product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Chk2 (A-12) Antibody
catalog :
sc-5278
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
A-12
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:100; loading ...; fig s9a
Laine A, Nagelli S, Farrington C, Butt U, Cvrljevic A, Vainonen J, et al. CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis. Cancer Res. 2021;81:4319-4331 pubmed publisher
  • flow cytometry; human; loading ...; fig 6b
Sun R, Hedl M, Abraham C. TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants. Cell Mol Gastroenterol Hepatol. 2021;11:249-272 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Kariolis M, Miao Y, Diep A, Nash S, Olcina M, Jiang D, et al. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017;127:183-198 pubmed publisher
  • western blot; human
Pattabiraman C, Hong S, Gunasekharan V, Pranatharthi A, Bajaj J, Srivastava S, et al. CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits. Cancer Res. 2014;74:6682-92 pubmed publisher
Di Luigi L, Duranti G, Antonioni A, Sgrò P, Ceci R, Crescioli C, et al. The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species. Antioxidants (Basel). 2020;9: pubmed publisher
Lu H, Yang X, Tian X, Tang S, Li L, Zhao S, et al. The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells. Oncotarget. 2016;7:56508-56525 pubmed publisher
Su W, Hsu S, Wu C, Chang S, Lin Y, Yang W, et al. Chronic treatment with cisplatin induces replication-dependent sister chromatid recombination to confer cisplatin-resistant phenotype in nasopharyngeal carcinoma. Oncotarget. 2014;5:6323-37 pubmed
Liu J, Guo S, Li Q, Yang L, Xia Z, Zhang L, et al. Phosphoglycerate dehydrogenase induces glioma cells proliferation and invasion by stabilizing forkhead box M1. J Neurooncol. 2013;111:245-55 pubmed publisher
Kari V, Shchebet A, Neumann H, Johnsen S. The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair. Cell Cycle. 2011;10:3495-504 pubmed publisher
Golan A, Pick E, Tsvetkov L, Nadler Y, Kluger H, Stern D. Centrosomal Chk2 in DNA damage responses and cell cycle progression. Cell Cycle. 2010;9:2647-56 pubmed
Bárta T, Vinarsky V, Holubcová Z, Dolezalova D, Verner J, Pospisilova S, et al. Human embryonic stem cells are capable of executing G1/S checkpoint activation. Stem Cells. 2010;28:1143-52 pubmed publisher
Chou W, Wang H, Wong F, Ding S, Wu P, Shieh S, et al. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J. 2008;27:3140-50 pubmed publisher
Chou Y, Ho Y, Wu C, Chai C, Chen S, Lee C, et al. Tubulozole-induced G2/M cell cycle arrest in human colon cancer cells through formation of microtubule polymerization mediated by ERK1/2 and Chk1 kinase activation. Food Chem Toxicol. 2007;45:1356-67 pubmed
Hong Y, Cervantes R, Stambrook P. DNA damage response and mutagenesis in mouse embryonic stem cells. Methods Mol Biol. 2006;329:313-26 pubmed
Chen J, Lin S, Tso W, Yeh G, Lee W, Tseng H, et al. Checkpoint kinase 1-mediated phosphorylation of Cdc25C and bad proteins are involved in antitumor effects of loratadine-induced G2/M phase cell-cycle arrest and apoptosis. Mol Carcinog. 2006;45:461-78 pubmed
Takagaki K, Katsuma S, Kaminishi Y, Horio T, Tanaka T, Ohgi T, et al. Role of Chk1 and Chk2 in Ara-C-induced differentiation of human leukemia K562 cells. Genes Cells. 2005;10:97-106 pubmed
product information
Product Name :
Chk2 (A-12) Antibody
Gene Name :
CHEK2
Size :
200 µg/ml
Catalog Number :
sc-5278
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Chk2
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM, ELISA
Epitope :
1-300 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA