| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; fig 4e
| Zhang W, Wang Q, Song P, Zou M. Liver kinase b1 is required for white adipose tissue growth and differentiation. Diabetes. 2013;62:2347-58 pubmed publisher |
- western blot knockout validation; mouse; fig 1
- immunohistochemistry; mouse; fig 7
| Denison F, Smith L, Muckett P, O Hara L, Carling D, Woods A. LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis. PLoS ONE. 2011;6:e28306 pubmed publisher |
- western blot; mouse; 1:1000; fig 2f
| Wu J, Xue X, Fan G, Gu Y, Zhou F, Zheng Q, et al. Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation. Front Pharmacol. 2021;12:754976 pubmed publisher |
- immunohistochemistry; mouse; 1:100; loading ...; fig 6a
| Chung W, Challagundla L, Zhou Y, Li M, Atfi A, Xu K. Loss of Jag1 cooperates with oncogenic Kras to induce pancreatic cystic neoplasms. Life Sci Alliance. 2021;4: pubmed publisher |
- immunohistochemistry; mouse; 1:50; loading ...; fig s3-1b
- western blot; mouse; 1:500; loading ...; fig 1b
| Khayati K, Bhatt V, Hu Z, Fahumy S, Luo X, Guo J. Autophagy compensates for Lkb1 loss to maintain adult mice homeostasis and survival. elife. 2020;9: pubmed publisher |
- western blot; mouse; loading ...; fig 6b, 7a
| Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, et al. Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway. Pharmacol Res. 2020;153:104678 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 3a
- western blot; human; loading ...; fig 3a
| Zeng J, Liu W, Fan Y, He D, Li L. PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy. Theranostics. 2018;8:109-123 pubmed publisher |
- western blot; rat; 1:2000
| Bernard L, Zhang H. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism. PLoS ONE. 2015;10:e0124816 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50
| Li J, Liu J, Li P, Mao X, Li W, Yang J, et al. Loss of LKB1 disrupts breast epithelial cell polarity and promotes breast cancer metastasis and invasion. J Exp Clin Cancer Res. 2014;33:70 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100
- immunoprecipitation; human
- western blot; human; 1:1000
| Bouchekioua Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, et al. LKB1 when associated with methylatedER? is a marker of bad prognosis in breast cancer. Int J Cancer. 2014;135:1307-18 pubmed publisher |
| Zhang D, Ning J, Okon I, Zheng X, Satyanarayana G, Song P, et al. Suppression of m6A mRNA modification by DNA hypermethylated ALKBH5 aggravates the oncological behavior of KRAS mutation/LKB1 loss lung cancer. Cell Death Dis. 2021;12:518 pubmed publisher |
| Lan F, Lin Y, Gao Z, Cacicedo J, Weikel K, Ido Y. Activation of LKB1 rescues 3T3-L1 adipocytes from senescence induced by Sirt1 knock-down: a pivotal role of LKB1 in cellular aging. Aging (Albany NY). 2020;12:18942-18956 pubmed publisher |
| Jin L, Zhao K, Xu L, Zhao R, Werle K, Wang Y, et al. LKB1 inactivation leads to centromere defects and genome instability via p53-dependent upregulation of survivin. Aging (Albany NY). 2020;12:14341-14354 pubmed publisher |
| Bie F, Wang G, Qu X, Wang Y, Huang C, Wang Y, et al. Loss of FGL1 induces epithelial‑mesenchymal transition and angiogenesis in LKB1 mutant lung adenocarcinoma. Int J Oncol. 2019;55:697-707 pubmed publisher |
| Bhatt V, Khayati K, Hu Z, Lee A, Kamran W, Su X, et al. Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis. Genes Dev. 2019;33:150-165 pubmed publisher |
| Zulato E, Ciccarese F, Agnusdei V, Pinazza M, Nardo G, Iorio E, et al. LKB1 loss is associated with glutathione deficiency under oxidative stress and sensitivity of cancer cells to cytotoxic drugs and γ-irradiation. Biochem Pharmacol. 2018;156:479-490 pubmed publisher |
| Li W, Wong C, Zhang X, Kang W, Nakatsu G, Zhao Q, et al. CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1α axis to inhibit gastric tumorigenesis. Oncogene. 2018;37:6383-6398 pubmed publisher |
| Zhang C, Hawley S, Zong Y, Li M, Wang Z, Gray A, et al. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 2017;548:112-116 pubmed publisher |
| Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, et al. The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling. Oncotarget. 2016;7:1120-43 pubmed publisher |
| Guo C, Hao C, Shao R, Fang B, Correa A, Hofstetter W, et al. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget. 2015;6:11114-24 pubmed |
| Salem A, Whitaker Menezes D, Lin Z, Martinez Outschoorn U, Tanowitz H, Al Zoubi M, et al. Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle. 2012;11:2545-56 pubmed publisher |
| Fu J, Jin J, Cichewicz R, Hageman S, Ellis T, Xiang L, et al. trans-(-)-?-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease. J Biol Chem. 2012;287:24460-72 pubmed publisher |
| Eneling K, Brion L, Pinto V, Pinho M, Sznajder J, Mochizuki N, et al. Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability. FASEB J. 2012;26:3230-9 pubmed publisher |
| Roy B, Kohno T, Iwakawa R, Moriguchi T, Kiyono T, Morishita K, et al. Involvement of LKB1 in epithelial-mesenchymal transition (EMT) of human lung cancer cells. Lung Cancer. 2010;70:136-45 pubmed publisher |
| Humbert N, Navaratnam N, Augert A, da Costa M, Martien S, Wang J, et al. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J. 2010;29:376-86 pubmed publisher |
| Carretero J, Medina P, Blanco R, Smit L, Tang M, Roncador G, et al. Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer. Oncogene. 2007;26:1616-25 pubmed |
