product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
MCT1 (H-1) Antibody
catalog :
sc-365501
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
H-1
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 21
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:100; loading ...; fig 5b
Malinowski D, Grzeg xf3 x142 kowski P, Piotrowska K, S x142 ojewski M, Dro x17a dzik M. Membrane Transporters and Carriers in Human Seminal Vesicles. J Clin Med. 2022;11: pubmed publisher
  • western blot; human; 1:200; loading ...; fig 1
Tavares Valente D, Sousa B, Schmitt F, Baltazar F, Queir xf3 s O. Disruption of pH Dynamics Suppresses Proliferation and Potentiates Doxorubicin Cytotoxicity in Breast Cancer Cells. Pharmaceutics. 2021;13: pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 4a
Drozdzik M, Szeląg Pieniek S, Grzegółkowska J, Łapczuk Romańska J, Post M, Domagała P, et al. Monocarboxylate Transporter 1 (MCT1) in Liver Pathology. Int J Mol Sci. 2020;21: pubmed publisher
  • western blot; human; loading ...; fig 6
Ferreira D, Silva A, Nóbrega F, Martins I, Barbosa Matos C, Granja S, et al. Rational Identification of a Colorectal Cancer Targeting Peptide through Phage Display. Sci Rep. 2019;9:3958 pubmed publisher
  • western blot; human; 1:500; loading ...; fig s16b
Persi E, Duran Frigola M, Damaghi M, Roush W, Aloy P, Cleveland J, et al. Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nat Commun. 2018;9:2997 pubmed publisher
  • immunocytochemistry; human; 1:15; loading ...; fig 5a
  • western blot; human; 1:25; loading ...; fig 5e
Van Rymenant E, Abranko L, Tumova S, Grootaert C, Van Camp J, Williamson G, et al. Chronic exposure to short-chain fatty acids modulates transport and metabolism of microbiome-derived phenolics in human intestinal cells. J Nutr Biochem. 2017;39:156-168 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Knudsen E, Balaji U, Freinkman E, McCue P, Witkiewicz A. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget. 2016;7:78396-78411 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2a
Lee J, Lee I, Chang W, Ahn S, Lim S, Kim H, et al. MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis. Oncotarget. 2016;7:43492-43503 pubmed publisher
  • immunocytochemistry; human; 1:50; fig 5
  • western blot; human; 1:25; fig 3
Ziegler K, Kerimi A, Poquet L, Williamson G. Butyric acid increases transepithelial transport of ferulic acid through upregulation of the monocarboxylate transporters SLC16A1 (MCT1) and SLC16A3 (MCT4). Arch Biochem Biophys. 2016;599:3-12 pubmed publisher
  • immunocytochemistry; human; 1:200; fig 1
  • immunohistochemistry; human; 1:500; fig 5
  • western blot; human; 1:500; fig 2
Morais Santos F, Granja S, Miranda Gonçalves V, Moreira A, Queirós S, Vilaça J, et al. Targeting lactate transport suppresses in vivo breast tumour growth. Oncotarget. 2015;6:19177-89 pubmed
  • western blot; human
Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald S. Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis. Oncogene. 2016;35:1926-42 pubmed publisher
  • flow cytometry; human
  • immunocytochemistry; human; 6.25 ug/ml
  • western blot; human; 1:1000
Kershaw S, Cummings J, Morris K, Tugwood J, Dive C. Optimisation of immunofluorescence methods to determine MCT1 and MCT4 expression in circulating tumour cells. BMC Cancer. 2015;15:387 pubmed publisher
  • immunohistochemistry; human; 1:500; fig 1
  • western blot; human; 1:500; fig 5
Pértega Gomes N, Felisbino S, Massie C, Vizcaíno J, Coelho R, Sandi C, et al. A glycolytic phenotype is associated with prostate cancer progression and aggressiveness: a role for monocarboxylate transporters as metabolic targets for therapy. J Pathol. 2015;236:517-30 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Valença I, Pértega Gomes N, Vizcaino J, Henrique R, Lopes C, Baltazar F, et al. Localization of MCT2 at peroxisomes is associated with malignant transformation in prostate cancer. J Cell Mol Med. 2015;19:723-33 pubmed publisher
Pemovska T, Bigenzahn J, Srndic I, Lercher A, Bergthaler A, César Razquin A, et al. Metabolic drug survey highlights cancer cell dependencies and vulnerabilities. Nat Commun. 2021;12:7190 pubmed publisher
Dong Q, Zhou C, Ren H, Zhang Z, Cheng F, Xiong Z, et al. Lactate-induced MRP1 expression contributes to metabolism-based etoposide resistance in non-small cell lung cancer cells. Cell Commun Signal. 2020;18:167 pubmed publisher
Benjamin D, Robay D, Hindupur S, Pohlmann J, Colombi M, El Shemerly M, et al. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. Cell Rep. 2018;25:3047-3058.e4 pubmed publisher
Updegraff B, Zhou X, Guo Y, Padanad M, Chen P, Yang C, et al. Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism. Cell Rep. 2018;25:2223-2233.e6 pubmed publisher
Latif A, Chadwick A, Kitson S, Gregson H, Sivalingam V, Bolton J, et al. Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer. BMC Clin Pathol. 2017;17:27 pubmed publisher
Pértega Gomes N, Vizcaíno J, Attig J, Jurmeister S, Lopes C, Baltazar F. A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer. BMC Cancer. 2014;14:352 pubmed publisher
McCleland M, Adler A, Deming L, Cosino E, Lee L, Blackwood E, et al. Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas. Clin Cancer Res. 2013;19:773-84 pubmed publisher
product information
Catalog Number :
sc-365501
Product Name :
MCT1 (H-1) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
H-1
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
MCT1
Specificity :
human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA