product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
β-Actin (C4) HRP
catalog :
sc-47778 HRP
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
HRP
clone name :
C4
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section
citations: 52
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:4000; fig s3
Latosinska A, Makridakis M, Frantzi M, Borràs D, Janssen B, Mullen W, et al. Integrative analysis of extracellular and intracellular bladder cancer cell line proteome with transcriptome: improving coverage and validity of -omics findings. Sci Rep. 2016;6:25619 pubmed publisher
  • western blot; human; fig s3
Weigel C, Veldwijk M, Oakes C, Seibold P, Slynko A, Liesenfeld D, et al. Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nat Commun. 2016;7:10893 pubmed publisher
  • western blot; human; fig 1
Golnik R, Lehmann A, Kloetzel P, Ebstein F. Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination. J Biol Chem. 2016;291:8805-15 pubmed publisher
  • western blot; human; 1:1000; fig 5
Zhang Z, Zhang H, Peng T, Li D, Xu J. Melittin suppresses cathepsin S-induced invasion and angiogenesis via blocking of the VEGF-A/VEGFR-2/MEK1/ERK1/2 pathway in human hepatocellular carcinoma. Oncol Lett. 2016;11:610-618 pubmed
  • western blot; mouse; fig 1
Chen H, Sun Y, Lai L, Wu H, Xiao Y, Ming B, et al. Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice. Neuroscience. 2015;308:157-68 pubmed publisher
  • western blot; human; 1:5000
Li C, Siragy H. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am J Physiol Endocrinol Metab. 2015;309:E302-10 pubmed publisher
  • western blot; human; 1:200
Breslin J, Zhang X, Worthylake R, Souza Smith F. Involvement of local lamellipodia in endothelial barrier function. PLoS ONE. 2015;10:e0117970 pubmed publisher
  • western blot; human; fig 2
Moody S, Schinzel A, Singh S, Izzo F, Strickland M, Luo L, et al. PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene. 2015;34:2061-71 pubmed publisher
  • western blot; human
Moiseeva E, Straatman K, Leyland M, Bradding P. CADM1 controls actin cytoskeleton assembly and regulates extracellular matrix adhesion in human mast cells. PLoS ONE. 2014;9:e85980 pubmed publisher
Yuan G, Yang S, Yang S. Regulator of G protein signaling 12 drives inflammatory arthritis by activating synovial fibroblasts through MYCBP2/KIF2A signaling. Mol Ther Nucleic Acids. 2023;31:197-210 pubmed publisher
Nguyen P, Deisl C, Fine M, Tippetts T, Uchikawa E, Bai X, et al. Structural basis for gating mechanism of the human sodium-potassium pump. Nat Commun. 2022;13:5293 pubmed publisher
Shen H, An O, Ren X, Song Y, Tang S, Ke X, et al. ADARs act as potent regulators of circular transcriptome in cancer. Nat Commun. 2022;13:1508 pubmed publisher
Mergener S, Siveke J, Peña Llopis S. Monosomy 3 Is Linked to Resistance to MEK Inhibitors in Uveal Melanoma. Int J Mol Sci. 2021;22: pubmed publisher
Liu C, Toth R, Bakr A, Goyal A, Islam M, Breuer K, et al. Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response. Cancers (Basel). 2021;13: pubmed publisher
Ryu H, Kim L, Jeong H, Yeo B, Lee J, Nam H, et al. GSK3B induces autophagy by phosphorylating ULK1. Exp Mol Med. 2021;53:369-383 pubmed publisher
Ye Z, Gould T, Zhang H, Jin J, Weyand C, Goronzy J. The GSK3β-β-catenin-TCF1 pathway improves naive T cell activation in old adults by upregulating miR-181a. NPJ Aging Mech Dis. 2021;7:4 pubmed publisher
Liu Z, Xu E, Zhao H, Cole T, West A. LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes. EMBO J. 2020;39:e104862 pubmed publisher
Gee M, Son S, Jeon S, Do J, Kim N, Ju Y, et al. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimers Res Ther. 2020;12:45 pubmed publisher
Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, et al. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell. 2020;37:324-339.e8 pubmed publisher
Rohrberg J, Van de Mark D, Amouzgar M, Lee J, Taileb M, Corella A, et al. MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020;30:3368-3382.e7 pubmed publisher
Kakiuchi N, Yoshida K, Uchino M, Kihara T, Akaki K, Inoue Y, et al. Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis. Nature. 2020;577:260-265 pubmed publisher
Nambiar D, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, et al. Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance. J Clin Invest. 2019;129:5553-5567 pubmed publisher
Vasavda C, Kothari R, Malla A, Tokhunts R, Lin A, Ji M, et al. Bilirubin Links Heme Metabolism to Neuroprotection by Scavenging Superoxide. Cell Chem Biol. 2019;26:1450-1460.e7 pubmed publisher
Borghesan M, Fafián Labora J, Eleftheriadou O, Carpintero Fernández P, Pàez Ribes M, Vizcay Barrena G, et al. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep. 2019;27:3956-3971.e6 pubmed publisher
Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, et al. PES1 is a critical component of telomerase assembly and regulates cellular senescence. Sci Adv. 2019;5:eaav1090 pubmed publisher
Bottermann M, Foss S, Caddy S, Clift D, van Tienen L, Vaysburd M, et al. Complement C4 Prevents Viral Infection through Capsid Inactivation. Cell Host Microbe. 2019;25:617-629.e7 pubmed publisher
Oakes B, Fellmann C, Rishi H, Taylor K, Ren S, Nadler D, et al. CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification. Cell. 2019;176:254-267.e16 pubmed publisher
Agajanian M, Walker M, Axtman A, Ruela de Sousa R, Serafin D, Rabinowitz A, et al. WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop. Cell Rep. 2019;26:79-93.e8 pubmed publisher
Lee J, Nam H, Kim L, Jeon Y, Min H, Ha S, et al. TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia. Autophagy. 2018;: pubmed publisher
Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, et al. Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis. Nat Commun. 2018;9:5116 pubmed publisher
Fletcher A, Vaysburd M, Maslen S, Zeng J, Skehel J, Towers G, et al. Trivalent RING Assembly on Retroviral Capsids Activates TRIM5 Ubiquitination and Innate Immune Signaling. Cell Host Microbe. 2018;24:761-775.e6 pubmed publisher
Saavedra P, Huang L, Ghazavi F, Kourula S, Vanden Berghe T, Takahashi N, et al. Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis. Nat Commun. 2018;9:4846 pubmed publisher
Torres A, Arriagada V, Erices J, Toro M, Rocha J, Niechi I, et al. FK506 Attenuates the MRP1-Mediated Chemoresistant Phenotype in Glioblastoma Stem-Like Cells. Int J Mol Sci. 2018;19: pubmed publisher
Cho R, Yang C, Tseng H, Hsiao L, Lin C, Yang C. Haem oxygenase-1 up-regulation by rosiglitazone via ROS-dependent Nrf2-antioxidant response elements axis or PPARγ attenuates LPS-mediated lung inflammation. Br J Pharmacol. 2018;175:3928-3946 pubmed publisher
Bertinat R, Westermeier F, Silva P, Gatica R, Oliveira J, Nualart F, et al. The Antidiabetic Agent Sodium Tungstate Induces Abnormal Glycogen Accumulation in Renal Proximal Tubules from Diabetic IRS2-Knockout Mice. J Diabetes Res. 2018;2018:5697970 pubmed publisher
Rocha R, Torres A, Ojeda K, Uribe D, Rocha D, Erices J, et al. The Adenosine A? Receptor Regulates Differentiation of Glioblastoma Stem-Like Cells to Endothelial Cells under Hypoxia. Int J Mol Sci. 2018;19: pubmed publisher
Zhang Q, Huang H, Zhang L, WU R, Chung C, Zhang S, et al. Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-Based Kinase Reporter. Mol Cell. 2018;69:334-346.e4 pubmed publisher
Van Opdenbosch N, Van Gorp H, Verdonckt M, Saavedra P, de Vasconcelos N, Gonçalves A, et al. Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4. Cell Rep. 2017;21:3427-3444 pubmed publisher
Pearsall E, Cheng R, Zhou K, Takahashi Y, Matlock H, Vadvalkar S, et al. PPAR? is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017;15:113 pubmed publisher
Clift D, McEwan W, Labzin L, Konieczny V, Mogessie B, James L, et al. A Method for the Acute and Rapid Degradation of Endogenous Proteins. Cell. 2017;171:1692-1706.e18 pubmed publisher
Perez Leal O, Barrero C, Merali S. Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses. J Biol Chem. 2017;292:14108-14121 pubmed publisher
Rabinowitz J, Robitaille A, Wang Y, Ray C, Thummel R, Gu H, et al. Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proc Natl Acad Sci U S A. 2017;114:E717-E726 pubmed publisher
Zhang X, Adderley S, Breslin J. Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. PLoS ONE. 2016;11:e0155490 pubmed publisher
Deere J, Chang W, Castillo L, Schmidt K, Kieu H, Renzette N, et al. Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS. PLoS ONE. 2016;11:e0155629 pubmed publisher
Liu C, Chan S, Guo F, Toloczko A, Cui L, Hong W. MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells. Oncotarget. 2016;7:13706-16 pubmed publisher
Yu G, Yu W, Jin G, Xu D, Chen Y, Xia T, et al. PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma. Mol Cancer. 2015;14:193 pubmed publisher
Bielig H, Lautz K, Braun P, Menning M, Machuy N, Brügmann C, et al. The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling. PLoS Pathog. 2014;10:e1004351 pubmed publisher
Yu W, Bonnet M, Farso M, Ma K, Chabot J, Martin E, et al. The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease. BMC Neurosci. 2014;15:73 pubmed publisher
Zhang Z, Dong Z, Lauxen I, Filho M, Nor J. Endothelial cell-secreted EGF induces epithelial to mesenchymal transition and endows head and neck cancer cells with stem-like phenotype. Cancer Res. 2014;74:2869-81 pubmed publisher
Seidl S, Braun U, Roos N, Li S, Lüdtke T, Kispert A, et al. Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5. PLoS ONE. 2013;8:e62756 pubmed publisher
Grolla A, Sim J, Lim D, Rodriguez J, Genazzani A, Verkhratsky A. Amyloid-? and Alzheimer's disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions. Cell Death Dis. 2013;4:e623 pubmed publisher
Ng K, Lee Y, Lai W, Chan Y, Fung M, Tse H, et al. Exogenous expression of human apoA-I enhances cardiac differentiation of pluripotent stem cells. PLoS ONE. 2011;6:e19787 pubmed publisher
product information
Catalog Number :
sc-47778 HRP
Product Name :
β-Actin (C4) HRP
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Conjugation :
horseradish peroxidase
Clone Name :
C4
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
gizzard Actin
Specificity :
mouse, rat, human, avian, bovine, canine, porcine, rabbit, D. discoideum, P. polycephalum
Uses :
WB, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA