product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
TNFα (52B83) Antibody
catalog :
sc-52746
quantity :
100 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
52B83
reactivity :
African green monkey, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 47
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rat; 1:25; loading ...; fig 1i
Formigari G, D xe1 tilo M, Vareda B, Bonfante I, Cavaglieri C, Lopes de Faria J, et al. Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy. Sci Rep. 2022;12:9062 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 7
Zhou Q, Li J, Xiang Z, Zou H, Shao X. Amelioration of Renal Injury by Resveratrol in a Rat Renal Transplantation Model via Activation of the SIRT1/NF-κB Signaling Pathway. Biomed Res Int. 2022;2022:7140961 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:150; loading ...; fig 1b, 4b, 7b
Poletti F, González Fernández R, García M, Rotoli D, Avila J, Mobasheri A, et al. Molecular-Morphological Relationships of the Scaffold Protein FKBP51 and Inflammatory Processes in Knee Osteoarthritis. Cells. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 11a
Santana K, Righetti R, Breda C, Domínguez Amorocho O, Ramalho T, Dantas F, et al. Cholesterol-Ester Transfer Protein Alters M1 and M2 Macrophage Polarization and Worsens Experimental Elastase-Induced Pulmonary Emphysema. Front Immunol. 2021;12:684076 pubmed publisher
  • western blot; mouse; 1:100; loading ...; fig 5a
Mohamed A, El Magd M, El Said K, El Sharnouby M, Tousson E, Salama A. Potential therapeutic effect of thymoquinone and/or bee pollen on fluvastatin-induced hepatitis in rats. Sci Rep. 2021;11:15688 pubmed publisher
  • immunohistochemistry - paraffin section; African green monkey; 1:200; loading ...; fig 6j
Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, et al. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein Cell. 2021;12:695-716 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 8o
Choudhuri S, Garg N. PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease. PLoS Pathog. 2020;16:e1008474 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 7
Oh W, Jung J, Choi Y, Mun J, Ku S, Song C. Protective effects of fermented rice extract on ulcerative colitis induced by dextran sodium sulfate in mice. Food Sci Nutr. 2020;8:1718-1728 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:400; loading ...; fig 3a
Wang G, Huang T, Hu Y, Wang K, Shi H, Yin L, et al. Corpus cavernosum smooth muscle cell dysfunction and phenotype transformation are related to erectile dysfunction in prostatitis rats with chronic prostatitis/chronic pelvic pain syndrome. J Inflamm (Lond). 2020;17:2 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 6a
Liu Q, Liu C, Jiang L, Li M, Long T, He W, et al. α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory effect in a chronic migraine rat model via the attenuation of glial cell activation. J Pain Res. 2018;11:1129-1140 pubmed publisher
  • western blot; mouse; 1:3000; loading ...; fig 3c
Ray M, Gabunia K, Vrakas C, Herman A, Kako F, Kelemen S, et al. Genetic Deletion of IL-19 (Interleukin-19) Exacerbates Atherogenesis in Il19-/-×Ldlr-/- Double Knockout Mice by Dysregulation of mRNA Stability Protein HuR (Human Antigen R). Arterioscler Thromb Vasc Biol. 2018;38:1297-1308 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Zhang Z, Zhang H, Chen R, Wang Z. Oral supplementation with ursolic acid ameliorates sepsis-induced acute kidney injury in a mouse model by inhibiting oxidative stress and inflammatory responses. Mol Med Rep. 2018;17:7142-7148 pubmed publisher
  • immunohistochemistry; rat; 1:100; loading ...; fig 4i
Gugliandolo E, Fusco R, D Amico R, Militi A, Oteri G, Wallace J, et al. Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. Pharmacol Res. 2018;132:220-231 pubmed publisher
  • western blot; mouse; loading ...; fig 2b
Koh J, Hancock C, Terada S, Higashida K, Holloszy J, Han D. PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise. Cell Metab. 2017;25:1176-1185.e5 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 6g
Seemann S, Lupp A. Administration of AMD3100 in endotoxemia is associated with pro-inflammatory, pro-oxidative, and pro-apoptotic effects in vivo. J Biomed Sci. 2016;23:68 pubmed
  • immunohistochemistry - paraffin section; human; 1:100; fig 4
Roth S, Spalinger M, Gottier C, Biedermann L, Zeitz J, Lang S, et al. Bilberry-Derived Anthocyanins Modulate Cytokine Expression in the Intestine of Patients with Ulcerative Colitis. PLoS ONE. 2016;11:e0154817 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; fig 5
Haas S, Zhou X, Machado V, Wree A, Krieglstein K, Spittau B. Expression of Tgfβ1 and Inflammatory Markers in the 6-hydroxydopamine Mouse Model of Parkinson's Disease. Front Mol Neurosci. 2016;9:7 pubmed publisher
  • western blot; human; fig 1
Eskicioğlu F, Özdemir A, Özdemir R, Turan G, Akan Z, Hasdemir S. The association of HLA-G and immune markers in recurrent miscarriages. J Matern Fetal Neonatal Med. 2016;29:3056-60 pubmed publisher
  • western blot; mouse; fig 5
Saveljeva S, Mc Laughlin S, Vandenabeele P, Samali A, Bertrand M. Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells. Cell Death Dis. 2015;6:e1587 pubmed publisher
  • western blot; rat; 1:200
Ortiz F, Acuña Castroviejo D, Doerrier C, Dayoub J, López L, Venegas C, et al. Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis. J Pineal Res. 2015;58:34-49 pubmed publisher
  • western blot; mouse; loading ...; fig 6
Bodine B, Bennion B, Leatham E, Jimenez F, Wright A, Jergensen Z, et al. Conditionally induced RAGE expression by proximal airway epithelial cells in transgenic mice causes lung inflammation. Respir Res. 2014;15:133 pubmed publisher
D Amico R, Trovato Salinaro A, Cordaro M, Fusco R, Impellizzeri D, Interdonato L, et al. Hidrox® and Chronic Cystitis: Biochemical Evaluation of Inflammation, Oxidative Stress, and Pain. Antioxidants (Basel). 2021;10: pubmed publisher
Khan I, Saeed K, Jo M, Kim M. 17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway. Antioxidants (Basel). 2021;10: pubmed publisher
Chen L, Huang C, Liao C, Chang H, Kuan Y, Tseng T, et al. Effects of Rutin on Wound Healing in Hyperglycemic Rats. Antioxidants (Basel). 2020;9: pubmed publisher
Kim S, Lee J, Shin S, Kim J, Silwal P, Kim Y, et al. ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota. Autophagy. 2020;:1-20 pubmed publisher
Badshah H, Ikram M, Ali W, Ahmad S, Hahm J, Kim M. Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. Biomolecules. 2019;9: pubmed publisher
Popovic D, Kocic G, Katic V, Zarubica A, Velickovic L, Ničković V, et al. Anthocyanins Protect Hepatocytes against CCl4-Induced Acute Liver Injury in Rats by Inhibiting Pro-inflammatory mediators, Polyamine Catabolism, Lipocalin-2, and Excessive Proliferation of Kupffer Cells. Antioxidants (Basel). 2019;8: pubmed publisher
Rojas Morales P, Tapia E, León Contreras J, González Reyes S, Jiménez Osorio A, Trujillo J, et al. Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury. Biomolecules. 2019;9: pubmed publisher
Ho D, Lee H, Son I, Seol W. G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses. Anim Cells Syst (Seoul). 2019;23:106-111 pubmed publisher
Kim T, Jin Y, Kim Y, Kim S, Kim J, Lee H, et al. SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions. Autophagy. 2019;15:1356-1375 pubmed publisher
You Z, Yu M, Zhang Y, Shi K. Progranulin protects the mouse retina under hypoxic conditions via inhibition of the Toll‑like receptor‑4‑NADPH oxidase 4 signaling pathway. Mol Med Rep. 2019;19:382-390 pubmed publisher
Fang J, Yan Y, Teng X, Wen X, Li N, Peng S, et al. Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress. Aging (Albany NY). 2018;10:2954-2972 pubmed publisher
Zhu L, Weng Z, Shen P, Zhou J, Zeng J, Weng F, et al. S100B regulates inflammatory response during osteoarthritis via fibroblast growth factor receptor 1 signaling. Mol Med Rep. 2018;18:4855-4864 pubmed publisher
Oh S, Yoon M, Lim K, Yu B, Jee I, Jung K. Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation. BMC Anesthesiol. 2018;18:97 pubmed publisher
Ho D, Je A, Lee H, Son I, Kweon H, Kim H, et al. LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation. Exp Neurobiol. 2018;27:171-180 pubmed publisher
Wu X, Tommasi di Vignano A, Zhou Q, Michel Dziunycz P, Bai F, Mi J, et al. The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin. PLoS Genet. 2018;14:e1007366 pubmed publisher
Ruiz Ojeda F, Gómez Llorente C, Aguilera C, Gil A, Ruperez A. Impact of 3-Amino-1,2,4-Triazole (3-AT)-Derived Increase in Hydrogen Peroxide Levels on Inflammation and Metabolism in Human Differentiated Adipocytes. PLoS ONE. 2016;11:e0152550 pubmed publisher
Prado A, Favaron P, da Silva L, Baccarin R, Miglino M, Maria D. Characterization of mesenchymal stem cells derived from the equine synovial fluid and membrane. BMC Vet Res. 2015;11:281 pubmed publisher
Zhao Y, Liu F, Liu Y, Zhou D, Dai Q, Liu S. Anti-Arthritic Effect of Chebulanin on Collagen-Induced Arthritis in Mice. PLoS ONE. 2015;10:e0139052 pubmed publisher
Yang C, Yuk J, Kim J, Hwang J, Lee C, Kim J, et al. Small heterodimer partner-targeting therapy inhibits systemic inflammatory responses through mitochondrial uncoupling protein 2. PLoS ONE. 2013;8:e63435 pubmed publisher
Manigrasso M, Sawyer R, Hutchens Z, Flynn E, Maric Bilkan C. Combined inhibition of aromatase activity and dihydrotestosterone supplementation attenuates renal injury in male streptozotocin (STZ)-induced diabetic rats. Am J Physiol Renal Physiol. 2012;302:F1203-9 pubmed publisher
Palmieri D, Pane B, Barisione C, Spinella G, Garibaldi S, Ghigliotti G, et al. Resveratrol counteracts systemic and local inflammation involved in early abdominal aortic aneurysm development. J Surg Res. 2011;171:e237-46 pubmed publisher
Park C, Shin T, Lee H, Kim S, Lee W. Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice. Korean J Physiol Pharmacol. 2011;15:115-22 pubmed publisher
Manigrasso M, Sawyer R, Marbury D, Flynn E, Maric C. Inhibition of estradiol synthesis attenuates renal injury in male streptozotocin-induced diabetic rats. Am J Physiol Renal Physiol. 2011;301:F634-40 pubmed publisher
Boehm J, Fischer K, Bohnert M. Putative role of TNF-alpha, interleukin-8 and ICAM-1 as indicators of an early inflammatory reaction after burn: a morphological and immunohistochemical study of lung tissue of fire victims. J Clin Pathol. 2010;63:967-71 pubmed publisher
Hamblin M, Chang L, Zhang H, Yang K, Zhang J, Chen Y. Vascular smooth muscle cell peroxisome proliferator-activated receptor-? deletion promotes abdominal aortic aneurysms. J Vasc Surg. 2010;52:984-93 pubmed publisher
Kim J, Kim J, Kim D, Ha Y, Ihm M, Kim H, et al. Wnt5a induces endothelial inflammation via beta-catenin-independent signaling. J Immunol. 2010;185:1274-82 pubmed publisher
product information
Catalog Number :
sc-52746
Product Name :
TNFα (52B83) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
52B83
Isotype :
IgG1
Size :
100 µg/ml
List Price :
316 USD
Immunogen :
TNFalpha
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), FCM, ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA