product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p-Atm (10H11.E12) Antibody
catalog :
sc-47739
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
antigen modification :
phosphorylated
clone name :
10H11.E12
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 27
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 2a
Shin S, Song J, Hwang B, Noh D, Park S, Kim W, et al. HSPA6 augments garlic extract-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; Implication for cell cycle dysregulation, signaling pathway alteration, and transcription factor-associated MMP-9 regulation. PLoS ONE. 2017;12:e0171860 pubmed publisher
  • western blot; human; fig 4
Lee J, Jung H, Han Y, Yoon Y, Yun C, Sun H, et al. Antioxidant effects of Cirsium setidens extract on oxidative stress in human mesenchymal stem cells. Mol Med Rep. 2016;14:3777-84 pubmed publisher
  • flow cytometry; human; 1:50; loading ...; fig 7d
  • western blot; human; 1:500; loading ...; fig 2b
Frum R, Love I, Damle P, Mukhopadhyay N, Palit Deb S, Deb S, et al. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016;14:423-36 pubmed publisher
  • western blot; mouse; fig 4a
Yang Y, Poe J, Yang L, Fedoriw A, Desai S, Magnuson T, et al. Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo. Nucleic Acids Res. 2016;44:4174-88 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig st3
  • western blot; human; 1:500; loading ...; fig st3
Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, et al. Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells. Nat Commun. 2016;7:10399 pubmed publisher
  • western blot; human
Rassoolzadeh H, Coucoravas C, Farnebo M. The proximity ligation assay reveals that at DNA double-strand breaks WRAP53β associates with γH2AX and controls interactions between RNF8 and MDC1. Nucleus. 2015;6:417-24 pubmed publisher
  • immunocytochemistry; human
Stellas D, Souliotis V, Bekyrou M, Smirlis D, Kirsch Volders M, Degrassi F, et al. Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability. Mutat Res. 2014;769:59-68 pubmed publisher
  • western blot; mouse
Xiong J, Todorova D, Su N, Kim J, Lee P, Shen Z, et al. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. J Cell Biol. 2015;208:513-20 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 2
  • western blot; human; fig s1
Clarke J, Lyra e Silva N, Figueiredo C, Frozza R, Ledo J, Beckman D, et al. Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015;7:190-210 pubmed publisher
  • western blot; human; fig 4b
Henriksson S, Rassoolzadeh H, Hedström E, Coucoravas C, Julner A, Goldstein M, et al. The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. Genes Dev. 2014;28:2726-38 pubmed publisher
  • immunocytochemistry; human; fig 2
Gad H, Koolmeister T, Jemth A, Eshtad S, Jacques S, Ström C, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014;508:215-21 pubmed publisher
  • western blot; mouse
Conradt L, Henrich A, Wirth M, Reichert M, Lesina M, Algül H, et al. Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death. Int J Cancer. 2013;132:2248-57 pubmed publisher
Zhang Y, Ramirez Martinez A, Chen K, McAnally J, Cai C, Durbacz M, et al. Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy. J Clin Invest. 2023;133: pubmed publisher
Perrone C, Pomella S, Cassandri M, Pezzella M, Giuliani S, Gasperi T, et al. Spermine oxidase induces DNA damage and sensitizes fusion negative rhabdomyosarcoma cells to irradiation. Front Cell Dev Biol. 2023;11:1061570 pubmed publisher
Lan B, Zeng S, Zhang S, Ren X, Xing Y, Kutschick I, et al. CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Cancers (Basel). 2022;14: pubmed publisher
Petsalaki E, Zachos G. An ATM-Chk2-INCENP pathway activates the abscission checkpoint. J Cell Biol. 2021;220: pubmed publisher
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, et al. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging (Albany NY). 2020;12:4688-4710 pubmed publisher
Gao Y, Kardos J, Yang Y, Tamir T, Mutter Rottmayer E, Weissman B, et al. The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells. Sci Rep. 2018;8:15304 pubmed publisher
Chen M, Hsu W, Hsu S, Yang Y, Chuang T, Lin W, et al. PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency. Cell Death Differ. 2019;26:1221-1234 pubmed publisher
Manzo S, Hartono S, Sanz L, Marinello J, De Biasi S, Cossarizza A, et al. DNA Topoisomerase I differentially modulates R-loops across the human genome. Genome Biol. 2018;19:100 pubmed publisher
Yosef R, Pilpel N, Papismadov N, Gal H, Ovadya Y, Vadai E, et al. p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling. EMBO J. 2017;36:2280-2295 pubmed publisher
Yang Y, Durando M, Smith Roe S, Sproul C, Greenwalt A, Kaufmann W, et al. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. Nucleic Acids Res. 2013;41:2296-312 pubmed publisher
Fiorito F, Ciarcia R, Granato G, Marfe G, Iovane V, Florio S, et al. 2,3,7,8-tetrachlorodibenzo-p-dioxin induced autophagy in a bovine kidney cell line. Toxicology. 2011;290:258-70 pubmed publisher
Mazumder Indra D, Mitra S, Roy A, Mondal R, Basu P, Roychoudhury S, et al. Alterations of ATM and CADM1 in chromosomal 11q22.3-23.2 region are associated with the development of invasive cervical carcinoma. Hum Genet. 2011;130:735-48 pubmed publisher
Horton J, Stefanick D, Zeng J, Carrozza M, Wilson S. Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition. DNA Repair (Amst). 2011;10:225-34 pubmed publisher
Zhang Z, Wang Y, Song T, Gao J, Wu G, Zhang J, et al. DNA double helix unwinding triggers transcription block-dependent apoptosis: a semiquantitative probe of the response of ATM, RNAPII, and p53 to two DNA intercalators. Chem Res Toxicol. 2009;22:483-91 pubmed publisher
Zhang Z, Wang Y, Zhang J, Song T, Qian X. Potency and property of DNA conformational damage determine ATM activation: two new DNA topological probes. Cell Biochem Funct. 2008;26:808-12 pubmed publisher
product information
Catalog Number :
sc-47739
Product Name :
p-Atm (10H11.E12) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Antigen Modification :
phosphorylation
Clone Name :
10H11.E12
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Atm
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA