product summary
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company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
SQSTM1 (D-3) Antibody
catalog :
sc-28359
quantity :
200 µg/ml
price :
316 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
D-3
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, proximity ligation assay, western blot knockout validation
citations: 140
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:1000; loading ...; fig 4b
  • immunocytochemistry; human; 1:1000; loading ...; fig 5d
Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, et al. p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance. Oncogene. 2019;38:1905-1919 pubmed publisher
  • western blot; human; 1:3000; loading ...; fig 7c
Zhang H, Yang X, Zhu L, Li Z, Zuo P, Wang P, et al. ASPM promotes hepatocellular carcinoma progression by activating Wnt/β-catenin signaling through antagonizing autophagy-mediated Dvl2 degradation. FEBS Open Bio. 2021;11:2784-2799 pubmed publisher
  • western blot; human; 1:1000; fig 2e
Ray U, Roy D, Jin L, Thirusangu P, Staub J, Xiao Y, et al. Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization. J Exp Clin Cancer Res. 2021;40:182 pubmed publisher
  • western blot; human; loading ...; fig 4a
Dahou H, Minati M, Jacquemin P, Assi M. Genetic Inactivation of Peroxiredoxin-I Impairs the Growth of Human Pancreatic Cancer Cells. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; human; loading ...; fig 3c
Tao S, Yang Y, Li J, Wang H, Ma Y. Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPARα Signals. Oxid Med Cell Longev. 2021;2021:6610124 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 5d
  • western blot; mouse; 1:1000; loading ...; fig 5a
Chung L, Liu S, Huang S, Salter D, Lee H, Hsu Y. High phosphate induces skeletal muscle atrophy and suppresses myogenic differentiation by increasing oxidative stress and activating Nrf2 signaling. Aging (Albany NY). 2020;12:21446-21468 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4e
Li Z, Zhang H, Huang Y, Huang J, Sun P, Zhou N, et al. Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation. Nat Commun. 2020;11:3806 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a
Lanzillotta C, Zuliani I, Vasavda C, Snyder S, Paul B, Perluigi M, et al. BVR-A Deficiency Leads to Autophagy Impairment through the Dysregulation of AMPK/mTOR Axis in the Brain-Implications for Neurodegeneration. Antioxidants (Basel). 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 1d
Kumar V, Ayasolla K, Jha A, Mishra A, Vashistha H, Lan X, et al. Disrupted APOL1-miR193a Axis Dedifferentiates Podocytes through Autophagy Blockade in APOL1 Risk Milieu. Am J Physiol Cell Physiol. 2019;: pubmed publisher
  • immunohistochemistry; human; loading ...; fig 8a
Huang X, Gan G, Wang X, Xu T, Xie W. The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance. Autophagy. 2019;15:1258-1279 pubmed publisher
  • western blot; human; loading ...; fig 5f
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, et al. Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab. Oncogene. 2019;38:3458-3474 pubmed publisher
  • western blot; human; loading ...; fig 1a
Wang W, Xia Z, Farre J, Subramani S. TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. Autophagy. 2018;14:1574-1585 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Skowron M, Niegisch G, Albrecht P, Van Koeveringe G, Romano A, Albers P, et al. Various Mechanisms Involve the Nuclear Factor (Erythroid-Derived 2)-Like (NRF2) to Achieve Cytoprotection in Long-Term Cisplatin-Treated Urothelial Carcinoma Cell Lines. Int J Mol Sci. 2017;18: pubmed publisher
  • western blot; human; 1:200; loading ...; fig 2a
Dai S, Dulcey A, Hu X, Wassif C, Porter F, Austin C, et al. Methyl-β-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 2017;13:1435-1451 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig s1f
Bakula D, Müller A, Zuleger T, Takacs Z, Franz Wachtel M, Thost A, et al. WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy. Nat Commun. 2017;8:15637 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s5e
Ramírez Peinado S, Ignashkova T, van Raam B, Baumann J, Sennott E, Gendarme M, et al. TRAPPC13 modulates autophagy and the response to Golgi stress. J Cell Sci. 2017;130:2251-2265 pubmed publisher
  • western blot; human; loading ...; fig 4c
Tawo R, Pokrzywa W, Kevei E, Akyuz M, Balaji V, Adrian S, et al. The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover. Cell. 2017;169:470-482.e13 pubmed publisher
  • western blot; human; loading ...; fig 3a
Tsai C, Li C, Cheng Y, Lee C, Liao P, Lin C, et al. The inhibition of lung cancer cell migration by AhR-regulated autophagy. Sci Rep. 2017;7:41927 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 6c
  • western blot; human; loading ...; fig 3a
Sun A, Wei J, Childress C, Shaw J, Peng K, Shao G, et al. The E3 ubiquitin ligase NEDD4 is an LC3-interactive protein and regulates autophagy. Autophagy. 2017;13:522-537 pubmed publisher
  • western blot; human; loading ...; fig 2e
Capizzi M, Strappazzon F, Cianfanelli V, Papaleo E, Cecconi F. MIR7-3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1. Autophagy. 2017;13:554-566 pubmed publisher
  • western blot; human; fig s2a
Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4a
Wei R, Lin S, Wu W, Chen L, Li C, Chen H, et al. A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells. Toxicol Appl Pharmacol. 2016;311:88-98 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 6e
  • immunocytochemistry; human; loading ...; fig 6d
  • western blot; human; loading ...; fig 6a
  • western blot; mouse; loading ...; fig 2b
Chi H, Chen S, Tsai C, Chuang W, Huang Y, Tsai M, et al. Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy. Autophagy. 2016;12:2271-2285 pubmed
  • immunohistochemistry - paraffin section; human; 1:1000; fig 1
Schmitz K, Ademi C, Bertram S, Schmid K, Baba H. Prognostic relevance of autophagy-related markers LC3, p62/sequestosome 1, Beclin-1 and ULK1 in colorectal cancer patients with respect to KRAS mutational status. World J Surg Oncol. 2016;14:189 pubmed publisher
  • western blot; human; 1:1000; fig 4
Hu Z, Zhong Z, Huang S, Wen H, Chen X, Chu H, et al. Decreased expression of Beclin?1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma. Mol Med Rep. 2016;14:1567-73 pubmed publisher
  • immunocytochemistry; human; 1:800; fig 6
  • western blot; human; 1:1000; fig 3
Andersson A, Andersson B, Lorell C, Raffetseder J, Larsson M, Blomgran R. Autophagy induction targeting mTORC1 enhances Mycobacterium tuberculosis replication in HIV co-infected human macrophages. Sci Rep. 2016;6:28171 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1a
Koskela A, Reinisalo M, Petrovski G, Sinha D, Olmiere C, Karjalainen R, et al. Nutraceutical with Resveratrol and Omega-3 Fatty Acids Induces Autophagy in ARPE-19 Cells. Nutrients. 2016;8: pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 9e
Ruiz R, Pérez Villegas E, Bachiller S, Rosa J, Armengol J. HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study. Front Neuroanat. 2016;10:42 pubmed publisher
  • western blot; human; fig 1
Dey A, Mustafi S, Saha S, Kumar Dhar Dwivedi S, Mukherjee P, Bhattacharya R. Inhibition of BMI1 induces autophagy-mediated necroptosis. Autophagy. 2016;12:659-70 pubmed publisher
  • western blot; human; loading ...; fig s15c
Park J, Jung C, Seo M, Otto N, Grunwald D, Kim K, et al. The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14. Autophagy. 2016;12:547-64 pubmed publisher
  • western blot; human; fig 3
Bretin A, Carrière J, Dalmasso G, Bergougnoux A, B chir W, Maurin A, et al. Activation of the EIF2AK4-EIF2A/eIF2?-ATF4 pathway triggers autophagy response to Crohn disease-associated adherent-invasive Escherichia coli infection. Autophagy. 2016;12:770-83 pubmed publisher
  • immunocytochemistry; mouse; fig s5
Budina Kolomets A, Webster M, Leu J, Jennis M, Krepler C, Guerrini A, et al. HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016;76:2720-30 pubmed publisher
  • western blot; human; 1:2000; fig 3d
Choi W, de Poot S, Lee J, Kim J, Han D, Kim Y, et al. Open-gate mutants of the mammalian proteasome show enhanced ubiquitin-conjugate degradation. Nat Commun. 2016;7:10963 pubmed publisher
  • western blot; human; 1:250; fig 5
Stefanovic M, Tutusaus A, Martinez Nieto G, Bárcena C, de Gregorio E, Moutinho C, et al. Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma. Oncotarget. 2016;7:8253-67 pubmed publisher
  • western blot; human; fig 1
Goulielmaki M, Koustas E, Moysidou E, Vlassi M, Sasazuki T, Shirasawa S, et al. BRAF associated autophagy exploitation: BRAF and autophagy inhibitors synergise to efficiently overcome resistance of BRAF mutant colorectal cancer cells. Oncotarget. 2016;7:9188-221 pubmed publisher
  • western blot; mouse; fig 1
Chen Y, Tsou B, Hu S, Ma H, Liu X, Yen Y, et al. Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells. Oncotarget. 2016;7:1984-99 pubmed publisher
  • western blot; human; fig 6
Fuchs M, Luthold C, Guilbert S, Varlet A, Lambert H, Jetté A, et al. A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis. PLoS Genet. 2015;11:e1005582 pubmed publisher
  • western blot; human; loading ...; fig 3a
Jeon J, Kim S, Park K, Yun M. The bifunctional autophagic flux by 2-deoxyglucose to control survival or growth of prostate cancer cells. BMC Cancer. 2015;15:623 pubmed publisher
  • western blot; rat; 1:1000; fig 3g
Zhang J, Tripathi D, Jing J, Alexander A, Kim J, Powell R, et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat Cell Biol. 2015;17:1259-1269 pubmed publisher
  • western blot; human; 1:1000
Wang Z, Li S, Ren R, Li J, Cui X. Recombinant Buckwheat Trypsin Inhibitor Induces Mitophagy by Directly Targeting Mitochondria and Causes Mitochondrial Dysfunction in Hep G2 Cells. J Agric Food Chem. 2015;63:7795-804 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2f
Coutts A, La Thangue N. Actin nucleation by WH2 domains at the autophagosome. Nat Commun. 2015;6:7888 pubmed publisher
  • western blot; human; 1:500; fig 4
Sargsyan A, Cai J, Fandino L, Labasky M, Forostyan T, Colosimo L, et al. Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor. Sci Rep. 2015;5:12397 pubmed publisher
  • immunocytochemistry; human; fig s14
  • western blot; human; 1:1000; fig s14
Ohashi A, Ohori M, Iwai K, Nakayama Y, Nambu T, Morishita D, et al. Aneuploidy generates proteotoxic stress and DNA damage concurrently with p53-mediated post-mitotic apoptosis in SAC-impaired cells. Nat Commun. 2015;6:7668 pubmed publisher
  • immunocytochemistry; human; fig 3
  • western blot; human; fig 5
Cha Molstad H, Sung K, Hwang J, Kim K, Yu J, Yoo Y, et al. Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding. Nat Cell Biol. 2015;17:917-29 pubmed publisher
  • western blot; human; fig 3
García Cano J, Ambroise G, Pascual Serra R, Carrión M, Serrano Oviedo L, Ortega Muelas M, et al. Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance. Oncotarget. 2015;6:15551-65 pubmed
  • proximity ligation assay; human; 1:200; fig 1
  • immunocytochemistry; human; 1:200; fig 1
Gauthier T, Claude Taupin A, Delage Mourroux R, Boyer Guittaut M, Hervouet E. Proximity Ligation In situ Assay is a Powerful Tool to Monitor Specific ATG Protein Interactions following Autophagy Induction. PLoS ONE. 2015;10:e0128701 pubmed publisher
  • western blot; human; fig 3
Luan Q, Jin L, Jiang C, Tay K, Lai F, Liu X, et al. RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy. Autophagy. 2015;11:975-94 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 6
  • western blot; human; 1:2000; fig 5
Sun T, Li X, Zhang P, Chen W, Zhang H, Li D, et al. Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Nat Commun. 2015;6:7215 pubmed publisher
  • western blot; human
Tatti M, Motta M, Scarpa S, Di Bartolomeo S, Cianfanelli V, Tartaglia M, et al. BCM-95 and (2-hydroxypropyl)-β-cyclodextrin reverse autophagy dysfunction and deplete stored lipids in Sap C-deficient fibroblasts. Hum Mol Genet. 2015;24:4198-211 pubmed publisher
  • western blot; human; fig 5
Brohée L, Demine S, Willems J, Arnould T, Colige A, Deroanne C. Lipin-1 regulates cancer cell phenotype and is a potential target to potentiate rapamycin treatment. Oncotarget. 2015;6:11264-80 pubmed
  • western blot; human; fig 2
Crauwels P, Bohn R, Thomas M, Gottwalt S, Jäckel F, Krämer S, et al. Apoptotic-like Leishmania exploit the host's autophagy machinery to reduce T-cell-mediated parasite elimination. Autophagy. 2015;11:285-97 pubmed publisher
  • western blot; mouse
Roux C, Aligny C, Lesueur C, Girault V, Brunel V, Ramdani Y, et al. NMDA receptor blockade in the developing cortex induces autophagy-mediated death of immature cortical GABAergic interneurons: An ex vivo and in vivo study in Gad67-GFP mice. Exp Neurol. 2015;267:177-93 pubmed publisher
  • western blot; human; 1:200; fig 1,2,3,4,5,6,7
Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 4b
Guo S, Liang Y, Murphy S, Huang A, Shen H, Kelly D, et al. A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications. Autophagy. 2015;11:560-72 pubmed publisher
  • western blot; human; fig 3c
Kim E, Shin J, Park S, Jo Y, Kim J, Kang I, et al. Inhibition of autophagy suppresses sertraline-mediated primary ciliogenesis in retinal pigment epithelium cells. PLoS ONE. 2015;10:e0118190 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Xu L, Long Z, Peng F, Liu Y, Xu J, Wang C, et al. Aurora kinase a suppresses metabolic stress-induced autophagic cell death by activating mTOR signaling in breast cancer cells. Oncotarget. 2014;5:7498-511 pubmed
  • western blot; human; fig 5b
Zaganjor E, Weil L, Gonzales J, Minna J, Cobb M. Ras transformation uncouples the kinesin-coordinated cellular nutrient response. Proc Natl Acad Sci U S A. 2014;111:10568-73 pubmed publisher
  • western blot; human; fig 3
Loukil A, Zonca M, Rebouissou C, Baldin V, Coux O, Biard Piechaczyk M, et al. High-resolution live-cell imaging reveals novel cyclin A2 degradation foci involving autophagy. J Cell Sci. 2014;127:2145-50 pubmed publisher
  • immunocytochemistry; human; 1:250; fig 6
  • western blot; human; 1:1500
Poillet L, Pernodet N, Boyer Guittaut M, Adami P, Borg C, Jouvenot M, et al. QSOX1 inhibits autophagic flux in breast cancer cells. PLoS ONE. 2014;9:e86641 pubmed publisher
  • western blot; human; fig 6f
Balaburski G, Leu J, Beeharry N, Hayik S, Andrake M, Zhang G, et al. A modified HSP70 inhibitor shows broad activity as an anticancer agent. Mol Cancer Res. 2013;11:219-29 pubmed publisher
Gui Y, Qian X, Ding Y, Chen Q, Fangyu Ye -, Ye Y, et al. c-Fos regulated by TMPO/ERK axis promotes 5-FU resistance via inducing NANOG transcription in colon cancer. Cell Death Dis. 2024;15:61 pubmed publisher
Varland S, Silva R, Kjos xe5 s I, Faustino A, Bogaert A, Billmann M, et al. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nat Commun. 2023;14:6774 pubmed publisher
Park J, Lee D, Kim D. Redefining the role of AMPK in autophagy and the energy stress response. Nat Commun. 2023;14:2994 pubmed publisher
Pellegrini F, De Martino S, Fianco G, Ventura I, Valente D, Fiore M, et al. Blockage of autophagosome-lysosome fusion through SNAP29 O-GlcNAcylation promotes apoptosis via ROS production. Autophagy. 2023;19:2078-2093 pubmed publisher
Cho Y, Jeong Y, Song K, Chung I, Magae J, Kwon T, et al. 4-O-Methylascochlorin-Mediated BNIP-3 Expression Controls the Balance of Apoptosis and Autophagy in Cervical Carcinoma Cells. Int J Mol Sci. 2022;23: pubmed publisher
Tan J, Finkel T. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. 2022;609:815-821 pubmed publisher
Lin Y, Huang C, Gao H, Li X, Lin Q, Zhou S, et al. AMBRA1 promotes dsRNA- and virus-induced apoptosis through interacting with and stabilizing MAVS. J Cell Sci. 2022;135: pubmed publisher
Lai J, Lian Y, Wu J, Wang Y, Bai Y. Verapamil induces autophagy to improve liver regeneration in non-alcoholic fatty liver mice. Adipocyte. 2021;10:532-545 pubmed publisher
Zhao X, Liberti R, Jian J, Fu W, Hettinghouse A, Sun Y, et al. Progranulin associates with Rab2 and is involved in autophagosome-lysosome fusion in Gaucher disease. J Mol Med (Berl). 2021;99:1639-1654 pubmed publisher
Peng K, Sun A, Zhu J, Gao J, Li Y, Shao G, et al. Restoration of the ATG5-dependent autophagy sensitizes DU145 prostate cancer cells to chemotherapeutic drugs. Oncol Lett. 2021;22:638 pubmed publisher
Hsu M, Hsiao Y, Lin Y, Chen C, Lee C, Liao W, et al. Quercetin Alleviates the Accumulation of Superoxide in Sodium Iodate-Induced Retinal Autophagy by Regulating Mitochondrial Reactive Oxygen Species Homeostasis through Enhanced Deacetyl-SOD2 via the Nrf2-PGC-1α-Sirt1 Pathway. Antioxidants (Basel). 2021;10: pubmed publisher
Ohnishi K, Yano S, Fujimoto M, Sakai M, Harumoto E, Furuichi A, et al. Identification of Dietary Phytochemicals Capable of Enhancing the Autophagy Flux in HeLa and Caco-2 Human Cell Lines. Antioxidants (Basel). 2020;9: pubmed publisher
Ogasawara M, Iida A, Kumutpongpanich T, Ozaki A, Oya Y, Konishi H, et al. CGG expansion in NOTCH2NLC is associated with oculopharyngodistal myopathy with neurological manifestations. Acta Neuropathol Commun. 2020;8:204 pubmed publisher
Chang J, Kam K, Chao W, Zhao P, Chen S, Chung H, et al. Berberine Derivatives Suppress Cellular Proliferation and Tumorigenesis In Vitro in Human Non-Small-Cell Lung Cancer Cells. Int J Mol Sci. 2020;21: pubmed publisher
Chu Y, Kang Y, Yan C, Yang C, Zhang T, Huo H, et al. LUBAC and OTULIN regulate autophagy initiation and maturation by mediating the linear ubiquitination and the stabilization of ATG13. Autophagy. 2020;:1-16 pubmed publisher
Lee D, Park S, Huh Y, Jung Kim M, Seo H, Ha T, et al. Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy. Biomed Pharmacother. 2020;125:109950 pubmed publisher
Nawas A, Kanchwala M, Thomas Jardin S, Dahl H, Daescu K, Bautista M, et al. IL-1-conferred gene expression pattern in ERα+ BCa and AR+ PCa cells is intrinsic to ERα- BCa and AR- PCa cells and promotes cell survival. BMC Cancer. 2020;20:46 pubmed publisher
Martisova A, Sommerova L, Kuricová K, Podhorec J, Vojtesek B, Kankova K, et al. AGR2 silencing contributes to metformin-dependent sensitization of colorectal cancer cells to chemotherapy. Oncol Lett. 2019;18:4964-4973 pubmed publisher
Denu R, Kaur G, Sass M, Lakkaraju A, Burkard M. Centrosome Amplification in Cancer Disrupts Autophagy and Sensitizes to Autophagy Inhibition. Mol Cancer Res. 2019;: pubmed publisher
Lee J, Tabata K, Twu W, Rahman M, Kim H, Yu J, et al. RACK1 mediates rewiring of intracellular networks induced by hepatitis C virus infection. PLoS Pathog. 2019;15:e1008021 pubmed publisher
Bouhamdani N, Comeau D, Cormier K, Turcotte S. STF-62247 accumulates in lysosomes and blocks late stages of autophagy to selectively target von Hippel-Lindau-inactivated cells. Am J Physiol Cell Physiol. 2019;316:C605-C620 pubmed publisher
Lazaro I, Lopez Sanz L, Bernal S, Oguiza A, Recio C, Melgar A, et al. Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms. Front Pharmacol. 2018;9:819 pubmed publisher
Brohée L, Peulen O, Nusgens B, Castronovo V, Thiry M, Colige A, et al. Propranolol sensitizes prostate cancer cells to glucose metabolism inhibition and prevents cancer progression. Sci Rep. 2018;8:7050 pubmed publisher
Lassak A, Dean M, Wyczechowska D, Wilk A, Marrero L, Trillo Tinoco J, et al. Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival. Mol Cell Biol. 2018;38: pubmed publisher
Kondratskyi A, Kondratska K, Vanden Abeele F, Gordienko D, Dubois C, Toillon R, et al. Ferroquine, the next generation antimalarial drug, has antitumor activity. Sci Rep. 2017;7:15896 pubmed publisher
Alegre F, Moragrega A, Polo M, Marti Rodrigo A, Esplugues J, Blas García A, et al. Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug-induced toxicity in vitro. Br J Pharmacol. 2017;: pubmed publisher
Li S, Xu L, Zhou W, YAO S, Wang C, Xia J, et al. p62/SQSTM1 interacts with vimentin to enhance breast cancer metastasis. Carcinogenesis. 2017;38:1092-1103 pubmed publisher
Poillet Perez L, Jacquet M, Hervouet E, Gauthier T, Fraichard A, Borg C, et al. GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells. Oncotarget. 2017;8:55998-56020 pubmed publisher
Ndoye A, Budina Kolomets A, Kugel C, Webster M, Kaur A, Behera R, et al. ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma. Cancer Res. 2017;77:5873-5885 pubmed publisher
de Oliveira R, Vicente Miranda H, Francelle L, Pinho R, Szego E, Martinho R, et al. The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease. PLoS Biol. 2017;15:e2000374 pubmed publisher
Jeong J, Yu K, Bak D, Lee J, Lee N, Jeong Y, et al. Intermittent fasting is neuroprotective in focal cerebral ischemia by minimizing autophagic flux disturbance and inhibiting apoptosis. Exp Ther Med. 2016;12:3021-3028 pubmed
Sone J, Mori K, Inagaki T, Katsumata R, Takagi S, Yokoi S, et al. Clinicopathological features of adult-onset neuronal intranuclear inclusion disease. Brain. 2016;139:3170-3186 pubmed
Xie M, Yu Y, Kang R, Zhu S, Yang L, Zeng L, et al. PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation. Nat Commun. 2016;7:13280 pubmed publisher
Wei Y, Liu D, Jin X, GAO P, Wang Q, Zhang J, et al. PA-MSHA inhibits the growth of doxorubicin-resistant MCF-7/ADR human breast cancer cells by downregulating Nrf2/p62. Cancer Med. 2016;5:3520-3531 pubmed publisher
Zhou J, Yao K, Zhang Y, Chen G, Lai K, Yin H, et al. Thioredoxin Binding Protein-2 Regulates Autophagy of Human Lens Epithelial Cells under Oxidative Stress via Inhibition of Akt Phosphorylation. Oxid Med Cell Longev. 2016;2016:4856431 pubmed
Ahola S, Auranen M, Isohanni P, Niemisalo S, Urho N, Buzková J, et al. Modified Atkins diet induces subacute selective ragged-red-fiber lysis in mitochondrial myopathy patients. EMBO Mol Med. 2016;8:1234-1247 pubmed publisher
Cubillos Rojas M, Schneider T, Hadjebi O, Pedrazza L, de Oliveira J, Langa F, et al. The HERC2 ubiquitin ligase is essential for embryonic development and regulates motor coordination. Oncotarget. 2016;7:56083-56106 pubmed publisher
Nuylan M, Kawano T, Inazawa J, Inoue J. Down-regulation of LAPTM5 in human cancer cells. Oncotarget. 2016;7:28320-8 pubmed publisher
Zhao F, Huang W, Zhang Z, Mao L, Han Y, Yan J, et al. Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells. Oncotarget. 2016;7:5366-82 pubmed publisher
Lu Q, Yan S, Sun H, Wang W, Li Y, Yang X, et al. Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Cell Death Dis. 2015;6:e2005 pubmed publisher
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product information
Catalog Number :
sc-28359
Product Name :
SQSTM1 (D-3) Antibody
Product Type :
Monoclonal
Host Species :
mouse
Clonality :
monoclonal
Clone Name :
D-3
Isotype :
IgG1
Size :
200 µg/ml
List Price :
316 USD
Immunogen :
SQSTM1
Specificity :
human
Uses :
WB, IP, IF, IHC(P), ELISA
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
https://www.scbt.com
1.800.457.3801
headquarters: USA