product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Pol II (CTD4H8) Antibody
catalog :
sc-47701
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
CTD4H8
reactivity :
human, mouse, rat, thale cress
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
citations: 33
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig s6d
  • immunocytochemistry; human; 1:200; loading ...; fig s4f
  • western blot; human; 1:5000; loading ...; fig 7a
Li Y, Liu Y, Xu H, Jiang G, Van der Jeught K, Fang Y, et al. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Nat Commun. 2018;9:4394 pubmed publisher
  • chromatin immunoprecipitation; human
Bujko M, Kober P, Statkiewicz M, Mikula M, Ligaj M, Zwierzchowski L, et al. Epigenetic-Mediated Downregulation of μ-Protocadherin in Colorectal Tumours. Gastroenterol Res Pract. 2015;2015:317093 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig s1
  • western blot; human; fig s3d
Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, et al. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature. 2015;520:697-701 pubmed publisher
  • chromatin immunoprecipitation; thale cress; fig 4
Dolata J, Guo Y, Kołowerzo A, Smoliński D, Brzyżek G, Jarmołowski A, et al. NTR1 is required for transcription elongation checkpoints at alternative exons in Arabidopsis. EMBO J. 2015;34:544-58 pubmed publisher
  • chromatin immunoprecipitation; human
Ji X, Lu H, Zhou Q, Luo K. LARP7 suppresses P-TEFb activity to inhibit breast cancer progression and metastasis. elife. 2014;3:e02907 pubmed publisher
  • chromatin immunoprecipitation; human
Attucks O, Jasmer K, Hannink M, Kassis J, Zhong Z, Gupta S, et al. Induction of heme oxygenase I (HMOX1) by HPP-4382: a novel modulator of Bach1 activity. PLoS ONE. 2014;9:e101044 pubmed publisher
  • chromatin immunoprecipitation; human; fig 4d
Veronese A, Pepe F, Chiacchia J, Pagotto S, Lanuti P, Veschi S, et al. Allele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia. Leukemia. 2015;29:86-95 pubmed publisher
  • chromatin immunoprecipitation; human
  • immunocytochemistry; human
Madak Erdogan Z, Ventrella R, Petry L, Katzenellenbogen B. Novel roles for ERK5 and cofilin as critical mediators linking ER?-driven transcription, actin reorganization, and invasiveness in breast cancer. Mol Cancer Res. 2014;12:714-27 pubmed publisher
  • chromatin immunoprecipitation; mouse
  • chromatin immunoprecipitation; human
Fowler T, Ghatak P, Price D, Conaway R, Conaway J, Chiang C, et al. Regulation of MYC expression and differential JQ1 sensitivity in cancer cells. PLoS ONE. 2014;9:e87003 pubmed publisher
Mersaoui S, Yu Z, Coulombe Y, Karam M, Busatto F, Masson J, et al. Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids. EMBO J. 2019;38:e100986 pubmed publisher
Wu S, Fatkhutdinov N, Rosin L, Luppino J, Iwasaki O, Tanizawa H, et al. ARID1A spatially partitions interphase chromosomes. Sci Adv. 2019;5:eaaw5294 pubmed publisher
Petrie J, Swan C, Ingram R, Frame F, Collins A, Dumay Odelot H, et al. Effects on prostate cancer cells of targeting RNA polymerase III. Nucleic Acids Res. 2019;47:3937-3956 pubmed publisher
Wu S, Fatkhutdinov N, Fukumoto T, Bitler B, Park P, Kossenkov A, et al. SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells. Nat Commun. 2018;9:4116 pubmed publisher
Haynes P, Bomsztyk K, Miller D. Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele. Epigenetics Chromatin. 2018;11:47 pubmed publisher
Sun C, Yin J, Fang Y, Chen J, Jeong K, Chen X, et al. BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell. 2018;33:401-416.e8 pubmed publisher
Koch M, House N, Cosetta C, Jong R, Salomon C, Joyce C, et al. The Chromatin Remodeler Isw1 Prevents CAG Repeat Expansions During Transcription in Saccharomyces cerevisiae. Genetics. 2018;208:963-976 pubmed publisher
Parvathaneni S, Lu X, Chaudhary R, Lal A, Madhusudan S, Sharma S. RECQ1 expression is upregulated in response to DNA damage and in a p53-dependent manner. Oncotarget. 2017;8:75924-75942 pubmed publisher
Mikula M, Bomsztyk K, Goryca K, Chojnowski K, Ostrowski J. Heterogeneous nuclear ribonucleoprotein (HnRNP) K genome-wide binding survey reveals its role in regulating 3'-end RNA processing and transcription termination at the early growth response 1 (EGR1) gene through XRN2 exonuclease. J Biol Chem. 2013;288:24788-98 pubmed publisher
Yamada K, Hayashi M, Madokoro H, Nishida H, Du W, Ohnuma K, et al. Nuclear localization of CD26 induced by a humanized monoclonal antibody inhibits tumor cell growth by modulating of POLR2A transcription. PLoS ONE. 2013;8:e62304 pubmed publisher
Zhang Z, Liu R, Townsend P, Proud C. p90(RSK)s mediate the activation of ribosomal RNA synthesis by the hypertrophic agonist phenylephrine in adult cardiomyocytes. J Mol Cell Cardiol. 2013;59:139-47 pubmed publisher
Komers R, Mar D, Denisenko O, Xu B, Oyama T, Bomsztyk K. Epigenetic changes in renal genes dysregulated in mouse and rat models of type 1 diabetes. Lab Invest. 2013;93:543-52 pubmed publisher
van Rensburg R, Beyer I, Yao X, Wang H, Denisenko O, Li Z, et al. Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells. Gene Ther. 2013;20:201-14 pubmed publisher
Yu J, Feng Q, Ruan Y, Komers R, Kiviat N, Bomsztyk K. Microplate-based platform for combined chromatin and DNA methylation immunoprecipitation assays. BMC Mol Biol. 2011;12:49 pubmed publisher
Melvin A, Mudie S, Rocha S. The chromatin remodeler ISWI regulates the cellular response to hypoxia: role of FIH. Mol Biol Cell. 2011;22:4171-81 pubmed publisher
Culver C, Melvin A, Mudie S, Rocha S. HIF-1α depletion results in SP1-mediated cell cycle disruption and alters the cellular response to chemotherapeutic drugs. Cell Cycle. 2011;10:1249-60 pubmed
van Uden P, Kenneth N, Webster R, Müller H, Mudie S, Rocha S. Evolutionary conserved regulation of HIF-1β by NF-κB. PLoS Genet. 2011;7:e1001285 pubmed publisher
Brody Y, Neufeld N, Bieberstein N, Causse S, Böhnlein E, Neugebauer K, et al. The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing. PLoS Biol. 2011;9:e1000573 pubmed publisher
Nelson J, Denisenko O, Bomsztyk K. Profiling RNA polymerase II using the fast chromatin immunoprecipitation method. Methods Mol Biol. 2011;703:219-34 pubmed publisher
Newton I, Kenneth N, Appleton P, Näthke I, Rocha S. Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection. Mol Biol Cell. 2010;21:3630-8 pubmed publisher
Mikula M, Gaj P, Dzwonek K, Rubel T, Karczmarski J, Paziewska A, et al. Comprehensive analysis of the palindromic motif TCTCGCGAGA: a regulatory element of the HNRNPK promoter. DNA Res. 2010;17:245-60 pubmed publisher
Mikula M, Hanusek K, Paziewska A, Dzwonek A, Rubel T, Bomsztyk K, et al. Halogenated imidazole derivatives block RNA polymerase II elongation along mitogen inducible genes. BMC Mol Biol. 2010;11:4 pubmed publisher
Birch J, Tan B, Panov K, Panova T, Andersen J, Owen Hughes T, et al. FACT facilitates chromatin transcription by RNA polymerases I and III. EMBO J. 2009;28:854-65 pubmed publisher
Kenneth N, Mudie S, van Uden P, Rocha S. SWI/SNF regulates the cellular response to hypoxia. J Biol Chem. 2009;284:4123-31 pubmed publisher
product information
Product Name :
Pol II (CTD4H8) Antibody
Gene Name :
POLR2A
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-47701
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Pol II
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P)
Epitope :
Ser-5 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA