product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
H-Ras (F235) Antibody
catalog :
sc-29
quantity :
50 µg/0.5 ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
F235
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 51
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:200; loading ...; fig 5c
Liu Z, Liu J, Dong X, Hu X, Jiang Y, Li L, et al. Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation. J Cell Mol Med. 2019;23:2083-2092 pubmed publisher
  • western blot; human; loading ...; fig 2c
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; 1:500; fig 5b
Kotsantis P, Silva L, Irmscher S, Jones R, Folkes L, Gromak N, et al. Increased global transcription activity as a mechanism of replication stress in cancer. Nat Commun. 2016;7:13087 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 1
Calaf G, Abarca Quinones J. Ras protein expression as a marker for breast cancer. Oncol Lett. 2016;11:3637-3642 pubmed
  • western blot; human; 1:50; loading ...; fig 2a
Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed publisher
  • western blot; mouse; fig 1
Park Y, Kim S, Kwon T, Kim J, Song I, Shin H, et al. Peroxiredoxin II promotes hepatic tumorigenesis through cooperation with Ras/Forkhead box M1 signaling pathway. Oncogene. 2016;35:3503-13 pubmed publisher
  • western blot; human; 1:1000
Cho M, Park J, Choi H, Park M, Won H, Park Y, et al. DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nat Commun. 2015;6:7821 pubmed publisher
  • western blot; human; fig 1
Kirschner K, Samarajiwa S, Cairns J, Menon S, Perez Mancera P, Tomimatsu K, et al. Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genet. 2015;11:e1005053 pubmed publisher
  • western blot; human; fig 2
Moody S, Schinzel A, Singh S, Izzo F, Strickland M, Luo L, et al. PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling. Oncogene. 2015;34:2061-71 pubmed publisher
  • western blot; human
BENTLEY C, Jurinka S, Kljavin N, Vartanian S, Ramani S, Gonzalez L, et al. A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation. Biochem J. 2013;452:313-20 pubmed publisher
  • western blot; human
Vartanian S, BENTLEY C, Brauer M, Li L, Shirasawa S, Sasazuki T, et al. Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines. J Biol Chem. 2013;288:2403-13 pubmed publisher
Duarte L, Young A, Wang Z, Wu H, Panda T, Kou Y, et al. Histone H3.3 and its proteolytically processed form drive a cellular senescence programme. Nat Commun. 2014;5:5210 pubmed publisher
Sheng Fowler L, Tu W, Fu H, Murata H, Lanning L, Foseh G, et al. A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc. PLoS ONE. 2014;9:e108926 pubmed publisher
Jin B, Wang Y, Wu C, Liu K, Chen H, Mao Z. PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. Aging Cell. 2014;13:879-89 pubmed publisher
Khenchouche A, Sadouki N, Boudriche A, Houali K, Graba A, Ooka T, et al. Human papillomavirus and Epstein-Barr virus co-infection in cervical carcinoma in Algerian women. Virol J. 2013;10:340 pubmed publisher
Kim E, Kang S, Kim J, Min K, Kim T. Modulation of bevacizumab-induced toxicity for cultured human corneal fibroblasts. Invest Ophthalmol Vis Sci. 2013;54:3922-31 pubmed publisher
Moiseeva O, Deschênes Simard X, St Germain E, Igelmann S, Huot G, Cadar A, et al. Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-?B activation. Aging Cell. 2013;12:489-98 pubmed publisher
Litlekalsoy J, Hostmark J, Costea D, Illemann M, Laerum O. Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9). Virchows Arch. 2012;461:541-51 pubmed publisher
Ikonomou G, Kostourou V, Shirasawa S, Sasazuki T, Samiotaki M, Panayotou G. Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation. J Proteomics. 2012;75:5356-69 pubmed publisher
Zhang T, Wang F, Xu H, Yi L, Qin Y, Chang H, et al. Activation of nuclear factor erythroid 2-related factor 2 and PPAR? plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury. Br J Nutr. 2013;109:223-35 pubmed publisher
Lafontaine J, Tchakarska G, Rodier F, Mes Masson A. Necdin modulates proliferative cell survival of human cells in response to radiation-induced genotoxic stress. BMC Cancer. 2012;12:234 pubmed publisher
Linley A, Mathieu M, Miles A, Rees R, McArdle S, Regad T. The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo. J Biol Chem. 2012;287:13633-43 pubmed publisher
Chien M, Ying T, Hsieh Y, Chang Y, Yeh C, Ko J, et al. Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity. Food Chem Toxicol. 2012;50:558-66 pubmed publisher
Wang Y, Romigh T, He X, Tan M, Orloff M, Silverman R, et al. Differential regulation of PTEN expression by androgen receptor in prostate and breast cancers. Oncogene. 2011;30:4327-38 pubmed publisher
Rauch J, Moran Jones K, Albrecht V, Schwarzl T, Hunter K, Gires O, et al. c-Myc regulates RNA splicing of the A-Raf kinase and its activation of the ERK pathway. Cancer Res. 2011;71:4664-74 pubmed publisher
de Carné Trécesson S, Guillemin Y, Bélanger A, Bernard A, Preisser L, Ravon E, et al. Escape from p21-mediated oncogene-induced senescence leads to cell dedifferentiation and dependence on anti-apoptotic Bcl-xL and MCL1 proteins. J Biol Chem. 2011;286:12825-38 pubmed publisher
Cho K, Hill M, Chigurupati S, Du G, Parton R, Hancock J. Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate ras signaling via phospholipase D2. Mol Cell Biol. 2011;31:1110-20 pubmed publisher
Takeuchi S, Takahashi A, Motoi N, Yoshimoto S, Tajima T, Yamakoshi K, et al. Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo. Cancer Res. 2010;70:9381-90 pubmed publisher
Moumtzi S, Roberts M, Joyce T, Evangelidou M, Probert L, Frillingos S, et al. Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells. Cancer Invest. 2010;28:563-87 pubmed publisher
Nyström A, Shaik Z, Gullberg D, Krieg T, Eckes B, Zent R, et al. Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood. 2009;114:4897-906 pubmed publisher
Medendorp K, van Groningen J, Vreede L, Hetterschijt L, van den Hurk W, de Bruijn D, et al. The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle. PLoS ONE. 2009;4:e7020 pubmed publisher
Jiang R, Cabras G, Sheng W, Zeng Y, Ooka T. Synergism of BARF1 with Ras induces malignant transformation in primary primate epithelial cells and human nasopharyngeal epithelial cells. Neoplasia. 2009;11:964-73 pubmed
Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, et al. A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth. BMC Cancer. 2009;9:198 pubmed publisher
Moiseeva O, Bourdeau V, Roux A, Deschênes Simard X, Ferbeyre G. Mitochondrial dysfunction contributes to oncogene-induced senescence. Mol Cell Biol. 2009;29:4495-507 pubmed publisher
Shah N, Trivedi T, Tankshali R, Goswami J, Jetly D, Shukla S, et al. Prognostic significance of molecular markers in oral squamous cell carcinoma: a multivariate analysis. Head Neck. 2009;31:1544-56 pubmed publisher
Hiruma Y, Honjo T, Jelinek D, Windle J, Shin J, Roodman G, et al. Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation. Blood. 2009;113:4894-902 pubmed publisher
Breitenbuecher F, Markova B, Kasper S, Carius B, Stauder T, Bohmer F, et al. A novel molecular mechanism of primary resistance to FLT3-kinase inhibitors in AML. Blood. 2009;113:4063-73 pubmed publisher
Miyazaki K, Inoue S, Yamada K, Watanabe M, Liu Q, Watanabe T, et al. Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells. Nucleic Acids Res. 2009;37:1438-51 pubmed publisher
Labalette C, Nouet Y, Levillayer F, Armengol C, Renard C, Soubigou G, et al. The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways. PLoS ONE. 2008;3:e3761 pubmed publisher
Zhou X, Coad J, Ducatman B, Agazie Y. SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis. Histopathology. 2008;53:389-402 pubmed publisher
Turner S, Zhuang S, Zhang T, Boss G, Pilz R. Effects of lovastatin on Rho isoform expression, activity, and association with guanine nucleotide dissociation inhibitors. Biochem Pharmacol. 2008;75:405-13 pubmed
Oishi N, Shilagardi K, Nakamoto Y, Honda M, Kaneko S, Murakami S. Hepatitis B virus X protein overcomes oncogenic RAS-induced senescence in human immortalized cells. Cancer Sci. 2007;98:1540-8 pubmed
Ganly I, Talbot S, Carlson D, Viale A, Maghami E, Osman I, et al. Identification of angiogenesis/metastases genes predicting chemoradiotherapy response in patients with laryngopharyngeal carcinoma. J Clin Oncol. 2007;25:1369-76 pubmed
Psahoulia F, Moumtzi S, Roberts M, Sasazuki T, Shirasawa S, Pintzas A. Quercetin mediates preferential degradation of oncogenic Ras and causes autophagy in Ha-RAS-transformed human colon cells. Carcinogenesis. 2007;28:1021-31 pubmed
Ehmann F, Horn S, Garcia Palma L, Wegner W, Fiedler W, Giehl K, et al. Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations. Leuk Lymphoma. 2006;47:1387-91 pubmed
Lu S, Shen K, Wang Y, Santner S, Chen J, Brooks S, et al. Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors. Carcinogenesis. 2006;27:848-55 pubmed
Mattingly R, Kraniak J, Dilworth J, Mathieu P, Bealmear B, Nowak J, et al. The mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor PD184352 (CI-1040) selectively induces apoptosis in malignant schwannoma cell lines. J Pharmacol Exp Ther. 2006;316:456-65 pubmed
Roberts M, Drosopoulos K, Vasileiou I, Stricker M, Taoufik E, Maercker C, et al. Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line. Int J Cancer. 2006;118:616-27 pubmed
Sharma R, Sud N, Chattopadhyay T, Ralhan R. TC21/R-Ras2 upregulation in esophageal tumorigenesis: potential diagnostic implications. Oncology. 2005;69:10-8 pubmed
Boivin B, Villeneuve L, Farhat N, Chevalier D, Allen B. Sub-cellular distribution of endothelin signaling pathway components in ventricular myocytes and heart: lack of preformed caveolar signalosomes. J Mol Cell Cardiol. 2005;38:665-76 pubmed
Tchevkina E, Agapova L, Dyakova N, Martinjuk A, Komelkov A, Tatosyan A. The small G-protein RalA stimulates metastasis of transformed cells. Oncogene. 2005;24:329-35 pubmed
product information
Catalog Number :
sc-29
Product Name :
H-Ras (F235) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
F235
Isotype :
IgG1
Size :
50 µg/0.5 ml
List Price :
316 USD
Immunogen :
H-Ras
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P)
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA