product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PDH-E1α (D-6) Antibody
catalog :
sc-377092
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-6
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 17
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; fig 2e
Phillips E, Balss J, Bethke F, Pusch S, Christen S, Hielscher T, et al. PFKFB4 interacts with FBXO28 to promote HIF-1α signaling in glioblastoma. Oncogenesis. 2022;11:57 pubmed publisher
  • western blot; human; loading ...; fig 4d
Yang Z, Wang Y, Zhang L, Zhao C, Wang D. Phosphorylated form of pyruvate dehydrogenase α1 mediates tumor necrosis factor α-induced glioma cell migration. Oncol Lett. 2021;21:176 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 6b
Zhang W, Zhou M, Lu W, Gong J, Gao F, Li Y, et al. CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes. Theranostics. 2020;10:3000-3021 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4s2c
Sharma A, Oonthonpan L, Sheldon R, Rauckhorst A, Zhu Z, Tompkins S, et al. Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness. elife. 2019;8: pubmed publisher
  • western blot; human; loading ...; fig 2b
Huang X, Gan G, Wang X, Xu T, Xie W. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy. 2019;15:1258-1279 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 3h
Nagaraj R, Sharpley M, Chi F, Braas D, Zhou Y, Kim R, et al. Nuclear Localization of Mitochondrial TCA Cycle Enzymes as a Critical Step in Mammalian Zygotic Genome Activation. Cell. 2017;168:210-223.e11 pubmed publisher
  • western blot; human; loading ...; fig 4b
Yin C, He D, Chen S, Tan X, Sang N. Exogenous pyruvate facilitates cancer cell adaptation to hypoxia by serving as an oxygen surrogate. Oncotarget. 2016;7:47494-47510 pubmed publisher
  • western blot; human; fig 4b
Hostrup M, Kalsen A, Onslev J, Jessen S, Haase C, Habib S, et al. Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men. J Appl Physiol (1985). 2015;119:475-86 pubmed publisher
Peng K, Wang S, Liu R, Zhou L, Jeong G, Jeong I, et al. Effects of UBE3A on Cell and Liver Metabolism through the Ubiquitination of PDHA1 and ACAT1. Biochemistry. 2023;62:1274-1286 pubmed publisher
Zhang W, Chen H, Ding L, Gong J, Zhang M, Guo W, et al. Trojan Horse Delivery of 4,4'-Dimethoxychalcone for Parkinsonian Neuroprotection. Adv Sci (Weinh). 2021;8:2004555 pubmed publisher
Naia L, Pinho C, Dentoni G, Liu J, Leal N, Ferreira D, et al. Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling. BMC Biol. 2021;19:57 pubmed publisher
Naiman S, Huynh F, Gil R, Glick Y, Shahar Y, Touitou N, et al. SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Rep. 2019;29:4127-4143.e8 pubmed publisher
Masui K, Harachi M, Ikegami S, Yang H, Onizuka H, Yong W, et al. mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma. J Biol Chem. 2019;294:19740-19751 pubmed publisher
Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, et al. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019;572:614-619 pubmed publisher
Willis I, Moir R, Hernandez N. Metabolic programming a lean phenotype by deregulation of RNA polymerase III. Proc Natl Acad Sci U S A. 2018;115:12182-12187 pubmed publisher
Liang X, Yee S, Chien H, Chen E, Luo Q, Zou L, et al. Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS Biol. 2018;16:e2002907 pubmed publisher
Qin X, Wei F, Tanokura M, Ishibashi N, Shimizu M, Moriwaki H, et al. The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells. PLoS ONE. 2013;8:e82860 pubmed publisher
product information
Catalog Number :
sc-377092
Product Name :
PDH-E1α (D-6) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
D-6
Isotype :
IgG2a
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
PDH-E1alpha
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA