product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Lamin A/C (E-1) Antibody
catalog :
sc-376248
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
E-1
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation
citations: 47
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 3a
Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam C, Garg P, et al. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019;572:335-340 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 7h
Yoshioka N, Kurose M, Yano M, Tran D, Okuda S, Mori Ochiai Y, et al. Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy. elife. 2022;11: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4f
Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, et al. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Res. 2020;48:6001-6018 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3c
Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, et al. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nat Commun. 2020;11:900 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4f
Lee C, Aizawa K, Jiang J, Kung S, Jain R. JLP-centrosome is essential for the microtubule-mediated nucleocytoplasmic transport induced by extracellular stimuli. Sci Adv. 2019;5:eaav0318 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 2a
Poleshko A, Smith C, Nguyen S, Sivaramakrishnan P, Wong K, Murray J, et al. H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis. elife. 2019;8: pubmed publisher
  • western blot; human; 1:250; loading ...; fig s1
Serebryannyy L, Misteli T. HiPLA: High-throughput imaging proximity ligation assay. Methods. 2019;157:80-87 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 4d
  • western blot; human; 1:200; fig 4c
Robijns J, Molenberghs F, Sieprath T, Corne T, Verschuuren M, De Vos W. In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells. Sci Rep. 2016;6:30325 pubmed publisher
  • western blot; human; fig 7
Graindorge D, Martineau S, Machon C, Arnoux P, Guitton J, Francesconi S, et al. Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication. PLoS ONE. 2015;10:e0140645 pubmed publisher
  • western blot; human
Chapnick D, Liu X. Leader cell positioning drives wound-directed collective migration in TGF?-stimulated epithelial sheets. Mol Biol Cell. 2014;25:1586-93 pubmed publisher
Neely A, Zhang Y, Blumensaadt L, Mao H, Brenner B, Sun C, et al. Nucleoporin downregulation modulates progenitor differentiation independent of nuclear pore numbers. Commun Biol. 2023;6:1033 pubmed publisher
Kechagia Z, S xe1 ez P, G xf3 mez Gonz xe1 lez M, Canales B, Viswanadha S, Zamarbide M, et al. The laminin-keratin link shields the nucleus from mechanical deformation and signalling. Nat Mater. 2023;22:1409-1420 pubmed publisher
Lee J, Lee J, Sohn E, Taglialatela A, O Sullivan R, Ciccia A, et al. Extrachromosomal Telomeres Derived from Excessive Strand Displacements. bioRxiv. 2023;: pubmed publisher
Danielsson B, George Abraham B, M xe4 ntyl xe4 E, Cabe J, Mayer C, Rekonen A, et al. Nuclear lamina strain states revealed by intermolecular force biosensor. Nat Commun. 2023;14:3867 pubmed publisher
Sprenger A, Carr H, Ulu A, Frost J. Src stimulates Abl-dependent phosphorylation of the guanine exchange factor Net1A to promote its cytosolic localization and cell motility. J Biol Chem. 2023;299:104887 pubmed publisher
Jaschke N, P xe4 hlig S, Sinha A, Adolph T, Colunga M, Hofmann M, et al. Dickkopf1 fuels inflammatory cytokine responses. Commun Biol. 2022;5:1391 pubmed publisher
Jana A, Tran A, Gill A, Kiepas A, Kapania R, Konstantopoulos K, et al. Sculpting Rupture-Free Nuclear Shapes in Fibrous Environments. Adv Sci (Weinh). 2022;9:e2203011 pubmed publisher
Shah P, McGuigan C, Cheng S, Vanpouille Box C, Demaria S, Weiss R, et al. ATM Modulates Nuclear Mechanics by Regulating Lamin A Levels. Front Cell Dev Biol. 2022;10:875132 pubmed publisher
Mishra S, Levy D. Nuclear F-actin and Lamin A antagonistically modulate nuclear shape. J Cell Sci. 2022;135: pubmed publisher
Whisenant D, Lim K, Revêchon G, Yao H, Bergo M, Machtel P, et al. Transient expression of an adenine base editor corrects the Hutchinson-Gilford progeria syndrome mutation and improves the skin phenotype in mice. Nat Commun. 2022;13:3068 pubmed publisher
Ciesielski P, Jóźwiak P, Forma E, Krzeslak A. TET3- and OGT-Dependent Expression of Genes Involved in Epithelial-Mesenchymal Transition in Endometrial Cancer. Int J Mol Sci. 2021;22: pubmed publisher
Xu H, Liu X, Li W, Xi Y, Su P, Meng B, et al. p38 MAPK-mediated loss of nuclear RNase III enzyme Drosha underlies amyloid beta-induced neuronal stress in Alzheimer's disease. Aging Cell. 2021;20:e13434 pubmed publisher
D Amico R, Trovato Salinaro A, Cordaro M, Fusco R, Impellizzeri D, Interdonato L, et al. Hidrox® and Chronic Cystitis: Biochemical Evaluation of Inflammation, Oxidative Stress, and Pain. Antioxidants (Basel). 2021;10: pubmed publisher
D Amico R, Trovato Salinaro A, Fusco R, Cordaro M, Impellizzeri D, Scuto M, et al. Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury. Antioxidants (Basel). 2021;10: pubmed publisher
Le Voyer T, Neehus A, Yang R, Ogishi M, Rosain J, Alroqi F, et al. Inherited deficiency of stress granule ZNFX1 in patients with monocytosis and mycobacterial disease. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Batlle C, Calvo I, Iglesias V, J Lynch C, Gil Garcia M, Serrano M, et al. MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation. Commun Biol. 2021;4:414 pubmed publisher
Diao Z, Ji Q, Wu Z, Zhang W, Cai Y, Wang Z, et al. SIRT3 consolidates heterochromatin and counteracts senescence. Nucleic Acids Res. 2021;49:4203-4219 pubmed publisher
Shah P, Lv W, Rhoades J, Poleshko A, Abbey D, Caporizzo M, et al. Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. Cell Stem Cell. 2021;: pubmed publisher
Gjelaj E, Hamel P. Distinct epithelial-to-mesenchymal transitions induced by PIK3CAH1047R and PIK3CB. J Cell Sci. 2021;134: pubmed publisher
Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, et al. Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration. Cell Res. 2021;31:187-205 pubmed publisher
Cordaro M, Fusco R, D Amico R, Siracusa R, Peritore A, Gugliandolo E, et al. Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein. Antioxidants (Basel). 2020;9: pubmed publisher
Siracusa R, Scuto M, Fusco R, Trovato A, Ontario M, Crea R, et al. Anti-inflammatory and Anti-oxidant Activity of Hidrox® in Rotenone-Induced Parkinson's Disease in Mice. Antioxidants (Basel). 2020;9: pubmed publisher
Widyastuti H, Norden Krichmar T, Grosberg A, Zaragoza M. Gene expression profiling of fibroblasts in a family with LMNA-related cardiomyopathy reveals molecular pathways implicated in disease pathogenesis. BMC Med Genet. 2020;21:152 pubmed publisher
Trümper V, Wittig I, Heidler J, Richter F, Brüne B, von Knethen A. Redox Regulation of PPARγ in Polarized Macrophages. PPAR Res. 2020;2020:8253831 pubmed publisher
Dunlevy K, Medvedeva V, Wilson J, Hoque M, Pellegrin T, Maynard A, et al. The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting. J Cell Sci. 2020;133: pubmed publisher
Hobson C, Kern M, O Brien E, Stephens A, Falvo M, Superfine R. Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics. Mol Biol Cell. 2020;31:1788-1801 pubmed publisher
van Gastel N, Stegen S, Eelen G, Schoors S, Carlier A, Daniëls V, et al. Lipid availability determines fate of skeletal progenitor cells via SOX9. Nature. 2020;579:111-117 pubmed publisher
Suzuki K, Yamamoto M, Hernández Benítez R, Li Z, Wei C, Soligalla R, et al. Precise in vivo genome editing via single homology arm donor mediated intron-targeting gene integration for genetic disease correction. Cell Res. 2019;29:804-819 pubmed publisher
Platanitis E, Demiröz D, Schneller A, Fischer K, Capelle C, Hartl M, et al. A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription. Nat Commun. 2019;10:2921 pubmed publisher
Jevtic P, Schibler A, Wesley C, Pegoraro G, Misteli T, Levy D. The nucleoporin ELYS regulates nuclear size by controlling NPC number and nuclear import capacity. EMBO Rep. 2019;20: pubmed publisher
Hu X, Liu Z, Chen X, Schulz V, Kumar A, Hartman A, et al. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation. Nat Commun. 2019;10:1695 pubmed publisher
Zhao W, Lu Q, Nguyen M, Su Y, Ziemann M, Wang L, et al. Stimulation of β-adrenoceptors up-regulates cardiac expression of galectin-3 and BIM through the Hippo signalling pathway. Br J Pharmacol. 2019;176:2465-2481 pubmed publisher
Yoon M, Kang S, Lee S, Woo T, Oh A, Park S, et al. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation. Cell Death Dis. 2019;10:107 pubmed publisher
Barazeghi E, Prabhawa S, Norlén O, Hellman P, Stalberg P, Westin G. Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors. BMC Cancer. 2018;18:764 pubmed publisher
Tsai K, Courtney D, Cullen B. Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication. PLoS Pathog. 2018;14:e1006919 pubmed publisher
Smith K, Starmer J, Miller S, Sethupathy P, Magnuson T. Long Noncoding RNA Moderates MicroRNA Activity to Maintain Self-Renewal in Embryonic Stem Cells. Stem Cell Reports. 2017;9:108-121 pubmed publisher
Cai K, Sewer M. cAMP-stimulated transcription of DGK? requires steroidogenic factor 1 and sterol regulatory element binding protein 1. J Lipid Res. 2013;54:2121-32 pubmed publisher
product information
Catalog Number :
sc-376248
Product Name :
Lamin A/C (E-1) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
E-1
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
Lamin A/C
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA