benkusky N, Solodin N, Reese R, et al. The Phosphorylated Estrogen Receptor α (ER) Cistrome Identifies a Subset of Active Enhancers Enriched for Direct ER-DNA Binding and the Transcription Factor GRHL2. Mol Cell Biol. 2019;39: pubmed publisher

Wang L, Ozark P, Smith E, Zhao Z, Marshall S, Rendleman E, et al. TET2 coactivates gene expression through demethylation of enhancers. Sci Adv. 2018;4:eaau6986 pubmed publisher

Traboulsi T, El Ezzy M, Dumeaux V, Audemard E, Mader S. Role of SUMOylation in differential ERα transcriptional repression by tamoxifen and fulvestrant in breast cancer cells. Oncogene. 2019;38:1019-1037 pubmed publisher

Lopes R, Korkmaz G, Revilla S, van Vliet R, Nagel R, Custers L, et al. CUEDC1 is a primary target of ER? essential for the growth of breast cancer cells. Cancer Lett. 2018;436:87-95 pubmed publisher

Lei J, Shao J, Zhang J, IGLESIA M, Chan D, Cao J, et al. Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer. Cell Rep. 2018;24:1434-1444.e7 pubmed publisher

Michalak E, Milevskiy M, Joyce R, Dekkers J, Jamieson P, Pal B, et al. Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids. PLoS Biol. 2018;16:e2004986 pubmed publisher

Stratikopoulos E, Kiess N, Szabolcs M, Pegno S, Kakit C, Wu X, et al. Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents. Oncogene. 2019;38:47-59 pubmed publisher

Simigdala N, Pancholi S, Ribas R, Folkerd E, Liccardi G, Nikitorowicz Buniak J, et al. Abiraterone shows alternate activity in models of endocrine resistant and sensitive disease. Br J Cancer. 2018;119:313-322 pubmed publisher

Serandour A, Mohammed H, Miremadi A, Mulder K, Carroll J. TRPS1 regulates oestrogen receptor binding and histone acetylation at enhancers. Oncogene. 2018;37:5281-5291 pubmed publisher

Yoo J, Kang H, Broaddus R, Risinger J, Choi K, Kim T. MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT. BMC Cancer. 2018;18:605 pubmed publisher

Gala K, Li Q, Sinha A, Razavi P, Dorso M, Sanchez Vega F, et al. KMT2C mediates the estrogen dependence of breast cancer through regulation of ERα enhancer function. Oncogene. 2018;37:4692-4710 pubmed publisher

Li W, Xu L, Che X, Li H, Zhang Y, Song N, et al. C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells. BMC Cancer. 2018;18:507 pubmed publisher

Guertin M, Cullen A, Markowetz F, Holding A. Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq. Nucleic Acids Res. 2018;46:e75 pubmed publisher

Ohoka N, Morita Y, Nagai K, Shimokawa K, Ujikawa O, Fujimori I, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018;293:6776-6790 pubmed publisher

Sugiaman Trapman D, Vitezic M, Jouhilahti E, Mathelier A, Lauter G, Misra S, et al. Characterization of the human RFX transcription factor family by regulatory and target gene analysis. BMC Genomics. 2018;19:181 pubmed publisher

Jeselsohn R, Bergholz J, Pun M, Cornwell M, Liu W, Nardone A, et al. Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations. Cancer Cell. 2018;33:173-186.e5 pubmed publisher

Wu Y, Zhang Z, Cenciarini M, Proietti C, Amasino M, Hong T, et al. Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis. Cancer Res. 2018;78:671-684 pubmed publisher

Martin L, Ribas R, Simigdala N, Schuster E, Pancholi S, Tenev T, et al. Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance. Nat Commun. 2017;8:1865 pubmed publisher

Campbell T, Castro M, de Oliveira K, Ponder B, Meyer K. ERα Binding by Transcription Factors NFIB and YBX1 Enables FGFR2 Signaling to Modulate Estrogen Responsiveness in Breast Cancer. Cancer Res. 2018;78:410-421 pubmed publisher

Tarallo R, Giurato G, Bruno G, Ravo M, Rizzo F, Salvati A, et al. The nuclear receptor ER? engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Genome Biol. 2017;18:189 pubmed publisher

Whirledge S, Kisanga E, Taylor R, Cidlowski J. Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells. Endocrinology. 2017;158:4076-4092 pubmed publisher

Zhao Y, Laws M, Guillen V, Ziegler Y, Min J, Sharma A, et al. Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors. Cancer Res. 2017;77:5602-5613 pubmed publisher

Finlay Schultz J, Gillen A, Brechbuhl H, Ivie J, Matthews S, Jacobsen B, et al. Breast Cancer Suppression by Progesterone Receptors Is Mediated by Their Modulation of Estrogen Receptors and RNA Polymerase III. Cancer Res. 2017;77:4934-4946 pubmed publisher

Min J, Guillen V, Sharma A, Zhao Y, Ziegler Y, Gong P, et al. Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells. J Med Chem. 2017;60:6321-6336 pubmed publisher

Ilsley M, Gillinder K, Magor G, Huang S, Bailey T, Crossley M, et al. Krüppel-like factors compete for promoters and enhancers to fine-tune transcription. Nucleic Acids Res. 2017;45:6572-6588 pubmed publisher

Jeselsohn R, Cornwell M, Pun M, Buchwalter G, Nguyen M, Bango C, et al. Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. Proc Natl Acad Sci U S A. 2017;114:E4482-E4491 pubmed publisher

Ferraiuolo R, Tubman J, Sinha I, Hamm C, Porter L. The cyclin-like protein, SPY1, regulates the ER? and ERK1/2 pathways promoting tamoxifen resistance. Oncotarget. 2017;8:23337-23352 pubmed publisher

Luecke Johansson S, Gralla M, Rundqvist H, Ho J, Johnson R, Gradin K, et al. A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase. Mol Cell Biol. 2017;37: pubmed publisher

Hübner S, Sunny D, Pöhlke C, Ruhnau J, Vogelgesang A, Reich B, et al. Protective Effects of Fetal Zone Steroids Are Comparable to Estradiol in Hyperoxia-Induced Cell Death of Immature Glia. Endocrinology. 2017;158:1419-1435 pubmed publisher

Padró M, Louie R, Lananna B, Krieg A, Timmerman L, Chan D. Genome-independent hypoxic repression of estrogen receptor alpha in breast cancer cells. BMC Cancer. 2017;17:203 pubmed publisher

Stender J, Nwachukwu J, Kastrati I, Kim Y, Strid T, Yakir M, et al. Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Mol Cell. 2017;65:1122-1135.e5 pubmed publisher

Droog M, Nevedomskaya E, Dackus G, Fles R, Kim Y, Hollema H, et al. Estrogen receptor ? wields treatment-specific enhancers between morphologically similar endometrial tumors. Proc Natl Acad Sci U S A. 2017;114:E1316-E1325 pubmed publisher

Ohoka N, Okuhira K, Ito M, Nagai K, Shibata N, Hattori T, et al. In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs). J Biol Chem. 2017;292:4556-4570 pubmed publisher

Diao Y, Azatyan A, Rahman M, Zhao C, Zhu J, Dahlman Wright K, et al. Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells. Oncotarget. 2016;7:71580-71593 pubmed publisher

Bouilly J, Beau I, Barraud S, Bernard V, Azibi K, Fagart J, et al. Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency. J Clin Endocrinol Metab. 2016;101:4541-4550 pubmed

Ladd B, Mazzola A, Bihani T, Lai Z, BRADFORD J, Collins M, et al. Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations. Oncotarget. 2016;7:54120-54136 pubmed publisher

Ronghe A, Chatterjee A, Bhat N, Padhye S, Bhat H. Tamoxifen synergizes with 4-(E)-{(4-hydroxyphenylimino)-methylbenzene, 1,2-diol} and 4-(E)-{(p-tolylimino)-methylbenzene-1,2-diol}, novel azaresveratrol analogs, in inhibiting the proliferation of breast cancer cells. Oncotarget. 2016;7:51747-51762 pubmed publisher

Neguembor M, Xynos A, Onorati M, Caccia R, Bortolanza S, Godio C, et al. FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis. J Mol Cell Biol. 2013;5:294-307 pubmed publisher