product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
IRP-2 (7H6) Antibody
catalog :
sc-33682
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7H6
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 16
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5b
Ast T, Meisel J, Patra S, Wang H, Grange R, Kim S, et al. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Grillo A, SantaMaria A, Kafina M, Cioffi A, Huston N, Han M, et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017;356:608-616 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4h
Kerins M, Vashisht A, Liang B, Duckworth S, Praslicka B, WOHLSCHLEGEL J, et al. Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; mouse; 1:1000; fig 8
Cloonan S, Glass K, Laucho Contreras M, Bhashyam A, Cervo M, Pabón M, et al. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016;22:163-74 pubmed publisher
  • western blot; human; 1:500; fig 2
Mancias J, Pontano Vaites L, Nissim S, Biancur D, Kim A, Wang X, et al. Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis. elife. 2015;4: pubmed publisher
  • western blot; human; 1:500; fig 2
Bauckman K, Haller E, Taran N, Rockfield S, Ruiz Rivera A, Nanjundan M. Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells. Biochem J. 2015;466:401-13 pubmed publisher
  • western blot; human
Yang N, Tan S, Ng S, Shi Y, Zhou J, Tan K, et al. Artesunate induces cell death in human cancer cells via enhancing lysosomal function and lysosomal degradation of ferritin. J Biol Chem. 2014;289:33425-41 pubmed publisher
  • western blot; human
Moroishi T, Yamauchi T, Nishiyama M, Nakayama K. HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. J Biol Chem. 2014;289:16430-41 pubmed publisher
  • western blot; human; 1:500
Mancias J, Wang X, Gygi S, Harper J, Kimmelman A. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105-9 pubmed publisher
Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, et al. Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. J Exp Med. 2019;216:950-965 pubmed publisher
Ramanathan M, Majzoub K, Rao D, Neela P, Zarnegar B, Mondal S, et al. RNA-protein interaction detection in living cells. Nat Methods. 2018;15:207-212 pubmed publisher
Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, et al. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017;36:4089-4099 pubmed publisher
Chollangi S, Thompson J, Ruiz J, Gardner K, Bruick R. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms. J Biol Chem. 2012;287:23710-7 pubmed publisher
Iordanova B, Ahrens E. In vivo magnetic resonance imaging of ferritin-based reporter visualizes native neuroblast migration. Neuroimage. 2012;59:1004-12 pubmed publisher
Condo I, Malisan F, Guccini I, Serio D, Rufini A, Testi R. Molecular control of the cytosolic aconitase/IRP1 switch by extramitochondrial frataxin. Hum Mol Genet. 2010;19:1221-9 pubmed publisher
DeMeo D, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, et al. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009;85:493-502 pubmed publisher
product information
Product Name :
IRP-2 (7H6) Antibody
Gene Name :
IREB2
Size :
200 µg/ml
Price :
279 USD
Catalog Number :
sc-33682
Type :
Monoclonal
Host :
mouse monoclonal
Antigen :
IRP-2
reactive species  :
human
Application :
WB, IP, IF, IHC(P), ELISA
Epitope :
FL (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA