product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Rho A (26C4) Antibody
catalog :
sc-418
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
26C4
reactivity :
marine lamprey, African green monkey, human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other, western blot knockout validation, immunohistochemistry knockout validation
citations: 272
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:200; loading ...; fig 1d
  • western blot knockout validation; mouse; loading ...; fig 1e
Xu J, Wen J, Fu L, Liao L, Zou Y, Zhang J, et al. Macrophage-specific RhoA knockout delays Wallerian degeneration after peripheral nerve injury in mice. J Neuroinflammation. 2021;18:234 pubmed publisher
  • western blot knockout validation; mouse; loading ...; fig 3a
Ge J, Burnier L, Adamopoulou M, Kwa M, Schaks M, Rottner K, et al. RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells. J Biol Chem. 2018;293:9358-9369 pubmed publisher
  • western blot; mouse; fig 3f
Jeong A, Cheng S, Zhong R, Bennett D, Bergo M, Li L. Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice. Acta Neuropathol Commun. 2021;9:129 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 6h
Fayad R, Rojas M, Partisani M, Finetti P, Dib S, Abélanet S, et al. EFA6B regulates a stop signal for collective invasion in breast cancer. Nat Commun. 2021;12:2198 pubmed publisher
  • western blot; human; loading ...; fig 1g
Rivas S, SILVA P, Reyes M, Sepulveda H, Solano L, Acuña J, et al. The RabGEF ALS2 is a hypoxia inducible target associated with the acquisition of aggressive traits in tumor cells. Sci Rep. 2020;10:22302 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1di
  • immunocytochemistry; mouse; 1:500; loading ...; fig 6b
Moon H, Hippenmeyer S, Luo L, Wynshaw Boris A. LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility. elife. 2020;9: pubmed publisher
  • western blot; dogs; 1:2000; loading ...; fig 6a
Rangel L, Bernabé Rubio M, Fernández Barrera J, Casares Arias J, Millan J, Alonso M, et al. Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity. Sci Rep. 2019;9:1116 pubmed publisher
  • western blot; mouse; fig s7a
Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed publisher
  • western blot; mouse; loading ...; fig 3a
Bobo Jiménez V, Delgado Esteban M, Angibaud J, Sánchez Morán I, de la Fuente A, Yajeya J, et al. APC/CCdh1-Rock2 pathway controls dendritic integrity and memory. Proc Natl Acad Sci U S A. 2017;114:4513-4518 pubmed publisher
  • western blot; mouse; loading ...; fig 7S1C
Jeannot P, Nowosad A, Perchey R, Callot C, Bennana E, Katsube T, et al. p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. elife. 2017;6: pubmed publisher
  • other; human; fig s2b
Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink R, Fielden M, et al. RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo. Proc Natl Acad Sci U S A. 2017;114:E1413-E1421 pubmed publisher
  • western blot; rat; loading ...; fig 3d
Lovric S, Gonçalves S, Gee H, Oskouian B, Srinivas H, Choi W, et al. Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. J Clin Invest. 2017;127:912-928 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4e
Chen Z, Givens C, Reader J, Tzima E. Haemodynamics Regulate Fibronectin Assembly via PECAM. Sci Rep. 2017;7:41223 pubmed publisher
  • western blot; mouse; loading ...; fig 6a
Jiang C, Diao F, Sang Y, Xu N, Zhu R, Wang X, et al. GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. PLoS Genet. 2017;13:e1006535 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig s3a
  • western blot; human; 1:100; loading ...; fig s3c
Priya R, Liang X, Teo J, Duszyc K, Yap A, Gomez G. ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Mol Biol Cell. 2017;28:12-20 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6a
Rafiq N, Lieu Z, Jiang T, Yu C, Matsudaira P, Jones G, et al. Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO. J Cell Biol. 2017;216:181-197 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4g
Bonan S, Albrengues J, Grasset E, Kuzet S, Nottet N, Bourget I, et al. Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts. Oncotarget. 2017;8:1304-1320 pubmed publisher
  • immunohistochemistry - paraffin section; marine lamprey; 1:200; loading ...; tbl 1
Hu J, Zhang G, Rodemer W, Jin L, Shifman M, Selzer M. The role of RhoA in retrograde neuronal death and axon regeneration after spinal cord injury. Neurobiol Dis. 2017;98:25-35 pubmed publisher
  • western blot; human; fig 7b
Yoo S, Leng L, Kim B, Du X, Tilstam P, Kim K, et al. MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016;113:E7917-E7926 pubmed
  • western blot; human; 1:1000; loading ...; fig 1d
Haak A, Appleton K, Lisabeth E, Misek S, Ji Y, Wade S, et al. Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma. Mol Cancer Ther. 2017;16:193-204 pubmed publisher
  • western blot; human; loading ...; fig 1e
Mardakheh F, Self A, Marshall C. RHO binding to FAM65A regulates Golgi reorientation during cell migration. J Cell Sci. 2016;129:4466-4479 pubmed
  • western blot; mouse; 1:500; loading ...; fig 2l
Shapiro L, Parsons R, Koleske A, Gourley S. Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development. J Neurosci Res. 2017;95:1123-1143 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 1j
Forrest C, McNair K, Vincenten M, Darlington L, Stone T. Selective depletion of tumour suppressors Deleted in Colorectal Cancer (DCC) and neogenin by environmental and endogenous serine proteases: linking diet and cancer. BMC Cancer. 2016;16:772 pubmed
  • western blot; mouse; loading ...; fig 2a
Kishi T, Mayanagi T, Iwabuchi S, Akasaka T, Sobue K. Myocardin-related transcription factor A (MRTF-A) activity-dependent cell adhesion is correlated to focal adhesion kinase (FAK) activity. Oncotarget. 2016;7:72113-72130 pubmed publisher
  • western blot; African green monkey; 1:1000; loading ...; fig 3f
McColl B, Garg R, Riou P, Riento K, Ridley A. Rnd3-induced cell rounding requires interaction with Plexin-B2. J Cell Sci. 2016;129:4046-4056 pubmed
  • immunocytochemistry; human; 1:100; loading ...; fig 3a
Priya R, Wee K, Budnar S, Gomez G, Yap A, Michael M. Coronin 1B supports RhoA signaling at cell-cell junctions through Myosin II. Cell Cycle. 2016;15:3033-3041 pubmed
  • western blot; human; 1:1000
Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Y, et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016;22:1033-1042 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 3b
Yuan W, Guo Y, Li X, Deng M, Shen Z, Bo C, et al. MicroRNA-126 inhibits colon cancer cell proliferation and invasion by targeting the chemokine (C-X-C motif) receptor 4 and Ras homolog gene family, member A, signaling pathway. Oncotarget. 2016;7:60230-60244 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 1d
Lee S, Jo Y, Namgoong S, Kim N. Anillin controls cleavage furrow formation in the course of asymmetric division during mouse oocyte maturation. Mol Reprod Dev. 2016;83:792-801 pubmed publisher
  • western blot; mouse; loading ...; fig s10b
Hodgson L, Spiering D, Sabouri Ghomi M, Dagliyan O, DerMardirossian C, Danuser G, et al. FRET binding antenna reports spatiotemporal dynamics of GDI-Cdc42 GTPase interactions. Nat Chem Biol. 2016;12:802-809 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4h
Whiting J, Ogier L, Forbush K, Bucko P, Gopalan J, Seternes O, et al. AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption. Proc Natl Acad Sci U S A. 2016;113:E4328-37 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 1
  • western blot; human; 1:200; fig 3
Li Y, Hu Y, Che L, Jia J, Chen M. Nucleolar localization of Small G protein RhoA is associated with active RNA synthesis in human carcinoma HEp-2 cells. Oncol Lett. 2016;11:3605-3610 pubmed
  • western blot; human; 1:200; fig 3
Matsumura S, Kojidani T, Kamioka Y, Uchida S, Haraguchi T, Kimura A, et al. Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1. Nat Commun. 2016;7:ncomms11858 pubmed publisher
  • western blot; mouse; loading ...
Park Y, Wood G, Kastner D, Chae J. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol. 2016;17:914-21 pubmed publisher
  • western blot; mouse; fig 3B
Chen L, DeWispelaere A, Dastvan F, Osborne W, Blechner C, Windhorst S, et al. Smooth Muscle-Alpha Actin Inhibits Vascular Smooth Muscle Cell Proliferation and Migration by Inhibiting Rac1 Activity. PLoS ONE. 2016;11:e0155726 pubmed publisher
  • western blot; human; fig 1
Marcos Ramiro B, García Weber D, Barroso S, Feito J, Ortega M, Cernuda Morollón E, et al. RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell border. J Cell Biol. 2016;213:385-402 pubmed publisher
  • western blot; human; loading ...; fig 6c
Wynn M, Yates J, Evans C, Van Wassenhove L, Wu Z, Bridges S, et al. RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells. J Biol Chem. 2016;291:13715-29 pubmed publisher
  • western blot; human; fig 1
Bzymek R, Horsthemke M, Isfort K, Mohr S, Tjaden K, Muller Tidow C, et al. Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep. 2016;6:25016 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 6c
Liu S, Zhou F, Shen Y, Zhang Y, Yin H, Zeng Y, et al. Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells. Oncotarget. 2016;7:32876-92 pubmed publisher
  • western blot; human; loading ...; fig 6a
Chen H, Gao Z, He C, Xiang R, van Kuppevelt T, Belting M, et al. GRP75 upregulates clathrin-independent endocytosis through actin cytoskeleton reorganization mediated by the concurrent activation of Cdc42 and RhoA. Exp Cell Res. 2016;343:223-236 pubmed publisher
  • western blot; human; fig 6c
Muramatsu T, Kozaki K, Imoto S, Yamaguchi R, Tsuda H, Kawano T, et al. The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene. 2016;35:5304-5316 pubmed publisher
  • immunocytochemistry; human; fig 4
Lasek A, McPherson B, Trueman N, Burkard M. The Functional Significance of Posttranslational Modifications on Polo-Like Kinase 1 Revealed by Chemical Genetic Complementation. PLoS ONE. 2016;11:e0150225 pubmed publisher
  • western blot; mouse; 1:500; fig 1
Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, et al. Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nat Commun. 2016;7:10664 pubmed publisher
  • western blot; human; fig 7
Fujiwara S, Ohashi K, Mashiko T, Kondo H, Mizuno K. Interplay between Solo and keratin filaments is crucial for mechanical force-induced stress fiber reinforcement. Mol Biol Cell. 2016;27:954-66 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 3
Uehara R, Kamasaki T, Hiruma S, Poser I, Yoda K, Yajima J, et al. Augmin shapes the anaphase spindle for efficient cytokinetic furrow ingression and abscission. Mol Biol Cell. 2016;27:812-27 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 4b
  • western blot; human; loading ...; fig 4b
Cui H, Wang S, Miao J, Fu Z, Feng F, Wu J, et al. CD147 regulates cancer migration via direct interaction with Annexin A2 and DOCK3-β-catenin-WAVE2 signaling. Oncotarget. 2016;7:5613-29 pubmed publisher
  • western blot; human
Kim M, Kim M, Park S, Lee C, Lim D. Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition. EMBO Rep. 2016;17:64-78 pubmed publisher
  • western blot; mouse; fig 4
Mayanagi T, Yasuda H, Sobue K. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci. 2015;35:14327-40 pubmed publisher
  • immunocytochemistry; human; 1:100; fig s3
  • western blot; human; 1:100; fig s1i
Priya R, Gomez G, Budnar S, Verma S, Cox H, Hamilton N, et al. Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol. 2015;17:1282-93 pubmed publisher
  • western blot; rat; fig 2
Namachivayam K, Mohankumar K, Arbach D, Jagadeeswaran R, Jain S, Natarajan V, et al. All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2. PLoS ONE. 2015;10:e0134003 pubmed publisher
  • western blot; human; loading ...; fig 4a
Cao X, Kaneko T, Li J, Liu A, Voss C, Li S. A phosphorylation switch controls the spatiotemporal activation of Rho GTPases in directional cell migration. Nat Commun. 2015;6:7721 pubmed publisher
  • western blot; human; 1:200; fig 4
Kontro H, Cannino G, Rustin P, Dufour E, Kainulainen H. DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells. PLoS ONE. 2015;10:e0131990 pubmed publisher
  • western blot; mouse; 1:200; loading ...; fig s4c
Schiffer M, Teng B, Gu C, Shchedrina V, Kasaikina M, Pham V, et al. Pharmacological targeting of actin-dependent dynamin oligomerization ameliorates chronic kidney disease in diverse animal models. Nat Med. 2015;21:601-9 pubmed publisher
  • immunocytochemistry; rat; 1:500; fig 4
Deglincerti A, Liu Y, Colak D, Hengst U, Xu G, Jaffrey S. Coupled local translation and degradation regulate growth cone collapse. Nat Commun. 2015;6:6888 pubmed publisher
  • western blot; human
Fukumoto M, Kurisu S, Yamada T, Takenawa T. α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation. PLoS ONE. 2015;10:e0120616 pubmed publisher
  • western blot; human; fig 4
Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
  • immunocytochemistry; human; fig 2
  • western blot; human; fig s1
Giehl K, Keller C, Muehlich S, Goppelt Struebe M. Actin-mediated gene expression depends on RhoA and Rac1 signaling in proximal tubular epithelial cells. PLoS ONE. 2015;10:e0121589 pubmed publisher
  • western blot; human; loading ...; fig 1
Ferru Clément R, Fresquet F, Norez C, Métayé T, Becq F, Kitzis A, et al. Involvement of the Cdc42 pathway in CFTR post-translational turnover and in its plasma membrane stability in airway epithelial cells. PLoS ONE. 2015;10:e0118943 pubmed publisher
  • western blot; rat
Zhang Z, Li J, Wang Q, Zhao W, Hong J, Lou S, et al. WNK1 is involved in Nogo66 inhibition of OPC differentiation. Mol Cell Neurosci. 2015;65:135-42 pubmed publisher
  • western blot; rat; 1:200
Briz V, Zhu G, Wang Y, Liu Y, Avetisyan M, Bi X, et al. Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci. 2015;35:2269-82 pubmed publisher
  • western blot; human; fig  5
Kaihola H, Olivier J, Poromaa I, Akerud H. The effect of antenatal depression and selective serotonin reuptake inhibitor treatment on nerve growth factor signaling in human placenta. PLoS ONE. 2015;10:e0116459 pubmed publisher
  • western blot; mouse; fig 11
Yuan Y, Rangarajan P, Kan E, Wu Y, Wu C, Ling E. Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. J Neuroinflammation. 2015;12:11 pubmed publisher
  • western blot; human
Gao K, Tang W, Li Y, Zhang P, Wang D, Yu L, et al. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. J Cell Sci. 2015;128:992-1000 pubmed publisher
  • western blot; human
Shen Y, Gao M, Ma Y, Yu H, Cui F, Gregersen H, et al. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration. Colloids Surf B Biointerfaces. 2015;126:188-97 pubmed publisher
  • immunohistochemistry - free floating section; mouse
  • immunocytochemistry; mouse
Toyo oka K, Wachi T, Hunt R, Baraban S, Taya S, Ramshaw H, et al. 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain. J Neurosci. 2014;34:12168-81 pubmed publisher
  • western blot; human; 1:1000
Zuo Y, Wu Y, Wehrli B, Chakrabarti S, Chakraborty C. Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells. J Cell Biochem. 2015;116:124-32 pubmed publisher
  • western blot; human
Bailon E, Ugarte Berzal E, Amigo Jiménez I, Van den Steen P, Opdenakker G, Garcia Marco J, et al. Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014;96:185-99 pubmed publisher
  • western blot; mouse
Mamouni K, Cristini A, Guirouilh Barbat J, Monferran S, Lemarie A, Faye J, et al. RhoB promotes ?H2AX dephosphorylation and DNA double-strand break repair. Mol Cell Biol. 2014;34:3144-55 pubmed publisher
  • western blot; mouse
Tang J, Ip J, Ye T, Ng Y, Yung W, Wu Z, et al. Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition. J Neurosci. 2014;34:7425-36 pubmed publisher
  • western blot; mouse; fig 5, 7
Zemljic Harpf A, Godoy J, Platoshyn O, Asfaw E, Busija A, Domenighetti A, et al. Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes. J Cell Sci. 2014;127:1104-16 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Nam H, Lee I, Jang S, Bae C, Kwak S, Lee J. p90 ribosomal S6 kinase 1 (RSK1) isoenzyme specifically regulates cytokinesis progression. Cell Signal. 2014;26:208-19 pubmed publisher
  • western blot; rat
Segatto M, Manduca A, Lecis C, Rosso P, Jozwiak A, Swiezewska E, et al. Simvastatin treatment highlights a new role for the isoprenoid/cholesterol biosynthetic pathway in the modulation of emotional reactivity and cognitive performance in rats. Neuropsychopharmacology. 2014;39:841-54 pubmed publisher
  • western blot; human; 1:200
Del Galdo S, Vettel C, Heringdorf D, Wieland T. The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. Cell Signal. 2013;25:2478-84 pubmed publisher
  • western blot; human; 1:50-500
O Brien M, Carbin S, Morrison J, Smith T. Decreased myometrial p160 ROCK-1 expression in obese women at term pregnancy. Reprod Biol Endocrinol. 2013;11:79 pubmed publisher
  • western blot; mouse
Thompson W, Guilluy C, Xie Z, Sen B, Brobst K, Yen S, et al. Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells. Stem Cells. 2013;31:2528-37 pubmed publisher
  • immunocytochemistry; human; 1:100
  • western blot; human; 1:1000
Kitagawa M, Fung S, Onishi N, Saya H, Lee S. Targeting Aurora B to the equatorial cortex by MKlp2 is required for cytokinesis. PLoS ONE. 2013;8:e64826 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Stergiou L, Bauer M, Mair W, Bausch Fluck D, Drayman N, Wollscheid B, et al. Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane. PLoS ONE. 2013;8:e55799 pubmed publisher
  • western blot; mouse; 1:250; fig 7
MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed publisher
  • western blot; human
Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, et al. Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science. 2010;329:1215-8 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100
Conrad S, Schluesener H, Trautmann K, Joannin N, Meyermann R, Schwab J. Prolonged lesional expression of RhoA and RhoB following spinal cord injury. J Comp Neurol. 2005;487:166-75 pubmed
  • western blot; human
Deroanne C, Hamelryckx D, Ho T, Lambert C, Catroux P, Lapiere C, et al. Cdc42 downregulates MMP-1 expression by inhibiting the ERK1/2 pathway. J Cell Sci. 2005;118:1173-83 pubmed
Lee S, Lee S. Prostaglandin F2 Alpha Triggers the Disruption of Cell Adhesion with Cytokeratin and Vimentin in Bovine Luteal Theca Cells. Animals (Basel). 2021;11: pubmed publisher
Chen A, Ulloa Severino L, Panagiotou T, Moraes T, Yuen D, Lavoie B, et al. Inhibition of polar actin assembly by astral microtubules is required for cytokinesis. Nat Commun. 2021;12:2409 pubmed publisher
Ma Y, Xia Z, Ye C, Lu C, Zhou S, Pan J, et al. AGTR1 promotes lymph node metastasis in breast cancer by upregulating CXCR4/SDF-1α and inducing cell migration and invasion. Aging (Albany NY). 2019;11:3969-3992 pubmed publisher
Zaoui K, Boudhraa Z, Khalifé P, Carmona E, Provencher D, Mes Masson A. Ran promotes membrane targeting and stabilization of RhoA to orchestrate ovarian cancer cell invasion. Nat Commun. 2019;10:2666 pubmed publisher
Adriaans I, Basant A, Ponsioen B, Glotzer M, Lens S. PLK1 plays dual roles in centralspindlin regulation during cytokinesis. J Cell Biol. 2019;218:1250-1264 pubmed publisher
McNair K, Forrest C, Vincenten M, Darlington L, Stone T. Serine protease modulation of Dependence Receptors and EMT protein expression. Cancer Biol Ther. 2018;:1-19 pubmed publisher
Niu X, Su L, Qi S, Gao Z, Zhang Q, Zhang S. GRP75 modulates oncogenic Dbl-driven endocytosis derailed via the CHIP-mediated ubiquitin degradation pathway. Cell Death Dis. 2018;9:971 pubmed publisher
Frank S, Köllmann C, Luong P, Galli G, Zou L, Bernards A, et al. p190 RhoGAP promotes contact inhibition in epithelial cells by repressing YAP activity. J Cell Biol. 2018;217:3183-3201 pubmed publisher
Yu O, Benitez J, Plouffe S, Ryback D, Klein A, Smith J, et al. YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity. Oncogene. 2018;37:5492-5507 pubmed publisher
Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, et al. Antagonizing CD105 enhances radiation sensitivity in prostate cancer. Oncogene. 2018;37:4385-4397 pubmed publisher
Zhang G, Hu J, Rodemer W, Li S, Selzer M. RhoA activation in axotomy-induced neuronal death. Exp Neurol. 2018;306:76-91 pubmed publisher
Guo L, Cai T, Chen K, Wang R, Wang J, Cui C, et al. Kindlin-2 regulates mesenchymal stem cell differentiation through control of YAP1/TAZ. J Cell Biol. 2018;217:1431-1451 pubmed publisher
Kawakami Y, Kurihara Y, Saito Y, Fujita Y, Yamashita T, Takei K. The Soluble Form of LOTUS inhibits Nogo Receptor-Mediated Signaling by Interfering with the Interaction Between Nogo Receptor Type 1 and p75 Neurotrophin Receptor. J Neurosci. 2018;38:2589-2604 pubmed publisher
Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, et al. TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling. Cell Discov. 2018;4:1 pubmed publisher
Shi G, Yang W, Jin L, Matter M, Ramos J. RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases. Proc Natl Acad Sci U S A. 2018;115:E190-E199 pubmed publisher
Cho H, Hwang Y, Yoon J, Lee M, Lee H, Daar I. EphrinB1 promotes cancer cell migration and invasion through the interaction with RhoGDI1. Oncogene. 2018;37:861-872 pubmed publisher
Tsuboi M, Taniuchi K, Shimizu T, Saito M, Saibara T. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 2017;292:17681-17702 pubmed publisher
Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert Hilger G, et al. The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif. J Biol Chem. 2017;292:17668-17680 pubmed publisher
Zaritsky A, Tseng Y, Rabadán M, Krishna S, Overholtzer M, Danuser G, et al. Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration. J Cell Biol. 2017;216:1543-1556 pubmed publisher
Lin C, Yao E, Zhang K, Jiang X, Croll S, Thompson Peer K, et al. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis. elife. 2017;6: pubmed publisher
van de Ven R, de Groot J, Park D, van Domselaar R, de Jong D, Szuhai K, et al. p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis. Nat Commun. 2016;7:13874 pubmed publisher
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product information
Product Name :
Rho A (26C4) Antibody
Gene Name :
RHOA
Size :
200 µg/ml
Catalog Number :
sc-418
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
Rho A
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), FCM
Epitope :
120-150 (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA