product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p53 (DO-7) Antibody
catalog :
sc-47698
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DO-7
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 26
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 3b
Ng S, Yoshida N, Christie A, Ghandi M, Dharia N, Dempster J, et al. Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models. Nat Commun. 2018;9:2024 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 5b
Solomon H, Dinowitz N, Pateras I, Cooks T, Shetzer Y, Molchadsky A, et al. Mutant p53 gain of function underlies high expression levels of colorectal cancer stem cells markers. Oncogene. 2018;37:1669-1684 pubmed publisher
  • western blot; human; loading ...; fig 2e
Zhao X, Huang L, Xu W, Chen X, Shen Y, Zeng W, et al. Physapubescin B inhibits tumorgenesis and circumvents taxol resistance of ovarian cancer cells through STAT3 signaling. Oncotarget. 2017;8:70130-70141 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Lian W, Zhang L, Yang L, Chen W. AP-2α reverses vincristine-induced multidrug resistance of SGC7901 gastric cancer cells by inhibiting the Notch pathway. Apoptosis. 2017;22:933-941 pubmed publisher
  • western blot; human; 1:400; loading ...; fig 3a
Xu S, Yang Z, Fan Y, Guan B, Jia J, Gao Y, et al. Curcumin enhances temsirolimus-induced apoptosis in human renal carcinoma cells through upregulation of YAP/p53. Oncol Lett. 2016;12:4999-5006 pubmed publisher
  • western blot; human; loading ...; fig 5e
Pires A, Marques C, Encarnação J, Abrantes A, Mamede A, Laranjo M, et al. Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile. Eur J Cell Biol. 2016;95:208-18 pubmed publisher
  • western blot; human; loading ...; fig 5a
Brito A, Ribeiro M, Abrantes A, Mamede A, Laranjo M, Casalta Lopes J, et al. New Approach for Treatment of Primary Liver Tumors: The Role of Quercetin. Nutr Cancer. 2016;68:250-66 pubmed publisher
  • western blot; human; loading ...; fig 1b
Xie X, Lozano G, Siddik Z. Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53. Oncogene. 2016;35:4798-806 pubmed publisher
  • western blot; human; loading ...; fig 7a
Ying M, Zhang L, Zhou Q, Shao X, Cao J, Zhang N, et al. The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα. Oncogene. 2016;35:4358-67 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
Chen S, Wang W, Wang L, Lin Q, Zhao G, Xu G, et al. Glioneuronal tumours with features of rosette-forming glioneuronal tumours of the fourth ventricle and dysembryoplastic neuroepithelial tumours: a report of three cases. Histopathology. 2016;68:378-87 pubmed publisher
  • western blot; human; fig 1
Magni M, Ruscica V, Buscemi G, Kim J, Nachimuthu B, Fontanella E, et al. Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis. Nucleic Acids Res. 2014;42:13150-60 pubmed publisher
Cho H, Min H, Won Y, Ahn H, Cho Y, Seo K. Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells. BMC Complement Altern Med. 2019;19:241 pubmed publisher
Wu Y, Li Y, Zhao X, Dong D, Tang C, Li E, et al. Combined detection of the expression of Nm23-H1 and p53 is correlated with survival rates of patients with stage II and III colorectal cancer. Oncol Lett. 2017;13:129-136 pubmed publisher
Ohashi T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Imamura T, et al. Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma. Br J Cancer. 2017;116:218-226 pubmed publisher
Varela A, Piperi C, Sigala F, Agrogiannis G, Davos C, Andri M, et al. Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity. Sci Rep. 2015;5:13461 pubmed publisher
Chen L, Rousseau R, Middleton S, Nichols G, Newell D, Lunec J, et al. Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma. Oncotarget. 2015;6:10207-21 pubmed
Pozzo F, Dal Bo M, Peragine N, Bomben R, Zucchetto A, Rossi F, et al. Detection of TP53 dysfunction in chronic lymphocytic leukemia by an in vitro functional assay based on TP53 activation by the non-genotoxic drug Nutlin-3: a proposal for clinical application. J Hematol Oncol. 2013;6:83 pubmed publisher
Shilkaitis A, Bratescu L, Green A, Yamada T, Christov K. Bexarotene induces cellular senescence in MMTV-Neu mouse model of mammary carcinogenesis. Cancer Prev Res (Phila). 2013;6:299-308 pubmed publisher
Ohshima S. Centrosome aberrations associated with cellular senescence and p53 localization at supernumerary centrosomes. Oxid Med Cell Longev. 2012;2012:217594 pubmed publisher
Wu X, Zhu Z, Li W, Fu X, Su D, Fu L, et al. Chromodomain helicase DNA binding protein 5 plays a tumor suppressor role in human breast cancer. Breast Cancer Res. 2012;14:R73 pubmed
Chen Y, Shen D, Gu Y, Zhong P, Xie J, Song Q. The diagnostic value of Ki-67, P53 and P63 in distinguishing partial Hydatidiform mole from hydropic abortion. Wien Klin Wochenschr. 2012;124:184-7 pubmed publisher
Shirakawa M, Fujiwara Y, Sugita Y, Moon J, Takiguchi S, Nakajima K, et al. Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma. Oncol Rep. 2012;27:940-6 pubmed publisher
Tagoug I, Sauty De Chalon A, Dumontet C. Inhibition of IGF-1 signalling enhances the apoptotic effect of AS602868, an IKK2 inhibitor, in multiple myeloma cell lines. PLoS ONE. 2011;6:e22641 pubmed publisher
Jing M, Mao X, Li C, Wei J, Liu C, Jin F. Estrogen receptor-alpha promoter methylation in sporadic basal-like breast cancer of Chinese women. Tumour Biol. 2011;32:713-9 pubmed publisher
Mao X, Fan C, Zheng H, Wei J, Yao F, Jin F. p53 nuclear accumulation and ERalpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women. J Exp Clin Cancer Res. 2010;29:112 pubmed publisher
Morselli E, Tasdemir E, Maiuri M, Galluzzi L, Kepp O, Criollo A, et al. Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle. 2008;7:3056-61 pubmed
product information
Product Name :
p53 (DO-7) Antibody
Gene Name :
TP53
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-47698
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
p53
reactive species  :
human
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
1-45 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA