Published Application/Species/Sample/Dilution | Reference |
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| Korsensky L, Haif S, Heller R, Rabinovitz S, Haddad Halloun J, Dahan N, et al. The tumor suppressor Sef is a scaffold for the classical NF-κB/RELA:P50 signaling module. Cell Signal. 2019;59:110-121 pubmed publisher
|
- western blot; human; loading ...; fig 1c
| Qiang L, Wang J, Zhang Y, Ge P, Chai Q, Li B, et al. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cell Mol Immunol. 2018;: pubmed publisher
|
- western blot; rat; 1:1000; loading ...; fig 3a
| Gugliandolo E, Fusco R, D Amico R, Militi A, Oteri G, Wallace J, et al. Anti-inflammatory effect of ATB-352, a H2S -releasing ketoprofen derivative, on lipopolysaccharide-induced periodontitis in rats. Pharmacol Res. 2018;132:220-231 pubmed publisher
|
- western blot; human; loading ...; fig 8c
| Pryke K, Abraham J, Sali T, Gall B, Archer I, Liu A, et al. A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio. 2017;8: pubmed publisher
|
- western blot; mouse; loading ...; fig 5b
| Shin C, Ito Y, Ichikawa S, Tokunaga M, Sakata Sogawa K, Tanaka T. MKRN2 is a novel ubiquitin E3 ligase for the p65 subunit of NF-κB and negatively regulates inflammatory responses. Sci Rep. 2017;7:46097 pubmed publisher
|
- western blot; human; 1:500; loading ...; fig 6a
| Paterniti I, Campolo M, Siracusa R, Cordaro M, Di Paola R, Calabrese V, et al. Liver X receptors activation, through TO901317 binding, reduces neuroinflammation in Parkinson's disease. PLoS ONE. 2017;12:e0174470 pubmed publisher
|
- western blot; mouse; loading ...; fig 4c
| Schweighoffer E, Nys J, Vanes L, Smithers N, Tybulewicz V. TLR4 signals in B lymphocytes are transduced via the B cell antigen receptor and SYK. J Exp Med. 2017;214:1269-1280 pubmed publisher
|
- western blot; human; fig 5a
| Gatla H, Zou Y, Uddin M, Singha B, Bu P, Vancura A, et al. Histone Deacetylase (HDAC) Inhibition Induces IκB Kinase (IKK)-dependent Interleukin-8/CXCL8 Expression in Ovarian Cancer Cells. J Biol Chem. 2017;292:5043-5054 pubmed publisher
|
- western blot; mouse; loading ...; fig 3b
| Zhang H, Wang W, Ren L, Zhao X, Wang Z, Zhuang D, et al. The mTORC2/Akt/NFκB Pathway-Mediated Activation of TRPC6 Participates in Adriamycin-Induced Podocyte Apoptosis. Cell Physiol Biochem. 2016;40:1079-1093 pubmed
|
- western blot; mouse; loading ...; fig 2a
| Huh H, Ra E, Lee T, Kang S, Park A, Lee E, et al. STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway. Sci Rep. 2016;6:38849 pubmed publisher
|
- western blot; human; loading ...; fig 2b
| Lim S, Hwang S, Yu J, Lim J, Kim H. Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells. Mol Nutr Food Res. 2017;61: pubmed publisher
|
- western blot; mouse; loading ...; fig 6c
| Filliol A, Piquet Pellorce C, Le Seyec J, Farooq M, Genet V, Lucas Clerc C, et al. RIPK1 protects from TNF-α-mediated liver damage during hepatitis. Cell Death Dis. 2016;7:e2462 pubmed publisher
|
- western blot; mouse; 1:200; loading ...; fig 7a
| Okabe T, Chavan R, Fonseca Costa S, Brenna A, Ripperger J, Albrecht U. REV-ERB? influences the stability and nuclear localization of the glucocorticoid receptor. J Cell Sci. 2016;129:4143-4154 pubmed
|
- immunohistochemistry; human; 1:500; loading ...; fig 2d
- western blot; human; loading ...; fig 1c
| Wurster K, Hummel F, Richter J, Giefing M, Hartmann S, Hansmann M, et al. Inactivation of the putative ubiquitin-E3 ligase PDLIM2 in classical Hodgkin and anaplastic large cell lymphoma. Leukemia. 2017;31:602-613 pubmed publisher
|
- western blot; human; loading ...; fig 4a
| Radke D, Ungefroren H, Helm O, Voigt S, Alp G, Braun H, et al. Negative control of TRAIL-R1 signaling by transforming growth factor ?1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1. Cell Signal. 2016;28:1652-62 pubmed publisher
|
- western blot; mouse; loading ...; fig 1b
| Lesina M, Wörmann S, Morton J, Diakopoulos K, Korneeva O, Wimmer M, et al. RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. J Clin Invest. 2016;126:2919-32 pubmed publisher
|
- western blot; mouse; loading ...; fig 2a
| Kang J, Park S, Jeong S, Han M, Lee C, Lee K, et al. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation. Proc Natl Acad Sci U S A. 2016;113:8771-6 pubmed publisher
|
- western blot; human; loading ...; fig 1b
| Kwon H, Choi G, Ryu S, Kwon S, Kim S, Booth C, et al. Stepwise phosphorylation of p65 promotes NF-?B activation and NK cell responses during target cell recognition. Nat Commun. 2016;7:11686 pubmed publisher
|
- western blot; human; loading ...; fig 7
| Pereira D, Simões A, Gomes S, Castro R, Carvalho T, Rodrigues C, et al. MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism. Oncotarget. 2016;7:34322-40 pubmed publisher
|
- western blot; mouse; fig 6a
| Bugajev V, Hálová I, Dráberová L, Bambousková M, Potůčková L, Draberova H, et al. Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells. Cell Mol Life Sci. 2016;73:1265-85 pubmed publisher
|
- western blot; mouse; fig 1
| Zhang J, Li L, Baldwin A, Friedman A, Paz Priel I. Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells. PLoS ONE. 2015;10:e0130441 pubmed publisher
|
| Schmitz M, Dreute J, Pfisterer M, Günther S, Kracht M, Chillappagari S. SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression. Heliyon. 2022;8:e09029 pubmed publisher
|
| Oleszycka E, Rodgers A, Xu L, Moynagh P. Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. J Immunol. 2021;207:2325-2336 pubmed publisher
|
| Lee S, Ha J, Park J, Kang E, Jeon S, Han S, et al. Antioxidant and Anti-Inflammatory Effects of Bischofia javanica (Blume) Leaf Methanol Extracts through the Regulation of Nrf2 and TAK1. Antioxidants (Basel). 2021;10: pubmed publisher
|
| Yasuda K, Matsubara T, Shirakawa T, Kawamoto T, Kokabu S. Protein phosphatase 1 regulatory subunit 18 suppresses the transcriptional activity of NFATc1 via regulation of c-fos. Bone Rep. 2021;15:101114 pubmed publisher
|
| Wu Y, Chou T, Young L, Hsieh F, Pan H, Mo S, et al. Tumor suppressor death-associated protein kinase 1 inhibits necroptosis by p38 MAPK activation. Cell Death Dis. 2020;11:305 pubmed publisher
|
| Palomer X, Román Azcona M, Pizarro Delgado J, Planavila A, Villarroya F, Valenzuela Alcaraz B, et al. SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation. Signal Transduct Target Ther. 2020;5:14 pubmed publisher
|
| Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, et al. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging. Aging (Albany NY). 2020;12:4688-4710 pubmed publisher
|
| Park Y, Lee H, Lim J, Kim H. Inhibitory Effect of β-Carotene on Helicobacter pylori-Induced TRAF Expression and Hyper-Proliferation in Gastric Epithelial Cells. Antioxidants (Basel). 2019;8: pubmed publisher
|
| DeSisto J, Flannery P, Lemma R, Pathak A, Mestnik S, Philips N, et al. Exportin 1 Inhibition Induces Nerve Growth Factor Receptor Expression to Inhibit the NF-κB Pathway in Preclinical Models of Pediatric High-Grade Glioma. Mol Cancer Ther. 2020;19:540-551 pubmed publisher
|
| Yu T, Gan S, Zhu Q, Dai D, Li N, Wang H, et al. Modulation of M2 macrophage polarization by the crosstalk between Stat6 and Trim24. Nat Commun. 2019;10:4353 pubmed publisher
|
| Waters M, Gupta A, Mockenhaupt K, Brown L, Biswas D, Kordula T. RelB acts as a molecular switch driving chronic inflammation in glioblastoma multiforme. Oncogenesis. 2019;8:37 pubmed publisher
|
| Gupta A, Waters M, Biswas D, Brown L, Surace M, Floros C, et al. RelB controls adaptive responses of astrocytes during sterile inflammation. Glia. 2019;67:1449-1461 pubmed publisher
|
| Jeon H, Ham S, Kim J, Jin X, Lee S, Shin Y, et al. Ly6G+ inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model. Cell Death Differ. 2019;: pubmed publisher
|
| Pereira D, Gomes S, Borralho P, Rodrigues C. MEK5/ERK5 activation regulates colon cancer stem-like cell properties. Cell Death Discov. 2019;5:68 pubmed publisher
|
| Li Y, Mooney E, Holden S, Xia X, Cohen D, Walsh S, et al. A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-κB Activity. J Immunol. 2019;202:2044-2056 pubmed publisher
|
| Yoon M, Kang S, Lee S, Woo T, Oh A, Park S, et al. p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation. Cell Death Dis. 2019;10:107 pubmed publisher
|
| Alameda J, Ramirez A, Garcia Fernandez R, Navarro M, Page A, Segovia J, et al. Premature aging and cancer development in transgenic mice lacking functional CYLD. Aging (Albany NY). 2019;11:127-159 pubmed publisher
|
| Enguita M, Razquin N, Pamplona R, Quiroga J, Prieto J, Fortes P. The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells. Cell Death Dis. 2019;10:14 pubmed publisher
|
| Aloor J, Azzam K, Guardiola J, Gowdy K, Madenspacher J, Gabor K, et al. Leucine-rich repeats and calponin homology containing 4 (Lrch4) regulates the innate immune response. J Biol Chem. 2019;294:1997-2008 pubmed publisher
|
| Murahashi Y, Yano F, Kobayashi H, Makii Y, Iba K, Yamashita T, et al. Intra-articular administration of IκBα kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-κB/HIF-2α axis. Sci Rep. 2018;8:16475 pubmed publisher
|
| Leonardi M, Perna E, Tronnolone S, Colecchia D, Chiariello M. Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy. Autophagy. 2018;:1-15 pubmed publisher
|
| Choi J, Yeo I, Kim K, Choi W, Jung J, Han S, et al. K284-6111 prevents the amyloid beta-induced neuroinflammation and impairment of recognition memory through inhibition of NF-κB-mediated CHI3L1 expression. J Neuroinflammation. 2018;15:224 pubmed publisher
|
| Prinz E, Aviram S, Aronheim A. WDR62 mediates TNFα-dependent JNK activation via TRAF2-MLK3 axis. Mol Biol Cell. 2018;29:2470-2480 pubmed publisher
|
| Wang P, Liu Z, Zhang X, Li J, Sun L, Ju Z, et al. CRISPR/Cas9-mediated gene knockout reveals a guardian role of NF-κB/RelA in maintaining the homeostasis of human vascular cells. Protein Cell. 2018;9:945-965 pubmed publisher
|
| Brenke J, Popowicz G, Schorpp K, Rothenaigner I, Roesner M, Meininger I, et al. Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. J Biol Chem. 2018;293:13191-13203 pubmed publisher
|
| Kimura A, Kitajima M, Nishida K, Serada S, Fujimoto M, Naka T, et al. NQO1 inhibits the TLR-dependent production of selective cytokines by promoting IκB-ζ degradation. J Exp Med. 2018;215:2197-2209 pubmed publisher
|
| Bigas J, Sevilla L, Carceller E, Boix J, Perez P. Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation. Cell Death Dis. 2018;9:588 pubmed publisher
|
| Zhu K, Liang W, Ma Z, Xu D, Cao S, Lu X, et al. Necroptosis promotes cell-autonomous activation of proinflammatory cytokine gene expression. Cell Death Dis. 2018;9:500 pubmed publisher
|
| Baek J, Cheon Y, Kwak S, Jun H, Yoon K, Lee M, et al. Claudin 11 regulates bone homeostasis via bidirectional EphB4-EphrinB2 signaling. Exp Mol Med. 2018;50:50 pubmed publisher
|
| Zhang X, Wang Y, Yuan J, Li N, Pei S, Xu J, et al. Macrophage/microglial Ezh2 facilitates autoimmune inflammation through inhibition of Socs3. J Exp Med. 2018;215:1365-1382 pubmed publisher
|
| Annibaldi A, Wicky John S, Vanden Berghe T, Swatek K, Ruan J, Liccardi G, et al. Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 2018;69:566-580.e5 pubmed publisher
|
| Zhang F, Brenner M, Yang W, Wang P. A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice. Sci Rep. 2018;8:3052 pubmed publisher
|
| Jiang M, Xu C, Guo Y, Luo Q, Li L, Liu H, et al. ?-arrestin 2 attenuates lipopolysaccharide-induced liver injury via inhibition of TLR4/NF-?B signaling pathway-mediated inflammation in mice. World J Gastroenterol. 2018;24:216-225 pubmed publisher
|
| Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, et al. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018;293:3965-3980 pubmed publisher
|
| Tsuchiya Y, Osaki K, Kanamoto M, Nakao Y, Takahashi E, Higuchi T, et al. Distinct B Subunits of PP2A Regulate the NF-?B Signaling Pathway through Dephosphorylation of IKK?, I?B?, and RelA. FEBS Lett. 2017;: pubmed publisher
|
| Meshram S, Paul D, Manne R, Choppara S, Sankaran G, Agrawal Y, et al. FBXO32 activates NF-κB through IκBα degradation in inflammatory and genotoxic stress. Int J Biochem Cell Biol. 2017;92:134-140 pubmed publisher
|
| Yoon S, Kovalenko A, Bogdanov K, Wallach D. MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation. Immunity. 2017;47:51-65.e7 pubmed publisher
|
| Petersheim D, Massaad M, Lee S, Scarselli A, Cancrini C, Moriya K, et al. Mechanisms of genotype-phenotype correlation in autosomal dominant anhidrotic ectodermal dysplasia with immune deficiency. J Allergy Clin Immunol. 2018;141:1060-1073.e3 pubmed publisher
|
| Van T, Polykratis A, Straub B, Kondylis V, Papadopoulou N, Pasparakis M. Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis. J Clin Invest. 2017;127:2662-2677 pubmed publisher
|
| van Wijk S, Fricke F, Herhaus L, Gupta J, Hötte K, Pampaloni F, et al. Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-?B and restricts bacterial proliferation. Nat Microbiol. 2017;2:17066 pubmed publisher
|
| Lundh M, Bugliani M, Dahlby T, Chou D, Wagner B, Ghiasi S, et al. The immunoproteasome is induced by cytokines and regulates apoptosis in human islets. J Endocrinol. 2017;233:369-379 pubmed publisher
|
| Choo M, Sano Y, Kim C, Yasuda K, Li X, Lin X, et al. TLR sensing of bacterial spore-associated RNA triggers host immune responses with detrimental effects. J Exp Med. 2017;214:1297-1311 pubmed publisher
|
| Ju H, Ying H, Tian T, Ling J, Fu J, Lu Y, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun. 2017;8:14437 pubmed publisher
|
| Chen Y, Li C, Xie H, Fan Y, Yang Z, Ma J, et al. Infiltrating mast cells promote renal cell carcinoma angiogenesis by modulating PI3K→︀AKT→︀GSK3β→︀AM signaling. Oncogene. 2017;36:2879-2888 pubmed publisher
|
| Della Mina E, Borghesi A, Zhou H, Bougarn S, Boughorbel S, Israel L, et al. Inherited human IRAK-1 deficiency selectively impairs TLR signaling in fibroblasts. Proc Natl Acad Sci U S A. 2017;114:E514-E523 pubmed publisher
|
| Rivera Serrano E, Sherry B. NF-?B activation is cell type-specific in the heart. Virology. 2017;502:133-143 pubmed publisher
|
| Lin J, Kato M, Nagata K, Okuwaki M. Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1. Nucleic Acids Res. 2017;45:3707-3723 pubmed publisher
|
| Fern ndez Majada V, Welz P, Ermolaeva M, Schell M, Adam A, Dietlein F, et al. The tumour suppressor CYLD regulates the p53 DNA damage response. Nat Commun. 2016;7:12508 pubmed publisher
|
| Oh B, Kim S, Lee Y, Hong H, Kim T, Kim S, et al. Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. Oncotarget. 2016;7:57066-57076 pubmed publisher
|
| Zhu L, Luo T, Xu X, Guo Y, Zhao X, Wang T, et al. E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. J Exp Med. 2016;213:1555-70 pubmed publisher
|
| Jiang C, Zhou Z, Quan Y, Zhang S, Wang T, Zhao X, et al. CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection. Cell Rep. 2016;14:2389-401 pubmed publisher
|
| Fauster A, Rebsamen M, Huber K, Bigenzahn J, Stukalov A, Lardeau C, et al. A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis. Cell Death Dis. 2015;6:e1767 pubmed publisher
|
| Kearns J, Basak S, Werner S, Huang C, Hoffmann A. IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. J Cell Biol. 2006;173:659-64 pubmed
|
| Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt Supprian M, et al. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. J Clin Invest. 2005;115:849-59 pubmed
|
| Xanthoulea S, Pasparakis M, Kousteni S, Brakebusch C, Wallach D, Bauer J, et al. Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. J Exp Med. 2004;200:367-76 pubmed
|
| Matsushima A, Kaisho T, Rennert P, Nakano H, Kurosawa K, Uchida D, et al. Essential role of nuclear factor (NF)-kappaB-inducing kinase and inhibitor of kappaB (IkappaB) kinase alpha in NF-kappaB activation through lymphotoxin beta receptor, but not through tumor necrosis factor receptor I. J Exp Med. 2001;193:631-6 pubmed
|
| Bajpai U, Zhang K, Teutsch M, Sen R, Wortis H. Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med. 2000;191:1735-44 pubmed
|