This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Brn-3a (C-20)
catalog :
sc-31984
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, ChIP-Seq, other
citations: 41
Published Application/Species/Sample/DilutionReference
  • ChIP-Seq; mouse; loading ...; fig 4d
  • chromatin immunoprecipitation; mouse; loading ...; fig 4e
Dahlet T, Truss M, Frede U, Al Adhami H, Bardet A, Dumas M, et al. E2F6 initiates stable epigenetic silencing of germline genes during embryonic development. Nat Commun. 2021;12:3582 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 7a
  • immunocytochemistry; rat; 1:200; loading ...; fig 5a
Chaphalkar R, Stankowska D, He S, Kodati B, Phillips N, Prah J, et al. Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells. Sci Rep. 2020;10:3571 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:500; loading ...; fig 9a
Mammone T, Chidlow G, Casson R, Wood J. Improved immunohistochemical detection of phosphorylated mitogen-activated protein kinases in the injured rat optic nerve head. Histochem Cell Biol. 2019;151:435-456 pubmed publisher
  • western blot; mouse; loading ...; fig 7d
Ko Y, Chan Y, Liu C, Liang J, Chuang T, Hsueh Y, et al. Blimp-1-Mediated Pathway Promotes Type I IFN Production in Plasmacytoid Dendritic Cells by Targeting to Interleukin-1 Receptor-Associated Kinase M. Front Immunol. 2018;9:1828 pubmed publisher
  • western blot; mouse; loading ...; fig s4a
Zhang H, Li H, Hillmer E, Zhao Y, Chrisikos T, Hu H, et al. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci U S A. 2018;115:E2311-E2319 pubmed publisher
  • western blot; human; loading ...; fig 7b
Wang Z, Kim M, Martinez Ferrando I, Koleske A, Pandey A, Cole P. Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase. Biochemistry. 2018;57:1390-1398 pubmed publisher
  • western blot; mouse; loading ...; fig 4a, 4b
  • western blot; human; loading ...; fig 4b
Comiskey D, Jacob A, Sanford B, Montes M, Goodwin A, Steiner H, et al. A novel mouse model of rhabdomyosarcoma underscores the dichotomy of MDM2-ALT1 function in vivo. Oncogene. 2018;37:95-106 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2
Bizzarro V, Belvedere R, Migliaro V, Romano E, Parente L, Petrella A. Hypoxia regulates ANXA1 expression to support prostate cancer cell invasion and aggressiveness. Cell Adh Migr. 2017;11:247-260 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 6b
Pamarthy S, Mao L, Katara G, Fleetwood S, Kulshreshta A, Gilman Sachs A, et al. The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling. Cell Death Dis. 2016;7:e2443 pubmed publisher
  • immunocytochemistry; mouse; 1:2000; loading ...; fig 2h
  • western blot; human; 1:2000; fig 7d
Luo W, Li S, Li C, Lian H, Yang Q, Zhong B, et al. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol. 2016;17:1057-66 pubmed publisher
  • immunohistochemistry; rat; 1:500; fig 4
Esquiva G, Avivi A, Hannibal J. Non-image Forming Light Detection by Melanopsin, Rhodopsin, and Long-Middlewave (L/W) Cone Opsin in the Subterranean Blind Mole Rat, Spalax Ehrenbergi: Immunohistochemical Characterization, Distribution, and Connectivity. Front Neuroanat. 2016;10:61 pubmed publisher
  • immunohistochemistry; rat; 1:100; loading ...; fig 1a
Reinehr S, Reinhard J, Wiemann S, Stute G, Kuehn S, Woestmann J, et al. Early remodelling of the extracellular matrix proteins tenascin-C and phosphacan in retina and optic nerve of an experimental autoimmune glaucoma model. J Cell Mol Med. 2016;20:2122-2137 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 7d
  • western blot; mouse; loading ...; fig 7d
Jin J, Valanejad L, Nguyen T, Lewis K, Wright M, Cast A, et al. Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease. Cell Rep. 2016;16:744-56 pubmed publisher
  • western blot; human; loading ...; fig 6d
  • western blot; dogs; loading ...; fig 1b
Chen C, Wang S, Chan P, Shen M, Chen H. Phosphorylation of E-cadherin at threonine 790 by protein kinase C? reduces ?-catenin binding and suppresses the function of E-cadherin. Oncotarget. 2016;7:37260-37276 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 6a
Larabee C, Hu Y, Desai S, Georgescu C, Wren J, Axtell R, et al. Myelin-specific Th17 cells induce severe relapsing optic neuritis with irreversible loss of retinal ganglion cells in C57BL/6 mice. Mol Vis. 2016;22:332-41 pubmed
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • immunohistochemistry; mouse; 1:750; fig 3
  • immunohistochemistry; rat; 1:750; fig 2
Vidal Sanz M, Valiente Soriano F, Ortín Martínez A, Nadal Nicolás F, Jiménez López M, Salinas Navarro M, et al. Retinal neurodegeneration in experimental glaucoma. Prog Brain Res. 2015;220:1-35 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 6e
  • western blot; human; loading ...; fig 6b
Keka I, Mohiuddin -, Maede Y, Rahman M, Sakuma T, Honma M, et al. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Nucleic Acids Res. 2015;43:6359-72 pubmed publisher
  • western blot; human; loading ...; fig 2b
Kim Y, Ahn J. Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus. PLoS Pathog. 2015;11:e1004785 pubmed publisher
  • western blot; human; loading ...; fig 3a
Le Saout C, Hasley R, Imamichi H, Tcheung L, Hu Z, Luckey M, et al. Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS Pathog. 2014;10:e1003976 pubmed publisher
Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, et al. The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathol Commun. 2021;9:6 pubmed publisher
Edwards G, Lee Y, Kim M, Bhanvadia S, Kim K, Ju W. Effect of Ubiquinol on Glaucomatous Neurodegeneration and Oxidative Stress: Studies for Retinal Ganglion Cell Survival and/or Visual Function. Antioxidants (Basel). 2020;9: pubmed publisher
Pita Thomas W, Mahar M, Joshi A, Gan D, Cavalli V. HDAC5 promotes optic nerve regeneration by activating the mTOR pathway. Exp Neurol. 2019;317:271-283 pubmed publisher
Zhou Y, Carmona S, Muhammad A, Bell S, Landeros J, Vazquez M, et al. Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model. J Clin Invest. 2019;130:1756-1771 pubmed publisher
Geeraerts E, Claes M, Dekeyster E, Salinas Navarro M, De Groef L, Van den Haute C, et al. Optogenetic Stimulation of the Superior Colliculus Confers Retinal Neuroprotection in a Mouse Glaucoma Model. J Neurosci. 2019;39:2313-2325 pubmed publisher
Xu Z, Fouda A, Lemtalsi T, Shosha E, Rojas M, Liu F, et al. Retinal Neuroprotection From Optic Nerve Trauma by Deletion of Arginase 2. Front Neurosci. 2018;12:970 pubmed publisher
Lin M, Liao P, Chen H, Chang C, Chen S, Chern Y. Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment. J Neurosci. 2019;39:1505-1524 pubmed publisher
Hill L, Mead B, Thomas C, Foale S, Feinstein E, Berry M, et al. TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma. Mol Vis. 2018;24:712-726 pubmed
Zaninello M, Scorrano L. Rapidly purified ganglion cells from neonatal mouse retinas allow studies of mitochondrial morphology and autophagy. Pharmacol Res. 2018;138:16-24 pubmed publisher
Norris G, Smirnov I, Filiano A, Shadowen H, Cody K, Thompson J, et al. Neuronal integrity and complement control synaptic material clearance by microglia after CNS injury. J Exp Med. 2018;215:1789-1801 pubmed publisher
Tang J, Qin N, Chong Y, Diao Y, Yiliguma -, Wang Z, et al. Nanowire arrays restore vision in blind mice. Nat Commun. 2018;9:786 pubmed publisher
Dieguez H, Romeo H, González Fleitas M, Aranda M, Milne G, Rosenstein R, et al. Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice. Dis Model Mech. 2018;11: pubmed publisher
Yang X, Huang Y, Lan M, Zhang T, Zhou J. Protective Effects of Leukemia Inhibitory Factor on Retinal Vasculature and Cells in Streptozotocin-induced Diabetic Mice. Chin Med J (Engl). 2018;131:75-81 pubmed publisher
Villain G, Poissonnier L, Noueihed B, Bonfils G, Rivera J, Chemtob S, et al. miR-126-5p promotes retinal endothelial cell survival through SetD5 regulation in neurons. Development. 2018;145: pubmed publisher
Schnichels S, Blak M, Hurst J, Dorfi T, Bartz Schmidt K, Ziemssen F, et al. Establishment of a retinal hypoxia organ culture model. Biol Open. 2017;6:1056-1064 pubmed publisher
Akopian A, Kumar S, Ramakrishnan H, Roy K, Viswanathan S, Bloomfield S. Targeting neuronal gap junctions in mouse retina offers neuroprotection in glaucoma. J Clin Invest. 2017;127:2647-2661 pubmed publisher
Zalis M, Johansson S, Englund Johansson U. Immunocytochemical Profiling of Cultured Mouse Primary Retinal Cells. J Histochem Cytochem. 2017;65:223-239 pubmed publisher
Xiao J, Li X, Chen L, Han X, Zhao W, Li L, et al. Apobec1 Promotes Neurotoxicity-Induced Dedifferentiation of Müller Glial Cells. Neurochem Res. 2017;42:1151-1164 pubmed publisher
Qu C, Bian D, Li X, Xiao J, Wu C, Li Y, et al. Transient Expression of Fez Family Zinc Finger 2 Protein Regulates the Brn3b Gene in Developing Retinal Ganglion Cells. J Biol Chem. 2016;291:7661-8 pubmed publisher
Partida G, Stradleigh T, Ogata G, Godzdanker I, Ishida A. Thy1 associates with the cation channel subunit HCN4 in adult rat retina. Invest Ophthalmol Vis Sci. 2012;53:1696-703 pubmed publisher
Hayashida Y, Rodríguez C, Ogata G, Partida G, Oi H, Stradleigh T, et al. Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation. J Neurosci. 2009;29:15001-16 pubmed publisher
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA