product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p21 Waf1/Cip1 (SX118) Antibody
catalog :
sc-53870
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SX118
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 22
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 1f
Rada M, Vasileva E, Lezina L, Marouco D, Antonov A, Macip S, et al. Human EHMT2/G9a activates p53 through methylation-independent mechanism. Oncogene. 2017;36:922-932 pubmed publisher
  • western blot; human; fig 6
Wu B, Chen H, Cai C, Fang J, Wu C, Huang L, et al. Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A 686. Oncotarget. 2016;7:6847-63 pubmed publisher
  • western blot; human; fig 4f
Myklebust L, Van Damme P, Støve S, Dörfel M, Abboud A, Kalvik T, et al. Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Hum Mol Genet. 2015;24:1956-76 pubmed publisher
  • western blot; mouse; 1:200
Brun C, Périé L, Baraige F, Vernus B, Bonnieu A, Blanquet V. Absence of hyperplasia in Gasp-1 overexpressing mice is dependent on myostatin up-regulation. Cell Physiol Biochem. 2014;34:1241-59 pubmed publisher
  • western blot; human
Cheng J, Fan Y, Xu X, Dou J, Tang Y, Zhong X, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5:e1079 pubmed publisher
Guiley K, Shokat K. A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability. Cancer Discov. 2023;13:56-69 pubmed publisher
Mohibi S, Chen X, Zhang J. ZFP14 Regulates Cancer Cell Growth and Migration by Modulating p53 Protein Stability as Part of the MDM2 E3 Ubiquitin Ligase Complex. Cancers (Basel). 2022;14: pubmed publisher
Sturmlechner I, Zhang C, Sine C, van Deursen E, Jeganathan K, Hamada N, et al. p21 produces a bioactive secretome that places stressed cells under immunosurveillance. Science. 2021;374:eabb3420 pubmed publisher
Pack L, Daigh L, Chung M, Meyer T. Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2. Nat Commun. 2021;12:3356 pubmed publisher
Liu S, Lei Z, Li J, Wang L, Jia R, Liu Z, et al. Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation. PLoS Pathog. 2020;16:e1008701 pubmed publisher
Sevilla Montero J, Bienes Martínez R, Labrousse Arias D, Fuertes Yebra E, Ordoñez A, Calzada M. pVHL-mediated regulation of the anti-angiogenic protein thrombospondin-1 decreases migration of Clear Cell Renal Carcinoma Cell Lines. Sci Rep. 2020;10:1175 pubmed publisher
Brückmann N, Bennedsen S, Duijf P, Terp M, Thomassen M, Larsen M, et al. A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence. Cell Death Dis. 2019;10:841 pubmed publisher
Datta N, Islam S, Chatterjee U, Chatterjee S, Panda C, Ghosh M. Promyelocytic Leukemia (PML) gene regulation: implication towards curbing oncogenesis. Cell Death Dis. 2019;10:656 pubmed publisher
Schüler F, Weiss J, Lindner S, Lohmüller M, Herzog S, Spiegl S, et al. Checkpoint kinase 1 is essential for normal B cell development and lymphomagenesis. Nat Commun. 2017;8:1697 pubmed publisher
Okuda A, Kurokawa S, Takehashi M, Maeda A, Fukuda K, Kubo Y, et al. Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells. BMC Neurosci. 2017;18:14 pubmed publisher
Chen Z, Wang L, Yao D, Yang T, Cao W, Dou J, et al. Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis. Sci Rep. 2016;6:38011 pubmed publisher
Lu J, Guan S, Zhao Y, Yu Y, Wang Y, Shi Y, et al. Novel MDM2 inhibitor SAR405838 (MI-773) induces p53-mediated apoptosis in neuroblastoma. Oncotarget. 2016;7:82757-82769 pubmed publisher
Li T, Liu X, Jiang L, MANFREDI J, Zha S, Gu W. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget. 2016;7:11838-49 pubmed publisher
Mandriota S, Valentijn L, Lesne L, Betts D, Marino D, Boudal Khoshbeen M, et al. Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism. Oncotarget. 2015;6:18558-76 pubmed
Fan Y, Cheng J, Vasudevan S, Dou J, Patel R, Ma I, et al. USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis. Cell Death Dis. 2013;4:e867 pubmed publisher
Zhang M, Zhang Z, Fu J, Yang Y, Yun J. Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma. J Transl Med. 2009;7:110 pubmed publisher
Kawamura T, Suzuki J, Wang Y, Menendez S, Morera L, Raya A, et al. Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature. 2009;460:1140-4 pubmed publisher
product information
Catalog Number :
sc-53870
Product Name :
p21 Waf1/Cip1 (SX118) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
SX118
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
p21 Waf1/Cip1
Specificity :
mouse, rat, human
Uses :
WB, IP, IF
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA