product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
cPLA2 (4-4B-3C) Antibody
catalog :
sc-454
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4-4B-3C
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500-1:1000; loading ...; fig 3
Suzuki S, Tanaka A, Nakamura H, Murayama T. Knockout of Ceramide Kinase Aggravates Pathological and Lethal Responses in Mice with Experimental Colitis. Biol Pharm Bull. 2018;41:797-805 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 5k
  • western blot; human; loading ...; fig 2a-c,3a
Roy D, Mondal S, Khurana A, Jung D, Hoffmann R, He X, et al. Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer. Sci Rep. 2017;7:41977 pubmed publisher
  • western blot; human; 1:1000; fig 1a
Lin C, Lin W, Cho R, Wang C, Hsiao L, Yang C. TNF-?-Induced cPLA2 Expression via NADPH Oxidase/Reactive Oxygen Species-Dependent NF-?B Cascade on Human Pulmonary Alveolar Epithelial Cells. Front Pharmacol. 2016;7:447 pubmed
  • western blot; human; 1:500; loading ...; fig 4a
Liu C, Guo C, Wang W, Zhu P, Li W, Mi Y, et al. Inhibition of Lysyl Oxidase by Cortisol Regeneration in Human Amnion: Implications for Rupture of Fetal Membranes. Endocrinology. 2016;157:4055-4065 pubmed
  • western blot; human; fig 2
Yao M, Xie C, Kiang M, Teng Y, Harman D, Tiffen J, et al. Targeting of cytosolic phospholipase A2α impedes cell cycle re-entry of quiescent prostate cancer cells. Oncotarget. 2015;6:34458-74 pubmed publisher
  • western blot; human; 1:1000
Kitsiouli E, Antoniou G, Gotzou H, Karagiannopoulos M, Basagiannis D, Christoforidis S, et al. Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells. Biochim Biophys Acta. 2015;1852:1288-97 pubmed publisher
  • western blot; human; fig 1
Zheng Z, He X, Xie C, Hua S, Li J, Wang T, et al. Targeting cytosolic phospholipase A2 α in colorectal cancer cells inhibits constitutively activated protein kinase B (AKT) and cell proliferation. Oncotarget. 2014;5:12304-16 pubmed
  • western blot; rat
Tajuddin N, Moon K, Marshall S, Nixon K, Neafsey E, Kim H, et al. Neuroinflammation and neurodegeneration in adult rat brain from binge ethanol exposure: abrogation by docosahexaenoic acid. PLoS ONE. 2014;9:e101223 pubmed publisher
  • western blot; human; fig 4
Esmaeili M, Bathen T, Engebraten O, Mælandsmo G, Gribbestad I, Moestue S. Quantitative (31)P HR-MAS MR spectroscopy for detection of response to PI3K/mTOR inhibition in breast cancer xenografts. Magn Reson Med. 2014;71:1973-81 pubmed publisher
Chao C, Gutiérrez Vázquez C, Rothhammer V, Mayo L, Wheeler M, Tjon E, et al. Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell. 2019;179:1483-1498.e22 pubmed publisher
Petersen C, Mahmood B, Badsted C, Dahlby T, Rasmussen H, Hansen M, et al. Possible predisposition for colorectal carcinogenesis due to altered gene expressions in normal appearing mucosa from patients with colorectal neoplasia. BMC Cancer. 2019;19:643 pubmed publisher
Tajuddin N, Kim H, Collins M. PARP Inhibition Prevents Ethanol-Induced Neuroinflammatory Signaling and Neurodegeneration in Rat Adult-Age Brain Slice Cultures. J Pharmacol Exp Ther. 2018;365:117-126 pubmed publisher
Hayashi G, Shen Y, Pedersen T, Newman J, Pook M, Cortopassi G. Frataxin deficiency increases cyclooxygenase 2 and prostaglandins in cell and animal models of Friedreich's ataxia. Hum Mol Genet. 2014;23:6838-47 pubmed publisher
Cridge A, Visweswaraiah J, Ramesh R, Sattlegger E. Semi-quantitative colony immunoassay for determining and optimizing protein expression in Saccharomyces cerevisiae and Escherichia coli. Anal Biochem. 2014;447:82-9 pubmed publisher
Bickford J, Beachy D, Newsom K, Barilovits S, Herlihy J, Qiu X, et al. A distal enhancer controls cytokine-dependent human cPLA2? gene expression. J Lipid Res. 2013;54:1915-26 pubmed publisher
Tajuddin N, Przybycien Szymanska M, Pak T, Neafsey E, Collins M. Effect of repetitive daily ethanol intoxication on adult rat brain: significant changes in phospholipase A2 enzyme levels in association with increased PARP-1 indicate neuroinflammatory pathway activation. Alcohol. 2013;47:39-45 pubmed publisher
Krouwer V, Hekking L, Langelaar Makkinje M, Regan Klapisz E, Post J. Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability. Vasc Cell. 2012;4:12 pubmed publisher
Last V, Williams A, Werling D. Inhibition of cytosolic Phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin. BMC Neurosci. 2012;13:106 pubmed publisher
Takei S, Hasegawa Ishii S, Uekawa A, Chiba Y, Umegaki H, Hosokawa M, et al. Immunohistochemical demonstration of increased prostaglandin F?? levels in the rat hippocampus following kainic acid-induced seizures. Neuroscience. 2012;218:295-304 pubmed publisher
Khatchadourian A, Bourque S, Richard V, Titorenko V, Maysinger D. Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia. Biochim Biophys Acta. 2012;1821:607-17 pubmed publisher
Dif F, Wu Y, Burgel P, Ollero M, Leduc D, Aarbiou J, et al. Critical role of cytosolic phospholipase A2{alpha} in bronchial mucus hypersecretion in CFTR-deficient mice. Eur Respir J. 2010;36:1120-30 pubmed publisher
Guo C, Li J, Myatt L, Zhu X, Sun K. Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. Mol Endocrinol. 2010;24:1052-61 pubmed publisher
Singh J, Xie C, Yao M, Hua S, Vignarajan S, Jardine G, et al. Food extracts consumed in Mediterranean countries and East Asia reduce protein concentrations of androgen receptor, phospho-protein kinase B, and phospho-cytosolic phospholipase A(2)alpha in human prostate cancer cells. J Nutr. 2010;140:786-91 pubmed publisher
Guo C, Ni X, Zhu P, Li W, Zhu X, Sun K. Induction of progesterone receptor A form attenuates the induction of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts. Reproduction. 2010;139:915-22 pubmed publisher
Kobayashi T, Kawamata T, Shibata N, Okada Y, Kobayashi M, Hori T. Angiotensin II type 1 receptor blocker telmisartan reduces cerebral infarct volume and peri-infarct cytosolic phospholipase A(2) level in experimental stroke. J Neurotrauma. 2009;26:2355-64 pubmed publisher
Godkin J, Roberts M, Elgayyar M, Guan W, Tithof P. Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin production. Reprod Biol Endocrinol. 2008;6:44 pubmed publisher
Cubells L, Vilà de Muga S, Tebar F, Bonventre J, Balsinde J, Pol A, et al. Annexin A6-induced inhibition of cytoplasmic phospholipase A2 is linked to caveolin-1 export from the Golgi. J Biol Chem. 2008;283:10174-83 pubmed publisher
Poulsen K, Pedersen S, Kolko M, Lambert I. Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants. Am J Physiol Cell Physiol. 2007;293:C1605-15 pubmed
Culver C, Laster S. Adenovirus type 5 exerts multiple effects on the expression and activity of cytosolic phospholipase A2, cyclooxygenase-2, and prostaglandin synthesis. J Immunol. 2007;179:4170-9 pubmed
Tithof P, Roberts M, Guan W, Elgayyar M, Godkin J. Distinct phospholipase A2 enzymes regulate prostaglandin E2 and F2alpha production by bovine endometrial epithelial cells. Reprod Biol Endocrinol. 2007;5:16 pubmed
Kolko M, Wang J, Zhan C, Poulsen K, Prause J, Nissen M, et al. Identification of intracellular phospholipases A2 in the human eye: involvement in phagocytosis of photoreceptor outer segments. Invest Ophthalmol Vis Sci. 2007;48:1401-9 pubmed
Diouf M, Sayasith K, Lefebvre R, Silversides D, Sirois J, Lussier J. Expression of phospholipase A2 group IVA (PLA2G4A) is upregulated by human chorionic gonadotropin in bovine granulosa cells of ovulatory follicles. Biol Reprod. 2006;74:1096-103 pubmed
Vine A, Leung Y, Bertram J. Transcriptional regulation of connexin 43 expression by retinoids and carotenoids: similarities and differences. Mol Carcinog. 2005;43:75-85 pubmed
product information
Product Name :
cPLA2 (4-4B-3C) Antibody
Gene Name :
PLA2G4A
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-454
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
cPLA2
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
1-216 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA