product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
FLIPS/L (G-11) Antibody
catalog :
sc-5276
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G-11
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; rat; loading ...; fig 5c
Wang F, Jia J, Lal N, Zhang D, Chiu A, Wan A, et al. High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovasc Res. 2016;112:656-668 pubmed
  • western blot; human; 1:1000; fig 1b
Gaidos G, Panaitiu A, Guo B, Pellegrini M, Mierke D. Identification and Characterization of the Interaction Site between cFLIPL and Calmodulin. PLoS ONE. 2015;10:e0141692 pubmed publisher
  • western blot; human; 1:200; fig 5
Braun F, Mathur R, Sehgal L, Wilkie Grantham R, Chandra J, Berkova Z, et al. Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLoS ONE. 2015;10:e0117994 pubmed publisher
  • western blot; rat; 1:100
Gao S, Andreeva K, Cooper N. Ischemia-reperfusion injury of the retina is linked to necroptosis via the ERK1/2-RIP3 pathway. Mol Vis. 2014;20:1374-87 pubmed
  • western blot; human; 1:200
Chondrogiannis G, Kastamoulas M, Kanavaros P, Vartholomatos G, Bai M, Baltogiannis D, et al. Cytokine effects on cell viability and death of prostate carcinoma cells. Biomed Res Int. 2014;2014:536049 pubmed publisher
  • western blot; human; fig 7d
Wilkie Grantham R, Matsuzawa S, Reed J. Novel phosphorylation and ubiquitination sites regulate reactive oxygen species-dependent degradation of anti-apoptotic c-FLIP protein. J Biol Chem. 2013;288:12777-90 pubmed publisher
  • western blot; human
Jin T, Kurakin A, Benhaga N, Abe K, Mohseni M, Sandra F, et al. Fas-associated protein with death domain (FADD)-independent recruitment of c-FLIPL to death receptor 5. J Biol Chem. 2004;279:55594-601 pubmed
Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, et al. Hepatic neuregulin 4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. J Clin Invest. 2017;127:4449-4461 pubmed publisher
Ram D, Ilyukha V, Volkova T, Buzdin A, Tai A, Smirnova I, et al. Balance between short and long isoforms of cFLIP regulates Fas-mediated apoptosis in vivo. Proc Natl Acad Sci U S A. 2016;113:1606-11 pubmed publisher
Gao J, Wang F, Wang W, Su Z, Guo C, Cao S. Emodin suppresses hyperglycemia-induced proliferation and fibronectin expression in mesangial cells via inhibiting cFLIP. PLoS ONE. 2014;9:e93588 pubmed publisher
Dinh P, Das A, Franco R, Pattnaik A. Heterogeneous nuclear ribonucleoprotein K supports vesicular stomatitis virus replication by regulating cell survival and cellular gene expression. J Virol. 2013;87:10059-69 pubmed publisher
Berger A, Quast S, Plötz M, Kammermeier A, Eberle J. Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax. Cell Death Dis. 2013;4:e477 pubmed publisher
Garau C, Miralles A, Garcia Sevilla J. Chronic treatment with selective I2-imidazoline receptor ligands decreases the content of pro-apoptotic markers in rat brain. J Psychopharmacol. 2013;27:123-34 pubmed publisher
al Yacoub N, Fecker L, Möbs M, Plötz M, Braun F, Sterry W, et al. Apoptosis induction by SAHA in cutaneous T-cell lymphoma cells is related to downregulation of c-FLIP and enhanced TRAIL signaling. J Invest Dermatol. 2012;132:2263-74 pubmed publisher
Chen S, Evans H, Evans D. FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short. PLoS ONE. 2012;7:e32971 pubmed publisher
Ramachandiran S, Cain J, Liao A, He Y, Guo X, Boise L, et al. The Smac mimetic RMT5265.2HCL induces apoptosis in EBV and HTLV-I associated lymphoma cells by inhibiting XIAP and promoting the mitochondrial release of cytochrome C and Smac. Leuk Res. 2012;36:784-90 pubmed publisher
Braun F, al Yacoub N, Plötz M, Möbs M, Sterry W, Eberle J. Nonsteroidal anti-inflammatory drugs induce apoptosis in cutaneous T-cell lymphoma cells and enhance their sensitivity for TNF-related apoptosis-inducing ligand. J Invest Dermatol. 2012;132:429-39 pubmed publisher
Harris J, Ibrahim H, Amen F, Karadimitris A, Naresh K, Macdonald D. Cellular (FLICE) like inhibitory protein (cFLIP) expression in diffuse large B-cell lymphoma identifies a poor prognostic subset, but fails to predict the molecular subtype. Hematol Oncol. 2012;30:8-12 pubmed publisher
Logan A, Wilson T, Fenning C, Cummins R, Kay E, Johnston P, et al. In vitro and in vivo characterisation of a novel c-FLIP-targeted antisense phosphorothioate oligonucleotide. Apoptosis. 2010;15:1435-43 pubmed publisher
Fecker L, Stockfleth E, Braun F, Rodust P, Schwarz C, Köhler A, et al. Enhanced death ligand-induced apoptosis in cutaneous SCC cells by treatment with diclofenac/hyaluronic acid correlates with downregulation of c-FLIP. J Invest Dermatol. 2010;130:2098-109 pubmed publisher
Stamatopoulos B, Meuleman N, De Bruyn C, Delforge A, Bron D, Lagneaux L. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells. Haematologica. 2010;95:1136-43 pubmed publisher
Bredholt T, Dimba E, Hagland H, Wergeland L, Skavland J, Fossan K, et al. Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer. 2009;8:101 pubmed publisher
Stamatopoulos B, Meuleman N, De Bruyn C, Mineur P, Martiat P, Bron D, et al. Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis. Leukemia. 2009;23:2281-9 pubmed publisher
Yang T, Barbone D, Fennell D, Broaddus V. Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids. Am J Respir Cell Mol Biol. 2009;41:14-23 pubmed publisher
García Fuster M, Ramos Miguel A, Rivero G, La Harpe R, Meana J, García Sevilla J. Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers. Neuroscience. 2008;157:105-19 pubmed publisher
Navara C, Redinger C, Mich Basso J, Oliver S, Ben Yehudah A, Castro C, et al. Derivation and characterization of nonhuman primate embryonic stem cells. Curr Protoc Stem Cell Biol. 2007;Chapter 1:Unit 1A.1 pubmed publisher
Braun F, Fecker L, Schwarz C, Walden P, Assaf C, Dürkop H, et al. Blockade of death receptor-mediated pathways early in the signaling cascade coincides with distinct apoptosis resistance in cutaneous T-cell lymphoma cells. J Invest Dermatol. 2007;127:2425-37 pubmed
Kurbanov B, Fecker L, Geilen C, Sterry W, Eberle J. Resistance of melanoma cells to TRAIL does not result from upregulation of antiapoptotic proteins by NF-kappaB but is related to downregulation of initiator caspases and DR4. Oncogene. 2007;26:3364-77 pubmed
Wang S, Wang S, Maeng H, Young D, Prakash O, Fayad L, et al. K1 protein of human herpesvirus 8 suppresses lymphoma cell Fas-mediated apoptosis. Blood. 2007;109:2174-82 pubmed
Cucina A, Biava P, D Anselmi F, Coluccia P, Conti F, Di Clemente R, et al. Zebrafish embryo proteins induce apoptosis in human colon cancer cells (Caco2). Apoptosis. 2006;11:1617-28 pubmed
Siu P, Pistilli E, Ryan M, Alway S. Aging sustains the hypertrophy-associated elevation of apoptotic suppressor X-linked inhibitor of apoptosis protein (XIAP) in skeletal muscle during unloading. J Gerontol A Biol Sci Med Sci. 2005;60:976-83 pubmed
Siu P, Bryner R, Murlasits Z, Alway S. Response of XIAP, ARC, and FLIP apoptotic suppressors to 8 wk of treadmill running in rat heart and skeletal muscle. J Appl Physiol (1985). 2005;99:204-9 pubmed
Zaichuk T, Shroff E, Emmanuel R, Filleur S, Nelius T, Volpert O. Nuclear factor of activated T cells balances angiogenesis activation and inhibition. J Exp Med. 2004;199:1513-22 pubmed
Mathas S, Lietz A, Anagnostopoulos I, Hummel F, Wiesner B, Janz M, et al. c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis. J Exp Med. 2004;199:1041-52 pubmed
product information
Product Name :
FLIPS/L (G-11) Antibody
Gene Name :
CFLAR
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-5276
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
FLIPS/L
reactive species  :
m, r, h
Application :
WB, IP, IF, ELISA
Epitope :
1-202 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA