product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
UHRF1 (H-8) Antibody
catalog :
sc-373750
quantity :
200 µg/ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H-8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, western blot knockout validation, immunohistochemistry knockout validation, immunocytochemistry knockout validation
citations: 17
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; mouse; 1:100; loading ...; fig s1f
  • immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig s1e
  • western blot knockout validation; mouse; 1:100; loading ...; fig s1d
Wu Y, Dong J, Feng S, Zhao Q, Duan P, Xiong M, et al. Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition. Front Cell Dev Biol. 2020;8:610773 pubmed publisher
  • western blot knockout validation; human; loading ...; fig s4k
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
  • chromatin immunoprecipitation; human; loading ...; fig 4g
  • western blot; mouse; fig 1c
Zhang J, Zhang H, Ding X, Hu J, Li Y, Zhang J, et al. Crosstalk between macrophage-derived PGE2 and tumor UHRF1 drives hepatocellular carcinoma progression. Theranostics. 2022;12:3776-3793 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 2c
Aibara D, Takahashi S, Yagai T, Kim D, Brocker C, Levi M, et al. Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation. iScience. 2022;25:104196 pubmed publisher
  • western blot; human; 1:100; loading ...; fig 3m
Zheng T, Liu X, Li X, Wang Q, Zhao Y, Li X, et al. Dickkopf-1 promotes Vascular Smooth Muscle Cell proliferation and migration through upregulating UHRF1 during Cyclic Stretch application. Int J Biol Sci. 2021;17:1234-1249 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s2a
Lopez Martinez D, Kupculak M, Yang D, Yoshikawa Y, Liang C, Wu R, et al. Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage. Cell Rep. 2019;27:2990-3005.e5 pubmed publisher
  • western blot; mouse; loading ...; fig 1c
Liu Y, Zhang B, Meng X, Korn M, Parent J, Lu L, et al. UHRF2 regulates local 5-methylcytosine and suppresses spontaneous seizures. Epigenetics. 2017;12:551-560 pubmed publisher
  • western blot; human; 1:1000; fig s5
Liang C, Li Z, Lopez Martinez D, Nicholson W, Venien Bryan C, Cohn M. The FANCD2-FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2. Nat Commun. 2016;7:12124 pubmed publisher
  • western blot; human; loading ...; fig 6b
Liu Y, Zhang B, Kuang H, Korakavi G, Lu L, Yu X. Zinc Finger Protein 618 Regulates the Function of UHRF2 (Ubiquitin-like with PHD and Ring Finger Domains 2) as a Specific 5-Hydroxymethylcytosine Reader. J Biol Chem. 2016;291:13679-88 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Kim K, Son H, Choi S, Hahm J, Jung H, Baek H, et al. H3K9 methyltransferase G9a negatively regulates UHRF1 transcription during leukemia cell differentiation. Nucleic Acids Res. 2015;43:3509-23 pubmed publisher
Haggerty C, Kretzmer H, Riemenschneider C, Kumar A, Mattei A, Bailly N, et al. Dnmt1 has de novo activity targeted to transposable elements. Nat Struct Mol Biol. 2021;28:594-603 pubmed publisher
Liu K, Wang Y, Zhu Q, Li P, Chen J, Tang Z, et al. Aberrantly expressed HORMAD1 disrupts nuclear localization of MCM8-MCM9 complex and compromises DNA mismatch repair in cancer cells. Cell Death Dis. 2020;11:519 pubmed publisher
Foster B, Stolz P, Mulholland C, Montoya A, Kramer H, Bultmann S, et al. Critical Role of the UBL Domain in Stimulating the E3 Ubiquitin Ligase Activity of UHRF1 toward Chromatin. Mol Cell. 2018;72:739-752.e9 pubmed publisher
Li T, Wang L, Du Y, Xie S, Yang X, Lian F, et al. Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation. Nucleic Acids Res. 2018;46:3218-3231 pubmed publisher
Turnbull A, Ioannidis S, Krajewski W, Pinto Fernandez A, Heride C, Martin A, et al. Molecular basis of USP7 inhibition by selective small-molecule inhibitors. Nature. 2017;550:481-486 pubmed publisher
Kan G, He H, Zhao Q, Li X, Li M, Yang H, et al. Functional dissection of the role of UHRF1 in the regulation of retinoblastoma methylome. Oncotarget. 2017;8:39497-39511 pubmed publisher
Wang K, Chen C, Tsai S, Shen C. Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-mCpG-Np95-Dnmt1 Axis. Sci Rep. 2016;6:37490 pubmed publisher
Benavente C, Finkelstein D, Johnson D, Marine J, Ashery Padan R, Dyer M. Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression. Oncotarget. 2014;5:9594-608 pubmed
product information
Product Name :
UHRF1 (H-8) Antibody
Gene Name :
UHRF1
Size :
200 µg/ml
Catalog Number :
sc-373750
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
UHRF1
reactive species  :
m, r, h
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
586-717 (m)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA