This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
PU.1 (Spi-1) (T-21)
catalog :
sc-352
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, chromatin immunoprecipitation, ChIP-Seq
citations: 16
Published Application/Species/Sample/DilutionReference
  • ChIP-Seq; mouse; fig 6
Eichenfield D, Troutman T, Link V, Lam M, Cho H, Gosselin D, et al. Tissue damage drives co-localization of NF-?B, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages. elife. 2016;5: pubmed publisher
  • immunocytochemistry; mouse; 8 ug/ml; loading ...; fig 3b
Hoppe P, Schwarzfischer M, Loeffler D, Kokkaliaris K, Hilsenbeck O, Moritz N, et al. Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios. Nature. 2016;535:299-302 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 5b
  • western blot; human; loading ...; fig s1b
Burda P, Vargova J, Curik N, Salek C, Papadopoulos G, Strouboulis J, et al. GATA-1 Inhibits PU.1 Gene via DNA and Histone H3K9 Methylation of Its Distal Enhancer in Erythroleukemia. PLoS ONE. 2016;11:e0152234 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 2
  • western blot; mouse; fig 1
Sive J, Basilico S, Hannah R, Kinston S, Calero Nieto F, Göttgens B. Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia. Leukemia. 2016;30:14-23 pubmed publisher
  • chromatin immunoprecipitation; human; fig 6.a,c
Zimmermann M, Aguilera F, Castellucci M, Rossato M, Costa S, Lunardi C, et al. Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils. Nat Commun. 2015;6:6061 pubmed publisher
Terrell J, Taylor S, Schneider A, Lu Y, Vernon T, Xhani S, et al. DNA selection by the master transcription factor PU.1. Cell Rep. 2023;42:112671 pubmed publisher
Zhu H, Zhang L, Wu Y, Dong B, Guo W, Wang M, et al. T-ALL leukemia stem cell 'stemness' is epigenetically controlled by the master regulator SPI1. elife. 2018;7: pubmed publisher
Heinz S, Texari L, Hayes M, Urbanowski M, Chang M, Givarkes N, et al. Transcription Elongation Can Affect Genome 3D Structure. Cell. 2018;174:1522-1536.e22 pubmed publisher
Gu X, Ebrahem Q, Mahfouz R, Hasipek M, Enane F, Radivoyevitch T, et al. Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates. J Clin Invest. 2018;128:4260-4279 pubmed publisher
Jin J, Britschgi A, Schläfli A, Humbert M, Shan Krauer D, Batliner J, et al. Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018;2018:1482795 pubmed publisher
Kim H, Tan Y, Ma W, Merkurjev D, Destici E, Ma Q, et al. Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. Nature. 2018;556:510-514 pubmed publisher
Czimmerer Z, Dániel B, Horvath A, Rückerl D, Nagy G, Kiss M, et al. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages. Immunity. 2018;48:75-90.e6 pubmed publisher
Antony Debré I, Paul A, Leite J, Mitchell K, Kim H, Carvajal L, et al. Pharmacological inhibition of the transcription factor PU.1 in leukemia. J Clin Invest. 2017;127:4297-4313 pubmed publisher
Soldi M, Mari T, Nicosia L, Musiani D, Sigismondo G, Cuomo A, et al. Chromatin proteomics reveals novel combinatorial histone modification signatures that mark distinct subpopulations of macrophage enhancers. Nucleic Acids Res. 2017;: pubmed publisher
Keightley M, Carradice D, Layton J, Pase L, Bertrand J, Wittig J, et al. The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger. Nat Commun. 2017;8:14911 pubmed publisher
Noguera N, Piredda M, Taulli R, Catalano G, Angelini G, Gaur G, et al. PML/RARa inhibits PTEN expression in hematopoietic cells by competing with PU.1 transcriptional activity. Oncotarget. 2016;7:66386-66397 pubmed publisher
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA