product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
hnRNP K (D-6) Antibody
catalog :
sc-28380
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-6
reactivity :
human, mouse, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, RNA immunoprecipitation
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; loading ...; fig 1a
  • immunoprecipitation; human; loading ...; fig 3a
  • immunocytochemistry; human; loading ...; fig 4b
  • western blot; human; loading ...; fig 5a
Li L, Yan S, Zhang H, Zhang M, Huang G, Chen M. Interaction of hnRNP K with MAP 1B-LC1 promotes TGF-β1-mediated epithelial to mesenchymal transition in lung cancer cells. BMC Cancer. 2019;19:894 pubmed publisher
  • western blot; human; loading ...; fig s5a
Marchesini M, Ogoti Y, Fiorini E, Aktaş Samur A, Nezi L, D Anca M, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017;32:88-100.e6 pubmed publisher
  • RNA immunoprecipitation; human; tbl 2
Hwang C, Wagley Y, Law P, Wei L, Loh H. Phosphorylation of poly(rC) binding protein 1 (PCBP1) contributes to stabilization of mu opioid receptor (MOR) mRNA via interaction with AU-rich element RNA-binding protein 1 (AUF1) and poly A binding protein (PABP). Gene. 2017;598:113-130 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 1
  • immunohistochemistry; human; 1:500; fig 6
  • western blot; human; fig 4
Gao X, Feng J, He Y, Xu F, Fan X, Huang W, et al. hnRNPK inhibits GSK3β Ser9 phosphorylation, thereby stabilizing c-FLIP and contributes to TRAIL resistance in H1299 lung adenocarcinoma cells. Sci Rep. 2016;6:22999 pubmed publisher
  • western blot; pigs ; loading ...; fig 7c
Wang G, Yang H, Yan S, Wang C, Liu X, Zhao B, et al. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Mol Neurodegener. 2015;10:42 pubmed publisher
  • immunocytochemistry; human; fig 7d
  • western blot; human; 1:1000
Haeusler A, Donnelly C, Periz G, Simko E, Shaw P, Kim M, et al. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 2014;507:195-200 pubmed publisher
de la Cruz Herrera C, Tatham M, Siddiqi U, Shire K, Marcon E, Greenblatt J, et al. Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1. PLoS Pathog. 2023;19:e1011477 pubmed publisher
Harley J, Hagemann C, Serio A, Patani R. TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain. Brain Commun. 2021;3:fcab166 pubmed publisher
Nguyen T, Kabotyanski E, Reineke L, Shao J, Xiong F, Lee J, et al. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020;48:2621-2642 pubmed publisher
Schertzer M, Braceros K, Starmer J, Cherney R, Lee D, Salazar G, et al. lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA. Mol Cell. 2019;: pubmed publisher
LaPointe A, Gebhart N, Meller M, Hardy R, Sokoloski K. Identification and Characterization of Sindbis Virus RNA-Host Protein Interactions. J Virol. 2018;92: pubmed publisher
Güzel N, Kasap M, Kanli A, Akpinar G, Gulkac M, Karaosmanoglu K. Exogenous Expressions of FTO Wild-Type and R316Q Mutant Proteins Caused an Increase in HNRPK Levels in 3T3-L1 Cells as Demonstrated by DIGE Analysis. Biomed Res Int. 2017;2017:8216180 pubmed publisher
Barboro P, Borzi L, Repaci E, Ferrari N, Balbi C. Androgen receptor activity is affected by both nuclear matrix localization and the phosphorylation status of the heterogeneous nuclear ribonucleoprotein K in anti-androgen-treated LNCaP cells. PLoS ONE. 2013;8:e79212 pubmed publisher
Gross H, Hennard C, Masouris I, Cassel C, Barth S, Stober Gr sser U, et al. Binding of the heterogeneous ribonucleoprotein K (hnRNP K) to the Epstein-Barr virus nuclear antigen 2 (EBNA2) enhances viral LMP2A expression. PLoS ONE. 2012;7:e42106 pubmed publisher
Guo Y, Zhao J, Bi J, Wu Q, Wang X, Lai Q. Heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a tissue biomarker for detection of early hepatocellular carcinoma in patients with cirrhosis. J Hematol Oncol. 2012;5:37 pubmed publisher
Barboro P, Repaci E, Rubagotti A, Salvi S, Boccardo S, Spina B, et al. Heterogeneous nuclear ribonucleoprotein K: altered pattern of expression associated with diagnosis and prognosis of prostate cancer. Br J Cancer. 2009;100:1608-16 pubmed publisher
Burnham A, Gong L, Hardy R. Heterogeneous nuclear ribonuclear protein K interacts with Sindbis virus nonstructural proteins and viral subgenomic mRNA. Virology. 2007;367:212-21 pubmed
Gorla L, Cantu M, Miccichè F, Patelli C, Mondellini P, Pierotti M, et al. RET oncoproteins induce tyrosine phosphorylation changes of proteins involved in RNA metabolism. Cell Signal. 2006;18:2272-82 pubmed
product information
Catalog Number :
sc-28380
Product Name :
hnRNP K (D-6) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
D-6
Isotype :
IgG2a
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
hnRNP K
Specificity :
mouse, rat, human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA