product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
HuR (3A2) Antibody
catalog :
sc-5261
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3A2
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, proximity ligation assay, RNA immunoprecipitation, cross-linking immunoprecipitation, western blot knockout validation, immunocytochemistry knockout validation
citations: 128
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; human; 1:100; loading ...; fig s4
  • western blot knockout validation; human; 1:500; loading ...; fig 1c, s5a
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig s1a
Wu X, Gardashova G, Lan L, Han S, Zhong C, Marquez R, et al. Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis. Commun Biol. 2020;3:193 pubmed publisher
  • immunocytochemistry knockout validation; human; loading ...; fig 1e
  • western blot knockout validation; human; loading ...; fig 1d
  • RNA immunoprecipitation; human; loading ...; fig 3b
Lal S, Cheung E, Zarei M, Preet R, Chand S, Mambelli Lisboa N, et al. CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. Mol Cancer Res. 2017;15:696-707 pubmed publisher
  • western blot knockout validation; human; 1:200; loading ...; fig s8e
Marceau C, Puschnik A, Majzoub K, Ooi Y, Brewer S, Fuchs G, et al. Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens. Nature. 2016;535:159-63 pubmed
  • western blot knockout validation; human; 1:1000-1:5000; fig 3
Estep J, Sternburg E, Sanchez G, Karginov F. Immunoblot screening of CRISPR/Cas9-mediated gene knockouts without selection. BMC Mol Biol. 2016;17:9 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s8d
Van Alstyne M, Tattoli I, Delestrée N, Recinos Y, Workman E, Shihabuddin L, et al. Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit. Nat Neurosci. 2021;24:930-940 pubmed publisher
  • immunohistochemistry; human; 1:1500; loading ...
Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, et al. Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3. Acta Neuropathol. 2020;139:99-118 pubmed publisher
  • immunoprecipitation; human; 1:1000; loading ...; fig 2a
  • western blot; human; 1:1000; loading ...; fig 2a
Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature. 2019;571:127-131 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2a
Morris K, Corbett A. The polyadenosine RNA-binding protein ZC3H14 interacts with the THO complex and coordinately regulates the processing of neuronal transcripts. Nucleic Acids Res. 2018;46:6561-6575 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Wu X, Tommasi di Vignano A, Zhou Q, Michel Dziunycz P, Bai F, Mi J, et al. The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin. PLoS Genet. 2018;14:e1007366 pubmed publisher
  • western blot; mouse; loading ...; fig 6c
Chen J, Martindale J, Cramer C, Gorospe M, Atasoy U, Drew P, et al. The RNA-binding protein HuR contributes to neuroinflammation by promoting C-C chemokine receptor 6 (CCR6) expression on Th17 cells. J Biol Chem. 2017;292:14532-14543 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
  • western blot; human; 1:1000; loading ...; fig 1c
Fragkouli A, Koukouraki P, Vlachos I, Paraskevopoulou M, Hatzigeorgiou A, Doxakis E. Neuronal ELAVL proteins utilize AUF-1 as a co-partner to induce neuron-specific alternative splicing of APP. Sci Rep. 2017;7:44507 pubmed publisher
  • western blot; human; loading ...; fig 3b
Janakiraman H, House R, Talwar S, Courtney S, Hazard E, Hardiman G, et al. Repression of caspase-3 and RNA-binding protein HuR cleavage by cyclooxygenase-2 promotes drug resistance in oral squamous cell carcinoma. Oncogene. 2017;36:3137-3148 pubmed publisher
  • western blot; human; fig 6c
Hwang C, Wagley Y, Law P, Wei L, Loh H. Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element RNA-binding protein 1 (AUF1) and poly A binding protein (PABP). Gene. 2017;598:113-130 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2d
  • western blot; human; 1:500; loading ...; fig 1c
Alfano L, Costa C, Caporaso A, Antonini D, Giordano A, Pentimalli F. HUR protects NONO from degradation by mir320, which is induced by p53 upon UV irradiation. Oncotarget. 2016;7:78127-78139 pubmed publisher
  • immunoprecipitation; human
  • immunocytochemistry; human; 1:200
  • western blot; human; 1:20,000; loading ...; fig 3b
Blanco F, Preet R, Aguado A, Vishwakarma V, Stevens L, Vyas A, et al. Impact of HuR inhibition by the small molecule MS-444 on colorectal cancer cell tumorigenesis. Oncotarget. 2016;7:74043-74058 pubmed publisher
  • western blot; human; 1:20,000; fig s3
Durand S, Franks T, Lykke Andersen J. Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay. Nat Commun. 2016;7:12434 pubmed publisher
  • immunoprecipitation; rat; loading ...; fig 3c
  • western blot; rat; loading ...; fig 2a
Wang H, Tri Anggraini F, Chen X, DeGracia D. Embryonic lethal abnormal vision proteins and adenine and uridine-rich element mRNAs after global cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab. 2017;37:1494-1507 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 2g
Byrd A, Zybailov B, Maddukuri L, Gao J, Marecki J, Jaiswal M, et al. Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem. 2016;291:18041-57 pubmed publisher
  • western blot; human; fig 5
Lo Dico A, Costa V, Martelli C, Diceglie C, Rajata F, Rizzo A, et al. MiR675-5p Acts on HIF-1? to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma. Theranostics. 2016;6:1105-18 pubmed publisher
  • western blot; human; fig 4
Mineo M, Ricklefs F, Rooj A, Lyons S, Ivanov P, Ansari K, et al. The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016;15:2500-9 pubmed publisher
  • immunocytochemistry; human; fig 4
Nelson E, Schmidt K, Deflubé L, Doğanay S, Banadyga L, Olejnik J, et al. Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions. J Virol. 2016;90:7268-7284 pubmed publisher
  • western blot; human; loading ...; fig 1b
Lyons S, Achorn C, Kedersha N, Anderson P, Ivanov P. YB-1 regulates tiRNA-induced Stress Granule formation but not translational repression. Nucleic Acids Res. 2016;44:6949-60 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Huang Y, Peng W, Furuuchi N, DuHadaway J, Jimbo M, Pirritano A, et al. Insights from HuR biology point to potential improvement for second-line ovarian cancer therapy. Oncotarget. 2016;7:21812-24 pubmed publisher
  • western blot; human; fig 1
Iavello A, Frech V, Gai C, Deregibus M, Quesenberry P, Camussi G. Role of Alix in miRNA packaging during extracellular vesicle biogenesis. Int J Mol Med. 2016;37:958-66 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Huang Y, Peng W, Furuuchi N, Gerhart J, Rhodes K, Mukherjee N, et al. Delivery of Therapeutics Targeting the mRNA-Binding Protein HuR Using 3DNA Nanocarriers Suppresses Ovarian Tumor Growth. Cancer Res. 2016;76:1549-59 pubmed publisher
  • western blot; human; fig 1c
Zhou J, Yang L, Zhong T, Mueller M, Men Y, Zhang N, et al. H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase. Nat Commun. 2015;6:10221 pubmed publisher
  • western blot; human; fig 1
Liwak Muir U, Dobson C, Naing T, Wylie Q, Chehade L, Baird S, et al. ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism. Oncotarget. 2016;7:1439-50 pubmed publisher
  • cross-linking immunoprecipitation; human; fig 4
Martinez N, Agosto L, Qiu J, Mallory M, Gazzara M, Barash Y, et al. Widespread JNK-dependent alternative splicing induces a positive feedback loop through CELF2-mediated regulation of MKK7 during T-cell activation. Genes Dev. 2015;29:2054-66 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 3a
  • immunoprecipitation; human; fig 2c
  • immunocytochemistry; human; fig 2a
  • western blot; human; fig 2e
Blanco F, Jimbo M, Wulfkuhle J, Gallagher I, Deng J, Enyenihi L, et al. The mRNA-binding protein HuR promotes hypoxia-induced chemoresistance through posttranscriptional regulation of the proto-oncogene PIM1 in pancreatic cancer cells. Oncogene. 2016;35:2529-41 pubmed publisher
  • western blot; human; 1:2000; fig 1
Jimbo M, Blanco F, Huang Y, Telonis A, Screnci B, Cosma G, et al. Targeting the mRNA-binding protein HuR impairs malignant characteristics of pancreatic ductal adenocarcinoma cells. Oncotarget. 2015;6:27312-31 pubmed publisher
  • immunocytochemistry; human; 1:2000; fig 5
Mahboubi H, Barisé R, Stochaj U. Data in support of 5'AMP-activated protein kinase alpha regulates stress granule biogenesis. Data Brief. 2015;4:54-9 pubmed publisher
  • western blot; mouse; 1:2000; fig 6
Agca C, Boldt K, Gubler A, Meneau I, Corpet A, Samardzija M, et al. Expression of leukemia inhibitory factor in Müller glia cells is regulated by a redox-dependent mRNA stability mechanism. BMC Biol. 2015;13:30 pubmed publisher
  • western blot; human; 1:200
Panas M, Kedersha N, McInerney G. Methods for the characterization of stress granules in virus infected cells. Methods. 2015;90:57-64 pubmed publisher
  • immunocytochemistry; human; 1:2000; fig 1
  • western blot; human; 1:2000; fig 5
Mahboubi H, Barisé R, Stochaj U. 5'-AMP-activated protein kinase alpha regulates stress granule biogenesis. Biochim Biophys Acta. 2015;1853:1725-37 pubmed publisher
  • proximity ligation assay; mouse; 1:100; fig 3
Hausburg M, Doles J, Clement S, Cadwallader A, Hall M, Blackshear P, et al. Post-transcriptional regulation of satellite cell quiescence by TTP-mediated mRNA decay. elife. 2015;4:e03390 pubmed publisher
  • immunocytochemistry; mouse; 1:100
ErLin S, WenJie W, LiNing W, BingXin L, MingDe L, Yan S, et al. Musashi-1 maintains blood-testis barrier structure during spermatogenesis and regulates stress granule formation upon heat stress. Mol Biol Cell. 2015;26:1947-56 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 5
Yan J, Zhang H, Yin Y, Li J, Tang Y, Purkayastha S, et al. Obesity- and aging-induced excess of central transforming growth factor-? potentiates diabetic development via an RNA stress response. Nat Med. 2014;20:1001-8 pubmed publisher
  • chromatin immunoprecipitation; mouse
  • western blot; mouse
Mamouni K, Cristini A, Guirouilh Barbat J, Monferran S, Lemarie A, Faye J, et al. RhoB promotes ?H2AX dephosphorylation and DNA double-strand break repair. Mol Cell Biol. 2014;34:3144-55 pubmed publisher
  • immunohistochemistry - paraffin section; human
Ramírez C, Lin C, Abdelmohsen K, Goedeke L, Yoon J, Madrigal Matute J, et al. RNA binding protein HuR regulates the expression of ABCA1. J Lipid Res. 2014;55:1066-76 pubmed publisher
  • western blot; mouse
Vreeland A, Yu S, Levi L, de Barros Rossetto D, Noy N. Transcript stabilization by the RNA-binding protein HuR is regulated by cellular retinoic acid-binding protein 2. Mol Cell Biol. 2014;34:2135-46 pubmed publisher
  • EMSA; human
González Feliciano J, Hernandez Perez M, Estrella L, Colón López D, Lopez A, Martinez M, et al. The role of HuR in the post-transcriptional regulation of interleukin-3 in T cells. PLoS ONE. 2014;9:e92457 pubmed publisher
  • immunoprecipitation; human; fig 2a
  • immunoprecipitation; mouse; fig 2a
  • western blot; mouse; fig 1e
Legnini I, Morlando M, Mangiavacchi A, Fatica A, Bozzoni I. A feedforward regulatory loop between HuR and the long noncoding RNA linc-MD1 controls early phases of myogenesis. Mol Cell. 2014;53:506-14 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:25
Lewis M, Jamison J, Dunbar J, DeGracia D. mRNA redistribution during permanent focal cerebral ischemia. Transl Stroke Res. 2013;4:604-17 pubmed publisher
  • immunohistochemistry; mouse
Lachke S, Alkuraya F, Kneeland S, Ohn T, Aboukhalil A, Howell G, et al. Mutations in the RNA granule component TDRD7 cause cataract and glaucoma. Science. 2011;331:1571-6 pubmed publisher
  • immunocytochemistry; human
Jamison J, Kayali F, Rudolph J, Marshall M, Kimball S, DeGracia D. Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion. Neuroscience. 2008;154:504-20 pubmed publisher
Di Luigi L, Duranti G, Antonioni A, Sgrò P, Ceci R, Crescioli C, et al. The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species. Antioxidants (Basel). 2020;9: pubmed publisher
Liebig J, Kuphal S, Bosserhoff A. HuRdling Senescence: HuR Breaks BRAF-Induced Senescence in Melanocytes and Supports Melanoma Growth. Cancers (Basel). 2020;12: pubmed publisher
Hildebrandt A, Brüggemann M, Rücklé C, Boerner S, Heidelberger J, Busch A, et al. The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation. Genome Biol. 2019;20:216 pubmed publisher
Jiang Q, Xie Q, Hu C, Yang Z, Huang P, Shen H, et al. Glioma malignancy is linked to interdependent and inverse AMOG and L1 adhesion molecule expression. BMC Cancer. 2019;19:911 pubmed publisher
Kumarasinghe N, Moss W. Analysis of a structured intronic region of the LMP2 pre-mRNA from EBV reveals associations with human regulatory proteins and nuclear actin. BMC Res Notes. 2019;12:33 pubmed publisher
Ji E, Kim C, Kang H, Ahn S, Jung M, Hong Y, et al. RNA Binding Protein HuR Promotes Autophagosome Formation by Regulating Expression of Autophagy-Related Proteins 5, 12, and 16 in Human Hepatocellular Carcinoma Cells. Mol Cell Biol. 2019;39: pubmed publisher
Chen Y, Yang F, Fang E, Xiao W, Mei H, Li H, et al. Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes. Cell Death Differ. 2019;26:1346-1364 pubmed publisher
Pan H, Strickland A, Madhu V, Johnson Z, Chand S, Brody J, et al. RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells. Matrix Biol. 2019;77:23-40 pubmed publisher
Christodoulou Vafeiadou E, Ioakeimidis F, Andreadou M, Giagkas G, Stamatakis G, Reczko M, et al. Divergent Innate and Epithelial Functions of the RNA-Binding Protein HuR in Intestinal Inflammation. Front Immunol. 2018;9:2732 pubmed publisher
Dogar A, Pauchard Batschulat R, Grisoni Neupert B, Richman L, Paillusson A, Pradervand S, et al. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. PLoS ONE. 2018;13:e0206823 pubmed publisher
Ricciardi L, Col J, Casolari P, Memoli D, Conti V, Vatrella A, et al. Differential expression of RNA-binding proteins in bronchial epithelium of stable COPD patients. Int J Chron Obstruct Pulmon Dis. 2018;13:3173-3190 pubmed publisher
House R, Majumder M, Janakiraman H, Ogretmen B, Kato M, Erkul E, et al. Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer. PLoS ONE. 2018;13:e0205077 pubmed publisher
Burgess H, Mohr I. Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS. J Virol. 2018;92: pubmed publisher
Badawi A, Biyanee A, Nasrullah U, Winslow S, Schmid T, Pfeilschifter J, et al. Inhibition of IRES-dependent translation of caspase-2 by HuR confers chemotherapeutic drug resistance in colon carcinoma cells. Oncotarget. 2018;9:18367-18385 pubmed publisher
Cioni J, Wong H, Bressan D, Kodama L, Harris W, Holt C. Axon-Axon Interactions Regulate Topographic Optic Tract Sorting via CYFIP2-Dependent WAVE Complex Function. Neuron. 2018;97:1078-1093.e6 pubmed publisher
Ouhara K, Munenaga S, Kajiya M, Takeda K, Matsuda S, Sato Y, et al. The induced RNA-binding protein, HuR, targets 3'-UTR region of IL-6 mRNA and enhances its stabilization in periodontitis. Clin Exp Immunol. 2018;192:325-336 pubmed publisher
Hornick E, Banoth B, Miller A, Zacharias Z, Jain N, Wilson M, et al. Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection. J Immunol. 2018;200:1188-1197 pubmed publisher
Cho D, Doles J. Single cell transcriptome analysis of muscle satellite cells reveals widespread transcriptional heterogeneity. Gene. 2017;636:54-63 pubmed publisher
Yu S, Parameswaran N, Li M, Wang Y, Jackson M, Liu H, et al. CRABP-II enhances pancreatic cancer cell migration and invasion by stabilizing interleukin 8 expression. Oncotarget. 2017;8:52432-52444 pubmed publisher
Zarei M, Lal S, Parker S, Nevler A, Vaziri Gohar A, Dukleska K, et al. Posttranscriptional Upregulation of IDH1 by HuR Establishes a Powerful Survival Phenotype in Pancreatic Cancer Cells. Cancer Res. 2017;77:4460-4471 pubmed publisher
Tan S, Ding K, Chong Q, Zhao J, Liu Y, Shao Y, et al. Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells. J Biol Chem. 2017;292:13551-13564 pubmed publisher
Villanueva E, Navarro P, Rovira Rigau M, Sibilio A, Mendez R, Fillat C. Translational reprogramming in tumour cells can generate oncoselectivity in viral therapies. Nat Commun. 2017;8:14833 pubmed publisher
Hoffman O, Burns N, Vadász I, Eltzschig H, Edwards M, Vohwinkel C. Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome. PLoS ONE. 2017;12:e0172116 pubmed publisher
Anantharaman A, Tripathi V, Khan A, Yoon J, Singh D, Gholamalamdari O, et al. ADAR2 regulates RNA stability by modifying access of decay-promoting RNA-binding proteins. Nucleic Acids Res. 2017;45:4189-4201 pubmed publisher
Habiba U, Kitamura T, Yanagawa Matsuda A, Higashino F, Hida K, Totsuka Y, et al. HuR and podoplanin expression is associated with a high risk of malignant transformation in patients with oral preneoplastic lesions. Oncol Lett. 2016;12:3199-3207 pubmed
Li Z, Chen Z, Zhang T, Wei C, Shi W. TGF-? and NF-?B signaling pathway crosstalk potentiates corneal epithelial senescence through an RNA stress response. Aging (Albany NY). 2016;8:2337-2354 pubmed publisher
Ahuja D, Goyal A, Ray P. Interplay between RNA-binding protein HuR and microRNA-125b regulates p53 mRNA translation in response to genotoxic stress. RNA Biol. 2016;13:1152-1165 pubmed
Claußen M, Lingner T, Pommerenke C, Opitz L, Salinas G, Pieler T. Global analysis of asymmetric RNA enrichment in oocytes reveals low conservation between closely related Xenopus species. Mol Biol Cell. 2015;26:3777-87 pubmed publisher
Guo X, Connick M, Vanderhoof J, Ishak M, Hartley R. MicroRNA-16 modulates HuR regulation of cyclin E1 in breast cancer cells. Int J Mol Sci. 2015;16:7112-32 pubmed publisher
Braun J, Misiak D, Busch B, Krohn K, Huttelmaier S. Rapid identification of regulatory microRNAs by miTRAP (miRNA trapping by RNA in vitro affinity purification). Nucleic Acids Res. 2014;42:e66 pubmed publisher
Su H, Kodiha M, Lee S, Stochaj U. Identification of novel markers that demarcate the nucleolus during severe stress and chemotherapeutic treatment. PLoS ONE. 2013;8:e80237 pubmed publisher
Leppek K, Stoecklin G. An optimized streptavidin-binding RNA aptamer for purification of ribonucleoprotein complexes identifies novel ARE-binding proteins. Nucleic Acids Res. 2014;42:e13 pubmed publisher
Li Y, Wang C, Zhou Y, Liao Z, Zhu S, Hu Y, et al. TLR9 signaling repressed tumor suppressor miR-7 expression through up-regulation of HuR in human lung cancer cells. Cancer Cell Int. 2013;13:90 pubmed publisher
D Agostino V, Adami V, Provenzani A. A novel high throughput biochemical assay to evaluate the HuR protein-RNA complex formation. PLoS ONE. 2013;8:e72426 pubmed publisher
Viiri J, Amadio M, Marchesi N, Hyttinen J, Kivinen N, Sironen R, et al. Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS ONE. 2013;8:e69563 pubmed publisher
Hsiao Y, Li C, Chi J, Tseng J, Chang Y, Hsu L, et al. CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma. Sci Signal. 2013;6:ra59 pubmed publisher
Naipauer J, Gattelli A, Degese M, Slomiansky V, Wertheimer E, LaMarre J, et al. The use of alternative polyadenylation sites renders integrin ?1 (Itgb1) mRNA isoforms with differential stability during mammary gland development. Biochem J. 2013;454:345-57 pubmed publisher
Cheng H, Sivachandran N, Lau A, Boudreau E, Zhao J, Baltimore D, et al. MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways. EMBO Mol Med. 2013;5:1017-34 pubmed publisher
Feng X, Shikama Y, Shichishima T, Noji H, Ikeda K, Ogawa K, et al. Impairment of FOS mRNA stabilization following translation arrest in granulocytes from myelodysplastic syndrome patients. PLoS ONE. 2013;8:e61107 pubmed publisher
Suswam E, Shacka J, Walker K, Lu L, Li X, Si Y, et al. Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth. J Neurooncol. 2013;113:195-205 pubmed publisher
Nakayama H, Fukuda S, Matsushita N, Nishida Fukuda H, Inoue H, Shirakata Y, et al. Human antigen R-mediated mRNA stabilization is required for ultraviolet B-induced autoinduction of amphiregulin in keratinocytes. J Biol Chem. 2013;288:10338-48 pubmed publisher
Agra Andrieu N, Motiño O, Mayoral R, Llorente Izquierdo C, Fernández Alvarez A, Bosca L, et al. Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells. PLoS ONE. 2012;7:e50935 pubmed publisher
Blechingberg J, Luo Y, Bolund L, Damgaard C, Nielsen A. Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions. PLoS ONE. 2012;7:e46251 pubmed publisher
Sirvent A, Vigy O, Orsetti B, Urbach S, Roche S. Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Mol Cell Proteomics. 2012;11:1937-50 pubmed publisher
Cote G, Zhu W, Thomas A, Martin E, Murad F, Sharina I. Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells. PLoS ONE. 2012;7:e41099 pubmed publisher
Amadio M, Osera C, Lupo G, Motta C, Drago F, Govoni S, et al. Protein kinase C activation affects, via the mRNA-binding Hu-antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model. Mol Vis. 2012;18:2153-64 pubmed
Kim I, Kwak H, Lee H, Hyun S, Jeong S. ?-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. Nucleic Acids Res. 2012;40:6863-72 pubmed publisher
Ramdzan Y, Polling S, Chia C, Ng I, Ormsby A, Croft N, et al. Tracking protein aggregation and mislocalization in cells with flow cytometry. Nat Methods. 2012;9:467-70 pubmed publisher
Shi J, Su X, Xu J, Zhang W, Shi Y. HuR post-transcriptionally regulates TNF-?-induced IL-6 expression in human pulmonary microvascular endothelial cells mainly via tristetraprolin. Respir Physiol Neurobiol. 2012;181:154-61 pubmed publisher
Ness G, Edelman J, Brooks P. Involvement of tristetraprolin in transcriptional activation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase by insulin. Biochem Biophys Res Commun. 2012;420:178-82 pubmed publisher
Mochizuki H, Murphy C, Brandt J, Kiuchi Y, Russell P. Altered stability of mRNAs associated with glaucoma progression in human trabecular meshwork cells following oxidative stress. Invest Ophthalmol Vis Sci. 2012;53:1734-41 pubmed publisher
Weissbach R, Scadden A. Tudor-SN and ADAR1 are components of cytoplasmic stress granules. RNA. 2012;18:462-71 pubmed publisher
Serini S, Fasano E, Piccioni E, Monego G, Cittadini A, Celleno L, et al. DHA induces apoptosis and differentiation in human melanoma cells in vitro: involvement of HuR-mediated COX-2 mRNA stabilization and ?-catenin nuclear translocation. Carcinogenesis. 2012;33:164-73 pubmed publisher
Jamison J, Szymanski J, DeGracia D. Organelles do not colocalize with mRNA granules in post-ischemic neurons. Neuroscience. 2011;199:394-400 pubmed publisher
Epis M, Barker A, Giles K, Beveridge D, Leedman P. The RNA-binding protein HuR opposes the repression of ERBB-2 gene expression by microRNA miR-331-3p in prostate cancer cells. J Biol Chem. 2011;286:41442-54 pubmed publisher
Jobi K, Rauch B, Dangwal S, Freidel K, Doller A, Eberhardt W, et al. Redox regulation of human protease-activated receptor-2 by activated factor X. Free Radic Biol Med. 2011;51:1758-64 pubmed publisher
Dredge B, Jensen K. NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2. PLoS ONE. 2011;6:e21585 pubmed publisher
Yuan Z, Sanders A, Ye L, Wang Y, Jiang W. Knockdown of human antigen R reduces the growth and invasion of breast cancer cells in vitro and affects expression of cyclin D1 and MMP-9. Oncol Rep. 2011;26:237-45 pubmed publisher
Szymanski J, Jamison J, DeGracia D. Texture analysis of poly-adenylated mRNA staining following global brain ischemia and reperfusion. Comput Methods Programs Biomed. 2012;105:81-94 pubmed publisher
Jayaseelan S, Doyle F, Currenti S, Tenenbaum S. RIP: an mRNA localization technique. Methods Mol Biol. 2011;714:407-22 pubmed publisher
Serini S, Donato V, Piccioni E, Trombino S, Monego G, Toesca A, et al. Docosahexaenoic acid reverts resistance to UV-induced apoptosis in human keratinocytes: involvement of COX-2 and HuR. J Nutr Biochem. 2011;22:874-85 pubmed publisher
Mitchell J, Mansfeld J, Capitanio J, Kutay U, Wozniak R. Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane. J Cell Biol. 2010;191:505-21 pubmed publisher
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product information
Product Name :
HuR (3A2) Antibody
Gene Name :
ELAVL1, ELAVL2, ELAVL3, ELAVL4
Size :
200 µg/ml
Catalog Number :
sc-5261
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
HuR
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA