product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p-Tyr (PY20) Antibody
catalog :
sc-508
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
PY20
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 109
Published Application/Species/Sample/DilutionReference
  • western blot; scFv; loading ...; fig 6
Cui L, Mahesutihan M, Zheng W, Meng L, Fan W, Li J, et al. CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein. Virology. 2018;525:40-47 pubmed publisher
  • western blot; scFv; loading ...; fig 1e
Mahajan K, Malla P, Lawrence H, Chen Z, Kumar Sinha C, Malik R, et al. ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer. Cancer Cell. 2017;31:790-803.e8 pubmed publisher
  • immunoprecipitation; scFv; 1:1000; loading ...; fig s4
Boo H, Min H, Jang H, Yun H, Smith J, Jin Q, et al. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells. Nat Commun. 2016;7:12961 pubmed publisher
  • western blot; scFv; 1:1000; fig 5
Bourgonje A, Verrijp K, Schepens J, Navis A, Piepers J, Palmen C, et al. Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma. Acta Neuropathol Commun. 2016;4:96 pubmed publisher
  • immunoprecipitation; scFv; fig 6
Winnay J, Solheim M, Dirice E, Sakaguchi M, Noh H, Kang H, et al. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. J Clin Invest. 2016;126:1401-12 pubmed publisher
  • immunoprecipitation; scFv; fig 3
He Y, Ryu T, Shrestha N, Yuan T, Kim H, Shrestha H, et al. Interaction of EGFR to δ-catenin leads to δ-catenin phosphorylation and enhances EGFR signaling. Sci Rep. 2016;6:21207 pubmed publisher
  • immunohistochemistry - paraffin section; scFv; fig 6
  • western blot; scFv; fig 5
Qiu M, Fan Q, Zhu Z, Kwan S, Chen L, Chen J, et al. KDM4B and KDM4A promote endometrial cancer progression by regulating androgen receptor, c-myc, and p27kip1. Oncotarget. 2015;6:31702-20 pubmed publisher
  • western blot; scFv
Ma S, Yin N, Qi X, Pfister S, Zhang M, Ma R, et al. Tyrosine dephosphorylation enhances the therapeutic target activity of epidermal growth factor receptor (EGFR) by disrupting its interaction with estrogen receptor (ER). Oncotarget. 2015;6:13320-33 pubmed
  • western blot; scFv
Kim D, Yeom J, Lee B, Lee K, Bae J, Rhee S. Inhibition of discoidin domain receptor 2-mediated lung cancer cells progression by gold nanoparticle-aptamer-assisted delivery of peptides containing transmembrane-juxtamembrane 1/2 domain. Biochem Biophys Res Commun. 2015;464:392-5 pubmed publisher
  • western blot; scFv; fig s7
Arruda A, Pers B, Parlakgül G, Güney E, Inouye K, Hotamisligil G. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014;20:1427-35 pubmed publisher
  • immunoprecipitation; scFv; fig 1
Goldshmit Y, Trangle S, Kloog Y, Pinkas Kramarski R. Interfering with the interaction between ErbB1, nucleolin and Ras as a potential treatment for glioblastoma. Oncotarget. 2014;5:8602-13 pubmed
  • western blot; scFv
Bailon E, Ugarte Berzal E, Amigo Jiménez I, Van den Steen P, Opdenakker G, Garcia Marco J, et al. Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014;96:185-99 pubmed publisher
  • western blot; scFv
Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed publisher
Pütz S. Mbt/PAK4 together with SRC modulates N-Cadherin adherens junctions in the developing Drosophila eye. Biol Open. 2019;8: pubmed publisher
Carrasco Garcia E, Martinez Lacaci I, Mayor López L, Tristante E, Carballo Santana M, Garcia Morales P, et al. PDGFR and IGF-1R Inhibitors Induce a G2/M Arrest and Subsequent Cell Death in Human Glioblastoma Cell Lines. Cells. 2018;7: pubmed publisher
Lampropoulou E, Logoviti I, Koutsioumpa M, Hatziapostolou M, Polytarchou C, Skandalis S, et al. Cyclin-dependent kinase 5 mediates pleiotrophin-induced endothelial cell migration. Sci Rep. 2018;8:5893 pubmed publisher
Luo W, Zhang J, Liang L, Wang G, Li Q, Zhu P, et al. Phospholipid scramblase 1 interacts with influenza A virus NP, impairing its nuclear import and thereby suppressing virus replication. PLoS Pathog. 2018;14:e1006851 pubmed publisher
Wang X, Gao Y, Song J, Tang C, Wang M, Que L, et al. The TIR/BB-loop mimetic AS-1 prevents non-alcoholic steatohepatitis and hepatic insulin resistance by inhibiting NLRP3-ASC inflammasome activation. Br J Pharmacol. 2017;174:1841-1856 pubmed publisher
Wolfson E, Goldenberg M, Solomon S, Frishberg A, Pinkas Kramarski R. Nucleolin-binding by ErbB2 enhances tumorigenicity of ErbB2-positive breast cancer. Oncotarget. 2016;7:65320-65334 pubmed publisher
Lee S, Shatadal S, Griep A. Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens. Invest Ophthalmol Vis Sci. 2016;57:707-18 pubmed publisher
Xu L, Ji J, Le W, Xu Y, Dou D, Pan J, et al. The STAT3 HIES mutation is a gain-of-function mutation that activates genes via AGG-element carrying promoters. Nucleic Acids Res. 2015;43:8898-912 pubmed publisher
Moazzam M, Ye L, Sun P, Kynaston H, Jiang W. Knockdown of WAVE3 impairs HGF induced migration and invasion of prostate cancer cells. Cancer Cell Int. 2015;15:51 pubmed publisher
Abourbeh G, Itamar B, Salnikov O, Beltsov S, Mishani E. Identifying erlotinib-sensitive non-small cell lung carcinoma tumors in mice using [(11)C]erlotinib PET. EJNMMI Res. 2015;5:4 pubmed publisher
Zhang W, DeRyckere D, Hunter D, Liu J, Stashko M, Minson K, et al. UNC2025, a potent and orally bioavailable MER/FLT3 dual inhibitor. J Med Chem. 2014;57:7031-41 pubmed publisher
Lind J, Backert S, Pfleiderer K, Berg D, Yamaoka Y, Sticht H, et al. Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains. PLoS ONE. 2014;9:e96488 pubmed publisher
Tsai F, Seki A, Yang H, Hayer A, Carrasco S, Malmersjö S, et al. A polarized Ca2+, diacylglycerol and STIM1 signalling system regulates directed cell migration. Nat Cell Biol. 2014;16:133-44 pubmed publisher
Panosa C, Tebar F, Ferrer Batallé M, Fonge H, Seno M, Reilly R, et al. Development of an epidermal growth factor derivative with EGFR blocking activity. PLoS ONE. 2013;8:e69325 pubmed publisher
Cousins E, Nicholas J. Role of human herpesvirus 8 interleukin-6-activated gp130 signal transducer in primary effusion lymphoma cell growth and viability. J Virol. 2013;87:10816-27 pubmed publisher
Miah S, Martin A, Lukong K. Constitutive activation of breast tumor kinase accelerates cell migration and tumor growth in vivo. Oncogenesis. 2012;1:e11 pubmed publisher
Wang S, Zhao Z, Bi Y, Sun L, Liu X, Liu W. Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling the nuclear import of M1. J Virol. 2013;87:6182-91 pubmed publisher
Cordero Herrera I, Martin M, Bravo L, Goya L, Ramos S. Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells. Mol Nutr Food Res. 2013;57:974-85 pubmed publisher
Shao Z, Zhu F, Song K, Zhang H, Liu K, Shang Z. EphA2/ephrinA1 mRNA expression and protein production in adenoid cystic carcinoma of salivary gland. J Oral Maxillofac Surg. 2013;71:869-78 pubmed publisher
Barros C, Haro A, Russo F, Schadock I, Almeida S, Ribeiro R, et al. Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes. PLoS ONE. 2012;7:e40573 pubmed publisher
Brown J, Krodel M, Pazos M, Lai C, Prieto A. Cross-phosphorylation, signaling and proliferative functions of the Tyro3 and Axl receptors in Rat2 cells. PLoS ONE. 2012;7:e36800 pubmed publisher
Batista T, Alonso Magdalena P, Vieira E, Amaral M, Cederroth C, Nef S, et al. Short-term treatment with bisphenol-A leads to metabolic abnormalities in adult male mice. PLoS ONE. 2012;7:e33814 pubmed publisher
Machado Neto J, Favaro P, Lazarini M, da Silva Santos Duarte A, Archangelo L, Lorand Metze I, et al. Downregulation of IRS2 in myelodysplastic syndrome: a possible role in impaired hematopoietic cell differentiation. Leuk Res. 2012;36:931-5 pubmed publisher
Kogan M, Fischer Smith T, Kaminsky R, Lehmicke G, Rappaport J. CSF-1R up-regulation is associated with response to pharmacotherapy targeting tyrosine kinase activity in AML cell lines. Anticancer Res. 2012;32:893-9 pubmed
Trerotola M, Li J, Alberti S, Languino L. Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the ?1 integrin-RACK1 axis. J Cell Physiol. 2012;227:3670-7 pubmed publisher
Riuzzi F, Sorci G, Beccafico S, Donato R. S100B engages RAGE or bFGF/FGFR1 in myoblasts depending on its own concentration and myoblast density. Implications for muscle regeneration. PLoS ONE. 2012;7:e28700 pubmed publisher
Gonzalez Rodriguez A, Mas Gutierrez J, Mirasierra M, Fernandez Perez A, Lee Y, Ko H, et al. Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging. Aging Cell. 2012;11:284-96 pubmed publisher
Borriello A, Caldarelli I, Basile M, Bencivenga D, Tramontano A, Perrotta S, et al. The tyrosine kinase inhibitor dasatinib induces a marked adipogenic differentiation of human multipotent mesenchymal stromal cells. PLoS ONE. 2011;6:e28555 pubmed publisher
Bakshi K, Kosciuk M, Nagele R, Friedman E, Wang H. Prenatal cocaine exposure increases synaptic localization of a neuronal RasGEF, GRASP-1 via hyperphosphorylation of AMPAR anchoring protein, GRIP. PLoS ONE. 2011;6:e25019 pubmed publisher
McWilliam I, Chong Kwan M, Hall D. Inkjet printing for the production of protein microarrays. Methods Mol Biol. 2011;785:345-61 pubmed publisher
Nakamura S, Takemura T, Tan L, Nagata Y, Yokota D, Hirano I, et al. Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells. Carcinogenesis. 2011;32:1758-72 pubmed publisher
Weis S. Evaluation of VEGF-induced vascular permeability in mice. Methods Mol Biol. 2011;763:403-15 pubmed publisher
ElAli A, Hermann D. Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells. Brain Pathol. 2012;22:175-87 pubmed publisher
Bhavsar S, Gu S, Bobbala D, Lang F. Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death. Cell Physiol Biochem. 2011;27:547-56 pubmed publisher
Lazaridis I, Charalampopoulos I, Alexaki V, Avlonitis N, Pediaditakis I, Efstathopoulos P, et al. Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis. PLoS Biol. 2011;9:e1001051 pubmed publisher
Jung A, Kaushansky A, MacBeath G, Kaushansky K. Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle. 2011;10:1838-44 pubmed
Nakamura S, Yokota D, Tan L, Nagata Y, Takemura T, Hirano I, et al. Down-regulation of Thanatos-associated protein 11 by BCR-ABL promotes CML cell proliferation through c-Myc expression. Int J Cancer. 2012;130:1046-59 pubmed publisher
Yin L, Li W, Chu Y, Li L. ERK pathway activation is required for amyloid-?(1-40)(-)induced neurotoxicity of THP-1 human monocytes towards SK-N-SH neuroblastoma. Brain Res. 2011;1378:9-17 pubmed publisher
Yuan Q, Lee E, Yeudall W, Yang H. Dendrimer-triglycine-EGF nanoparticles for tumor imaging and targeted nucleic acid and drug delivery. Oral Oncol. 2010;46:698-704 pubmed publisher
Kelleher A, Fairchild T, Keslacy S. STZ-induced skeletal muscle atrophy is associated with increased p65 content and downregulation of insulin pathway without NF-?B canonical cascade activation. Acta Diabetol. 2010;47:315-23 pubmed publisher
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Mercatelli N, Dimauro I, Ciafrè S, Farace M, Caporossi D. AlphaB-crystallin is involved in oxidative stress protection determined by VEGF in skeletal myoblasts. Free Radic Biol Med. 2010;49:374-82 pubmed publisher
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Gonzalez Rodriguez A, Mas Gutierrez J, Sanz González S, Ros M, Burks D, Valverde A. Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. Diabetes. 2010;59:588-99 pubmed publisher
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Tzatsos A. Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. J Biol Chem. 2009;284:22525-34 pubmed publisher
Bakshi K, Gennaro S, CHAN C, Kosciuk M, Liu J, Stucky A, et al. Prenatal cocaine reduces AMPA receptor synaptic expression through hyperphosphorylation of the synaptic anchoring protein GRIP. J Neurosci. 2009;29:6308-19 pubmed publisher
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Jeulin C, Seltzer V, Bailbe D, Andreau K, Marano F. EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src. Am J Physiol Lung Cell Mol Physiol. 2008;295:L489-96 pubmed publisher
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product information
Product Name :
p-Tyr (PY20) Antibody
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-508
Modification :
phosporylated
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
p-Tyr
Application :
WB, IP, IF, IHC(P), FCM
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA