product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
MDM2 (D-12) Antibody
catalog :
sc-5304
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-12
reactivity :
human
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 1a
Worrall C, Suleymanova N, Crudden C, Trocoli Drakensjö I, Candrea E, Nedelcu D, et al. Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma. Oncogene. 2017;: pubmed publisher
  • western blot; human; 1:500; loading ...; fig 2
Schwermer M, Dreesmann S, Eggert A, Althoff K, Steenpass L, Schramm A, et al. Pharmaceutically inhibiting polo-like kinase 1 exerts a broad anti-tumour activity in retinoblastoma cell lines. Clin Exp Ophthalmol. 2016;: pubmed publisher
  • western blot; human
Kardos G, Dai M, Robertson G. Growth inhibitory effects of large subunit ribosomal proteins in melanoma. Pigment Cell Melanoma Res. 2014;27:801-12 pubmed publisher
Swetzig W, Wang J, Das G. Estrogen receptor alpha (ERα/ESR1) mediates the p53-independent overexpression of MDM4/MDMX and MDM2 in human breast cancer. Oncotarget. 2016;7:16049-69 pubmed publisher
Karimi-Busheri F, Rasouli-Nia A, Mackey J, Weinfeld M. Senescence evasion by MCF-7 human breast tumor-initiating cells. Breast Cancer Res. 2010;12:R31 pubmed publisher
Lewis J, Meeke K, Osipo C, Ross E, Kidawi N, Li T, et al. Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. J Natl Cancer Inst. 2005;97:1746-59 pubmed
Samudio I, Duvvuri S, Clise-Dwyer K, Watt J, Mak D, Kantarjian H, et al. Activation of p53 signaling by MI-63 induces apoptosis in acute myeloid leukemia cells. Leuk Lymphoma. 2010;51:911-9 pubmed publisher
Farnebo L, Jerhammar F, Vainikka L, Grenman R, Norberg-Spaak L, Roberg K. Number of negative points: a novel method for predicting radiosensitivity in head and neck tumor cell lines. Oncol Rep. 2008;20:453-61 pubmed
Jiang Y, Rao K, Yang G, Chen X, Wang Q, Liu A, et al. Benzo(a)pyrene induces p73 mRNA expression and necrosis in human lung adenocarcinoma H1299 cells. Environ Toxicol. 2012;27:202-10 pubmed publisher
Ndoye A, Dolivet G, Høgset A, Leroux A, Fifre A, Erbacher P, et al. Eradication of p53-mutated head and neck squamous cell carcinoma xenografts using nonviral p53 gene therapy and photochemical internalization. Mol Ther. 2006;13:1156-62 pubmed
Niu J, Xu Z, Li X, Han Z. siRNA-mediated type 1 insulin-like growth factor receptor silencing induces chemosensitization of a human liver cancer cell line with mutant P53. Cell Biol Int. 2007;31:156-64 pubmed
Dinicola S, Cucina A, Pasqualato A, D'Anselmi F, Proietti S, Lisi E, et al. Antiproliferative and apoptotic effects triggered by Grape Seed Extract (GSE) versus epigallocatechin and procyanidins on colon cancer cell lines. Int J Mol Sci. 2012;13:651-64 pubmed publisher
Cucina A, Proietti S, D'Anselmi F, Coluccia P, Dinicola S, Frati L, et al. Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells. J Pineal Res. 2009;46:172-80 pubmed publisher
Proietti S, Cucina A, D'Anselmi F, Dinicola S, Pasqualato A, Lisi E, et al. Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells. J Pineal Res. 2011;50:150-8 pubmed publisher
Yang G, Zhou X, Wang J, Zhang W, Zheng H, Lu W, et al. MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food Chem Toxicol. 2012;50:2424-31 pubmed publisher
Pasqualato A, Palombo A, Cucina A, Mariggio M, Galli L, Passaro D, et al. Quantitative shape analysis of chemoresistant colon cancer cells: correlation between morphotype and phenotype. Exp Cell Res. 2012;318:835-46 pubmed publisher
product information
Product Name :
MDM2 (D-12) Antibody
Gene Name :
MDM2
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-5304
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
MDM2
reactive species  :
human
Application :
WB, IP, IF, FCM, ELISA
Epitope :
100-320 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA