This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Bax (N-20)
catalog :
sc-493
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section, other
citations: 60
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 6a
  • western blot; human; loading ...; fig 7a
Chollat Namy M, Ben Safta Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy. Cell Death Dis. 2019;10:695 pubmed publisher
  • western blot; mouse; loading ...; fig 4c
Loh J, Xu S, Huo J, Kim S, Wang Y, Lam K. Dok3-protein phosphatase 1 interaction attenuates Card9 signaling and neutrophil-dependent antifungal immunity. J Clin Invest. 2019;129:2717-2729 pubmed publisher
  • western blot; human; loading ...; fig 4b
Donadoni M, Cicalese S, Sarkar D, Chang S, Sariyer I. Alcohol exposure alters pre-mRNA splicing of antiapoptotic Mcl-1L isoform and induces apoptosis in neural progenitors and immature neurons. Cell Death Dis. 2019;10:447 pubmed publisher
  • western blot; mouse; loading ...; fig 4f
Nakai A, Fujimoto J, Miyata H, Stumm R, Narazaki M, Schulz S, et al. The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. J Exp Med. 2019;: pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Panigrahi S, Manterola M, Wolgemuth D. Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins. PLoS ONE. 2017;12:e0173926 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Iurlaro R, Püschel F, León Annicchiarico C, O Connor H, Martin S, Palou Gramón D, et al. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...; fig 4c
Ha S, Jin F, Kwak C, Abekura F, Park J, Park N, et al. Jellyfish extract induces apoptotic cell death through the p38 pathway and cell cycle arrest in chronic myelogenous leukemia K562 cells. Peerj. 2017;5:e2895 pubmed publisher
  • western blot; human; loading ...; fig 2a
Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem Biophys Res Commun. 2017;482:1334-1340 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4b
Zhao J, Sang M, Geng C, Wang S, Shan B. A novel curcumin analogue is a potent chemotherapy candidate for human hepatocellular carcinoma. Oncol Lett. 2016;12:4252-4262 pubmed
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 9a,9b
  • western blot; rat; 1:200; loading ...; fig 9d
Pan S, Li S, Hu Y, Zhang H, Liu Y, Jiang H, et al. Resveratrol post-treatment protects against neonatal brain injury after hypoxia-ischemia. Oncotarget. 2016;7:79247-79261 pubmed publisher
  • western blot; human; loading ...; fig 4c
Lee J, Westrate L, Wu H, Page C, Voeltz G. Multiple dynamin family members collaborate to drive mitochondrial division. Nature. 2016;540:139-143 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5a
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  • western blot; human; loading ...; fig 4e
Heulot M, Chevalier N, Puyal J, Margue C, Michel S, Kreis S, et al. The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. Oncotarget. 2016;7:64342-64359 pubmed publisher
  • western blot; human; loading ...; fig 1a
Nakajima W, Sharma K, Lee J, Maxim N, Hicks M, Vu T, et al. DNA damaging agent-induced apoptosis is regulated by MCL-1 phosphorylation and degradation mediated by the Noxa/MCL-1/CDK2 complex. Oncotarget. 2016;7:36353-36365 pubmed publisher
  • western blot; human; loading ...; fig 2a
Matsumoto M, Nakajima W, Seike M, Gemma A, Tanaka N. Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells. Biochem Biophys Res Commun. 2016;473:490-6 pubmed publisher
  • other; human; loading ...; fig st1
  • western blot; human; loading ...; fig st4
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; human; loading ...; fig 1
Nakajima W, Sharma K, Hicks M, Le N, Brown R, Krystal G, et al. Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer. Cancer Biol Ther. 2016;17:27-35 pubmed publisher
  • western blot; mouse; loading ...; fig 4e
Singh S, Chand H, Gundavarapu S, Saeed A, Langley R, Tesfaigzi Y, et al. HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. PLoS ONE. 2015;10:e0137757 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4,5
Gingras S, Earls L, Howell S, Smeyne R, Zakharenko S, Pelletier S. SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015;35:10510-22 pubmed publisher
  • western blot; human; loading ...; fig 2a
Kotipatruni R, Ren X, Thotala D, Jaboin J. NDRG4 is a novel oncogenic protein and p53 associated regulator of apoptosis in malignant meningioma cells. Oncotarget. 2015;6:17594-604 pubmed
Wang L, Wang P, Chen X, Yang H, Song S, Song Z, et al. Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance. EMBO Mol Med. 2023;15:e16235 pubmed publisher
Yi J, Gong X, Yin X, Wang L, Hou J, Chen J, et al. Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells. Front Oncol. 2022;12:988528 pubmed publisher
Choi Y, Luo Y, Lee S, Jin H, Yoon H, Hahn Y, et al. FOXL2 and FOXA1 cooperatively assemble on the TP53 promoter in alternative dimer configurations. Nucleic Acids Res. 2022;50:8929-8946 pubmed publisher
Bao Y, Bai M, Zhu H, Yuan Y, Wang Y, Zhang Y, et al. DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury. Cell Death Discov. 2021;7:167 pubmed publisher
Edwards G, Lee Y, Kim M, Bhanvadia S, Kim K, Ju W. Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function. Antioxidants (Basel). 2020;9: pubmed publisher
Rzemieniec J, Bratek E, Wnuk A, Przepiórska K, Salinska E, Kajta M. Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes. Apoptosis. 2020;25:747-762 pubmed publisher
Do M, Lee J, Ahn J, Hong M, Kim J, Kim S. Isosamidin from Peucedanum japonicum Roots Prevents Methylglyoxal-Induced Glucotoxicity in Human Umbilical Vein Endothelial Cells via Suppression of ROS-Mediated Bax/Bcl-2. Antioxidants (Basel). 2020;9: pubmed publisher
Di Meo F, Cuciniello R, Margarucci S, Bergamo P, Petillo O, Peluso G, et al. Ginkgo biloba Prevents Oxidative Stress-Induced Apoptosis Blocking p53 Activation in Neuroblastoma Cells. Antioxidants (Basel). 2020;9: pubmed publisher
Tian W, Zhao J, Lee J, Akanda M, Cho J, Kim S, et al. Neuroprotective Effects of Cornus officinalis on Stress-Induced Hippocampal Deficits in Rats and H2O2-Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells. Antioxidants (Basel). 2019;9: pubmed publisher
Han K, Po W, Sohn U, Kim H. Benzyl Isothiocyanate Induces Apoptosis via Reactive Oxygen Species-Initiated Mitochondrial Dysfunction and DR4 and DR5 Death Receptor Activation in Gastric Adenocarcinoma Cells. Biomolecules. 2019;9: pubmed publisher
Watanabe D, Nogami A, Okada K, Akiyama H, Umezawa Y, Miura O. FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. Cancers (Basel). 2019;11: pubmed publisher
Chen G, Park D, Magis A, Behera M, Ramalingam S, Owonikoko T, et al. Mcl-1 Interacts with Akt to Promote Lung Cancer Progression. Cancer Res. 2019;79:6126-6138 pubmed publisher
Dilshara M, Molagoda I, Jayasooriya R, Choi Y, Park C, Lee K, et al. p53-Mediated Oxidative Stress Enhances Indirubin-3'-Monoxime-Induced Apoptosis in HCT116 Colon Cancer Cells by Upregulating Death Receptor 5 and TNF-Related Apoptosis-Inducing Ligand Expression. Antioxidants (Basel). 2019;8: pubmed publisher
Bonafede R, Brandi J, Manfredi M, Scambi I, Schiaffino L, Merigo F, et al. The Anti-Apoptotic Effect of ASC-Exosomes in an In Vitro ALS Model and Their Proteomic Analysis. Cells. 2019;8: pubmed publisher
Videla Richardson G, Furmento V, Garcia C, Morris Hanon O, Sevlever G, Romorini L, et al. Human embryonic stem cells display a pronounced sensitivity to the cyclin dependent kinase inhibitor Roscovitine. BMC Mol Cell Biol. 2019;20:40 pubmed publisher
Franceschelli S, Lanuti P, Ferrone A, Gatta D, Speranza L, Pesce M, et al. Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione-L-Dopa Codrug Against H2O2-Induced Cellular Toxicity. Antioxidants (Basel). 2019;8: pubmed publisher
Kubickova J, Elefantová K, Pavlíková L, Cagala M, Sereš M, Safar P, et al. Screening of Phenanthroquinolizidine Alkaloid Derivatives for Inducing Cell Death of L1210 Leukemia Cells with Negative and Positive P-glycoprotein Expression. Molecules. 2019;24: pubmed publisher
Rzemieniec J, Wnuk A, Lason W, Bilecki W, Kajta M. The neuroprotective action of 3,3'-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling. Apoptosis. 2019;24:435-452 pubmed publisher
Zhang S, Sui L, Zhuang J, He S, Song Y, Ye Y, et al. ARHGAP24 regulates cell ability and apoptosis of colorectal cancer cells via the regulation of P53. Oncol Lett. 2018;16:3517-3524 pubmed publisher
Maruyama T, Baba T, Maemoto Y, Hara Miyauchi C, Hasegawa Ogawa M, Okano H, et al. Loss of DDHD2, whose mutation causes spastic paraplegia, promotes reactive oxygen species generation and apoptosis. Cell Death Dis. 2018;9:797 pubmed publisher
Roumane A, Berthenet K, El Fassi C, Ichim G. Caspase-independent cell death does not elicit a proliferative response in melanoma cancer cells. BMC Cell Biol. 2018;19:11 pubmed publisher
Jin Y, You L, Kim H, Lee H. Telomerase Reverse Transcriptase Contains a BH3-Like Motif and Interacts with BCL-2 Family Members. Mol Cells. 2018;41:684-694 pubmed publisher
Ishida S, Akiyama H, Umezawa Y, Okada K, Nogami A, Oshikawa G, et al. Mechanisms for mTORC1 activation and synergistic induction of apoptosis by ruxolitinib and BH3 mimetics or autophagy inhibitors in JAK2-V617F-expressing leukemic cells including newly established PVTL-2. Oncotarget. 2018;9:26834-26851 pubmed publisher
Kabashima A, Hirsova P, Bronk S, Hernandez M, Truty M, Rizvi S, et al. Fibroblast growth factor receptor inhibition induces loss of matrix MCL1 and necrosis in cholangiocarcinoma. J Hepatol. 2018;68:1228-1238 pubmed publisher
Zhang Q, Yin Z, Zhang F, Cao K, Sun H. CTHRC1 mediates IL?1??induced apoptosis in chondrocytes via JNK1/2 signaling. Int J Mol Med. 2018;41:2270-2278 pubmed publisher
Jeong B, Lee H, Park C, Kang J, Yu S, Choi D, et al. Oxidative stress caused by activation of NADPH oxidase 4 promotes contrast-induced acute kidney injury. PLoS ONE. 2018;13:e0191034 pubmed publisher
Gallagher S, Gunatilake D, Beaumont K, Sharp D, Tiffen J, Heinemann A, et al. HDAC inhibitors restore BRAF-inhibitor sensitivity by altering PI3K and survival signalling in a subset of melanoma. Int J Cancer. 2018;142:1926-1937 pubmed publisher
Zhao L, Liu J, He C, Yan R, Zhou K, Cui Q, et al. Protein kinase A determines platelet life span and survival by regulating apoptosis. J Clin Invest. 2017;127:4338-4351 pubmed publisher
Zhuge W, Chen R, Vladimir K, Dong X, Zia K, Sun X, et al. Costunolide specifically binds and inhibits thioredoxin reductase 1 to induce apoptosis in colon cancer. Cancer Lett. 2018;412:46-58 pubmed publisher
Apaijai N, Charoenphandhu N, Ittichaichareon J, Suntornsaratoon P, Krishnamra N, Aeimlapa R, et al. Estrogen deprivation aggravates cardiac hypertrophy in nonobese Type 2 diabetic Goto-Kakizaki (GK) rats. Biosci Rep. 2017;37: pubmed publisher
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher
Tahrir F, Shanmughapriya S, Ahooyi T, Knezevic T, Gupta M, Kontos C, et al. Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. J Cell Physiol. 2018;233:748-758 pubmed publisher
Li R, Ding C, Zhang J, Xie M, Park D, Ding Y, et al. Modulation of Bax and mTOR for Cancer Therapeutics. Cancer Res. 2017;77:3001-3012 pubmed publisher
Nikolic I, Andjelkovic M, Zaric M, Zelen I, Canovic P, Milosavljević Z, et al. Induction of mitochondrial apoptotic pathway by raloxifene and estrogen in human endometrial stromal ThESC cell line. Arch Med Sci. 2017;13:293-301 pubmed publisher
Moindjie H, Santos E, Gouesse R, Swierkowski Blanchard N, Serazin V, Barnea E, et al. Preimplantation factor is an anti-apoptotic effector in human trophoblasts involving p53 signaling pathway. Cell Death Dis. 2016;7:e2504 pubmed publisher
Matsuura K, Huang N, Cocce K, Zhang L, Kornbluth S. Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. Oncogene. 2017;36:1698-1706 pubmed publisher
Li Y, Cui S, Sun S, Shi W, Song Z, Wang S, et al. Chemoprevention of intestinal tumorigenesis by the natural dietary flavonoid myricetin in APCMin/+ mice. Oncotarget. 2016;7:60446-60460 pubmed publisher
Nilton A, Sayin V, Zou Z, Sayin S, Bondjers C, Gul N, et al. Targeting Zfp148 activates p53 and reduces tumor initiation in the gut. Oncotarget. 2016;7:56183-56192 pubmed publisher
Li Y, Wang W, Xu X, Sun S, Xu X, Qu X. {2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic Acid Methyl Ester Inhibited Hepatocellular Carcinoma Growth in Bel-7402 Cells and Its Resistant Variants by Activation of NOX4 and SIRT3. Biomed Res Int. 2015;2015:491205 pubmed publisher
Masiello M, Cucina A, Proietti S, Palombo A, Coluccia P, D Anselmi F, et al. Phenotypic switch induced by simulated microgravity on MDA-MB-231 breast cancer cells. Biomed Res Int. 2014;2014:652434 pubmed publisher
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA