product summary
Loading...
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
BECN1 (E-8) Antibody
catalog :
sc-48341
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
E-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 2a
Tan S, Liu X, Chen L, Wu X, Tao L, Pan X, et al. Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis. Cell Death Dis. 2021;12:474 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig 6s2a
Stavoe A, Gopal P, Gubas A, Tooze S, Holzbaur E. Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons. elife. 2019;8: pubmed publisher
  • immunoprecipitation; human; loading ...; fig 3b
  • western blot; human; 1:500; loading ...; fig 3a
Zhang L, Feng Q, Wang Z, Liu P, Cui S. Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism. Biosci Rep. 2019;39: pubmed publisher
  • western blot; mouse; loading ...; fig 8c
Liu J, Wang H, Gu J, Deng T, Yuan Z, Hu B, et al. BECN1-dependent CASP2 incomplete autophagy induction by binding to rabies virus phosphoprotein. Autophagy. 2017;13:739-753 pubmed publisher
  • western blot; rat; 1:500; fig 2
Gui L, Liu B, Lv G. Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism. Exp Ther Med. 2016;11:2233-2239 pubmed
  • immunoprecipitation; human; fig 6
  • western blot; human; fig 6
Luan Q, Jin L, Jiang C, Tay K, Lai F, Liu X, et al. RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy. Autophagy. 2015;11:975-94 pubmed publisher
  • western blot; human; 1:1000
Kim T, Kim H, Kang Y, Yoon S, Lee J, Choi W, et al. Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts. Biochim Biophys Acta. 2015;1850:401-10 pubmed publisher
  • immunoprecipitation; human
  • western blot; human
He W, Wang Q, Srinivasan B, Xu J, Padilla M, Li Z, et al. A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy. Oncogene. 2014;33:3004-13 pubmed publisher
Montero Vergara J, Plachetta K, Kinch L, Bernhardt S, Kashyap K, Levine B, et al. GRB2 is a BECN1 interacting protein that regulates autophagy. Cell Death Dis. 2024;15:14 pubmed publisher
Polo P, Gremke N, Stiewe T, Wanzel M. Robustness of the Autophagy Pathway to Somatic Copy Number Losses. Cells. 2022;11: pubmed publisher
Finetti F, Cassioli C, Cianfanelli V, Zevolini F, Onnis A, Gesualdo M, et al. The Intraflagellar Transport Protein IFT20 Recruits ATG16L1 to Early Endosomes to Promote Autophagosome Formation in T Cells. Front Cell Dev Biol. 2021;9:634003 pubmed publisher
Richard P, Feng S, Tsai Y, Li W, Rinchetti P, Muhith U, et al. SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation. Autophagy. 2020;: pubmed publisher
Rubio R, Mohr I. Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Wang L, Lu K, Hao H, Li X, Wang J, Wang K, et al. Decreased autophagy in rat heart induced by anti-?1-adrenergic receptor autoantibodies contributes to the decline in mitochondrial membrane potential. PLoS ONE. 2013;8:e81296 pubmed publisher
Wang J, Lu K, Liang F, Li X, Wang L, Yang C, et al. Decreased autophagy contributes to myocardial dysfunction in rats subjected to nonlethal mechanical trauma. PLoS ONE. 2013;8:e71400 pubmed publisher
Su J, Xu Y, Zhou L, Yu H, Kang J, Liu N, et al. Suppression of chloride channel 3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy. Anat Rec (Hoboken). 2013;296:595-603 pubmed publisher
He W, Wang Q, Xu J, Xu X, Padilla M, Ren G, et al. Attenuation of TNFSF10/TRAIL-induced apoptosis by an autophagic survival pathway involving TRAF2- and RIPK1/RIP1-mediated MAPK8/JNK activation. Autophagy. 2012;8:1811-21 pubmed publisher
Robert G, Gastaldi C, Puissant A, Hamouda A, Jacquel A, Dufies M, et al. The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death. Autophagy. 2012;8:637-49 pubmed publisher
product information
Product Name :
BECN1 (E-8) Antibody
Gene Name :
BECN1
Size :
200 µg/ml
Catalog Number :
sc-48341
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
BECN1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
1-300 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA