product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Sp1 (1C6) Antibody
catalog :
sc-420
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1C6
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 45
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig s2
Yu Y, Shang R, Chen Y, Li J, Liang Z, Hu J, et al. Tumor suppressive ZBTB4 inhibits cell growth by regulating cell cycle progression and apoptosis in Ewing sarcoma. Biomed Pharmacother. 2018;100:108-115 pubmed publisher
  • western blot; mouse; loading ...; fig 6b
Po A, Begalli F, Abballe L, Alfano V, Besharat Z, Catanzaro G, et al. ?-Arrestin1/miR-326 Transcription Unit Is Epigenetically Regulated in Neural Stem Cells Where It Controls Stemness and Growth Arrest. Stem Cells Int. 2017;2017:5274171 pubmed publisher
  • western blot; mouse; 1:100; fig 4
Hou X, Adeosun S, Zhang Q, Barlow B, Brents M, Zheng B, et al. Differential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's disease. Front Aging Neurosci. 2015;7:207 pubmed publisher
  • western blot; human
Tan K, Fujimoto M, Takii R, Takaki E, Hayashida N, Nakai A. Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity. Nat Commun. 2015;6:6580 pubmed publisher
  • western blot; human; fig 2
Wu Z, Wang C, Bai M, Li X, Mei Q, Li X, et al. An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks. Nucleic Acids Res. 2015;43:3167-79 pubmed publisher
  • western blot; human
Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, et al. Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol. 2013;7:484-96 pubmed publisher
Bianchi M, Crinelli R, Giacomini E, Carloni E, Radici L, Scarpa E, et al. A negative feedback mechanism links UBC gene expression to ubiquitin levels by affecting RNA splicing rather than transcription. Sci Rep. 2019;9:18556 pubmed publisher
Wang L, Xie W, Zhang L, Li D, Yu H, Xiong J, et al. CVB3 Nonstructural 2A Protein Modulates SREBP1a Signaling via the MEK/ERK Pathway. J Virol. 2018;92: pubmed publisher
Kong X, Xu P, Cai W, Wang H, Li B, Huang G, et al. ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells. BMC Cancer. 2018;18:419 pubmed publisher
Kim H, Jeong Y, Song I, Noh Y, Seo K, Kim M, et al. Glucocorticoid receptor positively regulates transcription of FNDC5 in the liver. Sci Rep. 2017;7:43296 pubmed publisher
Belluti S, Basile V, Benatti P, Ferrari E, Marverti G, Imbriano C. Concurrent inhibition of enzymatic activity and NF-Y-mediated transcription of Topoisomerase-II? by bis-DemethoxyCurcumin in cancer cells. Cell Death Dis. 2013;4:e756 pubmed publisher
Ye Q, Zhang X, Huang B, Zhu Y, Chen X. Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway. Mar Drugs. 2013;11:1019-34 pubmed publisher
Hunter C, Stein R. Characterization of an apparently novel ?-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes. J Biol Chem. 2013;288:3795-803 pubmed publisher
Gromnicova R, Romero I, Male D. Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues. PLoS ONE. 2012;7:e48189 pubmed publisher
Ren Y, Chaerkady R, Hu S, Wan J, Qian J, Zhu H, et al. Unbiased discovery of interactions at a control locus driving expression of the cancer-specific therapeutic and diagnostic target, mesothelin. J Proteome Res. 2012;11:5301-10 pubmed publisher
Estella C, Herrer I, Moreno Moya J, Quiñonero A, Martínez S, Pellicer A, et al. miRNA signature and Dicer requirement during human endometrial stromal decidualization in vitro. PLoS ONE. 2012;7:e41080 pubmed publisher
Karolczak Bayatti M, Abu Amara T, Europe Finner G. Expression of the GTP-binding protein G?s in human myometrial cells is regulated by ubiquitination and protein degradation: involvement of proteasomal inhibition by trichostatin A. Reprod Sci. 2012;19:1323-31 pubmed publisher
Miura A, Odahara N, Tominaga A, Inoue K, Kambe Y, Kurihara T, et al. Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells. FEBS Lett. 2012;586:1731-5 pubmed publisher
Keilani S, Chandwani S, Dolios G, Bogush A, Beck H, Hatzopoulos A, et al. Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element. J Neurosci. 2012;32:6808-18 pubmed publisher
Stanley J, Aruldhas M, Chandrasekaran M, Neelamohan R, Suthagar E, Annapoorna K, et al. Androgen receptor expression in human thyroid cancer tissues: a potential mechanism underlying the gender bias in the incidence of thyroid cancers. J Steroid Biochem Mol Biol. 2012;130:105-24 pubmed publisher
Heinemann A, Zhao F, Pechlivanis S, Eberle J, Steinle A, Diederichs S, et al. Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Res. 2012;72:460-71 pubmed publisher
Adwan L, Basha R, Abdelrahim M, Subaiea G, Zawia N. Tolfenamic acid interrupts the de novo synthesis of the ?-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway. Curr Alzheimer Res. 2011;8:385-92 pubmed
Tjarnlund Wolf A, Hultman K, Curtis M, Faull R, Medcalf R, Jern C. Allelic imbalance of tissue-type plasminogen activator (t-PA) gene expression in human brain tissue. Thromb Haemost. 2011;105:945-53 pubmed publisher
Li J, Ge Y, Yang Z, Guo C, Duan T, Myatt L, et al. The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts. J Clin Endocrinol Metab. 2011;96:E899-907 pubmed publisher
Ren Y, Patel K, Paun B, Kern S. Structural analysis of the cancer-specific promoter in mesothelin and in other genes overexpressed in cancers. J Biol Chem. 2011;286:11960-9 pubmed publisher
Mancarelli M, Zazzeroni F, Ciccocioppo L, Capece D, Po A, Murgo S, et al. The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumors. Mol Cancer. 2010;9:172 pubmed publisher
Deshane J, Kim J, Bolisetty S, Hock T, Hill Kapturczak N, Agarwal A. Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells. J Biol Chem. 2010;285:16476-86 pubmed publisher
Zukic B, Radmilovic M, Stojiljkovic M, Tosic N, Pourfarzad F, Dokmanovic L, et al. Functional analysis of the role of the TPMT gene promoter VNTR polymorphism in TPMT gene transcription. Pharmacogenomics. 2010;11:547-57 pubmed publisher
Shiota M, Yokomizo A, Kashiwagi E, Tada Y, Inokuchi J, Tatsugami K, et al. Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin. Cancer Sci. 2010;101:1177-85 pubmed publisher
Ohneda K, Ohmori S, Ishijima Y, Nakano M, Yamamoto M. Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development. J Biol Chem. 2009;284:30187-99 pubmed publisher
Jin H, Seo S, Woo S, Kim E, Lee H, Yoo D, et al. Activating transcription factor 4 and CCAAT/enhancer-binding protein-beta negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress. Free Radic Biol Med. 2009;46:1158-67 pubmed publisher
Hassan M, Selimovic D, Ghozlan H, Abdel kader O. Hepatitis C virus core protein triggers hepatic angiogenesis by a mechanism including multiple pathways. Hepatology. 2009;49:1469-82 pubmed publisher
Kumar S, Sun X, Wiseman D, Tian J, Umapathy N, Verin A, et al. Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol. 2009;28:119-29 pubmed publisher
Larsson L, Johansson P, Jansson A, Donati M, Rymo L, Berglundh T. The Sp1 transcription factor binds to the G-allele of the -1087 IL-10 gene polymorphism and enhances transcriptional activation. Genes Immun. 2009;10:280-4 pubmed publisher
Citron B, Dennis J, Zeitlin R, Echeverria V. Transcription factor Sp1 dysregulation in Alzheimer's disease. J Neurosci Res. 2008;86:2499-504 pubmed publisher
Marampon F, Casimiro M, Fu M, Powell M, Popov V, Lindsay J, et al. Nerve Growth factor regulation of cyclin D1 in PC12 cells through a p21RAS extracellular signal-regulated kinase pathway requires cooperative interactions between Sp1 and nuclear factor-kappaB. Mol Biol Cell. 2008;19:2566-78 pubmed publisher
Huang C, Ho W, Lee W, Sheu M, Wang Y, Tu S, et al. SP1-regulated p27/Kip1 gene expression is involved in terbinafine-induced human A431 cancer cell differentiation: an in vitro and in vivo study. Biochem Pharmacol. 2008;75:1783-96 pubmed publisher
Fujiki T, Miura T, Maura M, Shiraishi H, Nishimura S, Imada Y, et al. TAK1 represses transcription of the human telomerase reverse transcriptase gene. Oncogene. 2007;26:5258-66 pubmed
Butta N, Larrucea S, Alonso S, Rodriguez R, Arias Salgado E, Ayuso M, et al. Role of transcription factor Sp1 and CpG methylation on the regulation of the human podocalyxin gene promoter. BMC Mol Biol. 2006;7:17 pubmed
Armelin Correa L, Lin C, Barbosa A, Bagatini K, Winnischofer S, Sogayar M, et al. Characterization of human collagen XVIII promoter 2: interaction of Sp1, Sp3 and YY1 with the regulatory region and a SNP that increases transcription in hepatocytes. Matrix Biol. 2005;24:550-9 pubmed
Masotti C, Armelin Correa L, Splendore A, Lin C, Barbosa A, Sogayar M, et al. A functional SNP in the promoter region of TCOF1 is associated with reduced gene expression and YY1 DNA-protein interaction. Gene. 2005;359:44-52 pubmed
Li Weber M, Treiber M, Giaisi M, Palfi K, Stephan N, Parg S, et al. Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-kappa B signaling pathways. J Immunol. 2005;175:2132-43 pubmed
Vatsyayan J, Peng H, Chang H. Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript. J Biochem. 2005;137:703-9 pubmed
Yang J, Dai C, Liu Y. A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition. J Am Soc Nephrol. 2005;16:68-78 pubmed
Bajpai U, Zhang K, Teutsch M, Sen R, Wortis H. Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med. 2000;191:1735-44 pubmed
product information
Product Name :
Sp1 (1C6) Antibody
Gene Name :
SP1
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-420
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Sp1
reactive species  :
m, r, h
Application :
WB, IF, IHC(P), ELISA
Epitope :
609-627 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA