product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Alix (1A12) Antibody
catalog :
sc-53540
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1A12
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 6a, 7a
Lee J, Park H, Han S, Kang Y, Mun J, Shin D, et al. Alpha-2-macroglobulin as a novel diagnostic biomarker for human bladder cancer in urinary extracellular vesicles. Front Oncol. 2022;12:976407 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1c
Xie F, Zhou X, Su P, Li H, Tu Y, Du J, et al. Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling. Nat Commun. 2022;13:4461 pubmed publisher
  • western blot; rat; loading ...; fig 2g
Song L, Tian X, Schekman R. Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1. J Cell Biol. 2021;220: pubmed publisher
  • western blot; human; 1:400; loading ...; fig 2i, 6e
Wu A, Sung Y, Chen Y, Chou S, Guo V, Chien J, et al. Multiresolution Imaging Using Bioluminescence Resonance Energy Transfer Identifies Distinct Biodistribution Profiles of Extracellular Vesicles and Exomeres with Redirected Tropism. Adv Sci (Weinh). 2020;7:2001467 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1b
  • western blot; mouse; 1:1000; loading ...; fig 4b
Zhang H, Deng T, Ge S, Liu Y, Bai M, Zhu K, et al. Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7. Oncogene. 2019;38:2844-2859 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig s8a
Arii J, Watanabe M, Maeda F, Tokai Nishizumi N, Chihara T, Miura M, et al. ESCRT-III mediates budding across the inner nuclear membrane and regulates its integrity. Nat Commun. 2018;9:3379 pubmed publisher
  • western blot; human; loading ...; fig 9b
Gräßel L, Fast L, Scheffer K, Boukhallouk F, Spoden G, Tenzer S, et al. The CD63-Syntenin-1 Complex Controls Post-Endocytic Trafficking of Oncogenic Human Papillomaviruses. Sci Rep. 2016;6:32337 pubmed publisher
  • western blot; mouse; loading ...; fig 3h
Dinkins M, Enasko J, Hernandez C, Wang G, Kong J, Helwa I, et al. Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse. J Neurosci. 2016;36:8653-67 pubmed publisher
  • western blot; human; 1:500; fig 5
Song M, Wang Y, Shang Z, Liu X, Xie D, Wang Q, et al. Bystander autophagy mediated by radiation-induced exosomal miR-7-5p in non-targeted human bronchial epithelial cells. Sci Rep. 2016;6:30165 pubmed publisher
  • western blot; human; 1:1000; fig 4
Kharmate G, Hosseini Beheshti E, Caradec J, Chin M, Tomlinson Guns E. Epidermal Growth Factor Receptor in Prostate Cancer Derived Exosomes. PLoS ONE. 2016;11:e0154967 pubmed publisher
  • western blot; human; 1:1000; fig 1
Clark D, Fondrie W, Yang A, Mao L. Triple SILAC quantitative proteomic analysis reveals differential abundance of cell signaling proteins between normal and lung cancer-derived exosomes. J Proteomics. 2016;133:161-169 pubmed publisher
  • western blot; human; fig 1
Cypryk W, Ohman T, Eskelinen E, Matikainen S, Nyman T. Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon ?-glucan stimulation. J Proteome Res. 2014;13:2468-77 pubmed publisher
Martínez Greene J, Hernández Ortega K, Quiroz Baez R, Resendis Antonio O, Pichardo Casas I, Sinclair D, et al. Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography. J Extracell Vesicles. 2021;10:e12087 pubmed publisher
Chettimada S, Lorenz D, Misra V, Wolinsky S, Gabuzda D. Small RNA sequencing of extracellular vesicles identifies circulating miRNAs related to inflammation and oxidative stress in HIV patients. BMC Immunol. 2020;21:57 pubmed publisher
Gu D, Liu F, Meng M, Zhang L, Gordon M, Wang Y, et al. Elevated matrix metalloproteinase-9 levels in neuronal extracellular vesicles in Alzheimer's disease. Ann Clin Transl Neurol. 2020;: pubmed publisher
Lauritzen I, Bécot A, Bourgeois A, Pardossi Piquard R, Biferi M, Barkats M, et al. Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models. Transl Neurodegener. 2019;8:35 pubmed publisher
Karasmanis E, Hwang D, Nakos K, Bowen J, Angelis D, Spiliotis E. A Septin Double Ring Controls the Spatiotemporal Organization of the ESCRT Machinery in Cytokinetic Abscission. Curr Biol. 2019;: pubmed publisher
Yaddanapudi K, Meng S, Whitt A, Al Rayyan N, Richie J, Tu A, et al. Exosomes from GM-CSF expressing embryonic stem cells are an effective prophylactic vaccine for cancer prevention. Oncoimmunology. 2019;8:1561119 pubmed publisher
Gonzalez Lopez O, Rivera Serrano E, Hu F, Hensley L, McKnight K, Ren J, et al. Redundant Late Domain Functions of Tandem VP2 YPX3L Motifs in Nonlytic Cellular Egress of Quasi-enveloped Hepatitis A Virus. J Virol. 2018;92: pubmed publisher
Li Z, Mbah N, Maltese W. Vacuole-inducing compounds that disrupt endolysosomal trafficking stimulate production of exosomes by glioblastoma cells. Mol Cell Biochem. 2018;439:1-9 pubmed publisher
McKnight K, Xie L, González López O, Rivera Serrano E, Chen X, Lemon S. Protein composition of the hepatitis A virus quasi-envelope. Proc Natl Acad Sci U S A. 2017;114:6587-6592 pubmed publisher
product information
Catalog Number :
sc-53540
Product Name :
Alix (1A12) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
1A12
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Alix
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA