product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
IRAK-1 (F-4) Antibody
catalog :
sc-5288
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
F-4
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 21
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:50; loading ...; fig 5e
An L, Shen Y, Chopp M, Zacharek A, Venkat P, Chen Z, et al. Deficiency of Endothelial Nitric Oxide Synthase (eNOS) Exacerbates Brain Damage and Cognitive Deficit in A Mouse Model of Vascular Dementia. Aging Dis. 2021;12:732-746 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 7c
Ben J, Jiang B, Wang D, Liu Q, Zhang Y, Qi Y, et al. Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK-NF-κB signaling mediated inflammation. Nat Commun. 2019;10:1801 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 7d
McCarthy G, Bridges C, Blednov Y, Harris R. CNS cell-type localization and LPS response of TLR signaling pathways. F1000Res. 2017;6:1144 pubmed publisher
  • western blot; human; 1:500; fig 4c
Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, et al. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015;17:1049-61 pubmed publisher
Lee S, Ha J, Park J, Kang E, Jeon S, Han S, et al. Antioxidant and Anti-Inflammatory Effects of Bischofia javanica (Blume) Leaf Methanol Extracts through the Regulation of Nrf2 and TAK1. Antioxidants (Basel). 2021;10: pubmed publisher
Vogl T, Stratis A, Wixler V, Voller T, Thurainayagam S, Jorch S, et al. Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation. J Clin Invest. 2018;128:1852-1866 pubmed publisher
Hornick E, Banoth B, Miller A, Zacharias Z, Jain N, Wilson M, et al. Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection. J Immunol. 2018;200:1188-1197 pubmed publisher
Zhang W, He T, Wang Q, Li X, Wei J, Hou X, et al. Interleukin-1 receptor-associated kinase-2 genetic variant rs708035 increases NF-?B activity through promoting TRAF6 ubiquitination. J Biol Chem. 2014;289:12507-19 pubmed publisher
Tarantino N, Tinevez J, Crowell E, Boisson B, Henriques R, Mhlanga M, et al. TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures. J Cell Biol. 2014;204:231-45 pubmed publisher
Chang M, Kim D, Roh J, Middeldorp J, Kim Y, Kim S, et al. Epstein-Barr virus-encoded BARF1 promotes proliferation of gastric carcinoma cells through regulation of NF-?B. J Virol. 2013;87:10515-23 pubmed publisher
Casella C, Mitchell T. Inefficient TLR4/MD-2 heterotetramerization by monophosphoryl lipid A. PLoS ONE. 2013;8:e62622 pubmed publisher
Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, et al. Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol. 2012;13:1178-86 pubmed publisher
Laberge R, Zhou L, Sarantos M, Rodier F, Freund A, de Keizer P, et al. Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell. 2012;11:569-78 pubmed publisher
Li Y, Si R, Feng Y, Chen H, Zou L, Wang E, et al. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem. 2011;286:31308-19 pubmed publisher
Dudas J, Fullár A, Bitsche M, Schartinger V, Kovalszky I, Sprinzl G, et al. Tumor-produced, active interleukin-1? regulates gene expression in carcinoma-associated fibroblasts. Exp Cell Res. 2011;317:2222-9 pubmed publisher
Cui X, Jin Y, Poudyal D, Chumanevich A, Davis T, Windust A, et al. Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis. Carcinogenesis. 2010;31:1734-41 pubmed publisher
Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, et al. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal). J Biol Chem. 2010;285:18276-82 pubmed publisher
Bhaumik D, Scott G, Schokrpur S, Patil C, Orjalo A, Rodier F, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009;1:402-11 pubmed
Pacifico F, Crescenzi E, Mellone S, Iannetti A, Porrino N, Liguoro D, et al. Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146a. J Clin Endocrinol Metab. 2010;95:1421-30 pubmed publisher
Orjalo A, Bhaumik D, Gengler B, Scott G, Campisi J. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A. 2009;106:17031-6 pubmed publisher
Chao W, Shen Y, Zhu X, Zhao H, Novikov M, Schmidt U, et al. Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation. J Biol Chem. 2005;280:21997-2005 pubmed
product information
Product Name :
IRAK-1 (F-4) Antibody
Gene Name :
IRAK1
Size :
200 µg/ml
Catalog Number :
sc-5288
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
IRAK-1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
440-712 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA